Fusion to snowdrop lectin magnifies the oral activity of insecticidal ω-hexatoxin-Hv1a peptide by enabling its delivery to the central nervous system

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Fitches, Elaine C ^a   Pyati, Prashant ^b   King, Glenn F ^c   Gatehouse, John A ^b  

^a FOOD AND ENVIRONMENT RESEARCH AGENCY   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HV1A PEPTIDE; HV1A SNOWDROP LECTIN FUSION PROTEIN; HYBRID PROTEIN; INSECTICIDE; NEUROTOXIN; SNOWDROP LECTIN; SPIDER VENOM; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTHROPOD LARVA; ARTICLE; BRAIN LEVEL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEEDING; FLUORESCENCE ANALYSIS; GROWTH INHIBITION; HEMOLYMPH; INGESTION; INSECTICIDAL ACTIVITY; MAMESTRA BRASSICAE; MOTH; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PICHIA PASTORIS; PROTEIN BINDING; SURVIVAL RATE; TISSUE SPECIFICITY; TOXIN ANALYSIS; TOXIN STRUCTURE;

ANIMALS; INSECTICIDES; LARVA; MANNOSE-BINDING LECTINS; MOTHS; NERVOUS SYSTEM; PLANT LECTINS; SPIDER VENOMS;

EID: 84862659177     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039389     Document Type: Article

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