The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia

Haematologica

Volumn 92, Issue 3, 2007, Pages 308-314

  Bolufer, Pascual ^a   Collado, Maria ^a   Barragán, Eva ^a   Cervera, José ^a   Calasanz, María José ^b   Colomer, Dolors ^c   Roman Gómez, José ^d   Sanz, Miguel A ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Acute leukemia; Drug metabolizing enzymes; Gender; Polymorphisms; Risk

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THYMIDYLATE SYNTHASE; CYP3A4 PROTEIN, HUMAN; GLUTATHIONE S-TRANSFERASE T1; GLUTATHIONE TRANSFERASE T1; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NQO1 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENDER; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC RISK; HOMOZYGOSITY; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; RISK ASSESSMENT; SEX DIFFERENCE; ACUTE DISEASE; ACUTE LYMPHOCYTIC LEUKEMIA; AGE; CELL TRANSFORMATION; DISEASE PREDISPOSITION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; INFANT; LEUKEMIA; METHODOLOGY; MIDDLE AGED; MYELOID LEUKEMIA; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRESCHOOL CHILD; RISK; SPAIN;

ACUTE DISEASE; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE SUSCEPTIBILITY; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE TRANSFERASE; HUMANS; INFANT; LEUKEMIA; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NAD(P)H DEHYDROGENASE (QUINONE); POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK; SEX FACTORS; SPAIN; THYMIDYLATE SYNTHASE;

EID: 34247600674     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.10752     Document Type: Article

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