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Volumn 4, Issue 2, 2011, Pages 144-164

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

Author keywords

[No Author keywords available]

Indexed keywords

ANGUCYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BLEOMYCIN; BORRELIDIN; CHROMOMYCIN A3; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; ENEDIYNE; EXTRACHROMOSOMAL DNA; GELDANAMYCIN; MITHRAMYCIN; MITOMYCIN C; OVIEDOMYCIN; RAPAMYCIN; REBECCAMYCIN; SALINOSPORAMIDE A; STAUROSPORINE; TETRACYCLINE; THIOCORALINE; UNCLASSIFIED DRUG;

EID: 79951848091     PISSN: 17517907     EISSN: 17517915     Source Type: Journal    
DOI: 10.1111/j.1751-7915.2010.00231.x     Document Type: Review
Times cited : (31)

References (131)
  • 1
    • 77549085632 scopus 로고    scopus 로고
    • The activator/repressor protein DnrO of Streptomyces peucetius binds to DNA without changing its topology
    • Ajithkumar, V., and Prasad, R. (2010) The activator/repressor protein DnrO of Streptomyces peucetius binds to DNA without changing its topology. Int J Biol Macromol 46: 380-384.
    • (2010) Int J Biol Macromol , vol.46 , pp. 380-384
    • Ajithkumar, V.1    Prasad, R.2
  • 2
    • 0028321453 scopus 로고
    • Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae
    • August, P.R., Flickinger, M.C., and Sherman, D.H. (1994) Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae. J Bacteriol 176: 4448-4454.
    • (1994) J Bacteriol , vol.176 , pp. 4448-4454
    • August, P.R.1    Flickinger, M.C.2    Sherman, D.H.3
  • 3
    • 40549140724 scopus 로고    scopus 로고
    • Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity
    • Baig, I., Perez, M., Braña, A.F., Gomathinayagam, R., Damodaran, C., Salas, J.A., etal. (2008) Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod 71: 199-207.
    • (2008) J Nat Prod , vol.71 , pp. 199-207
    • Baig, I.1    Perez, M.2    Braña, A.F.3    Gomathinayagam, R.4    Damodaran, C.5    Salas, J.A.6
  • 4
    • 54849405130 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • Baltz, R.H. (2008) Renaissance in antibacterial discovery from actinomycetes. Curr Opin Pharmacol 8: 557-563.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 557-563
    • Baltz, R.H.1
  • 5
    • 54049156883 scopus 로고    scopus 로고
    • Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells
    • Bataller, M., Méndez, C., Salas, J.A., and Portugal, J. (2008) Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells. Mol Cancer Ther 7: 2988-2997.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2988-2997
    • Bataller, M.1    Méndez, C.2    Salas, J.A.3    Portugal, J.4
  • 6
    • 77951222417 scopus 로고    scopus 로고
    • Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells
    • Bataller, M., Méndez, C., Salas, J.A., and Portugal, J. (2010) Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells. Cancer Lett 292: 80-90.
    • (2010) Cancer Lett , vol.292 , pp. 80-90
    • Bataller, M.1    Méndez, C.2    Salas, J.A.3    Portugal, J.4
  • 7
    • 33947162005 scopus 로고    scopus 로고
    • Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica
    • Beer, L.L., and Moore, B.S. (2007) Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett 9: 845-848.
    • (2007) Org Lett , vol.9 , pp. 845-848
    • Beer, L.L.1    Moore, B.S.2
  • 8
    • 19644393308 scopus 로고    scopus 로고
    • Bioactive microbial metabolites
    • Bérdy, J. (2005) Bioactive microbial metabolites. J Antibiot 58: 1-26.
    • (2005) J Antibiot , vol.58 , pp. 1-26
    • Bérdy, J.1
  • 9
    • 0033984935 scopus 로고    scopus 로고
    • Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus
    • Blanco, G., Fernández, E., Fernández, M.J., Braña, A.F., Weissbach, U., Künzel, E., etal. (2000) Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus. Mol Gen Genet 262: 991-1000.
    • (2000) Mol Gen Genet , vol.262 , pp. 991-1000
    • Blanco, G.1    Fernández, E.2    Fernández, M.J.3    Braña, A.F.4    Weissbach, U.5    Künzel, E.6
  • 10
    • 44249098800 scopus 로고    scopus 로고
    • Natural products to drugs: natural product-derived compounds in clinical trials
    • Butler, M.S. (2008) Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 25: 475-516.
    • (2008) Nat Prod Rep , vol.25 , pp. 475-516
    • Butler, M.S.1
  • 11
    • 71049136512 scopus 로고    scopus 로고
    • Disruption of cagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore
    • Cui, Z., Wang, L., Wang, S., Li, G., and Hong, B. (2009) Disruption of cagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore. FEMS Microbiol Lett 301: 57-68.
    • (2009) FEMS Microbiol Lett , vol.301 , pp. 57-68
    • Cui, Z.1    Wang, L.2    Wang, S.3    Li, G.4    Hong, B.5
  • 12
    • 0028844229 scopus 로고
    • Identification of Streptomyces olivaceus Tü2353 genes involved in the production of the polyketide elloramycin
    • Decker, H., Rohr, J., Motamedi, H., Zähner, H., and Hutchinson, C.R. (1995) Identification of Streptomyces olivaceus Tü2353 genes involved in the production of the polyketide elloramycin. Gene 166: 121-126.
    • (1995) Gene , vol.166 , pp. 121-126
    • Decker, H.1    Rohr, J.2    Motamedi, H.3    Zähner, H.4    Hutchinson, C.R.5
  • 13
    • 45749125659 scopus 로고    scopus 로고
    • Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
    • Eustáquio, A.S., and Moore, B.S. (2008) Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl 47: 3936-3938.
    • (2008) Angew Chem Int Ed Engl , vol.47 , pp. 3936-3938
    • Eustáquio, A.S.1    Moore, B.S.2
  • 14
    • 77950455094 scopus 로고    scopus 로고
    • Engineering fluorometabolite production: fluorinase expression in Salinispora tropica yields fluorosalinosporamide
    • Eustáquio, A.S., O'Hagan, D., and Moore, B.S. (2010) Engineering fluorometabolite production: fluorinase expression in Salinispora tropica yields fluorosalinosporamide. J Nat Prod 73: 378-382.
    • (2010) J Nat Prod , vol.73 , pp. 378-382
    • Eustáquio, A.S.1    O'Hagan, D.2    Moore, B.S.3
  • 15
    • 0029840323 scopus 로고    scopus 로고
    • An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus
    • Fernández, E., Lombó, F., Méndez, C., and Salas, J.A. (1996) An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus. Mol Gen Genet 251: 692-698.
    • (1996) Mol Gen Genet , vol.251 , pp. 692-698
    • Fernández, E.1    Lombó, F.2    Méndez, C.3    Salas, J.A.4
  • 16
    • 0031690038 scopus 로고    scopus 로고
    • Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin
    • Fernández, E., Weissbach, U., Sánchez Reillo, C., Braña, A.F., Méndez, C., Rohr, J., and Salas, J.A. (1998) Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin. J Bacteriol 180: 4929-4937.
    • (1998) J Bacteriol , vol.180 , pp. 4929-4937
    • Fernández, E.1    Weissbach, U.2    Sánchez Reillo, C.3    Braña, A.F.4    Méndez, C.5    Rohr, J.6    Salas, J.A.7
  • 17
    • 33748631825 scopus 로고    scopus 로고
    • Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms
    • Fischbach, M.A., and Walsh, C.T. (2006) Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 106: 3468-3496.
    • (2006) Chem Rev , vol.106 , pp. 3468-3496
    • Fischbach, M.A.1    Walsh, C.T.2
  • 18
    • 0036854694 scopus 로고    scopus 로고
    • Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT
    • Fischer, C., Rodríguez, L., Patallo, E.P., Lipata, F., Braña, A.F., Méndez, C., etal. (2002) Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT. J Nat Prod 65: 1685-1689.
    • (2002) J Nat Prod , vol.65 , pp. 1685-1689
    • Fischer, C.1    Rodríguez, L.2    Patallo, E.P.3    Lipata, F.4    Braña, A.F.5    Méndez, C.6
  • 19
    • 33744537000 scopus 로고    scopus 로고
    • Combinatorial biosynthesis-potential and problems
    • Floss, H.G. (2006) Combinatorial biosynthesis-potential and problems. J Biotechnol 124: 242-257.
    • (2006) J Biotechnol , vol.124 , pp. 242-257
    • Floss, H.G.1
  • 20
    • 10344221578 scopus 로고    scopus 로고
    • The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA binding protein involved in the regulation of daunorubicin biosynthesis
    • Furuya, K., and Hutchinson, C.R. (1996) The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA binding protein involved in the regulation of daunorubicin biosynthesis. J Bacteriol 178: 6310-6318.
    • (1996) J Bacteriol , vol.178 , pp. 6310-6318
    • Furuya, K.1    Hutchinson, C.R.2
  • 21
    • 0345404399 scopus 로고    scopus 로고
    • The DrrC protein of Streptomyces peucetius, a UvrA-like protein, is a DNA-binding protein whose gene is induced by daunorubicin
    • Furuya, K., and Hutchinson, C.R. (1998) The DrrC protein of Streptomyces peucetius, a UvrA-like protein, is a DNA-binding protein whose gene is induced by daunorubicin. FEMS Microbiol Lett 168: 243-249.
    • (1998) FEMS Microbiol Lett , vol.168 , pp. 243-249
    • Furuya, K.1    Hutchinson, C.R.2
  • 22
    • 57449121088 scopus 로고    scopus 로고
    • In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC 15003 revealing new insights into its biosynthetic pathway
    • Galm, U., Wang, L., Wendt-Pienkowski, E., Yang, R., Liu, W., Tao, M., etal. (2008) In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC 15003 revealing new insights into its biosynthetic pathway. J Biol Chem 283: 28236-28245.
    • (2008) J Biol Chem , vol.283 , pp. 28236-28245
    • Galm, U.1    Wang, L.2    Wendt-Pienkowski, E.3    Yang, R.4    Liu, W.5    Tao, M.6
  • 23
    • 0034193797 scopus 로고    scopus 로고
    • Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus
    • Garcia-Bernardo, J., Braña, A.F., Méndez, C., and Salas, J.A. (2000) Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus. FEMS Microbiol Lett 186: 61-65.
    • (2000) FEMS Microbiol Lett , vol.186 , pp. 61-65
    • Garcia-Bernardo, J.1    Braña, A.F.2    Méndez, C.3    Salas, J.A.4
  • 24
    • 23044465228 scopus 로고    scopus 로고
    • Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis
    • Gregory, M.A., Petkovic, H., Lill, R.E., Moss, S.J., Wilkinson, B., Gaisser, S., etal. (2005) Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angew Chem Int Ed Engl 44: 4757-4760.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 4757-4760
    • Gregory, M.A.1    Petkovic, H.2    Lill, R.E.3    Moss, S.J.4    Wilkinson, B.5    Gaisser, S.6
  • 25
    • 34249002384 scopus 로고    scopus 로고
    • Hydroxyquinone O-methylation in mitomycin biosynthesis
    • Grüschow, S., Chang, L.C., Mao, Y., and Sherman, D.H. (2007) Hydroxyquinone O-methylation in mitomycin biosynthesis. J Am Chem Soc 129: 6470-6476.
    • (2007) J Am Chem Soc , vol.129 , pp. 6470-6476
    • Grüschow, S.1    Chang, L.C.2    Mao, Y.3    Sherman, D.H.4
  • 26
    • 0025999987 scopus 로고
    • A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin
    • Guilfoile, P.G., and Hutchinson, C.R. (1991) A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin. Proc Natl Acad Sci USA 88: 8553-8557.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8553-8557
    • Guilfoile, P.G.1    Hutchinson, C.R.2
  • 27
    • 66349117644 scopus 로고    scopus 로고
    • Chasing the treasures of the sea - bacterial marine natural products
    • Gulder, T.A., and Moore, B.S. (2009) Chasing the treasures of the sea - bacterial marine natural products. Curr Opin Microbiol 12: 252-260.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 252-260
    • Gulder, T.A.1    Moore, B.S.2
  • 28
    • 33745143939 scopus 로고    scopus 로고
    • Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin
    • Gullón, S., Olano, C., Abdelfattah, M.S., Braña, A.F., Rohr, J., Méndez, C., and Salas, J.A. (2006) Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol 72: 4172-4183.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 4172-4183
    • Gullón, S.1    Olano, C.2    Abdelfattah, M.S.3    Braña, A.F.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 29
    • 54049115940 scopus 로고    scopus 로고
    • Cloning of the gene cluster responsible for the biosynthesis of brasilicardin A, a unique diterpenoid
    • Hayashi, Y., Matsuura, N., Toshima, H., Itoh, N., Ishikawa, J., Mikami, Y., and Dairi, T. (2008) Cloning of the gene cluster responsible for the biosynthesis of brasilicardin A, a unique diterpenoid. J Antibiot 61: 164-174.
    • (2008) J Antibiot , vol.61 , pp. 164-174
    • Hayashi, Y.1    Matsuura, N.2    Toshima, H.3    Itoh, N.4    Ishikawa, J.5    Mikami, Y.6    Dairi, T.7
  • 30
    • 42949119908 scopus 로고    scopus 로고
    • Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus
    • Hirano, S., Tanaka, K., Ohnishi, Y., and Horinouchi, S. (2008) Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus. Microbiology 154: 905-914.
