Innate Memory T cells

Advances in Immunology

Volumn 126, Issue , 2015, Pages 173-213

  Jameson, Stephen C ^a   Lee, You Jeong ^a   Hogquist, Kristin A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

CD8 T cells; Cytokines; Homeostasis; Immune memory; NKT cells

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; T LYMPHOCYTE RECEPTOR; CYTOKINE;

ANTIGEN INDUCED MEMORY T CELL; ARTICLE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; HOMEOSTASIS; HUMAN; INNATE IMMUNITY; INTERLEUKIN 4 INDUCED MEMORY T CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; LYMPHOPENIA INDUCED MEMORY T CELL; MEMORY T LYMPHOCYTE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL DIFFERENTIATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOPENIA; MICE; NATURAL KILLER T-CELLS; T-LYMPHOCYTE SUBSETS;

EID: 84923316420     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/bs.ai.2014.12.001     Document Type: Chapter

References (155)

1. Akue A.D., Lee J.Y., Jameson S.C. Derivation and maintenance of virtual memory CD8 T cells. Journal of Immunology 2012, 188:2516-2523.
2. Alonzo E.S., Gottschalk R.A., Das J., Egawa T., Hobbs R.M., Pandolfi P.P., et al. Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. Journal of Immunology 2010, 184:1268-1279.
3. Andreotti A.H., Schwartzberg P.L., Joseph R.E., Berg L.J. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harbor Perspectives in Biology 2010, 2:a002287.
4. Arndt B., Krieger T., Kalinski T., Thielitz A., Reinhold D., Roessner A., et al. The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS One 2011, 6:e23761.
5. Atherly L.O., Lucas J.A., Felices M., Yin C.C., Reiner S.L., Berg L.J. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 2006, 25:79-91.
6. Barthlott T., Kassiotis G., Stockinger B. T cell regulation as a side effect of homeostasis and competition. The Journal of Experimental Medicine 2003, 197:451-460.
7. Bendelac A., Savage P.B., Teyton L. The biology of NKT cells. Annual Review of Immunology 2007, 25:297-336.
8. Bender J., Mitchell T., Kappler J., Marrack P. CD4(+) T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. Journal of Experimental Medicine 1999, 190:367-374.
9. Berg L.J. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nature Reviews. Immunology 2007, 7:479-485.
10. Beutner U., MacDonald H.R. TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host. International Immunology 1998, 10:305-310.
11. Bou Ghanem E.N., Nelson C.C., D'Orazio S.E. T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-gamma in the absence of antigen. Journal of Immunology 2011, 186:1703-1712.
12. Boyman O., Kovar M., Rubinstein M.P., Surh C.D., Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006, 311:1924-1927.
13. Boyman O., Ramsey C., Kim D.M., Sprent J., Surh C.D. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. Journal of Immunology 2008, 180:7265-7275.
14. Brocker T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. Journal of Experimental Medicine 1997, 186:1223-1232.
15. Broussard C., Fleischacker C., Horai R., Chetana M., Venegas A.M., Sharp L.L., et al. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 2006, 25:93-104.
16. Byrne J.A., Stankovic A.K., Cooper M.D. A novel subpopulation of primed T cells in the human fetus. Journal of Immunology 1994, 152:3098-3106.
17. Carrette F., Surh C.D. IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Seminars in Immunology 2012, 24:209-217.
18. Cheung K.P., Yang E., Goldrath A.W. Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells. Journal of Immunology 2009, 183:3364-3372.
19. Chiu B.C., Martin B.E., Stolberg V.R., Chensue S.W. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. Journal of Immunology 2013, 191:5793-5796.
20. Cho J.H., Kim H.O., Surh C.D., Sprent J. T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity 2010, 32:214-226.
21. Cho B.K., Rao V.P., Ge Q., Eisen H.N., Chen J. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. The Journal of Experimental Medicine 2000, 192:549-556.
22. Choi E.Y., Jung K.C., Park H.J., Chung D.H., Song J.S., Yang S.D., et al. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 2005, 23:387-396.
23. Clarke S.R., Rudensky A.Y. Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes. Journal of Immunology 2000, 165:2458-2464.
24. Constantinides M.G., Bendelac A. Transcriptional regulation of the NKT cell lineage. Current Opinion in Immunology 2013, 25:161-167.
