Non-ribosomal peptide synthetase module fusions to produce derivatives of daptomycin in Streptomyces roseosporus

Microbiology

Volumn 154, Issue 9, 2008, Pages 2872-2880

  Doekel, Sascha ^a   Gal, Marie Françoise Coëffet Le ^a   Gu, Jian Qiao ^a   Chu, Min ^a   Baltz, Richard H ^a   Brian, Paul ^a  

^a CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLGLUTAMIC ACID; DAPTOMYCIN; GENE PRODUCT; GLUTAMIC ACID; KYNURENIC ACID; NON RIBOSOMAL PEPTIDE SYNTHASE; PEPTIDE SYNTHASE; PROTEIN DPTD; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; DRUG DERIVATIVE; HYBRID PROTEIN; NON-RIBOSOMAL PEPTIDE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE DELETION; GENE FUSION; GENE INSERTION; HYBRID GENE; NONHUMAN; NONRIBOSOMAL PEPTIDE SYNTHESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES ROSEOSPORUS; AMINO ACID SEQUENCE; BIOSYNTHESIS; ENZYMOLOGY; FERMENTATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PLASMID; PROTEIN ENGINEERING; PROTEIN MOTIF;

STREPTOMYCES FILAMENTOSUS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DAPTOMYCIN; FERMENTATION; MOLECULAR SEQUENCE DATA; PEPTIDE SYNTHASES; PLASMIDS; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; STREPTOMYCES;

EID: 53449085206     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2008/020685-0     Document Type: Article

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