Adreno-leukodystrophy: Oxidative stress of mice and men

Journal of Neuropathology and Experimental Neurology

Volumn 64, Issue 12, 2005, Pages 1067-1079

  Powers, James M ^a   Pei, Zhengtong ^b   Heinzer, Ann K ^b   Deering, Rebecca ^b   Moser, Ann B ^b   Moser, Hugo W ^b   Watkins, Paul A ^b   Smith, Kirby D ^b,c  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fatty acids; Knockout; Mitochondria; Oxidative stress; Peroxisome; X linked adreno leukodystrophy

Indexed keywords

4 HYDROXYNONENAL; ABCD1 PROTEIN; CHEMOKINE; CYTOKINE; FATTY ACID; GAMMA INTERFERON; GENE PRODUCT; HEME OXYGENASE 1; INTERLEUKIN 12; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MYELIN; PEROXYNITRITE; UNCLASSIFIED DRUG; 3 NITROTYROSINE; 3-NITROTYROSINE; BETA CHEMOKINE; BIOLOGICAL MARKER; CCL22 CHEMOKINE; DRUG DERIVATIVE; SUPEROXIDE DISMUTASE; TYROSINE;

ABCD1 GENE; ADOLESCENT; ADRENAL CORTEX; ADRENOLEUKODYSTROPHY; ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; DEMYELINATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DISORDERS OF PEROXISOMAL FUNCTIONS; FEMALE; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; INFLAMMATION; KIDNEY CORTEX; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; MALE; MOUSE; NERVE FIBER DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; TH1 CELL; X CHROMOSOME LINKED DISORDER; ANIMAL; BRAIN; ENZYMOLOGY; METABOLISM; METHODOLOGY; MITOCHONDRION; MOUSE MUTANT; PATHOLOGY;

ADRENAL CORTEX; ADRENOLEUKODYSTROPHY; ANIMALS; BIOCHEMISTRY; BIOLOGICAL MARKERS; BRAIN; CHEMOKINES, CC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; KIDNEY CORTEX; LIVER; MICE; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; TYROSINE;

EID: 33644793371     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000190064.28559.a4     Document Type: Article

References (48)