25. D'Cruz L.M., Stradner M.H., Yang C.Y., Goldrath A.W. E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. Journal of Immunology 2014, 192:2227-2236.
26. Dickgreber N., Farrand K.J., van Panhuys N., Knight D.A., McKee S.J., Chong M.L., et al. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. Journal of Leukocyte Biology 2012, 92:999-1009.
27. Do J.S., Valujskikh A., Vignali D.A., Fairchild R.L., Min B. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:12698-12703.
28. Dubois A., Deruytter N., Adams B., Kanda A., Delbauve S., Fleury S., et al. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. Journal of Immunology 2010, 185:884-891.
29. Dudley M.E., Wunderlich J.R., Robbins P.F., Yang J.C., Hwu P., Schwartzentruber D.J., et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002, 1076514.
30. Dummer W., Ernst B., LeRoy E., Lee D., Surh C. Autologous regulation of naive T cell homeostasis within the T cell compartment. Journal of Immunology 2001, 166:2460-2468.
31. Dummer W., Niethammer A.G., Baccala R., Lawson B.R., Reisfeld R.A., Theofilopoulos A.N. T cell homeostatic proliferation elicits effective anti-tumor autoimmunity. The Journal of Clinical Investigation 2002, 110:185-192.
32. Engel I., Kronenberg M. Transcriptional control of the development and function of Valpha14i NKT cells. Current Topics in Microbiology and Immunology 2014, 381:51-81.
33. Ernst B., Lee D.S., Chang J.M., Sprent J., Surh C.D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 1999, 11:173-181.
34. Felices M., Yin C.C., Kosaka Y., Kang J., Berg L.J. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:8308-8313.
35. Feng X., Wang H., Takata H., Day T.J., Willen J., Hu H. Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nature Immunology 2011, 12:544-550.
36. Ferreira C., Barthlott T., Garcia S., Zamoyska R., Stockinger B. Differential survival of naive CD4 and CD8 T cells. Journal of Immunology 2000, 165:3689-3694.
37. Fukuyama T., Kasper L.H., Boussouar F., Jeevan T., van Deursen J., Brindle P.K. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Molecular and Cellular Biology 2009, 29:3894-3904.
38. Ge Q., Bai A., Jones B., Eisen H.N., Chen J. Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:3041-3046.
39. Goldrath A.W. Maintaining the status quo: T-cell homeostasis. Microbes and Infection 2002, 4:539-545.
40. Goldrath A.W., Bevan M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 1999, 11:183-190.
41. Goldrath A.W., Bogatzki L.Y., Bevan M.J. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. The Journal of Experimental Medicine 2000, 192:557-564.
42. Goldrath A.W., Luckey C.J., Park R., Benoist C., Mathis D. The molecular program induced in T cells undergoing homeostatic proliferation. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:16885-16890.
43. Goldrath A.W., Sivakumar P.V., Glaccum M., Kennedy M.K., Bevan M.J., Benoist C., et al. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. The Journal of Experimental Medicine 2002, 195:1515-1522.
44. Gordon S.M., Carty S.A., Kim J.S., Zou T., Smith-Garvin J., Alonzo E.S., et al. Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. Journal of Immunology 2011, 186:4573-4578.
45. Graham D.B., Bell M.P., McCausland M.M., Huntoon C.J., van Deursen J., Faubion W.A., et al. Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. Journal of Immunology 2006, 176:291-300.
46. Gudmundsdottir H., Turka L.A. A closer look at homeostatic proliferation of CD4+ T cells: Costimulatory requirements and role in memory formation. Journal of Immunology 2001, 167:3699-3707.
47. Gugasyan R., Horat E., Kinkel S.A., Ross F., Grigoriadis G., Gray D., et al. The NF-kappaB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. The EMBO Journal 2012, 31:692-706.
48. Hagen K.A., Moses C.T., Drasler E.F., Podetz-Pedersen K.M., Jameson S.C., Khoruts A. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. Journal of Immunology 2004, 173:3909-3915.
49. Haluszczak C., Akue A.D., Hamilton S.E., Johnson L.D., Pujanauski L., Teodorovic L., et al. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. The Journal of Experimental Medicine 2009, 206:435-448.
