Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae

Applied Microbiology and Biotechnology

Volumn 76, Issue 6, 2007, Pages 1373-1381

  Jung, Won Seok ^a   Han, Ah Reum ^a   Hong, Jay Sung Joong ^a   Park, Sung Ryeol ^b   Choi, Cha Yong ^a   Park, Je Won ^b   Yoon, Yeo Joon ^b  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Auxiliary protein; Combinatorial biosynthesis; Glycosyltransferase; Macrolide; Streptomyces

Indexed keywords

AUXILIARY PROTEIN; COMBINATORIAL BIOSYNTHESIS; GLYCOSYLTRANSFERASE; MACROLIDE; STREPTOMYCES;

AMINES; BIOSYNTHESIS; ENZYMES; GENE ENCODING; STRAIN; SUBSTRATES;

GENETIC ENGINEERING;

10 DEOXYMETHYNOLIDE; AGLYCONE; AMINE; BACTERIAL ENZYME; BACTERIAL PROTEIN; DEOXYSUGAR; DESOSAMINE; DESVII PROTEIN; DESVIII PROTEIN; GLYCOSYLTRANSFERASE; LACTONE DERIVATIVE; MACROLIDE; NARBONOLIDE; PIKROMYCIN; POLYKETIDE SYNTHASE; PROTYLONOLIDE; THYMIDINE DIPHOSPHATE; THYMIDINE DIPHOSPHATE DEXTRO OLIVOSE; THYMIDINE DIPHOSPHATE DEXTRO QUINOVOSE; TYLMII PROTEIN; TYLMIII PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTICS; BACTERIUM; PHOSPHATE; PROTEIN;

ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; BIOSYNTHESIS; BIOTRANSFORMATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENE CLUSTER; GENETIC ENGINEERING; GENETIC MANIPULATION; GLYCOSYLATION; HYBRID; IN VIVO STUDY; NONHUMAN; PROTEIN EXPRESSION; STREPTOMYCES FRADIAE; STREPTOMYCES VENEZUELAE;

ANTI-BACTERIAL AGENTS; GENE DELETION; GENETIC ENGINEERING; GLYCOSYLATION; MACROLIDES; MOLECULAR STRUCTURE; STREPTOMYCES; SUBSTRATE SPECIFICITY;

STREPTOMYCES; STREPTOMYCES FRADIAE; STREPTOMYCES VENEZUELAE;

EID: 34648822399     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-1101-y     Document Type: Article

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