Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

Toxicology

Volumn 131, Issue 1, 1998, Pages 9-20

  Lake, Brian G ^a   Renwick, Anthony B ^a   Cunninghame, Morag E ^a   Price, Roger J ^a   Surry, Dominic ^b   Evans, David C ^b  

^a BIBRA INTERNATIONAL   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Cell replication; CYP3A inducers; Cytochrome P450 isoforms; Enzyme induction; Rat liver

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANTIBODY; BARBITURIC ACID; BETA NAPHTHOFLAVONE; BROXURIDINE; CLOTRIMAZOLE; CYTOCHROME P450; DEXAMETHASONE; DNA; ENZYME INDUCING AGENT; ISONIAZID; LIVER ENZYME; METHYLCLOFENAPATE; MICONAZOLE; OXYGENASE; PHENOBARBITAL; TROLEANDOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; IMMUNOBLOTTING; LIVER MICROSOME; LIVER WEIGHT; MITOGENESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; OSMOTIC PUMP; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CLOTRIMAZOLE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DNA REPLICATION; ENZYME INDUCTION; FEMALE; ISOENZYMES; LIVER; MICONAZOLE; MITOGENS; OXIDOREDUCTASES, N-DEMETHYLATING; PREGNENOLONE CARBONITRILE; RATS; RATS, SPRAGUE-DAWLEY; TROLEANDOMYCIN;

EID: 0031794525     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00085-7     Document Type: Article

References (40)