50. Hamilton S.E., Jameson S.C. The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18484-18489.
51. Hamilton S.E., Wolkers M.C., Schoenberger S.P., Jameson S.C. The generation of protective memory-like CD8(+) T cells during homeostatic proliferation requires CD4(+) T cells. Nature Immunology 2006, 7:475-481.
52. Hirose S., Touma M., Go R., Katsuragi Y., Sakuraba Y., Gondo Y., et al. Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner 2014, International Immunology.
53. Hogquist K.A., Jameson S.C. The self-obsession of T cells: How TCR signaling thresholds affect fate decisions in the thymus and effector function in the periphery. Nature Immunology 2014, 15:815-823. in press.
54. Hu H.-M., Poehlein C.H., Urba W.J., Fox B.A. Development of antitumor immune responses in reconstituted lymphopenic hosts. Cancer Research 2002, 62:3914-3919.
55. Jameson S.C. Maintaining the norm: T-cell homeostasis. Nature Reviews. Immunology 2002, 2:547-556.
56. Jiang Q., Li W.Q., Aiello F.B., Mazzucchelli R., Asefa B., Khaled A.R., et al. Cell biology of IL-7, a key lymphotrophin. Cytokine & Growth Factor Reviews 2005, 16:513-533.
57. Johnson L.D., Jameson S.C. Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation. Journal of Immunology 2010, 184:5604-5611.
58. Jordan M.S., Smith J.E., Burns J.C., Austin J.E., Nichols K.E., Aschenbrenner A.C., et al. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 2008, 28:359-369.
59. Kamimura D., Bevan M.J. Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo. The Journal of Experimental Medicine 2007, 204:1803-1812.
60. Kieper W.C., Burghardt J.T., Surh C.D. A role for TCR affinity in regulating naive T cell homeostasis. Journal of Immunology 2004, 172:40-44.
61. Kieper W.C., Jameson S.C. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:13306-13311.
62. Kieper W.C., Tan J.T., Bondi-Boyd B., Gapin L., Sprent J., Ceredig R., et al. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. The Journal of Experimental Medicine 2002, 195:1533-1539.
63. Kieper W.C., Troy A., Burghardt J.T., Ramsey C., Lee J.Y., Jiang H.Q., et al. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. Journal of Immunology 2005, 174:3158-3163.
64. Kim P.J., Pai S.Y., Brigl M., Besra G.S., Gumperz J., Ho I.C. GATA-3 regulates the development and function of invariant NKT cells. Journal of Immunology 2006, 177:6650-6659.
65. Kirberg J., Berns A., von Boehmer H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. Journal of Experimental Medicine 1997, 186:1269-1275.
66. Klebanoff C.A., Khong H.T., Antony P.A., Palmer D.C., Restifo N.P. Sinks, suppressors and antigen presenters: How lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends in Immunology 2005, 26:111-117.
67. Knudson K.M., Hamilton S.E., Daniels M.A., Jameson S.C., Teixeiro E. Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. Journal of Immunology 2013, 191:5797-5801.
68. Kovalovsky D., Uche O.U., Eladad S., Hobbs R.M., Yi W., Alonzo E., et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nature Immunology 2008, 9:1055-1064.
69. Kurzweil V., Laroche A., Oliver P.M. Increased peripheral IL-4 leads to an expanded virtual memory CD8+ population. Journal of Immunology 2014, 192:5643-5651.
70. Kwon S.J., Crespo-Barreto J., Zhang W., Wang T., Kim D.S., Krensky A., et al. KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells. Journal of Immunology 2014, 192:5703-5709.
71. La Gruta N.L., Rothwell W.T., Cukalac T., Swan N.G., Valkenburg S.A., Kedzierska K., et al. Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. The Journal of Clinical Investigation 2010, 120:1885-1894.
72. Lai D., Zhu J., Wang T., Hu-Li J., Terabe M., Berzofsky J.A., et al. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. The Journal of Experimental Medicine 2011, 208:1093-1103.
73. Lauritsen J.P., Wong G.W., Lee S.Y., Lefebvre J.M., Ciofani M., Rhodes M., et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity 2009, 31:565-575.
74. Le Campion A., Bourgeois C., Lambolez F., Martin B., Leaument S., Dautigny N., et al. Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:4538-4543.
