Electrostatic and steric contributions to block of the skeletal muscle sodium channel by μ-conotoxin

Journal of General Physiology

Volumn 119, Issue 1, 2002, Pages 45-54

  Hui, Kwokyin ^a   Lipkind, Gregory ^b   Fozzard, Harry A ^b   French, Robert J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Ion permeation; Lipid bilayers; Peptide toxins; Pore block; Single channel conductance

Indexed keywords

CHARYBDOTOXIN; ION CHANNEL; OMEGA CONOTOXIN; PEPTIDE; POTASSIUM CHANNEL; SAXITOXIN; SODIUM CHANNEL; TETRODOTOXIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; ELECTRICITY; ION CONDUCTANCE; ION PERMEABILITY; LIPID BILAYER; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MOLECULAR MODEL; NONHUMAN; PATCH CLAMP; PEPTIDE SYNTHESIS; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; CALCIUM CHANNEL BLOCKERS; CONOTOXINS; ELECTROSTATICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STEREOISOMERISM;

EID: 0036141825     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.119.1.45     Document Type: Article

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4. Molecular motions within the pore of voltage-dependent sodium channels
5. Characterizing the μ-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations
6. Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the μ-conotoxin GIIIA binding site
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17. Calculation of electrostatic potentials in an enzyme active site
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36. Electrostatic interactions in macromolecules: Theory and applications
37. Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3
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39. Strategy for rapid immobilization of prey by a fish-hunting marine snail
40. + channels is produced by a structural rearrangement of the outer vestibule
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43. Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis