Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

Acta Neuropathologica

Volumn 129, Issue 3, 2015, Pages 399-415

  Launay, Nathalie ^a,b   Aguado, Carmen ^b,c   Fourcade, Stéphane ^a,b   Ruiz, Montserrat ^a,b   Grau, Laia ^a,b   Riera, Jordi ^a,b   Guilera, Cristina ^a,b   Giròs, Marisa ^b,d   Ferrer, Isidre ^a,b   Knecht, Erwin ^b,c   Pujol, Aurora ^a,b,e  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^d Institut de Bioquimica Clinica Barcelona   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Autophagy; mTOR; Temsirolimus; VLCFA; X ALD

Indexed keywords

BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P62; TEMSIROLIMUS; TARGET OF RAPAMYCIN KINASE;

ADRENOLEUKODYSTROPHY; AGGRESOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL SPECIFICITY; CONTROLLED STUDY; DENSE BODY; DISEASE COURSE; DNA DAMAGE; DOWN REGULATION; ELECTRON MICROSCOPY; ENERGY METABOLISM; FIBROBLAST; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MACROAUTOPHAGY; MOTONEURON; MOUSE; NERVE FIBER DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PEROXISOME; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; X LINKED ADRENOLEUKODYSTROPHY; ADULT; ANIMAL; CELL CULTURE; DISEASE MODEL; FEMALE; KNOCKOUT MOUSE; MALE; METABOLISM; MIDDLE AGED; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY;

ADRENOLEUKODYSTROPHY; ADULT; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NERVE DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84922984849     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1378-8     Document Type: Article

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