75. Lee J.Y., Hamilton S.E., Akue A.D., Hogquist K.A., Jameson S.C. Virtual memory CD8 T cells display unique functional properties. Proceedings of the National Academy of Sciences of the United States of America 2013, 110:13498-13503.
76. Lee Y.J., Holzapfel K.L., Zhu J., Jameson S.C., Hogquist K.A. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nature Immunology 2013, 14:1146-1154.
77. Lee Y.J., Jameson S.C., Hogquist K.A. Alternative memory in the CD8 T cell lineage. Trends in Immunology 2011, 32:50-56.
78. Lee Y.J., Jeon Y.K., Kang B.H., Chung D.H., Park C.G., Shin H.Y., et al. Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. The Journal of Experimental Medicine 2010, 207(237-246):S231-S237.
79. Lees R.K., Ferrero I., MacDonald H.R. Tissue-specific segregation of TCRgamma delta+NKT cells according to phenotype TCR repertoire and activation status: Parallels with TCR alphabeta+ NKT cells. European Journal of Immunology 2001, 31:2901-2909.
80. Li W., Kim M.G., Gourley T.S., McCarthy B.P., Sant'Angelo D.B., Chang C.H. An alternate pathway for CD4 T cell development: Thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 2005, 23:375-386.
81. Li Q., Rao R.R., Araki K., Pollizzi K., Odunsi K., Powell J.D., et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 2011, 34:541-553.
82. Li W., Sofi M.H., Rietdijk S., Wang N., Terhorst C., Chang C.H. The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction. Immunity 2007, 27:763-774.
83. Markiewicz M.A., Girao C., Opferman J.T., Sun J., Hu Q., Agulnik A.A., et al. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:3065-3070.
84. Martin B., Bourgeois C., Dautigny N., Lucas B. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:6021-6026.
85. Mazzucchelli R., Durum S.K. Interleukin-7 receptor expression: Intelligent design. Nature Reviews. Immunology 2007, 7:144-154.
86. Michel M.L., Mendes-da-Cruz D., Keller A.C., Lochner M., Schneider E., Dy M., et al. Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:19845-19850.
87. Min B., Foucras G., Meier-Schellersheim M., Paul W.E. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:3874-3879.
88. Min H.S., Lee Y.J., Jeon Y.K., Kim E.J., Kang B.H., Jung K.C., et al. MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells. Journal of Immunology 2011, 186:5749-5757.
89. Min B., McHugh R., Sempowski G.D., Mackall C., Foucras G., Paul W.E. Neonates support lymphopenia-induced proliferation. Immunity 2003, 18:131-140.
90. Min B., Paul W.E. Endogenous proliferation: Burst-like CD4 T cell proliferation in lymphopenic settings. Seminars in Immunology 2005, 17:201-207.
91. Min B., Yamane H., Hu-Li J., Paul W.E. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. Journal of Immunology 2005, 174:6039-6044.
92. Mold J.E., McCune J.M. Immunological tolerance during fetal development: From mouse to man. Advances in Immunology 2012, 115:73-111.
93. Moon J.J., Chu H.H., Pepper M., McSorley S.J., Jameson S.C., Kedl R.M., et al. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 2007, 27:203-213.
94. Morris S.C., Heidorn S.M., Herbert D.R., Perkins C., Hildeman D.A., Khodoun M.V., et al. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. Journal of Immunology 2009, 182:1429-1438.
95. Moses C.T., Thorstenson K.M., Jameson S.C., Khoruts A. Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:1185-1190.
96. Murali-Krishna K., Ahmed R. Cutting edge: Naive T cells masquerading as memory cells. Journal of Immunology 2000, 165:1733-1737.
97. Muranski P., Chmielowski B., Ignatowicz L. Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery. Journal of Immunology 2000, 164:3087-3094.
98. Nayar R., Enos M., Prince A., Shin H., Hemmers S., Jiang J.K., et al. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:E2794-E2802.
99. Nesic D., Vukmanovic S. MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. Journal of Immunology 1998, 160:3705-3712.
100. Oliver P.M., Cao X., Worthen G.S., Shi P., Briones N., MacLeod M., et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity 2006, 25:929-940.
