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Volumn 113, Issue 10, 2009, Pages 2284-2289

Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID DERIVATIVE; GLYCINE HYDROXYMETHYLTRANSFERASE; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; NICOTINAMIDE METHYLTRANSFERASE; REDUCED FOLATE CARRIER; THYMIDYLATE SYNTHASE;

EID: 64049110710     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-07-165928     Document Type: Article
Times cited : (136)

References (54)
  • 1
    • 0032573077 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetra-hydrofolates in red blood cells
    • Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetra-hydrofolates in red blood cells. Proc Natl Acad Sci U S A. 1998;95:13217-13220.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13217-13220
    • Bagley, P.J.1    Selhub, J.2
  • 2
    • 1042292043 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate
    • Sohn KJ, Croxford R, Yates Z, Lucock M, Kim YI. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst. 2004;96:134-144.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 134-144
    • Sohn, K.J.1    Croxford, R.2    Yates, Z.3    Lucock, M.4    Kim, Y.I.5
  • 3
    • 1342301546 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: Relationships with 5-fluorouracil sensitivity
    • Etienne MC, Ilc K, Formento JL, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer. 2004;90:526-534.
    • (2004) Br J Cancer , vol.90 , pp. 526-534
    • Etienne, M.C.1    Ilc, K.2    Formento, J.L.3
  • 4
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5́-termi-nal regulatory region of the human gene for thy-midylate synthase
    • Horie N, AibaH, Oguro K, Hojo H,Takeishi K. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5́-termi-nal regulatory region of the human gene for thy-midylate synthase. Cell Struct Funct. 1995;20:191-197.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3    Hojo, H.4    Takeishi, K.5
  • 5
    • 10344250989 scopus 로고    scopus 로고
    • Polymorphism of the thymidylate synthase gene and thy-midylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients
    • Mauritz R, Beumer IJ, Marsh S, et al. Polymorphism of the thymidylate synthase gene and thy-midylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients. Nucleosides Nucleotides Nucleic Acids. 2004;23:1381-1384.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , pp. 1381-1384
    • Mauritz, R.1    Beumer, I.J.2    Marsh, S.3
  • 6
    • 0033007272 scopus 로고    scopus 로고
    • Folate and carcinogenesis: Evidence, mechanisms, and implications
    • Kim YI. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem.1999;10:66-88.
    • (1999) J Nutr Biochem , vol.10 , pp. 66-88
    • Kim, Y.I.1
  • 7
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA.1997;94:3290-3295.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3290-3295
    • Blount, B.C.1    Mack, M.M.2    Wehr, C.M.3
  • 8
    • 16544395591 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004;22:4632-4642.
    • (2004) J Clin Oncol , vol.22 , pp. 4632-4642
    • Das, P.M.1    Singal, R.2
  • 10
    • 0742304414 scopus 로고    scopus 로고
    • Is folic acid the ultimate functional food component for disease prevention?
    • Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ. 2004;328:211-214.
    • (2004) BMJ , vol.328 , pp. 211-214
    • Lucock, M.1
  • 11
    • 0033607241 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reduc-tase gene are associated with susceptibility to acute leukemia in adults
    • Skibola CF, Smith MT, Kane E, et al. Polymorphisms in the methylenetetrahydrofolate reduc-tase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A. 1999;96:12810-12815.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12810-12815
    • Skibola, C.F.1    Smith, M.T.2    Kane, E.3
  • 12
    • 0035874520 scopus 로고    scopus 로고
    • Association between polymorphisms of folate-and methi-onine-metabolizing enzymes and susceptibility to malignant lymphoma
    • Matsuo K, Suzuki R, Hamajima N, et al. Association between polymorphisms of folate-and methi-onine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood. 2001;97:3205-3209.