    • (2008) Microbiology , vol.154 , pp. 905-914
    • Hirano, S.1    Tanaka, K.2    Ohnishi, Y.3    Horinouchi, S.4
  • 31
    • 0031903650 scopus 로고    scopus 로고
    • Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria
    • Hosoya, Y., Okamoto, S., Muramatsu, H., and Ochi, K. (1998) Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria. Antimicrob Agents Chemother 42: 2041-2047.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2041-2047
    • Hosoya, Y.1    Okamoto, S.2    Muramatsu, H.3    Ochi, K.4
  • 32
    • 0001716655 scopus 로고    scopus 로고
    • Biosynthetic studies of daunorubicin and tetracenomycin C
    • Hutchinson, C.R. (1997) Biosynthetic studies of daunorubicin and tetracenomycin C. Chem Rev 97: 2525-2536.
    • (1997) Chem Rev , vol.97 , pp. 2525-2536
    • Hutchinson, C.R.1
  • 33
    • 0037415016 scopus 로고    scopus 로고
    • The biosynthesis of indolocarbazoles in a heterologous E. coli host
    • Hyun, C.G., Bililign, T., Liao, J., and Thorson, J.S. (2003) The biosynthesis of indolocarbazoles in a heterologous E. coli host. Chembiochem 4: 114-117.
    • (2003) Chembiochem , vol.4 , pp. 114-117
    • Hyun, C.G.1    Bililign, T.2    Liao, J.3    Thorson, J.S.4
  • 34
    • 33747180825 scopus 로고    scopus 로고
    • Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius
    • Jiang, H., and Hutchinson, C.R. (2006) Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. Res Microbiol 157: 666-674.
    • (2006) Res Microbiol , vol.157 , pp. 666-674
    • Jiang, H.1    Hutchinson, C.R.2
  • 35
  • 36
    • 77952061156 scopus 로고    scopus 로고
    • The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry
    • Keller, U., Lang, M., Crnovcic, I., Pfennig, F., and Schauwecker, F. (2010) The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry. J Bacteriol 192: 2583-2595.
    • (2010) J Bacteriol , vol.192 , pp. 2583-2595
    • Keller, U.1    Lang, M.2    Crnovcic, I.3    Pfennig, F.4    Schauwecker, F.5
  • 37
    • 38849174356 scopus 로고    scopus 로고
    • Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products
    • Kennedy, J. (2008) Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat Prod Rep 25: 25-34.
    • (2008) Nat Prod Rep , vol.25 , pp. 25-34
    • Kennedy, J.1
  • 38
    • 34347388220 scopus 로고    scopus 로고
    • Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus
    • Kuscer, E., Coates, N., Challis, I., Gregory, M., Wilkinson, B., Sheridan, R., and Petković, H. (2007) Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. J Bacteriol 189: 4756-4763.
    • (2007) J Bacteriol , vol.189 , pp. 4756-4763
    • Kuscer, E.1    Coates, N.2    Challis, I.3    Gregory, M.4    Wilkinson, B.5    Sheridan, R.6    Petković, H.7
  • 39
    • 0033984077 scopus 로고    scopus 로고
    • Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein
    • Liu, W., and Shen, B. (2000) Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein. Antimicrob Agents Chemother 44: 382-392.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 382-392
    • Liu, W.1    Shen, B.2
  • 40
    • 0347721776 scopus 로고    scopus 로고
    • Biosynthesis of the enediyne antitumor antibiotic C-1027
    • Liu, W., Christenson, S.D., Standage, S., and Shen, B. (2002) Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297: 1170-1173.
    • (2002) Science , vol.297 , pp. 1170-1173
    • Liu, W.1    Christenson, S.D.2    Standage, S.3    Shen, B.4
  • 41
    • 0029934431 scopus 로고    scopus 로고
    • Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
    • Lombó, F., Blanco, G., Fernández, E., Méndez, C., and Salas, J.A. (1996) Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene 172: 87-91.
    • (1996) Gene , vol.172 , pp. 87-91
    • Lombó, F.1    Blanco, G.2    Fernández, E.3    Méndez, C.4    Salas, J.A.5
  • 42
    • 0030995327 scopus 로고    scopus 로고
    • Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin
    • Lombó, F., Siems, K., Braña, A.F., Méndez, C., Bindseil, K., and Salas, J.A. (1997) Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin. J Bacteriol 179: 3354-3357.
    • (1997) J Bacteriol , vol.179 , pp. 3354-3357
    • Lombó, F.1    Siems, K.2    Braña, A.F.3    Méndez, C.4    Bindseil, K.5    Salas, J.A.6
  • 43
    • 0032902411 scopus 로고    scopus 로고
    • The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster
    • Lombó, F., Braña, A.F., Méndez, C., and Salas, J.A. (1999) The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster. J Bacteriol 181: 642-647.
    • (1999) J Bacteriol , vol.181 , pp. 642-647
    • Lombó, F.1    Braña, A.F.2    Méndez, C.3    Salas, J.A.4
  • 44
    • 4644326961 scopus 로고    scopus 로고
    • Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891
    • Lombó, F., Braña, A.F., Salas, J.A., and Méndez, C. (2004a) Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem 5: 1181-1187.
    • (2004) Chembiochem , vol.5 , pp. 1181-1187
    • Lombó, F.1    Braña, A.F.2    Salas, J.A.3    Méndez, C.4
  • 45
    • 10644221353 scopus 로고    scopus 로고
    • Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin
    • Lombó, F., Gibson, M., Greenwell, L., Braña, A.F., Rohr, J., Salas, J.A., and Méndez, C. (2004b) Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol 11: 1709-1718.
    • (2004) Chem Biol , vol.11 , pp. 1709-1718
    • Lombó, F.1    Gibson, M.2    Greenwell, L.3    Braña, A.F.4    Rohr, J.5    Salas, J.A.6    Méndez, C.7
  • 46
    • 32344437742 scopus 로고    scopus 로고
    • Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species
    • Lombó, F., Velasco, A., Castro, A., de la Calle, F., Braña, A.F., Sánchez-Puelles, J.M., etal. (2006) Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species. Chembiochem 7: 366-376.
    • (2006) Chembiochem , vol.7 , pp. 366-376
    • Lombó, F.1    Velasco, A.2    Castro, A.3    de la Calle, F.4    Braña, A.F.5    Sánchez-Puelles, J.M.6
  • 47
    • 60349090133 scopus 로고    scopus 로고
    • Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity
    • Lombó, F., Abdelfattah, M.S., Braña, A.F., Salas, J.A., Rohr, J., and Méndez, C. (2009) Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem 10: 296-303.
    • (2009) Chembiochem , vol.10 , pp. 296-303
    • Lombó, F.1    Abdelfattah, M.S.2    Braña, A.F.3    Salas, J.A.4    Rohr, J.5    Méndez, C.6
  • 48
    • 0029950580 scopus 로고    scopus 로고
    • The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production
    • Lomovskaya, N., Hong, S.K., Kim, S.U., Fonstein, L., Furuya, K., and Hutchinson, R.C. (1996) The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production. J Bacteriol 178: 3238-3245.