101. Oliver J.A., Stolberg V.R., Chensue S.W., King P.D. IL-4 acts as a potent stimulator of IFN-gamma expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet. Cytokine 2012, 57:191-199.
102. Palmer M.J., Mahajan V.S., Chen J., Irvine D.J., Lauffenburger D.A. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naive CD8(+) T cells. Immunology and Cell Biology 2011, 89:581-594.
103. Park J.H., Yu Q., Erman B., Appelbaum J.S., Montoya-Durango D., Grimes H.L., et al. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: A novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 2004, 21:289-302.
104. Pereira R.M., Martinez G.J., Engel I., Cruz-Guilloty F., Barboza B.A., Tsagaratou A., et al. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nature Communications 2014, 5:4540.
105. Posevitz V., Arndt B., Krieger T., Warnecke N., Schraven B., Simeoni L. Regulation of T cell homeostasis by the transmembrane adaptor protein SIT. Journal of Immunology 2008, 180:1634-1642.
106. Qi Q., Xia M., Hu J., Hicks E., Iyer A., Xiong N., et al. Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production. Blood 2009, 114:564-571.
107. Rao R.R., Li Q., Odunsi K., Shrikant P.A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010, 32:67-78.
108. Renkema K.R., Li G., Wu A., Smithey M.J., Nikolich-Zugich J. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. Journal of Immunology 2014, 192:151-159.
109. Rudd B.D., Venturi V., Li G., Samadder P., Ertelt J.M., Way S.S., et al. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:13694-13699.
110. Sandau M.M., Winstead C.J., Jameson S.C. IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. Journal of Immunology 2007, 179:120-125.
111. Savage A.K., Constantinides M.G., Han J., Picard D., Martin E., Li B., et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 2008, 29:391-403.
112. Schluns K.S., Kieper W.C., Jameson S.C., Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nature Immunology 2000, 1:426-432.
113. Schluns K.S., Lefrancois L. Cytokine control of memory T-cell development and survival. Nature Reviews. Immunology 2003, 3:269-279.
114. Schuler T., Hammerling G.J., Arnold B. Cutting edge: IL-7-dependent homeostatic proliferation of CD8+ T cells in neonatal mice allows the generation of long-lived natural memory T cells. Journal of Immunology 2004, 172:15-19.
115. Seddon B., Legname G., Tomlinson P., Zamoyska R. Long-term survival but impaired homeostatic proliferation of naive T cells in the absence of p56lck. Science 2000, 290:127-131.
116. Seddon B., Zamoyska R. TCR and IL-7 receptor signals can operate independently or synergize to promote lymphopenia-induced expansion of naive T cells. Journal of Immunology 2002, 169:3752-3759.
117. Seddon B., Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. Journal of Immunology 2002, 169:2997-3005.
118. Sharma A., Chen Q., Nguyen T., Yu Q., Sen J.M. T cell factor-1 and beta-catenin control the development of memory-like CD8 thymocytes. Journal of Immunology 2012, 188:3859-3868.
119. Shedlock D.J., Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003, 300:337-339.
120. Singh N.J., Schwartz R.H. The lymphopenic mouse in immunology: From patron to pariah. Immunity 2006, 25:851-855.
121. Sintes J., Cuenca M., Romero X., Bastos R., Terhorst C., Angulo A., et al. Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells. Journal of Immunology 2013, 190:21-26.
122. Skon C.N., Jameson S.C. Fox factors fight over T cell quiescence. Nature Immunology 2011, 12:522-524.
123. Smith K., Seddon B., Purbhoo M.A., Zamoyska R., Fisher A.G., Merkenschlager M. Sensory adaptation in naive peripheral CD4 T cells. The Journal of Experimental Medicine 2001, 194:1253-1261.
124. Sosinowski T., White J.T., Cross E.W., Haluszczak C., Marrack P., Gapin L., et al. CD8alpha+dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. Journal of Immunology 2013, 190:1936-1947.
125. Sprent J., Surh C.D. Normal T cell homeostasis: The conversion of naive cells into memory-phenotype cells. Nature Immunology 2011, 12:478-484.
126. Su L.F., Davis M.M. Antiviral memory phenotype T cells in unexposed adults. Immunological Reviews 2013, 255:95-109.
127. Su L.F., Kidd B.A., Han A., Kotzin J.J., Davis M.M. Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity 2013, 38:373-383.
