KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine Receptors

Immunity

Volumn 31, Issue 1, 2009, Pages 122-130

  Weinreich, Michael A ^a   Takada, Kensuke ^a   Skon, Cara ^a   Reiner, Steven L ^b   Jameson, Stephen C ^a   Hogquist, Kristin A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; EOMESODERMIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; KRUPPEL LIKE FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CXCR3 PROTEIN, MOUSE; KLF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; L SELECTIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; T BOX TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOGLOBULIN BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT;

ANIMALS; IMMUNOGLOBULIN E; INTERLEUKIN-4; KRUPPEL-LIKE TRANSCRIPTION FACTORS; L-SELECTIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CXCR3; RECEPTORS, LYSOSPHINGOLIPID; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES; UP-REGULATION;

EID: 68249134207     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.05.011     Document Type: Article

References (32)

1. Allende M.L., Dreier J.L., Mandala S., and Proia R.L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279 (2004) 15396-15401
2. Ansel K.M., Djuretic I., Tanasa B., and Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 24 (2006) 607-656
3. Apfeld J., and Kenyon C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95 (1998) 199-210
4. Arbones M.L., Ord D.C., Ley K., Ratech H., Maynard-Curry C., Otten G., Capon D.J., and Tedder T.F. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1 (1994) 247-260
5. Bai A., Hu H., Yeung M., and Chen J. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and Sphingosine-1-phosphate receptor 1 transcription. J. Immunol. 178 (2007) 7632-7639
6. Carlson C.M., Endrizzi B.T., Wu J., Ding X., Weinreich M.A., Walsh E.R., Wani M.A., Lingrel J.B., Hogquist K.A., and Jameson S.C. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442 (2006) 299-302
7. Coffman R.L., Ohara J., Bond M.W., Carty J., Zlotnik A., and Paul W.E. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136 (1986) 4538-4541
8. Dang X., Raffler N.A., and Ley K. Transcriptional regulation of mouse l-selectin. Biochim. Biophys. Acta 1789 (2009) 146-152
9. Hogquist K.A., Jameson S.C., Heath W.R., Howard J.L., Bevan M.J., and Carbone F.R. T cell receptor antagonist peptides induce positive selection. Cell 76 (1994) 17-27
10. Intlekofer A.M., Banerjee A., Takemoto N., Gordon S.M., Dejong C.S., Shin H., Hunter C.A., Wherry E.J., Lindsten T., and Reiner S.L. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321 (2008) 408-411
11. Kuo C.T., Veselits M.L., Barton K.P., Lu M.M., Clendenin C., and Leiden J.M. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 11 (1997) 2996-3006
12. Kuo C.T., Veselits M.L., and Leiden J.M. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science 277 (1997) 1986-1990
13. Lee J.S., Yu Q., Shin J.T., Sebzda E., Bertozzi C., Chen M., Mericko P., Stadtfeld M., Zhou D., Cheng L., et al. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev. Cell 11 (2006) 845-857
14. Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., Perez-Melgosa M., Sweetser M.T., Schlissel M.S., Nguyen S., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15 (2001) 763-774
15. Lo C.G., Xu Y., Proia R.L., and Cyster J.G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201 (2005) 291-301
16. Lord G.M., Rao R.M., Choe H., Sullivan B.M., Lichtman A.H., Luscinskas F.W., and Glimcher L.H. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106 (2005) 3432-3439
17. Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
18. Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., and Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
19. McCaughtry T.M., Wilken M.S., and Hogquist K.A. Thymic emigration revisited. J. Exp. Med. 204 (2007) 2513-2520
20. Ohara J., and Paul W.E. Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression. Proc. Natl. Acad. Sci. USA 85 (1988) 8221-8225
21. Pearson R., Fleetwood J., Eaton S., Crossley M., and Bao S. Kruppel-like transcription factors: A functional family. Int. J. Biochem. Cell Biol. 40 (2008) 1996-2001
22. Ramalingam T.R., Pesce J.T., Sheikh F., Cheever A.W., Mentink-Kane M.M., Wilson M.S., Stevens S., Valenzuela D.M., Murphy A.J., Yancopoulos G.D., et al. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat. Immunol. 9 (2008) 25-33
23. Schnell F.J., Zoller A.L., Patel S.R., Williams I.R., and Kersh G.J. Early growth response gene 1 provides negative feedback to inhibit entry of progenitor cells into the thymus. J. Immunol. 176 (2006) 4740-4747
24. Schober S.L., Kuo C.T., Schluns K.S., Lefrancois L., Leiden J.M., and Jameson S.C. Expression of the transcription factor lung Kruppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. J. Immunol. 163 (1999) 3662-3667
25. Sebzda E., Zou Z., Lee J.S., Wang T., and Kahn M.L. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat. Immunol. 9 (2008) 292-300
26. Shiow L.R., Rosen D.B., Brdickova N., Xu Y., An J., Lanier L.L., Cyster J.G., and Matloubian M. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440 (2006) 540-544
27. Smiley S.T., Kaplan M.H., and Grusby M.J. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275 (1997) 977-979
28. Snapper C.M., and Paul W.E. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236 (1987) 944-947
29. Stadtfeld M., and Graf T. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development 132 (2005) 203-213
30. Takemoto N., Intlekofer A.M., Northrup J.T., Wherry E.J., and Reiner S.L. Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J. Immunol. 177 (2006) 7515-7519
31. Whyatt D., and Grosveld F. Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes. EMBO Rep. 3 (2002) 130-135
32. Zhu J., and Paul W.E. CD4 T cells: fates, functions, and faults. Blood 112 (2008) 1557-1569