Different T cell receptor signals determine CD8+ memory versus effector development

Science

Volumn 323, Issue 5913, 2009, Pages 502-505

  Teixeiro, Emma ^a,b   Daniels, Mark A ^a,b   Hamilton, Sara E ^c   Schrum, Adam G ^a,e   Bragado, Rafael ^d   Jameson, Stephen C ^c   Palmer, Ed ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b University of Missouri   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^e MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; GAMMA INTERFERON; GRANZYME B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 7 RECEPTOR; LEUKOSIALIN; PADGEM PROTEIN; PROTEIN KINASE C THETA; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR ALPHA;

CELL ORGANELLE; IMMUNE RESPONSE; MUTATION; PATHOGEN;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL POLARITY; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA BINDING; EFFECTOR CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MOUSE; MUTANT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SYNAPSE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; GENES, T-CELL RECEPTOR BETA; IMMUNIZATION; IMMUNOLOGIC MEMORY; IMMUNOLOGICAL SYNAPSES; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LYMPHOCYTE COUNT; MICE; MICE, TRANSGENIC; NF-KAPPA B; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 58849158737     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1163612     Document Type: Article

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26. We thank D. Roubaty, B. Hausmann, V. Jäggin, G. E. Fernandez, H. Karauzum, M. Schmaler, and Z. Rajacic for technical assistance; R. Landmann-Suter for technical advice; and C. Pernas Pernas for helpful discussion. This work was supported by Mission Enhancement Program, University of Missouri (E.T. and M.A.D.) fellowships from the Fundación Ramón Areces, Spain (E.T.), the American Cancer Society (S.E.H.), the Cancer Research Institute (M.A.D.), the Spanish Ministry of Science and Education (MEC) (BFU 2005-02807) (R.B.), Novartis, Roche, Sybilla (EUFP7) and the Swiss National Science Foundation (E.P.).