Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood all in North India

Experimental Oncology

Volumn 34, Issue 1, 2012, Pages 43-48

  Nikbakht, M ^a,d   MalekZadeh, K ^b   Kumar Jha, A ^a   Askari, M ^a   Marwaha, R K ^a   Kaul, D ^c   Kaur, J ^a  

^a PANJAB UNIVERSITY   (India)

^b HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

5 Methyltetrahydrofolate homocysteine methyltransferase; Acute lymphoblastic leukemia; Hypomethylation; Methylenetetrahydrofolate reductase

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC CORRELATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INDIA; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADOLESCENT; AGE FACTORS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; INFANT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84862496495     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535-48.
2. Lichtman M, Beutler E, Kaushansky K, Kipps T, Seligsohn U, Prchal J. William's Hematology. 7th Edition. McGraw-Hill: 2005.
3. Sinnett D, Krajinovic M, Labuda D. Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma 2000; 38: 447-62. (Pubitemid 30614530)
4. Young-In K. Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutrition Rev 2009; 58: 205-09.
5. Wagner C. Biochemical role of folate in cellular metabolism. In: Folate in Health and Disease. Bailey L.B. eds. Marcel Dekker. New York1995: 23-42.
6. Miller JW, Nadeau MR, Smith J, et al. Folate deficiency- induced homocysteinemia in rats: disruption of S-adenosylmethionine coordinate regulation of homocysteine metabolism. Biochem J 1994; 298: 415-9.
7. Ryan BM, Weir DG. Relevance of folate metabolism in the pathogenesis of colorectal cancer. J Lab Clin Med 2001; 138: 164-76. (Pubitemid 32812229)
8. Duthie SJ, Narayanan S, Brand GM, et al. Impact of folate deficiency on DNA stability. J Nutr 2002; 132: 2444-9.
9. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004; 328: 211-4. (Pubitemid 38147076)
10. Skibola CF, Smith MT, Kane L, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 1999; 96: 12810-5. (Pubitemid 29513584)
11. Dianov GL, Timchenko TV, Sinitsina OI, et al. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol Gen Genet 1991; 225: 448-52.
12. Goyette P, Summers JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification. Nat Genet 1994; 7: 195-200. (Pubitemid 24174661)
13. de Franchis R, Sebastio G, Mandato C, et al. Spina bifida. 677T->C mutation, and role of folate. Lancet 1995; 346: 1703. (Pubitemid 26003335)
14. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
15. Botto N, Andreassi MG, Manfredi S, et al. Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur J Hum Genet 2003; 11: 671-8. (Pubitemid 37160988)
16. Lightfoot TJ, Skibola CF, Willett EV, et al. Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. Cancer Epidemiol Biomarkers Prev 2005; 14: 2999-3003.
17. van der Put NMJ, Gabreels F, Stevens EMB, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998; 26: 1044-51.
18. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998; 95: 13217-20. (Pubitemid 28509551)
19. Etienne MC, Ilc K, Formento JL, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer 2004; 90: 526-34. (Pubitemid 38250655)
20. Leclerc D, Campeau E, Goyette P, et al. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cbIG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996; 5: 1867-74. (Pubitemid 26413628)
21. Matsuo K, Suzuki R, Hamajima N, et al. Association between polymorphisms of folateand methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 2001; 97: 3205-9.
22. Kim YI. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999; 10: 66-88.
23. Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a huge minireview. Am J Epidemiol 2003; 157: 571-82. (Pubitemid 36368527)
24. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 2002; 132: 2350S-5.
25. Kim YI. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev 1999; 57: 314-21.
26. Ma J, Stampfer MJ, Giovannucci E, et al. Methyl-enetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57: 1098-102. (Pubitemid 27138608)
27. Pogribny IP, Muskhelishvili L, Miller BJ, James SJ. Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats. Carcinogenesis 1997; 18: 2071-7.
28. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998; 95: 13217-20. (Pubitemid 28509551)
29. Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520-6. (Pubitemid 29001189)
30. Friso S, Choi SW, Girelli D, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002; 99: 5606-11. (Pubitemid 34411596)
31. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998; 95: 13217-20. (Pubitemid 28509551)
32. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94: 3290-5.
33. Wiemels JL, Smith RN, Taylor GM, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001; 98: 4004-9. (Pubitemid 32249888)
34. Sood S, Das R, Trehan A, et al. Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians. Leukemia Lymphoma 2010; 51: 928-32.
35. Skibola CF, Smith MT, Hubbard A, et al. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 2002; 99: 3786-91. (Pubitemid 34534552)
36. Gemmati D, Ongaro A, Scapoli GL, et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004; 13: 787-94. (Pubitemid 38737868)
37. Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2003; 103: 252-7.
38. de Jonge R, Tissing WJ, Hooijberg JH, et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood 2009; 113: 2284-9.
39. Reddy H, Jamil K. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma 2006; 47: 1333-9. (Pubitemid 44269642)
40. Yeoh AE, Lu Y, Chan JY, et al. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res 2010; 34: 276-83.
41. Wang J, Zhan P, Chen B, et al. MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leukemia Res 2010; 34: 1596-600.
42. Kamel AM, Moussa HS, Ebid GT, et al. Synergistic effect of methyltetrahydrofolate reductase (MTHFR), C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Nat Cancer Inst 2007: 19: 96-105.
43. Lincz LF, Scorgie FE, Kerridge I, et al. Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma. Br J Haematol 2003; 120: 1051-4. (Pubitemid 36411565)
44. Rosenberg N, Murata M, Ikeda Y, et al. The Frequent 5, 10-Methylenetetrahydrofolate Reductase C6677T Polymorphism is Associated with a Common Haplotype in Whites, Japanese and Africans. Am J Hum. Genet. 2002; 70 (3): 758-762. (Pubitemid 34177929)