Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children

Journal of Pediatric Hematology/Oncology

Volumn 32, Issue 4, 2010, Pages e148-e150

  Damnjanovic, Tatjana ^a   Milicevic, Radomir ^b   Novkovic, Tanja ^b   Jovicic, Olivera ^b   Bunjevacki, Vera ^a   Jekic, Biljana ^a   Lukovic, Ljiljana ^a   Novakovic, Ivana ^a   Redzic, Danka ^c   Milasin, Jelena ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b INSTITUTE FOR BASIC SCIENCE   (Serbia)

^c Mother and Child Health Institute Belgrade rs   (Serbia)

Author keywords

Acute lymphoblastic leukemia; MTHFR polymorphisms; Risk factor

Indexed keywords

METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CASE CONTROL STUDY; CHILD; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; INFANT; MALE; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; RISK FACTOR; SERBIA; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RISK FACTORS; SERBIA;

EID: 77952749179     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3181cbd252     Document Type: Article

References (13)

1. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001; 293: 1068-1670.
2. Duthie SJ. Folic acid instability and cancer: mechanism of DNA instability. Br Med Bull. 1999; 55: 578-592.
3. Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk. Am J Epidemiol. 2003; 157: 571-582.
4. Franco RF, Simões BP, Tone LG, et al. The methylenetetrahydrofolate reductase C677 T gene polymorphism decreases the risk of childhood acute lymphocytic leukemia. Br J Haemat. 2001; 115: 616-618.
5. Wiemels JL, Smith RN, Taylor GM, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci. 2001; 98: 4004-4009.
6. Skibola CF, Smith MT, Kane E, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci. 1999; 96: 5606-5611.
7. Krajinovic M, Lamothe S, Labuda D, et al. The role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004; 103: 252-257.
8. Schnakenberg E, Mehles A, Cario G, et al. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet. 2005; 6: 23.
9. Chiusolo P, Reddiconto G, Cimino G, et al. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica. 2004; 89: 139-144.
10. Amorim MR, Zanrosso CW, Magalhães IQ, et al. MTHFR 677C-> T and 1298A-> C polymorphisms in children with Down syndrome and acute myeloid leukemia in Brazil. Pediatr Hematol Oncol. 2008; 25: 744-750.
11. Oliveira E, Alves S, Quental S, et al. The MTHFR C677 T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol. 2005; 27: 425-429.
12. Sinnett D, Labuda D, Krajinovic M. Challenges identifying genetic determinants of pediatric cancers--the childhood leukemia experience. Fam Cancer. 2006; 5: 35-47.
13. Nückel H, Frey UH, Dürig J, et al. Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia. Leukemia. 2004; 18: 1816-1823.