    • (1996) J Bacteriol , vol.178 , pp. 3238-3245
    • Lomovskaya, N.1    Hong, S.K.2    Kim, S.U.3    Fonstein, L.4    Furuya, K.5    Hutchinson, R.C.6
  • 49
    • 0031969350 scopus 로고    scopus 로고
    • The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis
    • Lomovskaya, N., Doi-Katayama, Y., Filippini, S., Nastro, C., Fonstein, L., Gallo, M., etal. (1998) The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis. J Bacteriol 180: 2379-2386.
    • (1998) J Bacteriol , vol.180 , pp. 2379-2386
    • Lomovskaya, N.1    Doi-Katayama, Y.2    Filippini, S.3    Nastro, C.4    Fonstein, L.5    Gallo, M.6
  • 50
    • 0032899534 scopus 로고    scopus 로고
    • Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene
    • Lomovskaya, N., Otten, S.L., Doi-Katayama, Y., Fonstein, L., Liu, X.C., Takatsu, T., etal. (1999) Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene. J Bacteriol 181: 305-318.
    • (1999) J Bacteriol , vol.181 , pp. 305-318
    • Lomovskaya, N.1    Otten, S.L.2    Doi-Katayama, Y.3    Fonstein, L.4    Liu, X.C.5    Takatsu, T.6
  • 51
    • 34250310872 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase
    • Luzhetskyy, A., Mayer, A., Hoffmann, J., Pelzer, S., Holzenkämper, M., Schmitt, B., etal. (2007) Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem 8: 599-602.
    • (2007) Chembiochem , vol.8 , pp. 599-602
    • Luzhetskyy, A.1    Mayer, A.2    Hoffmann, J.3    Pelzer, S.4    Holzenkämper, M.5    Schmitt, B.6
  • 52
    • 45749102516 scopus 로고    scopus 로고
    • Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
    • McGlinchey, R.P., Nett, M., Eustáquio, A.S., Asolkar, R.N., Fenical, W., and Moore, B.S. (2008) Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130: 7822-7823.
    • (2008) J Am Chem Soc , vol.130 , pp. 7822-7823
    • McGlinchey, R.P.1    Nett, M.2    Eustáquio, A.S.3    Asolkar, R.N.4    Fenical, W.5    Moore, B.S.6
  • 53
    • 0028915915 scopus 로고
    • Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius
    • Madduri, K., and Hutchinson, C.R. (1995) Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. J Bacteriol 177: 1208-1215.
    • (1995) J Bacteriol , vol.177 , pp. 1208-1215
    • Madduri, K.1    Hutchinson, C.R.2
  • 54
    • 0031974553 scopus 로고    scopus 로고
    • Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
    • Madduri, K., Kennedy, J., Rivola, G., Inventi-Solari, A., Filippini, S., Zanuso, G., etal. (1998) Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. Nat Biotechnol 16: 69-74.
    • (1998) Nat Biotechnol , vol.16 , pp. 69-74
    • Madduri, K.1    Kennedy, J.2    Rivola, G.3    Inventi-Solari, A.4    Filippini, S.5    Zanuso, G.6
  • 55
    • 0034801471 scopus 로고    scopus 로고
    • Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa
    • Madduri, K., Waldron, C., and Merlo, D.J. (2001) Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa. J Bacteriol 183: 5632-5638.
    • (2001) J Bacteriol , vol.183 , pp. 5632-5638
    • Madduri, K.1    Waldron, C.2    Merlo, D.J.3
  • 56
    • 67650375958 scopus 로고    scopus 로고
    • Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius
    • Malla, S., Niraula, N.P., Liou, K., and Sohng, J.K. (2009) Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius. J Biosci Bioeng 108: 92-98.
    • (2009) J Biosci Bioeng , vol.108 , pp. 92-98
    • Malla, S.1    Niraula, N.P.2    Liou, K.3    Sohng, J.K.4
  • 57
    • 77954460353 scopus 로고    scopus 로고
    • Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement
    • Malla, S., Niraula, N.P., Liou, K., and Sohng, J.K. (2010a) Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement. Microbiol Res 165: 259-267.
    • (2010) Microbiol Res , vol.165 , pp. 259-267
    • Malla, S.1    Niraula, N.P.2    Liou, K.3    Sohng, J.K.4
  • 58
    • 77949913523 scopus 로고    scopus 로고
    • Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius
    • Malla, S., Niraula, N.P., Liou, K., and Sohng, J.K. (2010b) Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius. Res Microbiol 161: 109-117.
    • (2010) Res Microbiol , vol.161 , pp. 109-117
    • Malla, S.1    Niraula, N.P.2    Liou, K.3    Sohng, J.K.4
  • 59
    • 0033117369 scopus 로고    scopus 로고
    • Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564
    • Mao, Y., Varoglu, M., and Sherman, D.H. (1999a) Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chem Biol 6: 251-263.
    • (1999) Chem Biol , vol.6 , pp. 251-263
    • Mao, Y.1    Varoglu, M.2    Sherman, D.H.3
  • 60
    • 0032936733 scopus 로고    scopus 로고
    • Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C
    • Mao, Y., Varoglu, M., and Sherman, D.H. (1999b) Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. J Bacteriol 181: 2199-2208.
    • (1999) J Bacteriol , vol.181 , pp. 2199-2208
    • Mao, Y.1    Varoglu, M.2    Sherman, D.H.3
  • 61
    • 0141513836 scopus 로고    scopus 로고
    • On the generation of novel anticancer drugs by recombinant DNA technology: the use of combinatorial biosynthesis to produce novel drugs
    • Méndez, C., and Salas, J.A. (2003) On the generation of novel anticancer drugs by recombinant DNA technology: the use of combinatorial biosynthesis to produce novel drugs. Comb Chem High Throughput Screen 6: 513-526.
    • (2003) Comb Chem High Throughput Screen , vol.6 , pp. 513-526
    • Méndez, C.1    Salas, J.A.2
  • 62
    • 0036091676 scopus 로고    scopus 로고
    • Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC 11891
    • Méndez, C., Künzel, E., Lipata, F., Lombó, F., Cotham, W., Walla, M., etal. (2002) Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC 11891. J Nat Prod 65: 779-782.
    • (2002) J Nat Prod , vol.65 , pp. 779-782
    • Méndez, C.1    Künzel, E.2    Lipata, F.3    Lombó, F.4    Cotham, W.5    Walla, M.6
  • 63
    • 47249097524 scopus 로고    scopus 로고
    • Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern
    • Méndez, C., Luzhetskyy, A., Bechthold, A., and Salas, J.A. (2008) Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem 8: 710-724.
    • (2008) Curr Top Med Chem , vol.8 , pp. 710-724
    • Méndez, C.1    Luzhetskyy, A.2    Bechthold, A.3    Salas, J.A.4
  • 67
    • 34948856450 scopus 로고    scopus 로고
    • Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis
    • Menéndez, N., Braña, A.F., Salas, J.A., and Méndez, C. (2007) Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis. Microbiology 153: 3061-3070.
