Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 4, 2014, Pages 1634-1639

  Moses, Tessa ^a,b,c   Pollier, Jacob ^a,b   Almagro, Lorena ^d   Buyst, Dieter ^b   Van Montagu, Marc ^a,b   Pedreño, María A ^d   Martins, José C ^b   Thevelein, Johan M ^a,c   Goossens, Alain ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF MURCIA   (Spain)

Author keywords

Amyrin; Cyclodextrin; Metabolic engineering; Triterpenoid

Indexed keywords

BETA CYCLODEXTRIN; SAPOGENIN; SAPONIN; STEROID 16ALPHA MONOOXYGENASE;

ARTICLE; BUPLEURUM; BUPLEURUM FALCATUM; COMBINATORIAL BIOSYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SYNTHETIC BIOLOGY; YEAST CELL;

AMYRIN; CYCLODEXTRIN; METABOLIC ENGINEERING; TRITERPENOID;

BUPLEURUM; COMBINATORIAL CHEMISTRY TECHNIQUES; CULTURE MEDIA; HYDROXYLATION; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SAPOGENINS; SAPONINS; STEROID 16-ALPHA-HYDROXYLASE;

EID: 84893351504     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323369111     Document Type: Article

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