Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity

Archives of Toxicology

Volumn 89, Issue 1, 2015, Pages 57-72

  Lim, Yun Ping ^a,b   Cheng, Ching Hao ^a,c   Chen, Wei Cheng ^a   Chang, Shih Yu ^d   Hung, Dong Zong ^a,b   Chen, Jih Jung ^e   Wan, Lei ^a   Ma, Wei Chih ^a   Lin, Yu Hsien ^a   Chen, Cing Yu ^a   Yokoi, Tsuyoshi ^f   Nakajima, Miki ^f   Chen, Chao Jung ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e TAJEN UNIVERSITY   (Taiwan)

^f KANAZAWA UNIVERSITY   (Japan)

Author keywords

Allyl isothiocyanate; Constitutive androstane receptor; Cytochrome P450 2B6; Cytochrome P450 3A4; Drug induced cytotoxicity; Inducer drug interaction; Pregnane X receptor

Indexed keywords

ALLYL ISOTHIOCYANATE; AMIODARONE; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2B6 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 2B6; CYTOCHROME P450 3A; ISOTHIOCYANIC ACID DERIVATIVE; PARACETAMOL; PREGNANE X RECEPTOR; STEROID RECEPTOR;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE; WESTERN BLOTTING;

ACETAMINOPHEN; AMIODARONE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROME P-450 CYP2B6; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOTHIOCYANATES; MICE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 84923903421     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1230-x     Document Type: Article

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