    • (2007) Microbiology , vol.153 , pp. 3061-3070
    • Menéndez, N.1    Braña, A.F.2    Salas, J.A.3    Méndez, C.4
  • 68
    • 34250704344 scopus 로고    scopus 로고
    • Combinatorial biosynthesis for drug development
    • Menzella, H.G., and Reeves, C.D. (2007) Combinatorial biosynthesis for drug development. Curr Opin Microbiol 10: 238-245.
    • (2007) Curr Opin Microbiol , vol.10 , pp. 238-245
    • Menzella, H.G.1    Reeves, C.D.2
  • 69
    • 0029883934 scopus 로고    scopus 로고
    • Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
    • Molnár, I., Aparicio, J.F., Haydock, S.F., Khaw, L.E., Schwecke, T., König, A., etal. (1996) Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene 169: 1-7.
    • (1996) Gene , vol.169 , pp. 1-7
    • Molnár, I.1    Aparicio, J.F.2    Haydock, S.F.3    Khaw, L.E.4    Schwecke, T.5    König, A.6
  • 70
    • 33744909883 scopus 로고    scopus 로고
    • Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues
    • Moss, S.J., Carletti, I., Olano, C., Sheridan, R.M., Ward, M., Math, V., etal. (2006) Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. Chem Commun 22: 2341-2343.
    • (2006) Chem Commun , vol.22 , pp. 2341-2343
    • Moss, S.J.1    Carletti, I.2    Olano, C.3    Sheridan, R.M.4    Ward, M.5    Math, V.6
  • 71
    • 1442358950 scopus 로고    scopus 로고
    • Biochemical characterization of the SgcA1 alpha-d-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production
    • Murrell, J.M., Liu, W., and Shen, B. (2004) Biochemical characterization of the SgcA1 alpha-d-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production. J Nat Prod 67: 206-213.
    • (2004) J Nat Prod , vol.67 , pp. 206-213
    • Murrell, J.M.1    Liu, W.2    Shen, B.3
  • 72
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D.J., and Cragg, G.M. (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 73
    • 21044441008 scopus 로고    scopus 로고
    • Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII
    • Nur-e-Alam, M., Méndez, C., Salas, J.A., and Rohr, J. (2005) Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem 6: 632-636.
    • (2005) Chembiochem , vol.6 , pp. 632-636
    • Nur-e-Alam, M.1    Méndez, C.2    Salas, J.A.3    Rohr, J.4
  • 74
    • 77954532065 scopus 로고    scopus 로고
    • Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952
    • Oh, T.J., Niraula, N.P., Liou, K., and Sohng, J.K. (2010) Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952. J Appl Microbiol 109: 398-407.
    • (2010) J Appl Microbiol , vol.109 , pp. 398-407
    • Oh, T.J.1    Niraula, N.P.2    Liou, K.3    Sohng, J.K.4
  • 75
    • 0344099408 scopus 로고    scopus 로고
    • Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
    • Olano, C., Wilkinson, B., Moss, S.J., Braña, A.F., Méndez, C., Leadlay, P.F., and Salas, J.A. (2003) Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun 22: 2780-2782.
    • (2003) Chem Commun , vol.22 , pp. 2780-2782
    • Olano, C.1    Wilkinson, B.2    Moss, S.J.3    Braña, A.F.4    Méndez, C.5    Leadlay, P.F.6    Salas, J.A.7
  • 76
    • 1142281943 scopus 로고    scopus 로고
    • Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions
    • Olano, C., Wilkinson, B., Sánchez, C., Moss, S.J., Sheridan, R., Math, V., etal. (2004a) Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol 11: 87-97.
    • (2004) Chem Biol , vol.11 , pp. 87-97
    • Olano, C.1    Wilkinson, B.2    Sánchez, C.3    Moss, S.J.4    Sheridan, R.5    Math, V.6
  • 77
    • 3042594469 scopus 로고    scopus 로고
    • Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation
    • Olano, C., Moss, S.J., Braña, A.F., Sheridan, R.M., Math, V., Weston, A.J., etal. (2004b) Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Mol Microbiol 52: 1745-1756.
    • (2004) Mol Microbiol , vol.52 , pp. 1745-1756
    • Olano, C.1    Moss, S.J.2    Braña, A.F.3    Sheridan, R.M.4    Math, V.5    Weston, A.J.6
  • 78
    • 50249084003 scopus 로고    scopus 로고
    • Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
    • Olano, C., Lombó, F., Méndez, C., and Salas, J.A. (2008a) Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng 10: 281-292.
    • (2008) Metab Eng , vol.10 , pp. 281-292
    • Olano, C.1    Lombó, F.2    Méndez, C.3    Salas, J.A.4
  • 79
    • 40949145314 scopus 로고    scopus 로고
    • Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity
    • Olano, C., Abdelfattah, M.S., Gullón, S., Braña, A.F., Rohr, J., Méndez, C., and Salas, J.A. (2008b) Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity. Chembiochem 9: 624-633.
    • (2008) Chembiochem , vol.9 , pp. 624-633
    • Olano, C.1    Abdelfattah, M.S.2    Gullón, S.3    Braña, A.F.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 80
    • 73449131956 scopus 로고    scopus 로고
    • Antitumor compounds from marine actinomycetes
    • Olano, C., Méndez, C., and Salas, J.A. (2009a) Antitumor compounds from marine actinomycetes. Mar Drugs 7: 210-248.
    • (2009) Mar Drugs , vol.7 , pp. 210-248
    • Olano, C.1    Méndez, C.2    Salas, J.A.3
  • 81
    • 65349093437 scopus 로고    scopus 로고
    • Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis
    • Olano, C., Méndez, C., and Salas, J.A. (2009b) Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep 26: 628-660.
    • (2009) Nat Prod Rep , vol.26 , pp. 628-660
    • Olano, C.1    Méndez, C.2    Salas, J.A.3
  • 82
    • 77950127253 scopus 로고    scopus 로고
    • Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
    • Olano, C., Méndez, C., and Salas, J.A. (2010) Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep 27: 571-616.
    • (2010) Nat Prod Rep , vol.27 , pp. 571-616
    • Olano, C.1    Méndez, C.2    Salas, J.A.3
  • 83
    • 0036952785 scopus 로고    scopus 로고
    • Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans
    • Onaka, H., Taniguchi, S., Igarashi, Y., and Furumai, T. (2002) Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans. J Antibiot 55: 1063-1071.
    • (2002) J Antibiot , vol.55 , pp. 1063-1071
    • Onaka, H.1    Taniguchi, S.2    Igarashi, Y.3    Furumai, T.4
  • 84
    • 0025313642 scopus 로고
    • Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius
    • Otten, S.L., Stutzman-Engwall, K.J., and Hutchinson, C.R. (1990) Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius. J Bacteriol 172: 3427-3434.
    • (1990) J Bacteriol , vol.172 , pp. 3427-3434
    • Otten, S.L.1    Stutzman-Engwall, K.J.2    Hutchinson, C.R.3
  • 85
    • 0028853826 scopus 로고
    • Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis
    • Otten, S.L., Liu, X., Ferguson, J., and Hutchinson, C.R. (1995a) Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis. J Bacteriol 177: 6688-6692.
    • (1995) J Bacteriol , vol.177 , pp. 6688-6692
    • Otten, S.L.1    Liu, X.2    Ferguson, J.3    Hutchinson, C.R.4
  • 86
    • 0028937624 scopus 로고
    • Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus
    • Otten, S.L., Ferguson, J., and Hutchinson, C.R. (1995b) Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. J Bacteriol 177: 1216-1224.
    • (1995) J Bacteriol , vol.177 , pp. 1216-1224
    • Otten, S.L.1    Ferguson, J.2    Hutchinson, C.R.3
  • 87
    • 0030794691 scopus 로고    scopus 로고
    • Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-l-daunosamine
    • Otten, S.L., Gallo, M.A., Madduri, K., Liu, X., and Hutchinson, C.R. (1997) Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-l-daunosamine. J Bacteriol 179: 4446-4450.
    • (1997) J Bacteriol , vol.179 , pp. 4446-4450
    • Otten, S.L.1    Gallo, M.A.2    Madduri, K.3    Liu, X.4    Hutchinson, C.R.5
  • 88
    • 0034081435 scopus 로고    scopus 로고
    • The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene
    • Otten, S.L., Olano, C., and Hutchinson, C.R. (2000) The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene. Microbiology 146: 1457-1468.
    • (2000) Microbiology , vol.146 , pp. 1457-1468
    • Otten, S.L.1    Olano, C.2    Hutchinson, C.R.3
  • 89
    • 20444390097 scopus 로고    scopus 로고
    • Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952
    • Parajuli, N., Viet, H.T., Ishida, K., Tong, H.T., Lee, H.C., Liou, K., and Sohng, J.K. (2005) Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Res Microbiol 156: 707-712.
    • (2005) Res Microbiol , vol.156 , pp. 707-712
    • Parajuli, N.1    Viet, H.T.2    Ishida, K.3    Tong, H.T.4    Lee, H.C.5    Liou, K.6    Sohng, J.K.7
  • 91
    • 17444374633 scopus 로고    scopus 로고
    • Combining sugar biosynthesis genes for the generation of l- and d-amicetose and formation of two novel antitumor tetracenomycins
    • Pérez, M., Lombó, F., Zhu, L., Gibson, M., Braña, A.F., Rohr, J., etal. (2005) Combining sugar biosynthesis genes for the generation of l- and d-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun 12: 1604-1606.
    • (2005) Chem Commun , vol.12 , pp. 1604-1606
    • Pérez, M.1    Lombó, F.2    Zhu, L.3    Gibson, M.4    Braña, A.F.5    Rohr, J.6
  • 92
    • 33750087290 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: reconstitution of 'unnatural natural gene clusters' for the biosynthesis of four 2,6-d-dideoxyhexoses
    • Pérez, M., Lombó, F., Baig, I., Braña, A.F., Rohr, J., Salas, J.A., and Méndez, C. (2006) Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: reconstitution of 'unnatural natural gene clusters' for the biosynthesis of four 2, 6-d-dideoxyhexoses. Appl Environ Microbiol 72: 6644-6652.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 6644-6652
    • Pérez, M.1    Lombó, F.2    Baig, I.3    Braña, A.F.4    Rohr, J.5    Salas, J.A.6    Méndez, C.7
  • 93
    • 54349108393 scopus 로고    scopus 로고
    • Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis
    • Pérez, M., Baig, I., Braña, A.F., Salas, J.A., Rohr, J., and Méndez, C. (2008) Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem 9: 2295-2304.
    • (2008) Chembiochem , vol.9 , pp. 2295-2304
    • Pérez, M.1    Baig, I.2    Braña, A.F.3    Salas, J.A.4    Rohr, J.5    Méndez, C.6
  • 94
    • 42949168430 scopus 로고    scopus 로고
    • Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
    • Ramos, A., Lombó, F., Braña, A.F., Rohr, J., Méndez, C., and Salas, J.A. (2008) Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology 154: 781-788.
    • (2008) Microbiology , vol.154 , pp. 781-788
    • Ramos, A.1    Lombó, F.2    Braña, A.F.3    Rohr, J.4    Méndez, C.5    Salas, J.A.6
  • 95
    • 65249143793 scopus 로고    scopus 로고
    • Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis
    • Ramos, A., Olano, C., Braña, A.F., Méndez, C., and Salas, J.A. (2009) Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis. J Bacteriol 191: 2871-2875.
    • (2009) J Bacteriol , vol.191 , pp. 2871-2875
    • Ramos, A.1    Olano, C.2    Braña, A.F.3    Méndez, C.4    Salas, J.A.5
  • 97
    • 0037469308 scopus 로고    scopus 로고
    • Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602
    • Rascher, A., Hu, Z., Viswanathan, N., Schirmer, A., Reid, R., Nierman, W.C., etal. (2003) Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602. FEMS Microbiol Lett 218: 223-230.
    • (2003) FEMS Microbiol Lett , vol.218 , pp. 223-230
    • Rascher, A.1    Hu, Z.2    Viswanathan, N.3    Schirmer, A.4    Reid, R.5    Nierman, W.C.6
  • 98
    • 0037181040 scopus 로고    scopus 로고
    • Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway
    • Remsing, L.L., Garcia-Bernardo, J., Gonzalez, A., Künzel, E., Rix, U., Braña, A.F., etal. (2002) Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway. J Am Chem Soc 124: 1606-1614.
    • (2002) J Am Chem Soc , vol.124 , pp. 1606-1614
    • Remsing, L.L.1    Garcia-Bernardo, J.2    Gonzalez, A.3    Künzel, E.4    Rix, U.5    Braña, A.F.6
  • 99
    • 0038701795 scopus 로고    scopus 로고
    • Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis
    • Remsing, L.L., González, A.M., Nur-e-Alam, M., Fernández-Lozano, M.J., Braña, A.F., Rix, U., etal. (2003) Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis. J Am Chem Soc 125: 5745-5753.
    • (2003) J Am Chem Soc , vol.125 , pp. 5745-5753
    • Remsing, L.L.1    González, A.M.2    Nur-e-Alam, M.3    Fernández-Lozano, M.J.4    Braña, A.F.5    Rix, U.6
  • 100
    • 0035986693 scopus 로고    scopus 로고
    • Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds
    • Rodríguez, L., Aguirrezabalaga, I., Allende, N., Braña, A.F., Méndez, C., and Salas, J.A. (2002) Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. Chem Biol 9: 721-729.
    • (2002) Chem Biol , vol.9 , pp. 721-729
    • Rodríguez, L.1    Aguirrezabalaga, I.2    Allende, N.3    Braña, A.F.4    Méndez, C.5    Salas, J.A.6
  • 101
    • 26244438853 scopus 로고    scopus 로고
    • Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase
    • Salas, A.P., Zhu, L., Sánchez, C., Braña, A.F., Rohr, J., Méndez, C., and Salas, J.A. (2005) Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol 58: 17-27.
    • (2005) Mol Microbiol , vol.58 , pp. 17-27
    • Salas, A.P.1    Zhu, L.2    Sánchez, C.3    Braña, A.F.4    Rohr, J.5    Méndez, C.6    Salas, J.A.7
  • 102
    • 34247511117 scopus 로고    scopus 로고
    • Engineering the glycosylation of natural products in actinomycetes
    • Salas, J.A., and Méndez, C. (2007) Engineering the glycosylation of natural products in actinomycetes. Trends Microbiol 15: 219-232.
    • (2007) Trends Microbiol , vol.15 , pp. 219-232
    • Salas, J.A.1    Méndez, C.2
  • 103
    • 65349130889 scopus 로고    scopus 로고
    • Indolocarbazole antitumour compounds by combinatorial biosynthesis
    • Salas, J.A., and Méndez, C. (2009) Indolocarbazole antitumour compounds by combinatorial biosynthesis. Curr Opin Chem Biol 13: 152-160.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 152-160
    • Salas, J.A.1    Méndez, C.2
  • 104
    • 0036235877 scopus 로고    scopus 로고
    • The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives
    • Sánchez, C., Butovich, I.A., Braña, A.F., Rohr, J., Méndez, C., and Salas, J.A. (2002) The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol 9: 519-531.
    • (2002) Chem Biol , vol.9 , pp. 519-531
    • Sánchez, C.1    Butovich, I.A.2    Braña, A.F.3    Rohr, J.4    Méndez, C.5    Salas, J.A.6
  • 105
    • 67649872012 scopus 로고    scopus 로고
    • Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles
    • Sánchez, C., Salas, A.P., Braña, A.F., Palomino, M., Pineda-Lucena, A., Carbajo, R.J., etal. (2009) Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles. Chem Commun 27: 4118-4120.
    • (2009) Chem Commun , vol.27 , pp. 4118-4120
    • Sánchez, C.1    Salas, A.P.2    Braña, A.F.3    Palomino, M.4    Pineda-Lucena, A.5    Carbajo, R.J.6
  • 106
    • 0031958021 scopus 로고    scopus 로고
    • Molecular cloning of the actinomycin synthetase gene cluster from Streptomyces chrysomallus and functional heterologous expression of the gene encoding actinomycin synthetase II
    • Schauwecker, F., Pfennig, F., Schröder, W., and Keller, U. (1998) Molecular cloning of the actinomycin synthetase gene cluster from Streptomyces chrysomallus and functional heterologous expression of the gene encoding actinomycin synthetase II. J Bacteriol 180: 2468-2474.
    • (1998) J Bacteriol , vol.180 , pp. 2468-2474
    • Schauwecker, F.1    Pfennig, F.2    Schröder, W.3    Keller, U.4
  • 108
    • 0030451725 scopus 로고    scopus 로고
    • Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis
    • Scotti, C., and Hutchinson, C.R. (1996) Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis. J Bacteriol 178: 7316-7321.
    • (1996) J Bacteriol , vol.178 , pp. 7316-7321
    • Scotti, C.1    Hutchinson, C.R.2
  • 109
    • 77955660167 scopus 로고    scopus 로고
    • Overexpression of aveBIV leading to the improvement of 4'-epidaunorubicin production in Streptomyces coeruleorubidus strain SIPI-A0707
    • Shao, L., Huang, J., Jing, L., Chen, J.Y., Kan, S.D., Wang, M., etal. (2010) Overexpression of aveBIV leading to the improvement of 4'-epidaunorubicin production in Streptomyces coeruleorubidus strain SIPI-A0707. Appl Microbiol Biotechnol 87: 1057-1064.
    • (2010) Appl Microbiol Biotechnol , vol.87 , pp. 1057-1064
    • Shao, L.1    Huang, J.2    Jing, L.3    Chen, J.Y.4    Kan, S.D.5    Wang, M.6
  • 110
    • 0031053670 scopus 로고    scopus 로고
    • Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae
    • Sheldon, P.J., Johnson, D.A., August, P.R., Liu, H.W., and Sherman, D.H. (1997) Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae. J Bacteriol 179: 1796-1804.
    • (1997) J Bacteriol , vol.179 , pp. 1796-1804
    • Sheldon, P.J.1    Johnson, D.A.2    August, P.R.3    Liu, H.W.4    Sherman, D.H.5
  • 111
    • 0032906549 scopus 로고    scopus 로고
    • Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system
    • Sheldon, P.J., Mao, Y., He, M., and Sherman, D.H. (1999) Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system. J Bacteriol 181: 2507-2512.
    • (1999) J Bacteriol , vol.181 , pp. 2507-2512
    • Sheldon, P.J.1    Mao, Y.2    He, M.3    Sherman, D.H.4
  • 112
    • 0036229192 scopus 로고    scopus 로고
    • Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI
    • Sheldon, P.J., Busarow, S.B., and Hutchinson, C.R. (2002) Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI. Mol Microbiol 44: 449-460.
    • (2002) Mol Microbiol , vol.44 , pp. 449-460
    • Sheldon, P.J.1    Busarow, S.B.2    Hutchinson, C.R.3
  • 113
    • 0037398774 scopus 로고    scopus 로고
    • Biosynthesis of aromatic polyketides
    • Shen, B. (2003) Biosynthesis of aromatic polyketides. Curr Opin Chem Biol 7: 285-295.
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 285-295
    • Shen, B.1
  • 114
    • 0036193515 scopus 로고    scopus 로고
    • Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC 15003
    • Shen, B., Du, L., Sanchez, C., Edwards, D.J., Chen, M., and Murrell, J.M. (2002) Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC 15003. J Nat Prod 65: 422-431.
    • (2002) J Nat Prod , vol.65 , pp. 422-431
    • Shen, B.1    Du, L.2    Sanchez, C.3    Edwards, D.J.4    Chen, M.5    Murrell, J.M.6
  • 115
    • 53149091352 scopus 로고    scopus 로고
    • Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427
    • Shin, J.C., Na, Z., Lee, D.H., Kim, W.C., Lee, K., Shen, Y.M., etal. (2008) Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427. J Microbiol Biotechnol 18: 1101-1108.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 1101-1108
    • Shin, J.C.1    Na, Z.2    Lee, D.H.3    Kim, W.C.4    Lee, K.5    Shen, Y.M.6
  • 116
    • 76649116524 scopus 로고    scopus 로고
    • Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952
    • Singh, B., Lee, C.B., and Sohng, J.K. (2010) Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952. Appl Microbiol Biotechnol 85: 1565-1574.
