Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs

Drug Metabolism and Disposition

Volumn 37, Issue 12, 2009, Pages 2275-2283

  Ahlin, Gustav ^a   Hilgendorf, Constanze ^b   Karlsson, Johan ^b   Szigyarto, Cristina Al Khalili ^c   Uhlén, Mathias ^c   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; ILEAL BILE ACID TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 5; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 3; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PROTEIN OATP1B3; PROTEIN OCTN1; PROTEIN OCTN2; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CELL STRAIN HEK293; CELL STRAIN HEPG2; CELL STRAIN HL 60; CELL STRAIN K 562; DRUG TRANSPORT; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL ADHESION; DRUG DISCOVERY; GENE EXPRESSION PROFILING; HELA CELLS; HEP G2 CELLS; HL-60 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; K562 CELLS; MEMBRANE TRANSPORT PROTEINS; MONOCARBOXYLIC ACID TRANSPORTERS; PHARMACEUTICAL PREPARATIONS; PROTEOMICS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYMPORTERS; TRANSFECTION;

EID: 71049160053     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028654     Document Type: Article

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