5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children

Pediatric Blood and Cancer

Volumn 51, Issue 2, 2008, Pages 178-182

  Alcasabas, Patricia ^a,b   Ravindranath, Yaddanapudi ^b   Goyette, Gerard ^b   Haller, Andrew ^c   Del Rosario, Luz ^a   Lesaca Medina, Maria Ysabel ^a   Darga, Linda ^c   Ostrea Jr , Enrique M ^b   Taub, Jeffrey W ^b   Everson, Richard B ^c,d  

^a PHILIPPINE GENERAL HOSPITAL   (Philippines)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Cancer genetics; Epidemiology; Molecular biology of ALL

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE MARROW BIOPSY; CANCER GENETICS; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DNA ISOLATION; FILIPINO; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; INFANT; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MORPHOLOGY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD; FEMALE; GENETICS; LYMPHATIC LEUKEMIA; MALE; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK FACTORS;

EID: 45549104666     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21511     Document Type: Article

References (33)

1. Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997;94:3290-3295.
2. Koury MJ, Park DJ, Martincic D, et al. Folate deficiency delays the onset but increases the incidence of leukemia in friend virus-infected mice. Blood 1997;90:4054-4061.
3. Duthie SJ, Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J 1998;12:1 491-1497.
4. Robien K, Ulrich CM. 5,10-methylenetetrahydrofolate reductase polymorphisms and leukemia risk: A huge minireview. Am J Epidemiol 2003;157:571-582.
5. Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004;103:252-257.
6. Wiemels JL, Smith RN, Taylor GM, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001;98:4004-4009.
7. Thirumaran RK, Gast A, Flohr T, et al. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005;106:2590-2591, author reply 2591-2592.
8. Oliveira E, Alves S, Quental S, et al. The MTHFR C677T and Al298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol 2005;27:425-429.
9. Laudico AV, Esteban D. The department of health-Rizal cancer registry. IARC Sci Publ 1998;2:211-215.
10. Ries LAG, Hankey BF, Percy CL, et al. SEER Program, 1983-1992. In: Parkin EKDM, Draper GJ, Masuyer E, Michaelis J, Neglia J, Qureshi S, Stiller CA, editors. International incidence of childhood cancer, Vol. II. Lyon, France: International Agency for Research on Cancer; 1998. pp 131-142.
11. Cheong RL, Mardiaga JR, Desnacido JM, et al. Assessment of Folates status of some Filipino pregnant women. Philipp J Nutr 2002;49:3-4.
12. Munger RG, Sauberlich HE, Corcoran C, et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol 2004;70:464-471.
13. Murray JC, Daack-Hirsch S, Buetow KH, et al. Clinical and epidemiologic studies of cleft lip and palate in the Philippines. Cleft Palate Craniofac J 1997;34:7-10.
14. Singer VL, Jones LJ, Yue ST, et al. Characterization of picogreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation. Anal Biochem 1997;249:228-238.
15. Boyle EB, Steinbuch M, Tekautz T, et al. Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies. Cancer Epidemiol Biomarkers Prev 1998;7:1127-1131.
16. Aplenc R, Orudjev E, Swoyer J, et al. Differential bone marrow aspirate DNA yields from commercial extraction kits. Leukemia 2002;16:1865-1866.
17. Vince A, Poljak M, Seme K. DNA extraction from archival giemsa-stained bone-marrow slides: Comparison of six rapid methods. Br J Haematol 1998;101:349-351.
18. Sjoholm MI, Hoffmann G, Lindgren S, et al. Comparison of archival plasma and formalin-fixed paraffin-embedded tissue for genotyping in hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 2005;14:251-255.
19. Andreassen CN, Sorensen FB, Overgaard J, et al. Optimisation and validation of methods to assess single nucleotide polymorphisms (SNPS) in archival histological material. Radiother Oncol 2004;72:351-356.
20. Chen M, Xia B, Rodriguez-Gueant RM, et al. Genotypes 677TT and 677CT +1298ac of methylenetetrahydrofolate reductase are associated with the severity of ulcerative colitis in central china. Gut 2005;54:733-734.
21. Ling KH, Rosli R, Duraisamy G, et al. The prevalence of MTHFR 677C->T missense mutation, total plasma homocysteine levels and associated risk factors in Malay subjects. Med J Malays 2003;58:243-254.
22. Rady PL, Szucs S, Grady J, et al. Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A. Am J Med Genet 2002;107:162-168.
23. Keku T, Millikan R, Worley K, et al. 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and Whites. Cancer Epidemiol Biomarkers Prev 2002;11:1611-1621.
24. Zanrosso CW, Hatagima A, Emerenciano M, et al. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res 2006;30:477-481.
25. Pan American Health Organization. Health in the Americas edition Volume II. Washington, DC: PAHO Scientific Publication; 1998. pp 112-129.
26. Frisco S, Girelli D, Trabetti E, et al. The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lyphocytes. Cancer Epidemiol Biomarkers Prev 2005;14:938-943.
27. Miao X, Xing D, Tan W, et al. Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population. Cancer Epidemiol Biomarkers Prev 2002;11:1454-1458.
28. Das PM, Singal R. DNA methylation and cancer. J Clin Oncol 2004;22:4632-4642.
29. Marugame T, Tsuji E, Kiyohara C, et al. Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas. Int J Epidemiol 2003;32:64-66.
30. Margolin JF, Steuber CP, Poplack DG. Acute lymphoblastic leukemia. In: Pizzo PA, Poplack DG, editors. Priciples and practice of pediatric oncology. Philadelphia: Lippincott Williams and Wilkins; 2006. p 541.
31. Kham SK, Foo CT, Ariffin Hany A, et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism decreases risk of childhood acute lymphoblastic leukemia (ALL): A study of the Chinese and Malay population. Blood 2005;106:1459.
32. Aldrich MC, Zhang L, Wiemels JL, et al. Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev 2006;15:578-581.
33. Siraj AK, Kamat S, Gutierrez MI, et al. Frequencies of the major subgroups of precursor B-cell acute lymphoblastic leukemia in Indian children differ from the west. Leukemia 2003;17:1192-1193.