Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: A meta-analysis

Leukemia and Lymphoma

Volumn 55, Issue 6, 2014, Pages 1388-1393

  Xia, Jia ^a   Wang, Yadan ^a   Zhang, Hang ^b   Hu, Yu ^a  

^a UNION HOSPITAL   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Childhood acute lymphoblastic leukemia; Meta analysis; Methionine synthase; Polymorphism

Indexed keywords

METHIONINE SYNTHASE; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; MTR PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CASE CONTROL STUDY; CHILDHOOD LEUKEMIA; COHORT ANALYSIS; DISEASE ASSOCIATION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; META ANALYSIS; PRIORITY JOURNAL; RISK FACTOR; RISK REDUCTION; ALLELE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; PUBLISHING; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ALLELES; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PUBLICATION BIAS;

EID: 84901341871     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.830304     Document Type: Article

References (34)

1. Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004; 103: 252-257. (Pubitemid 38029946
2. Karathanasis NV, Choumerianou DM, Kalmanti M. Gene polymorphisms in childhood ALL. Pediatr Blood Cancer 2009; 52 : 318-323
3. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 2006; 6: 193-203. (Pubitemid 43292563
4. Greaves MF. Aetiology of acute leukaemia. Lancet 1997; 349 : 344-349. (Pubitemid 27056837
5. Koppen I J, Hermans F J, Kaspers G J. F olate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2010; 148: 3-14
6. Skibola CF, Smith MT, Hubbard A, et al. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 2002; 99: 3786-3791. (Pubitemid 34534552
7. Jones P A, Laird P W. Cancer epigenetics comes of age. N at Genet 1999; 21: 163-167
8. Lau J, Ioannidis J P, Schmid C H. Quantitative synthesis in systematic reviews. Ann Intern Med 1997; 127: 820-826
9. Higgins J P, Thompson S G, Deeks J J, et al. Measuring inconsistency in meta-Analyses. Br Med J 2003; 327: 555-560
10. Egger M, Davey SG, Schneider M, et al. Bias in meta-Analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634. (Pubitemid 27387172
11. Gemmati D, Ongaro A, Scapoli GL, et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004; 13: 787-794. (Pubitemid 38737868
12. Kim HN, Kim YK, Lee IK, et al. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Leuk Res 2009; 33: 82-87
13. Metayer C, Scélo G, Chokkalingam AP, et al. Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control 2011; 22: 1243-1258
14. Yang L, Liu L, Wang J, et al. Polymorphisms in folate-related genes: Impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese. Leuk Lymphoma 2011; 52: 1770-1776
15. Rahimi Z, Ahmadian Z, Akramipour R, et al. Thymidylate synthase and methionine synthase polymorphisms are not associated wiThsusceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran. Mol Biol Rep 2012; 39: 2195-2200
16. Nikbakht M, Malek Zadeh K, Kumar J A, et al. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in NorthIndia. Exp Oncol 2012; 34: 43-48
17. Lightfoot T J, Johnston W T, Painter D, et al. Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood 2010; 115: 3923-3932
18. de Jonge R, Tissing W J, Hooijberg J H, et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood 2009; 113: 2284-2293
19. Petra BG, Janez J, Vita D. Gene-gene interaction in the folate metabolic pathway infl uence the risk of acute lymphoblastic leukemia in children. Leuk Lymphoma 2007; 48: 786-792
20. Gast A, Bermejo J L, Flohr T, et al. Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: A casecontrol study. Leukemia 2007; 21: 320-325. (Pubitemid 46158126
21. Leclerc D, Campeau E, Goyette P, et al. Human methionine synthase: CDNA cloning and identifi cation of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996; 5: 1867-1874. (Pubitemid 26413628
22. Friso S, Choi SW, Girelli D, et al. Acommon mutation in the 5,10-methylenetetrahydrofolate reductase gene aff ects genomic DNA methylation through an interaction wiThfolate status. Proc Natl Acad Sci USA 2002; 99: 5606-5611. (Pubitemid 34411596
23. Baur AS, Shaw P, Burri N, et al. Frequent methylation silencing of p15(INK4b) (MTS2) and p16(INK4a) (MTS1) in B-cell and T-cell lymphomas. Blood 1999; 94: 1773-1781. (Pubitemid 29411328
24. Nakamura M, Sugita K, Inukai T, et al. P16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia wiTh11q23 translocation. Leukemia 1999; 13: 884-890. (Pubitemid 29292139
25. Guo SX, Taki T, Ohnishi H, et al. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leuk Res 2000; 24: 39-46
26. Moller MB, Ino Y, Gerdes AM, et al. Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diff use large B cell lymphoma. Leukemia 1999; 13: 453-459. (Pubitemid 29108084
27. Harmon DL, Shields DC, Woodside JV, et al. Methionine synthase D919G polymorphism is a signifi cant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 1999; 17: 298-309. (Pubitemid 29522203
28. Davidsson J, Lilljebjorn H, Andersson A, et al. The DNAmethylome of pediatric acute lymphoblastic leukemia. Hum Mol Genet 2009 ; 18: 4054-4065
29. Ly A, Hoyt L, Crowell J, et al. Folate and DNA methylation. Antioxid Redox Signal 2012; 17: 302-326
30. Blount BC, Mack MM, Wehr CM, et al. Folate defi ciency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94: 3290-3295
31. Das PM, Singal R. DNA methylation and cancer. JClin Oncol 2004; 22: 4632-4642. (Pubitemid 41185132
32. Duthie S J, Narayanan S, Brand G M, et al. Impact of folate defi ciency on DNA stability. J Nutr 2002; 132: 2444S-2449S.
33. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004; 328: 211-214
34. Lunetta KL. Genetic association studies. Circulation 2008 ; 118: 96-101