Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms

Toxicon

Volumn 52, Issue 2, 2008, Pages 309-317

  Billen, Bert ^a   Vassilevski, Alexander ^b   Nikolsky, Anton ^b   Tytgat, Jan ^a   Grishin, Eugene ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Inhibitor cystine knot; Neurotoxin; Sodium channel inhibitor; Spider venom

Indexed keywords

CYSTINE; HM 1 TOXIN; HM 2 TOXIN; SODIUM CHANNEL BLOCKING AGENT; SPIDER VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

AMIDATION; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; DISULFIDE BOND; HERIAEUS MELLOTEEI; HYPERPOLARIZATION; IC 50; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SODIUM CURRENT; SPIDER; STEADY STATE; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; FEMALE; MOLECULAR SEQUENCE DATA; NEUROTOXINS; OVUM; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; SEQUENCE ANALYSIS, PROTEIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIDER VENOMS; SPIDERS; XENOPUS LAEVIS;

ARANEAE; MAMMALIA; THOMISIDAE;

EID: 49649105989     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.05.018     Document Type: Article

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