Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia

Chinese Journal of Medical Genetics

Volumn 30, Issue 4, 2013, Pages 451-455

  Zheng, Miao Miao ^a   Yue, Li Jie ^a   Zhang, Hong Hong ^a   Yang, Chun Lan ^a   Xie, Cai ^a  

^a SHENZHEN CHILDREN'S HOSPITAL   (China)

Author keywords

Acute lymphoblastic leukemia; Acute myeloid leukemia; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CANCER RISK; CHINESE; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE DISEASE; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; LEUKEMIA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84883499962     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.1003-9406.2013.04.016     Document Type: Article

References (15)

1. Yang TY. Acute leukemia. In: Zhang ZN. ed. Criteria of diagnosis and therapeutic efficacy in hamatoloigic diseases. 2nd ed. Beijing: Science Press, 1998. 168-214.
2. Tong N, Sheng X, Wang M, et al. Methylenetetrahydrofolate reductase gene polymorphism and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies. Leuk Lymphoma, 2011, 52:1949-1960.
3. Skibola CF, Smith MT, Kane E, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A, 1999, 96:12810-12815. (Pubitemid 29513584)
4. Nikbakht M, MalekZadeh K, Kumar JHA, et al. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India. Exp Oncol, 2012, 34:43-48.
5. Lightfoot TJ, Johnston WT, Painter D, et al. Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood, 2010, 115:3923-3929.
6. Tong N, Fang Y, Li J, et al. Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population. Cancer Sci, 2010, 101:782-786.
7. Kim HN, Kim YK, Lee IK, et al. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Leuk Res, 2009, 33:82-87.
8. Ramos FJ, Muniz MT, Silva VC, et al. Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children. Leuk Lymphoma, 2006, 47:2070-2075. (Pubitemid 44650082)
9. Hur M, Park JY, Cho HC, et al. Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population. Clin Lab Haematol, 2006, 28:154-159.
10. Moon HW, Kim TY, Oh BR, et al. MTHFR 677CC/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea. Leuk Res, 2007, 31:1213-1217.
11. Vahid P, Farnaz R, Zaker F, et al. Methylenetetrahydrofolate reductase gene polymorphisms and risk of myeloid leukemia. Labmedicine, 2010, 41:490-494.
12. Robien K, Ulrich CM. 5, 10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol, 2003, 157:571-582. (Pubitemid 36368527)
13. Hussain SR, Naqvi H, Raza ST, et al. Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population. Cancer Epidemiol, 2012, 36:e227-231.
14. Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood, 2004, 103:252-257. (Pubitemid 38029946)
15. Chiusolo P, Reddiconto G, Cimino G, et al. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica, 2004, 89:139-144. (Pubitemid 38796487)