    • (2001) Blood , vol.97 , pp. 3205-3209
    • Matsuo, K.1    Suzuki, R.2    Hamajima, N.3
  • 13
    • 9644294470 scopus 로고    scopus 로고
    • Methyl-enetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma
    • Matsuo K, Hamajima N, Suzuki R, et al. Methyl-enetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma. Am J Hematol. 2004;77:351-357.
    • (2004) Am J Hematol , vol.77 , pp. 351-357
    • Matsuo, K.1    Hamajima, N.2    Suzuki, R.3
  • 14
    • 0035957379 scopus 로고    scopus 로고
    • Methylenetetrahy-drofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
    • Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylenetetrahy-drofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A. 2001;98:4004-4009.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4004-4009
    • Wiemels, J.L.1    Smith, R.N.2    Taylor, G.M.3    Eden, O.B.4    Alexander, F.E.5    Greaves, M.F.6
  • 15
    • 0035672957 scopus 로고    scopus 로고
    • The methylenetetrahydrofo-late reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
    • Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RP. The methylenetetrahydrofo-late reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol. 2001;115:616-618.
    • (2001) Br J Haematol , vol.115 , pp. 616-618
    • Franco, R.F.1    Simoes, B.P.2    Tone, L.G.3    Gabellini, S.M.4    Zago, M.A.5    Falcao, R.P.6
  • 16
    • 0346966836 scopus 로고    scopus 로고
    • Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
    • Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004;103:252-257.
    • (2004) Blood , vol.103 , pp. 252-257
    • Krajinovic, M.1    Lamothe, S.2    Labuda, D.3
  • 17
    • 0037377977 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydro-folate reductase polymorphisms and leukemiarisk: A HuGE minireview
    • Robien K, Ulrich CM. 5,10-Methylenetetrahydro-folate reductase polymorphisms and leukemiarisk: a HuGE minireview. Am J Epidemiol. 2003;157:571-582.
    • (2003) Am J Epidemiol , vol.157 , pp. 571-582
    • Robien, K.1    Ulrich, C.M.2
  • 18
    • 2942608990 scopus 로고    scopus 로고
    • Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lym-phoma in adults
    • Gemmati D, Ongaro A, Scapoli GL, et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lym-phoma in adults. Cancer Epidemiol Biomarkers Prev. 2004;13:787-794.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 787-794
    • Gemmati, D.1    Ongaro, A.2    Scapoli, G.L.3
  • 19
    • 0037093272 scopus 로고    scopus 로고
    • Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia
    • Skibola CF, Smith MT, Hubbard A, et al. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood. 2002;99:3786-3791.
    • (2002) Blood , vol.99 , pp. 3786-3791
    • Skibola, C.F.1    Smith, M.T.2    Hubbard, A.3
  • 20
    • 0037946769 scopus 로고    scopus 로고
    • Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma
    • Hishida A, Matsuo K, Hamajima N, et al. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. Haematologica. 2003;88:159-166.
    • (2003) Haematologica , vol.88 , pp. 159-166
    • Hishida, A.1    Matsuo, K.2    Hamajima, N.3
  • 21
    • 22144446041 scopus 로고    scopus 로고
    • Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
    • de Jonge R, Hooijberg JH, van Zelst BD, et al. Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood. 2005;106:717-720.
    • (2005) Blood , vol.106 , pp. 717-720
    • de Jonge, R.1    Hooijberg, J.H.2    van Zelst, B.D.3
  • 22
    • 0033805360 scopus 로고    scopus 로고
    • A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia
    • Chango A, Emery-Fillon N, de Courcy GP, et al. A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab.2000;70:310-315.
    • (2000) Mol Genet Metab , vol.70 , pp. 310-315
    • Chango, A.1    Emery-Fillon, N.2    de Courcy, G.P.3
  • 23
    • 1942469552 scopus 로고    scopus 로고
    • Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population
    • Relton CL, Wilding CS, Pearce MS, et al. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. J Med Genet. 2004;41:256-260.
