Prevention of neointimal proliferation by immunosuppression in synthetic vascular grafts

European Journal of Cardio-thoracic Surgery

Volumn 19, Issue 4, 2001, Pages 487-492

  Walpoth, Beat H ^a   Pavlicek, Michael ^a   Celik, Bülent ^a   Nicolaus, Beatrice ^a   Schaffner, Thomas ^a   Althaus, Ulrich ^a   Hess, Otto M ^a   Carrel, Thierry ^a   Morris, Randall E ^b  

^a PSI   (Switzerland)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Immunosuppression; Intimal hyperplasia; Toxicity; Vascular prosthesis

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; POLITEF; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL GRAFT; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; END TO END ANASTOMOSIS; HAIR LOSS; HISTOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL; WEIGHT GAIN; WOUND HEALING IMPAIRMENT;

ANASTOMOSIS, SURGICAL; ANIMALS; BLOOD VESSEL PROSTHESIS; HYPERPLASIA; IMMUNOSUPPRESSIVE AGENTS; MODELS, ANIMAL; MYCOPHENOLIC ACID; POLYTETRAFLUOROETHYLENE; RATS; RATS, WISTAR; SIROLIMUS; TUNICA INTIMA; VASCULAR PATENCY;

EID: 0035069061     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1010-7940(01)00582-6     Document Type: Article

References (16)

1. Predictors of graft patency 3 years after coronary artery bypass graft surgery
2. Improvement of patency rate in heparin-coated small synthetic vascular grafts
3. Advances in tissue engineering of blood vessels and other tissues
4. Pretreatment of donors and grafts with Rapamycins: the effect on graft survival and the tissue drug retention
5. Inhibition of intimal hyperplasia in rat aortic allografts with cyclosporine
6. Rapamycins (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries: evidence that Rapamycins antagonizes growth factor action on immune and non-immune cells
7. Treatment with Rapamycin blocks arterial intimal thickening following mechanical and alloimmune injury
8. Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury
9. Suppression of acute rejection prevents graft arteriosclerosis after allogeneic aorta transplantation in the rat
10. Rapamycin inhibits transplant vasculopathy in long-surviving rat heart allografts
11. The impact of acute rejection on the development of intimal hyperplasia associated with chronic rejection
12. Vascular smooth muscle cells and neointimal hyperplasia in chronic transplant rejection
13. Pathogenesis of early thrombus formation in experimental vein graft
14. Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat
15. Cyclosporine inhibits intimal hyperplasia in rat aortic allograft
16. Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts