Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide: MHC complexes

Journal of Immunology

Volumn 165, Issue 5, 2000, Pages 2458-2464

  Clarke, S R M ^a   Rudensky, A Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; HOMEOSTASIS; IMMUNOSTIMULATION; LYMPHOCYTOPENIA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0034284220     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.5.2458     Document Type: Article

References (38)

1. Positive selection of thymocytes
2. Selection of the T cell repertoire
3. Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype
4. The life span of naive α/β T cells in secondary lymphoid organs
5. Turnover of naive- and memory-phenotype T cells
6. T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses
7. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells
8. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo
9. Post-thymic in vivo expansion of mature αβ T cells
10. Peripheral selection of the T cell repertoire
11. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing
12. Differential requirements for survival and proliferation of CD8 naive or memory T cells
13. The peripheral T-cell pool: Regulation by non-antigen induced proliferation?
14. TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host
15. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide: Self-MHC complex recognition
16. Naive cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?
17. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
18. + T cells in lymphopenic hosts
19. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands
20. + T cells, but affect their long-term life span
21. Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses
22. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
23. + thymic emigrants
24. Survival of naive CD4 T cells: Roles of restricting versus selecting MHC class II and cytokine milieu
25. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells
26. + T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection
27. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
28. Determination of lymphocyte division by flow cytometry
29. Antigen presentation and T cell development in H2-M-deficient mice
30. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
31. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
32. + T cells in H-2Ma0/0 mice
33. + T cells
34. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire
35. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity
36. Immunological memory
37. Naive T cells transiently acquire a memory-like phenotype during homeostatis-driven proliferation
38. Persistence of memory CD8 T cells in MHC class I-deficient mice