The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

FEBS Journal

Volumn 282, Issue 5, 2015, Pages 904-920

  Bende, Niraj S ^a   Dziemborowicz, Sławomir ^b   Herzig, Volker ^a   Ramanujam, Venkatraman ^a   Brown, Geoffrey W ^c   Bosmans, Frank ^d,e   Nicholson, Graham M ^b   King, Glenn F ^a   Mobli, Mehdi ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c DEPARTMENT OF AGRICULTURE AND FISHERIES   (Australia)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

disulfide rich peptide; heteronuclear NMR; pore blocker; spider toxin; voltage gated sodium channel

Indexed keywords

KNOTTIN; SF1A PEPTIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; INSECTICIDE; RECOMBINANT PROTEIN; SPIDER VENOM; TOXIN; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; ANIMAL; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GENETICS; METABOLISM; NERVE CELL; PERIPLANETA; PHYSIOLOGY; PROTEIN CONFORMATION;

ARANEAE; BACTERIA (MICROORGANISMS); HEXAPODA; VERTEBRATA;

ANIMALS; ESCHERICHIA COLI; INSECTICIDES; MAGNETIC RESONANCE SPECTROSCOPY; NEURONS; PERIPLANETA; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPIDER VENOMS; TOXINS, BIOLOGICAL; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84923870269     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13189     Document Type: Article

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