    • (2004) J Med Genet , vol.41 , pp. 256-260
    • Relton, C.L.1    Wilding, C.S.2    Pearce, M.S.3
  • 24
    • 33645635701 scopus 로고    scopus 로고
    • Interactions among polymorphisms in folate-metabolizing genes and serum total homocys-teine concentrations in a healthy elderly population
    • Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH. Interactions among polymorphisms in folate-metabolizing genes and serum total homocys-teine concentrations in a healthy elderly population. Am J Clin Nutr. 2006;83:708-713.
    • (2006) Am J Clin Nutr , vol.83 , pp. 708-713
    • Devlin, A.M.1    Clarke, R.2    Birks, J.3    Evans, J.G.4    Halsted, C.H.5
  • 25
    • 0035187308 scopus 로고    scopus 로고
    • Single nu-cleotide polymorphisms in the human reduced folate carrier: Characterization of a high-frequency G/A variant at position 80 and transportproperties of the His(27) and Arg(27) carriers
    • Whetstine JR, Gifford AJ, Witt T, et al. Single nu-cleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transportproperties of the His(27) and Arg(27) carriers. Clin Cancer Res. 2001;7:3416-3422.
    • (2001) Clin Cancer Res , vol.7 , pp. 3416-3422
    • Whetstine, J.R.1    Gifford, A.J.2    Witt, T.3
  • 26
    • 24744443273 scopus 로고    scopus 로고
    • G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non ho-mocysteine related mechanism
    • Yates Z, Lucock M. G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non ho-mocysteine related mechanism. Life Sci. 2005;77:2735-2742.
    • (2005) Life Sci , vol.77 , pp. 2735-2742
    • Yates, Z.1    Lucock, M.2
  • 27
    • 0345291171 scopus 로고    scopus 로고
    • Reduced folate carrier expression in acute lympho-blastic leukemia: A mechanism for ploidy but not lineage differences in methotrexate accumulation
    • Belkov VM, Krynetski EY, Schuetz JD, et al. Reduced folate carrier expression in acute lympho-blastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation. Blood. 1999;93:1643-1650.
    • (1999) Blood , vol.93 , pp. 1643-1650
    • Belkov, V.M.1    Krynetski, E.Y.2    Schuetz, J.D.3
  • 28
    • 0031669954 scopus 로고    scopus 로고
    • Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: Relationship to immuno-phenotype and ploidy
    • Zhang L, Taub JW, Williamson M, et al. Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immuno-phenotype and ploidy. Clin Cancer Res. 1998;4:2169-2177.
    • (1998) Clin Cancer Res , vol.4 , pp. 2169-2177
    • Zhang, L.1    Taub, J.W.2    Williamson, M.3
  • 29
    • 30344462708 scopus 로고    scopus 로고
    • Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes
    • Lightfoot TJ, Skibola CF, Willett EV, et al. Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. Cancer Epidemiol Biomarkers Prev. 2005;14:2999-3003.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 2999-3003
    • Lightfoot, T.J.1    Skibola, C.F.2    Willett, E.V.3
  • 30
    • 4644243438 scopus 로고    scopus 로고
    • Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma
    • Skibola CF, Forrest MS, Coppede F, et al. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood.2004;104:2155-2162.
    • (2004) Blood , vol.104 , pp. 2155-2162
    • Skibola, C.F.1    Forrest, M.S.2    Coppede, F.3
  • 31
    • 1842418757 scopus 로고    scopus 로고
    • Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy
    • Relton CL, Wilding CS, Laffling AJ, et al. Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab. 2004;81:273-281.
    • (2004) Mol Genet Metab , vol.81 , pp. 273-281
    • Relton, C.L.1    Wilding, C.S.2    Laffling, A.J.3
  • 32
    • 28644446615 scopus 로고    scopus 로고
    • Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine syn-thase and risk of colon cancer
    • Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML. Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine syn-thase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:2509-2516.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 2509-2516
    • Ulrich, C.M.1    Curtin, K.2    Potter, J.D.3    Bigler, J.4    Caan, B.5    Slattery, M.L.6
  • 33
    • 34247599285 scopus 로고    scopus 로고
    • Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer
    • Gotze T, Rocken C, Rohl FW, et al. Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett. 2007;251:228-236.