128. Sun J.C., Bevan M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 2003, 300:339-342.
129. Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity 2008, 29:848-862.
130. Takada K., Jameson S.C. Naive T cell homeostasis: From awareness of space to a sense of place. Nature Reviews. Immunology 2009, 9:823-832.
131. + T cells, but affect their long-term life span. Immunity 1996, 5:217-228.
132. Tan J.T., Ernst B., Kieper W.C., LeRoy E., Sprent J., Surh C.D. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. The Journal of Experimental Medicine 2002, 195:1523-1532.
133. Tanchot C., Le Campion A., Leaument S., Dautigny N., Lucas B. Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients. European Journal of Immunology 2001, 31:2256-2265.
134. Tchao N.K., Turka L.A. Lymphodepletion and homeostatic proliferation: Implications for transplantation. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012, 12:1079-1090.
135. Teixeiro E., Daniels M.A., Hamilton S.E., Schrum A.G., Bragado R., Jameson S.C., et al. Different T cell receptor signals determine CD8+ memory versus effector development. Science 2009, 323:502-505.
136. Troy A.E., Shen H. Cutting edge: Homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. Journal of Immunology 2003, 170:672-676.
137. Ueda-Hayakawa I., Mahlios J., Zhuang Y. Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. Journal of Immunology 2009, 182:5306-5316.
138. Ventre E., Brinza L., Schicklin S., Mafille J., Coupet C.A., Marcais A., et al. Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells. Journal of Immunology 2012, 189:3480-3489.
139. Verykokakis M., Boos M.D., Bendelac A., Adams E.J., Pereira P., Kee B.L. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One 2010, 5:e9303.
140. Verykokakis M., Boos M.D., Bendelac A., Kee B.L. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity 2010, 33:203-215.
141. Verykokakis M., Krishnamoorthy V., Iavarone A., Lasorella A., Sigvardsson M., Kee B.L. Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. Journal of Immunology 2013, 191:5973-5983.
142. Viret C., Wong F.S., Janeway C.A. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition. Immunity 1999, 10:559-568.
143. Vos Q., Jones L.A., Kruisbeek A.M. Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells. Journal of Immunology 1992, 149:1204-1210.
144. Wang L.X., Li R., Yang G., Lim M., O'Hara A., Chu Y., et al. Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing. Cancer Research 2005, 65:10569-10577.
145. Watarai H., Sekine-Kondo E., Shigeura T., Motomura Y., Yasuda T., Satoh R., et al. Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biology 2012, 10:e1001255.
146. Weinreich M.A., Odumade O.A., Jameson S.C., Hogquist K.A. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nature Immunology 2010, 11:709-716.
147. Weinreich M.A., Takada K., Skon C., Reiner S.L., Jameson S.C., Hogquist K.A. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 2009, 31:122-130.
148. Wiede F., La Gruta N.L., Tiganis T. PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nature Communications 2014, 5:3073.
149. Wiede F., Shields B.J., Chew S.H., Kyparissoudis K., van Vliet C., Galic S., et al. T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. The Journal of Clinical Investigation 2011, 121:4758-4774.
150. Winstead C.J., Reilly C.S., Moon J.J., Jenkins M.K., Hamilton S.E., Jameson S.C., et al. CD4+ CD25+ Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. Journal of Immunology 2010, 184:4749-4760.
151. Workman C.J., Vignali D.A. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). Journal of Immunology 2005, 174:688-695.
152. Wu Z., Bensinger S.J., Zhang J., Chen C., Yuan X., Huang X., et al. Homeostatic proliferation is a barrier to transplantation tolerance. Nature Medicine 2004, 10:87-92.
153. Yin C.C., Cho O.H., Sylvia K.E., Narayan K., Prince A.L., Evans J.W., et al. The Tec kinase ITK regulates thymic expansion, emigration, and maturation of gammadelta NKT cells. Journal of Immunology 2013, 190:2659-2669.
154. Yuan J., Nguyen C.K., Liu X., Kanellopoulou C., Muljo S.A. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 2012, 335:1195-1200.
155. Zhou X., Yu S., Zhao D.M., Harty J.T., Badovinac V.P., Xue H.H. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 2010, 33:229-240.