Sesamin: A naturally occurring lignan inhibits CYP3A4 by antagonizing the pregnane X receptor activation

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Lim, Yun Ping ^a,b   Ma, Chia Yun ^a   Liu, Cheng Ling ^c   Lin, Yu Hsien ^a   Hu, Miao Lin ^c   Chen, Jih Jung ^d   Hung, Dong Zong ^a,b   Hsieh, Wen Tsong ^e   Huang, Jin Ding ^f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d TAJEN UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BETA ACTIN; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A1; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIGAND; LIGNAN; MESSENGER RNA; PACLITAXEL; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RETINOID X RECEPTOR ALPHA; RIFAMPICIN; SESAME SEED OIL; SESAMIN; STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; DRUG RECEPTOR BINDING; DRUG SAFETY; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 84862275724     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/242810     Document Type: Article

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