    • (2007) Cancer Lett , vol.251 , pp. 228-236
    • Gotze, T.1    Rocken, C.2    Rohl, F.W.3
  • 34
    • 34247890013 scopus 로고    scopus 로고
    • MTHFR and RFC-1 gene polymorphisms and the risk of Down syndrome in Italy
    • Coppede F, Colognato R, Migliore L. MTHFR and RFC-1 gene polymorphisms and the risk of Down syndrome in Italy. Am J Med Genet A. 2007;143:1018-1019.
    • (2007) Am J Med Genet A , vol.143 , pp. 1018-1019
    • Coppede, F.1    Colognato, R.2    Migliore, L.3
  • 35
    • 33646240576 scopus 로고    scopus 로고
    • Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
    • Coppede F, Marini G, Bargagna S, et al. Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women. Am J Med Genet A. 2006;140:1083-1091.
    • (2006) Am J Med Genet A , vol.140 , pp. 1083-1091
    • Coppede, F.1    Marini, G.2    Bargagna, S.3
  • 36
    • 33747873426 scopus 로고    scopus 로고
    • Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring
    • Scala I, Granese B, Sellitto M, et al. Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring. Genet Med. 2006;8:409-416.
    • (2006) Genet Med , vol.8 , pp. 409-416
    • Scala, I.1    Granese, B.2    Sellitto, M.3
  • 37
    • 34248379711 scopus 로고    scopus 로고
    • Ancestry and pharmacogenetics of antileukemic drug toxicity
    • Kishi S, Cheng C, French D, et al. Ancestry and pharmacogenetics of antileukemic drug toxicity. Blood. 2007;109:4151-4157.
    • (2007) Blood , vol.109 , pp. 4151-4157
    • Kishi, S.1    Cheng, C.2    French, D.3
  • 38
    • 51649094290 scopus 로고    scopus 로고
    • Polymorphisms in folate-related genes:association with side effects of high-dose metho-trexate in childhood acute lymphoblastic leukemia
    • Huang L, Tissing WJ, de Jonge R, van Zelst BD, Pieters R. Polymorphisms in folate-related genes:association with side effects of high-dose metho-trexate in childhood acute lymphoblastic leukemia. Leukemia. 2008;22:1798-1800.
    • (2008) Leukemia , vol.22 , pp. 1798-1800
    • Huang, L.1    Tissing, W.J.2    de Jonge, R.3    van Zelst, B.D.4    Pieters, R.5
  • 39
    • 1442300286 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in folate metabolism and colorectal neo-plasia: A HuGE review
    • Sharp L, Little J. Polymorphisms in genes involved in folate metabolism and colorectal neo-plasia: a HuGE review. Am J Epidemiol. 2004;159:423-443.
    • (2004) Am J Epidemiol , vol.159 , pp. 423-443
    • Sharp, L.1    Little, J.2
  • 40
    • 33750497230 scopus 로고    scopus 로고
    • Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahy-drofolate reductase polymorphisms and acutelymphoblastic leukemia risk: A meta-analysis
    • PereiraTV, Rudnicki M, PereiraAC, Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahy-drofolate reductase polymorphisms and acutelymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:1956-1963.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1956-1963
    • Pereira, T.V.1    Rudnicki, M.2    Pereira, A.C.3
  • 41
    • 0035830288 scopus 로고    scopus 로고
    • Maternal folate supplementation in pregnancy and protection against acute lym-phoblastic leukaemia in childhood: A case-control study
    • Thompson JR, Gerald PF, Willoughby ML, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lym-phoblastic leukaemia in childhood: a case-control study. Lancet. 2001;358:1935-1940.
