μ-Conotoxin PIIIa, a new peptide for discriminating among tetrodotoxin- sensitive Na channel subtypes

Journal of Neuroscience

Volumn 18, Issue 12, 1998, Pages 4473-4481

  Shon, Ki Joon ^a   Olivera, Baldomero M ^b   Watkins, Maren ^c   Jacobsen, Richard B ^b   Gray, William R ^b   Floresca, Christina Z ^b,d   Cruz, Lourdes J ^b,d   Hillyard, David R ^c   Brink, Anette ^e   Terlau, Heinrich ^e   Yoshikami, Doju ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d University of the Philippines Diliman   (Philippines)

^e MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Ion channel subtype; Na channels; Neuromuscular transmission; Peptide; Tetrodotoxin; Conotoxin

Indexed keywords

CONOTOXIN; DISULFIDE; MU CONOTOXIN PIIIA; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG;

AMPHIBIA; ARTICLE; ELECTROPHYSIOLOGY; MOLECULAR CLONING; NEUROMUSCULAR TRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 0032526716     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-12-04473.1998     Document Type: Article

References (26)

1. Becker S, Atherton E, Gordon RD (1989) Synthesis and characterization of μ-conotoxin IIIA. Eur J Biochem 185:79-84.
2. Becker S, Prusak-Sochaczewski E, Zamponi G, Beck-Sickinger AG, Gordon RD, French RJ (1992) Action of derivatives of μ-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry 31:8229-8238.
3. Catterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:S15-S48.
4. ColJedge CJ, Hunsperger JP, Imperial JS, Hillyard DR (1992) Precursor structure of ω-conotoxin GVIA determined from a cDNA clone. Toxicon 30:1111-1116.
5. Cruz LJ, Gray WR, Olivera BM, Zeikus RD, Kerr L, Yoshikami D, Moczydlowski E (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem 260:9280-9288.
6. 3H[saxttoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. J Gen Physiol 101:153-182.
7. Dudley SC, Todt H, Lipkind G, Fozzard HA (1995) A μ-conotoxin-insensitive Na channel mutant: possible localization of a binding site at the outer vestibule. Biophys J 69:1657-1665.
8. French RJ, Prusak-Sochaczewski E, Zamponi GW, Becker S, Kularatna AS. Horn R (1996) Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry. Neuron 16:407-413.
9. Gray WR (1993) Disulfide structures of highly bridged peptides: a new strategy for analysis. Protein Sci 2:1732-1748.
10. 2+ channels. Neuron 9:69-77.
11. Hopkins C, Grilley M, Miller C, Shon K-J, Cruz LJ, Gray WR, Dykert J, Rivier J, Yoshikami D, Olivera BM (1995) A new family of Conus peptides targeted to the nicotinic acetylcholine receptor. J Biol Chem 270:22361-22367.
12. Katz B, Miledi R (1968) The effect of local blockage of motor nerve terminals. J Physiol (Lond) 199:729-741.
13. Mclntosh JM, Hasson A, Spira ME, Li W, Marsh M, Hillyard DR, Olivera BM (1995) A new family of conotoxins which block sodium channels. J Biol Chem 270:16796-16802.
14. Narahashi T, Moore JW, Scott WR (1964) Tetrodotoxin blockage of sodium conductance increase in lobster giant neurons. J Gen Physiol 47:965-974.
15. Noda M, Ikeda T, Kayano T, Suzuki H, Takeshima H, Karusaki M, Takahashi H, Numa S (1986) Existence of distinct sodium channel messenger RNAs in rat brain. Nature 320:188-191.
16. Olivera BM, Gray WR, Zeikus R, Mclntosh JM, Varga J, Rivier J, de Santos V, Cruz LJ (1985) Peptide neurotoxins from fish-hunting cone snails. Science 230:1338-1343.
17. Olivera BM, Hillyard DR, Rivier J, Woodward S, Gray WR, Corpuz G, Cruz LJ (1990) Conotoxins: targeted peptide ligands from snail venoms. In: Marine toxins: origin, structure and molecular pharmacology (Hall S, Strichartz G, eds), pp 256-278. Washington, DC: American Chemical Society.
18. Olivera BM, Miljanich G, Ramachandran J, Adams ME (1994) Calcium channel diversity and neurotransmitter release: the ω-conotoxins and w-agatoxins. Annu Rev Biochem 63:823-867.
19. Sato K, Ishida Y, Wakamatsu K, Kato R, Honda H, Ohizumi Y, Nakamura H, Ohya M, Lancelin J-M, Kohda D, Inagaki F (1991) Active site μ-conotoxin GIIIA, a peptide blocker of muscle sodium channels. J Biol Chem 266:16989-16991.
20. Sato S, Nakamura H, Ohizumi Y, Kobayashi J, Hirata Y (1983) The amino acid sequences of homologous hydroxyproline containing myotoxins from the marine snail Conus geographus venom. FEBS Lett 155:277-280.
21. Shon K, Grilley MM, Marsh M, Yoshikami D, Hall AR, Kurz B, Gray WR, Imperial JS, Hillyard DR, Olivera BM (1995) Purification, characterization, and cloning of the lockjaw peptide from Conus purpurascens venom. Biochemistry 34:4913-4918.
22. Stone BL, Gray WR (1982) Occurrence of hydroxyproline in a toxin from the marine snail Conus geographus. Arch Biochem Biophys 216:756-767.
23. Stühmer W (1992) Electrophysiological recordings from Xenopus oocytes. Methods Enzymol 207:319-339.
24. Trimmer JS, Cooperman SS, Tomiko SA, Z hou J, Crean SM, Boyle MB, Kallen RG, Sheng Z, Barchi L, Sigworth FJ, Goodman RH, Agnew WS, Mandel G (1989) Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 3:33-49.
25. Woodward SR, Cruz LJ, Olivera BM, Hillyard DR (1990) Constant and hypervariable regions in conotoxin propeptides. EMBO J 1:1015-1020.
26. Yoshikami D, Bagabaldo Z, Olivera BM (1989) The inhibitory effects of omega-conotoxins on calcium channels and synapses. Ann NY Acad Sci 560:230-248.