Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)

Toxicology and Applied Pharmacology

Volumn 209, Issue 2, 2005, Pages 123-133

  Jacobs, Miriam N ^a,c   Nolan, Gail T ^b   Hood, Steven R ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Lignans; PCBs; Phytoestrogens; PXR; Transient transfection assays; Triclosan

Indexed keywords

4 HYDROXYTAMOXIFEN; BACTERICIDE; COLECALCIFEROL; CYTOCHROME P450 3A; DRUG METABOLITE; ENTEROLACTONE; FAT; FULVESTRANT; HERBACEOUS AGENT; LIGNAN; ORGANOCHLORINE DERIVATIVE; PESTICIDE; PHYTOESTROGEN; POLYCHLORINATED BIPHENYL DERIVATIVE; PREGNANE X RECEPTOR; RESVERATROL; RIFAMPICIN; STEROID; TAMOXIFEN; TRICLOSAN;

ARTICLE; CHLORINATION; COMPARATIVE STUDY; CONCENTRATION PROCESS; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG EFFECT; DRUG METABOLISM; DRUG POTENCY; FOOD CONTAMINATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYDROXYLATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR SENSITIVITY; STEROID METABOLISM; TOXICOKINETICS; VITAMIN D METABOLISM; XENOBIOTIC METABOLISM;

ALKALINE PHOSPHATASE; ANTI-BACTERIAL AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; HYDROCARBONS, CHLORINATED; KINETICS; LIGNANS; LIVER NEOPLASMS; PHYTOESTROGENS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RETINOID X RECEPTORS; RIFAMPIN; TRANSFECTION;

EID: 27744577633     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.03.015     Document Type: Article

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