    • (2001) Lancet , vol.358 , pp. 1935-1940
    • Thompson, J.R.1    Gerald, P.F.2    Willoughby, M.L.3    Armstrong, B.K.4
  • 42
    • 16844372846 scopus 로고    scopus 로고
    • Methyl-enetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lympho-blastic leukemia
    • Aplenc R, Thompson J, Han P, et al. Methyl-enetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lympho-blastic leukemia. Cancer Res. 2005;65:2482-2487.
    • (2005) Cancer Res , vol.65 , pp. 2482-2487
    • Aplenc, R.1    Thompson, J.2    Han, P.3
  • 43
    • 40049103754 scopus 로고    scopus 로고
    • Meta-and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: A huge-GSEC review
    • Boccia S, Hung R, Ricciardi G, et al. Meta-and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol. 2008;167:505-516.
    • (2008) Am J Epidemiol , vol.167 , pp. 505-516
    • Boccia, S.1    Hung, R.2    Ricciardi, G.3
  • 44
    • 0029049553 scopus 로고
    • Acandidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. Acandidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 46
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 47
    • 0034743914 scopus 로고    scopus 로고
    • The 1298A->C polymorphism in methylenetetrahy-drofolate reductase (MTHFR): In vitro expression and association with homocysteine
    • Weisberg IS, Jacques PF, Selhub J, et al. The 1298A->C polymorphism in methylenetetrahy-drofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. 2001;156:409-415.
    • (2001) Atherosclerosis , vol.156 , pp. 409-415
    • Weisberg, I.S.1    Jacques, P.F.2    Selhub, J.3
  • 48
    • 0031687887 scopus 로고    scopus 로고
    • Asecond genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S,Rozen R. Asecond genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64:169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 49
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetra-hydrofolate reductase gene: An additional risk factor for neural-tube defects?
    • van der Put NM, Gabreels F, Stevens EM, et al. A second common mutation in the methylenetetra-hydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998;62:1044-1051.
    • (1998) Am J Hum Genet , vol.62 , pp. 1044-1051
    • van der Put, N.M.1    Gabreels, F.2    Stevens, E.M.3
  • 50
    • 0034808335 scopus 로고    scopus 로고
    • Asecond common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk
    • Lievers KJ, Boers GH, Verhoef P, et al. Asecond common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med. 2001;79:522-528.
    • (2001) J Mol Med , vol.79 , pp. 522-528
    • Lievers, K.J.1    Boers, G.H.2    Verhoef, P.3
  • 51
    • 21044434160 scopus 로고    scopus 로고
    • A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: Results from the GAIT project
    • Souto JC, Blanco-Vaca F, Soria JM, et al. A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet.2005;76:925-933.
    • (2005) Am J Hum Genet , vol.76 , pp. 925-933
    • Souto, J.C.1    Blanco-Vaca, F.2    Soria, J.M.3
  • 52
    • 25144515912 scopus 로고    scopus 로고
    • Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer
    • RoesslerM, RollingerW, Palme S,et al. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res. 2005;11:6550-6557.
    • (2005) Clin Cancer Res , vol.11 , pp. 6550-6557
    • Roessler, M.1    Rollinger, W.2    Palme, S.3
  • 53
    • 34548471787 scopus 로고    scopus 로고
    • Nicotin-amide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma
    • Sartini D, Santarelli A, Rossi V, et al. Nicotin-amide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med. 2007;13:415-421.
    • (2007) Mol Med , vol.13 , pp. 415-421
    • Sartini, D.1    Santarelli, A.2    Rossi, V.3
  • 54
    • 0033104709 scopus 로고    scopus 로고
    • Role of folylpolyglutamate synthetase and folylpolygluta-mate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
    • Rots MG, Pieters R, Peters GJ, et al. Role of folylpolyglutamate synthetase and folylpolygluta-mate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. Blood. 1999;93:1677-1683. 2290-2297
    • (1999) Blood , vol.93
    • Rots, M.G.1    Pieters, R.2    Peters, G.J.3


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