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Volumn 133, Issue 13, 2011, Pages 4746-4749
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Cytotoxic tetramic acid derivative produced by a plant type-III polyketide synthase
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Author keywords
[No Author keywords available]
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Indexed keywords
A PLANTS;
AMINOACYL;
ANTIOXIDANT ACTIVITIES;
ANTIPROLIFERATIVE ACTIVITIES;
BENZALACETONE;
CATALYTIC VERSATILITY;
CYTOTOXIC;
D-AMINO ACID;
MALONYL-COA;
NATURAL PRODUCTS;
POLYKETIDE SYNTHASES;
POLYKETIDES;
STRUCTURAL FEATURE;
SUBSTRATE SPECIFICITY;
SYNTHASES;
SYNTHETASES;
TETRAMIC ACIDS;
THIOESTERS;
AMINO ACIDS;
CONDENSATION;
PLANTS (BOTANY);
ORGANIC ACIDS;
AMINO ACID;
ANTINEOPLASTIC AGENT;
AURANTOSIDE A;
BENZALACETONE SYNTHASE;
CYLINDRAMIDE;
DIMER;
DISCODERMIDE;
MALONYL COENZYME A;
POLYKETIDE SYNTHASE;
REUTERICYCLIN;
TETRAMIC ACID DERIVATIVE;
UNCLASSIFIED DRUG;
VEGETABLE PROTEIN;
ANIMAL CELL;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CHEMICAL REACTION;
CONTROLLED STUDY;
CYCLIZATION;
DECARBOXYLATION;
DIMERIZATION;
DRUG CYTOTOXICITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ELECTROSPRAY MASS SPECTROMETRY;
ENZYME ACTIVE SITE;
ENZYME MECHANISM;
ENZYME SUBSTRATE;
LEUKEMIA CELL;
LIQUID CHROMATOGRAPHY;
NONHUMAN;
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
RHUBARB;
ANIMALS;
ANTI-BACTERIAL AGENTS;
ANTINEOPLASTIC AGENTS;
BACTERIA;
BIOCATALYSIS;
BIOLOGICAL FACTORS;
CATALYTIC DOMAIN;
CELL LINE, TUMOR;
CELL PROLIFERATION;
DRUG SCREENING ASSAYS, ANTITUMOR;
MICE;
MICROBIAL SENSITIVITY TESTS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
POLYKETIDE SYNTHASES;
PYRROLIDINONES;
RHEUM;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 79953855889
PISSN: 00027863
EISSN: 15205126
Source Type: Journal
DOI: 10.1021/ja2006737 Document Type: Article |
Times cited : (26)
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References (27)
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