    • (2010) Appl Microbiol Biotechnol , vol.85 , pp. 1565-1574
    • Singh, B.1    Lee, C.B.2    Sohng, J.K.3
  • 117
    • 34547096248 scopus 로고    scopus 로고
    • Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitN-encoded aziridine N-methyltransferase
    • Sitachitta, N., Lopanik, N.B., Mao, Y., and Sherman, D.H. (2007) Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitN-encoded aziridine N-methyltransferase. J Biol Chem 282: 20941-20947.
    • (2007) J Biol Chem , vol.282 , pp. 20941-20947
    • Sitachitta, N.1    Lopanik, N.B.2    Mao, Y.3    Sherman, D.H.4
  • 118
    • 77749328113 scopus 로고    scopus 로고
    • Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation
    • Srinivasan, P., Palani, S.N., and Prasad, R. (2010) Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. FEMS Microbiol Lett 305: 18-27.
    • (2010) FEMS Microbiol Lett , vol.305 , pp. 18-27
    • Srinivasan, P.1    Palani, S.N.2    Prasad, R.3
  • 119
    • 0026537421 scopus 로고
    • Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius
    • Stutzman-Engwall, K.J., Otten, S.L., and Hutchinson, C.R. (1992) Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J Bacteriol 174: 144-154.
    • (1992) J Bacteriol , vol.174 , pp. 144-154
    • Stutzman-Engwall, K.J.1    Otten, S.L.2    Hutchinson, C.R.3
  • 120
    • 0028575322 scopus 로고
    • Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin
    • Sugiyama, M., Thompson, C.J., Kumagai, T., Suzuki, K., Deblaere, R., Villarroel, R., and Davies, J. (1994a) Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin. Gene 151: 11-16.
    • (1994) Gene , vol.151 , pp. 11-16
    • Sugiyama, M.1    Thompson, C.J.2    Kumagai, T.3    Suzuki, K.4    Deblaere, R.5    Villarroel, R.6    Davies, J.7
  • 121
    • 0028176329 scopus 로고
    • Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus
    • Sugiyama, M., Kumagai, T., Shionoya, M., Kimura, E., and Davies, J.E. (1994b) Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus. FEMS Microbiol Lett 121: 81-85.
    • (1994) FEMS Microbiol Lett , vol.121 , pp. 81-85
    • Sugiyama, M.1    Kumagai, T.2    Shionoya, M.3    Kimura, E.4    Davies, J.E.5
  • 122
    • 33644619706 scopus 로고    scopus 로고
    • Prokaryotic nucleotide excision repair: the UvrABC system
    • Truglio, J.J., Croteau, D.L., Van Houten, B., and Kisker, C. (2006) Prokaryotic nucleotide excision repair: the UvrABC system. Chem Rev 106: 233-252.
    • (2006) Chem Rev , vol.106 , pp. 233-252
    • Truglio, J.J.1    Croteau, D.L.2    Van Houten, B.3    Kisker, C.4
  • 123
    • 34447302758 scopus 로고    scopus 로고
    • Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    • Udwary, D.W., Zeigler, L., Asolkar, R.N., Singan, V., Lapidus, A., Fenical, W., etal. (2007) Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci USA 104: 10376-10381.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10376-10381
    • Udwary, D.W.1    Zeigler, L.2    Asolkar, R.N.3    Singan, V.4    Lapidus, A.5    Fenical, W.6
  • 124
    • 23944436899 scopus 로고    scopus 로고
    • Biosynthesis of the β-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring β-amino acyl-S-carrier protein intermediates
    • Van Lanen, S.G., Dorrestein, P.C., Christenson, S.D., Liu, W., Ju, J., Kelleher, N.L., and Shen, B. (2005) Biosynthesis of the β-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring β-amino acyl-S-carrier protein intermediates. J Am Chem Soc 127: 11594-11595.
    • (2005) J Am Chem Soc , vol.127 , pp. 11594-11595
    • Van Lanen, S.G.1    Dorrestein, P.C.2    Christenson, S.D.3    Liu, W.4    Ju, J.5    Kelleher, N.L.6    Shen, B.7
  • 125
    • 38649097499 scopus 로고    scopus 로고
    • Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism
    • Van Lanen, S.G., Linm, S., and Shen, B. (2008) Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc Natl Acad Sci USA 105: 494-499.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 494-499
    • Van Lanen, S.G.1    Linm, S.2    Shen, B.3
  • 126
    • 0035017135 scopus 로고    scopus 로고
    • Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa
    • Waldron, C., Matsushima, P., Rosteck, P.R., Jr, Broughton, M.C., Turner, J., Madduri, K., etal. (2001) Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa. Chem Biol 8: 487-499.
    • (2001) Chem Biol , vol.8 , pp. 487-499
    • Waldron, C.1    Matsushima, P.2    Rosteck Jr, P.R.3    Broughton, M.C.4    Turner, J.5    Madduri, K.6
  • 127
    • 43049129603 scopus 로고    scopus 로고
    • Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations
    • Wang, G., Hosaka, T., and Ochi, K. (2008) Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations. Appl Environ Microbiol 74: 2834-2840.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 2834-2840
    • Wang, G.1    Hosaka, T.2    Ochi, K.3
  • 128
    • 62849108933 scopus 로고    scopus 로고
    • Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027
    • Wang, L., Hu, Y., Zhang, Y., Wang, S., Cui, Z., Bao, Y., etal. (2009) Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027. BMC Microbiol 9: 1-12.
    • (2009) BMC Microbiol , vol.9 , pp. 1-12
    • Wang, L.1    Hu, Y.2    Zhang, Y.3    Wang, S.4    Cui, Z.5    Bao, Y.6
  • 129
    • 33749235707 scopus 로고    scopus 로고
    • Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain
    • Wilkinson, B., Gregory, M.A., Moss, S.J., Carletti, I., Sheridan, R.M., Kaja, A., etal. (2006) Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorg Med Chem Lett 16: 5814-5817.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 5814-5817
    • Wilkinson, B.1    Gregory, M.A.2    Moss, S.J.3    Carletti, I.4    Sheridan, R.M.5    Kaja, A.6
  • 130
    • 0037062404 scopus 로고    scopus 로고
    • The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum
    • Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., etal. (2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. Proc Natl Acad Sci USA 99: 7968-7973.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7968-7973
    • Yu, T.W.1    Bai, L.2    Clade, D.3    Hoffmann, D.4    Toelzer, S.5    Trinh, K.Q.6
  • 131
    • 37549071045 scopus 로고    scopus 로고
    • Drug discovery beyond the 'rule-of-five'
    • Zhang, M.Q., and Wilkinson, B. (2007) Drug discovery beyond the 'rule-of-five'. Curr Opin Biotechnol 18: 478-488.
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 478-488
    • Zhang, M.Q.1    Wilkinson, B.2


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