1. Andersen M.E., Mills J.J., Jirtle R.L., Greenlee W.F. Negative selection in hepatic tumor promotion in relation to risk assessment. Toxicology. 102:1995;223-237.
2. Barrass N.C., Price R.J., Lake B.G., Orton T.C. Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liver. Carcinogenesis. 14:1993;1451-1456.
3. Conney A.H. Induction of microsomal cytochrome P-450 enzymes. The first Bernard B. Brodie Lecture at Pennsylvania State University. Life Sci. 39:1986;2493-2518.
4. Cooper K.O., Reik L.M., Jayyosi Z., Bandiera S., Kelley M., Ryan D.E., Daniel R., McCluskey S.A., Levin W., Thomas P.E. Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch. Biochem. Biophys. 301:1993;345-354.
5. Cunningham M.L. Role of increased DNA replication in the carcinogenic risk of non-mutagenic chemical carcinogens. Mutat. Res. 365:1996;59-69.
6. DeLuca J.G., Dysart G.R., Rasnick D., Bradley M.O. A direct, highly sensitive assay for cytochrome P-450 catalysed O-deethylation using a novel coumarin analog. Biochem. Pharmacol. 37:1988;1731-1739.
7. Goldsworthy T.L., Conolly R.B., Fransson-Steen R. Apoptosis and cancer risk assessment. Mutat. Res. 365:1996;71-90.
8. Grasso P., Hinton R.H. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver. Mutat. Res. 248:1991;271-290.
9. Gray T.J.B., Lake B.G., Beamand J.A., Foster J.R., Gangolli S.D. Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol. 67:1983;15-25.
10. Hostetler K.A., Wrighton S.A., Molowa D.T., Thomas P.E., Levin W., Guzelian P.S. Coinduction of multiple hepatic cytochrome P450 proteins and their mRNAs in rats treated with imidazole antimycotic agents. Mol. Pharmacol. 35:1989;279-285.
11. Japenga A.C., Davies S., Price R.J., Lake B.G. Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver. Xenobiotica. 23:1993;169-179.
12. Jirtle R.L. Liver tumor promotion and breast cancer chemoprevention: common mechanisms. Cockburn A., Smith L. Nongenotoxic Carcinogenesis. Ernst Schering Research Foundation Workshop 10. 1994;157-171 Springer, Berlin.
13. Lake B.G. Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism. Snell K., Mullock B. Biochemical Toxicology: A Practical Approach. 1987;183-215 IRL Press, Oxford.
14. Lake B.G. Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals. Annu. Rev. Pharmacol. Toxicol. 35:1995;483-507.
15. Lake B.G., Lewis D.F.V. The CYP4 family. Ioannides C. Cytochromes P450: Metabolic and Toxicological Aspects. 1996;271-297 CRC Press, Boca Raton, FL.
16. Lake B.G., Rumsby P.C., Brown K.L., Price R.J., Cunninghame M.E. Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-β1 (TGF-β1) gene expression. Toxicologist. 15:1995;241.
17. Loury D.J., Goldsworthy T.L., Butterworth B.E. The value of measuring cell replication as a predictive index of tissue-specific tumorigenic potential. Butterworth B.E., Slaga T.J. Non-genotoxic Mechanisms in Carcinogenesis, Banbury Report 25. 1987;119-136 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
19. Maurel P. The CYP3 family. Ioannides C. Cytochromes P450: Metabolic and Toxicological Aspects. 1996;241-270 CRC Press, Boca Raton, FL.
20. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily: update on new sequences, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
21. Nims R.W., Lubet R.A. The CYP2B subfamily. Ioannides C. Cytochromes P450: Metabolic and Toxicological Aspects. 1996;135-160 CRC Press, Boca Raton, FL.
22. Nims R.W., Devor D.E., Henneman J.R., Lubet R.A. Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with tumor-promoting potential in a series of barbiturates. Carcinogenesis. 8:1987;67-71.
23. Okey A.B. Enzyme induction in the cytochrome P450 system. Pharmacol. Ther. 45:1990;241-298.
24. Parkinson A. Biotransformation of xenobiotics. Klaassen C.D. Casarett and Doulls' Toxicology. The Basic Science of Poisons. 5th edn:1996;113-186 McGraw-Hill, New York.
25. Parzefall W., Monschau P., Schulte-Hermann R. Induction by cyproterone acetate of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes in serum free medium. Arch. Toxicol. 63:1989;456-461.
26. Popp J.A., Cattley R.C. Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogenesis. Gibson G., Lake B. Peroxisomes: Biology and Importance in Toxicology and Medicine. 1993;653-665 Taylor and Francis, London.
27. Rice J.M., Diwan B.A., Hu H., Ward J.M., Nims R.W., Lubet R.A. Enhancement of carcinogenesis and induction of specific cytochrome P450-dependent monooxygenase activites by the barbiturates allobarbital, aprobarbital, pentobarbital, secobarbital and 5-phenyl- and 5-ethylbarbituric acids. Carcinogensis. 15:1994;395-402.
28. Ritter J.K., Franklin M.R. High magnitude hepatic cytochrome P-450 induction by an N-substituted imidazole antimycotic, clotrimazole. Biochem. Pharmacol. 36:1987;2783-2787.
29. Ritter J.K., Franklin M.R. Clotrimazole induction of cytochrome P450: dose-differentiated isozyme induction. Mol. Pharmacol. 31:1987;135-139.
30. Schulte-Hermann R., Parzefall W. Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. I. Induction of drug metabolizing enzymes. Chem. Biol. Interact. 31:1980;279-286.
31. Schulte-Hermann R., Hoffman V., Parzefall W., Kallenbach M., Gerhardt A., Schuppler J. Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. II. Induction of growth. Chem. Biol. Interact. 31:1980;287-300.
32. Setaro F., Morley C.G.D. A modified fluorimetric method for the determination of microgram quantities of DNA from cell or tissue cultures. Anal. Biochem. 71:1976;313-317.
33. Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F.P. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Therap. 270:1994;414-423.
34. Sonderfan A.J., Arlotto M.P., Dutton D.R., McMillen S.K., Parkinson A. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450. Arch. Biochem. Biophys. 255:1987;27-41.
35. Thatcher N.J., Caldwell J. Enzyme induction, cell proliferation and liver pathological responses to dexamethasone (DEX) and pregnenolone 16α-carbonitrile (PCN) in female Sprague-Dawley rats. Hum. Exp. Toxicol. 13:1994;295.
36. Tucker M.J., Kalinowski A.E., Orton T.C. Carcinogenicity of cyproterone acetate in the mouse. Carcinogenesis. 17:1996;1473-1476.
37. Whysner J., Ross P.M., Williams G.M. Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71:1996;153-191.
38. Wrighton S.A., Maurel P., Schuetz E.G., Watkins P.B., Young B., Guzelian P.S. Identification of the cytochrome P450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P450p. Biochemistry. 24:1985;2171-2178.
39. Wrighton S.A., Vandenbranden M., Stevens J.C., Shipley L.A., Ring B.J., Rettie A.E., Cashman J.R. In vitro methods for assessing human drug metabolism: their use in drug development. Drug Metab. Rev. 25:1993;453-484.
40. Yamasaki H. Role of disrupted gap junctional intercellular communication in detection and characterization of carcinogens. Mutat. Res. 365:1996;91-105.