Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength

Journal of Immunology

Volumn 191, Issue 12, 2013, Pages 5797-5801

  Knudson, Karin M ^a   Hamilton, Sara E ^b   Daniels, Mark A ^a   Jameson, Stephen C ^b   Teixeiro, Emma ^a  

^a University of Missouri   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 84890409537     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300905     Document Type: Article

References (31)

1. de Visser, K. E., T. A. Cordaro, D. Kioussis, J. B. Haanen, T. N. Schumacher, and A. M. Kruisbeek. 2000. Tracing and characterization of the low-avidity self-specific T cell repertoire. Eur. J. Immunol. 30: 1458-1468.
2. Smith-Garvin, J. E., J. C. Burns, M. Gohil, T. Zou, J. S. Kim, J. S. Maltzman, E. J. Wherry, G. A. Koretzky, and M. S. Jordan. 2010. T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood 116: 5548-5559.
3. Zehn, D., M. J. Turner, L. Lefrançois, and M. J. Bevan. 2010. Lack of original antigenic sin in recall CD8(+) T cell responses. J. Immunol. 184: 6320-6326.
4. Kieper, W. C., and S. C. Jameson. 1999. Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. USA 96: 13306-13311.
5. Zehn, D., S. Y. Lee, and M. J. Bevan. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458: 211-214.
6. Goldrath, A. W., and M. J. Bevan. 1999. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 11: 183-190.
7. Hamilton, S. E., M. C. Wolkers, S. P. Schoenberger, and S. C. Jameson. 2006. The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat. Immunol. 7: 475-481.
8. Surh, C. D., and J. Sprent. 2008. Homeostasis of naive and memory T cells. Immunity 29: 848-862.
9. Cheung, K. P., E. Yang, and A. W. Goldrath. 2009. Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells. J. Immunol. 183: 3364-3372.
10. Edwards, L. J., and B. D. Evavold. 2011. T cell recognition of weak ligands: roles of signaling, receptor number, and affinity. Immunol. Res. 50: 39-48.
11. Corse, E., R. A. Gottschalk, and J. P. Allison. 2011. Strength of TCR-peptide/MHC interactions and in vivo T cell responses. Journal of immunology (Baltimore, Md: 1950) 186: 5039-5045.
12. Daniels, M. A., E. Teixeiro, J. Gill, B. Hausmann, D. Roubaty, K. Holmberg, G. Werlen, G. A. Holländer, N. R. J. Gascoigne, and E. Palmer. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444: 724-729.
13. Teixeiro, E., M. A. Daniels, S. E. Hamilton, A. G. Schrum, R. Bragado, S. C. Jameson, and E. Palmer. 2009. Different T cell receptor signals determine CD8+ memory versus effector development. Science 323: 502-505.
14. Leignadier, J., and N. Labrecque. 2010. Epitope density influences CD8+ memory T cell differentiation. PLoS ONE 5: e13740.
15. Hamilton, S. E., V. P. Badovinac, A. Khanolkar, and J. T. Harty. 2006. Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity. J. Immunol. 177: 4012-4020.
16. Akue, A. D., J. Y. Lee, and S. C. Jameson. 2012. Derivation and maintenance of virtual memory CD8 T cells. J. Immunol. 188: 2516-2523.
17. King, C. G., S. Koehli, B. Hausmann, M. Schmaler, D. Zehn, and E. Palmer. 2012. T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology. Immunity 37: 709-720.
18. Kurtulus, S., P. Tripathi, J. T. Opferman, and D. A. Hildeman. 2010. Contracting the 'mus cells' - does down-sizing suit us for diving into the memory pool? Immunol. Rev. 236: 54-67.
19. Hamilton, S. E., and S. C. Jameson. 2008. The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells. Proc. Natl. Acad. Sci. USA 105: 18484-18489.
20. Teixeiro, E., A. García-Sahuquillo, B. Alarcón, and R. Bragado. 1999. Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription. Eur. J. Immunol. 29: 745-754.
21. Teixeiro, E., M. A. Daniels, B. Hausmann, A. G. Schrum, D. Naeher, I. Luescher, M. Thome, R. Bragado, and E. Palmer. 2004. T cell division and death are segregated by mutation of TCRbeta chain constant domains. Immunity 21: 515-526.
22. Vallabhapurapu, S., and M. Karin. 2009. Regulation and function of NFkappaB transcription factors in the immune system. Annu. Rev. Immunol. 27: 693-733.
23. Krikos, A., C. D. Laherty, and V. M. Dixit. 1992. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J. Biol. Chem. 267: 17971-17976.
24. Düwel, M., V. Welteke, A. Oeckinghaus, M. Baens, B. Kloo, U. Ferch, B. G. Darnay, J. Ruland, P. Marynen, and D. Krappmann. 2009. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J. Immunol. 182: 7718-7728.
25. Paul, S., and B. C. Schaefer. 2013. A new look at T cell receptor signaling to nuclear factor-κB. Trends Immunol. 34: 269-281.
26. Hayden, M. S., and S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132: 344-362.
27. Kingeter, L. M., S. Paul, S. K. Maynard, N. G. Cartwright, and B. C. Schaefer. 2010. Cutting edge: TCR ligation triggers digital activation of NF-kappaB. J. Immunol. 185: 4520-4524.
28. Prlic, M., G. Hernandez-Hoyos, and M. J. Bevan. 2006. Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response. J. Exp. Med. 203: 2135-2143.
29. Corse, E., R. A. Gottschalk, M. Krogsgaard, and J. P. Allison. 2010. Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol. 8: e1000481.
30. Jameson, S. C., and D. Masopust. 2009. Diversity in T cell memory: an embarrassment of riches. Immunity 31: 859-871.
31. Gerlach, C., J. C. Rohr, L. Perié, N. van Rooij, J. W. van Heijst, A. Velds, J. Urbanus, S. H. Naik, H. Jacobs, J. B. Beltman, et al. 2013. Heterogeneous differentiation patterns of individual CD8+ T cells. Science 340: 635-639.