1. Moser HW, Smith KD, Watkins PA, Powers J, Moser AB. X-linked adrenoleukodystrophy. In: Scriver CR, Beaudet al, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill, 2001:3257-3301
2. Schaumburg HH, Powers JM, Raine CS, Suzuki K, Richardson EP Jr. Adrenoleukodystrophy. A clinical and pathological study of 17 cases. Arch Neurol 1975;33:577-91
3. Powers JM, Schaumburg HH, Johnson AB, Raine CS. A correlative study of the adrenal cortex in adreno-leukodystrophy - Evidence for a fatal intoxication with very long chain saturated fatty acids. Invest Cell Pathol 1980;3:353-76
4. Powers JM. Adreno-leukodystrophy (adreno-testiculo-leukomyelo- neuropathic-complex). Clin Neuropathol 1985;4:181-99
5. Powers JM, Liu Y, Moser AB, Moser HW. The inflammatory myelinopathy of adreno-leukodystrophy: Cells, effector molecules, and pathogenetic implications. J Neuropathol Exp Neurol 1992;51:630-43
6. Ito M, Blumberg BM, Mock DJ, et al. Potential environmental and host participants in the early white matter lesion of adreno-leukodystrophy: Morphologic evidence for CD8 cytotoxic T cells, cytolysis of oligodendrocytes, and CD1-mediated lipid antigen presentation. J Neuropathol Exp Neurol 2001;60:1004-19
7. Migeon BR, Moser HW, Moser AB, Axelman J, Sillence D, Norum RA. Adrenoleukodystrophy: Evidence for X-linkage, inactivation and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A 1981;78:5066-70
8. Mosser J, Douar AM, Sarde CO, et al. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 1993;361:726-30
9. Mosser J, Lutz Y, Stoeckel ME, et al. The gene responsible for adrenoleukodystrophy encodes a peroxisomal membrane protein. Hum Mol Genet 1994;3:265-71
10. McGuinness MC, Lu J-F, Zhang H-P, et al. Role of ALDP (ABDC1) and mitochondria in X-linked adrenoleukodystrophy. Mol Cell Biol 2003;23:744-53
11. Heinzer AK, McGuinness MC, Lu J-F, et al. Mouse models and genetic modifiers in X-linked adrenoleukodystrophy. Adv Exp Med Biol 2003;544:75-93
12. Tsuji S, Ohno T, Miyatake T, Suzuki A, Yamakawa T. Fatty acid elongation activity in fibroblasts from patients with adrenoleukodystrophy (ALD). J Biochem 1984;96:1241-47
13. Lu J-F, Lawler AM, Watkins PA, et al. A mouse model for X-linked adrenoleukodystrophy. Proc Natl Acad Sci U S A 1997;94:9366-71
14. Kobayashi T, Shinnoh N, Kondo A, Yamada T. Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem Biophys Res Commun 1997;232:631-36
15. Forss-Petter S, Werner H, Berger J, et al. Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. J Neurosci Res 1997;50:829-43
16. Pujol A, Ferrer I, Camps C, et al. Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: A therapeutic target for X-adrenoleukodystrophy. Hum Mol Genet 2004;13:2997-3006
17. Pujol A, Hindelang C, Callizot N, Bartsch U, Schachner M, Mandel JL. Late onset neurological phenotype of the X-ALD gene inactivation in mice: A mouse model for adrenomyeloneuropathy. Hum Mol Genet 2002;11:499-505
18. Schaumburg HH, Powers JM, Raine CS, et al. Adrenomyeloneuropathy: A probable variant of adrenoleukodystrophy. Neurology 1977;27:1114-19
19. Powers JM, DeCiero DP, Ito M, Moser AB, Moser HW. Adrenomyeloneuropathy: A neuropathologic review featuring its noninflammatory myelopathy. J Neuropathol Exp Neurol 2000;59:89-102
20. Baumgart E, Vanhorebeek I, Grabenbauer M, et al. Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse). Am J Pathol 2001;159:1477-94
21. Gilg AG, Singh AK, Singh I. Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy. J Neuropathol Exp Neurol 2000;59:1063-69
22. Beckman JS. Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury. In: Chiueh CC, Gilbert DL, Colton CA, eds. The Neurobiology of NO. and. OH. New York: The New York Academy of Sciences, 1994:69-75
23. Meij JTA, Haselton CL, Hillman KL, Muralikrishnan D, Ebadi M, Yu L. Differential mechanisms of nitric oxide- and peroxynitrite-induced cell death. Mol Pharmacol 2004;66:1043-45
24. Vargas CR, Wajner M, Sirtori LR, et al. Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. Biochim Biophys Acta 2004;1688:26-32
25. Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? Br J Pharmacol 2004;142:231-55
26. Halliwell B, Gutteridge JMC. Oxygen radicals and the nervous system. TINS 1985;8:22-26
27. Watkins PA, Gould SJ, Smith MA, et al. Altered expression of ALDP in X-linked adrenoleukodystrophy. Am J Hum Genet 1995;57:292-301
28. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86:271-78
29. Reznick AZ, Packer L. Oxidative damage to proteins: Spectrophotometric method for carbonyl assay. Methods Enzymol 1994;233:357-63
30. Bourne GH. Comparative anatomy and embryology of the adrenal glands. In: Moon HD, ed. The Adrenal Cortex. New York: Paul B. Hoeber, Inc, 1961:12-14
31. Allen J, Kepic T, Garwicki D, Yunns M. Adrenal defect in adrenomyelodystrophy. South Med J 1982;75:877-79
32. Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia 1996;17:83-89
33. Sanyal B, Szuchet S. Tumor necrosis factor α induces the transcription of the H chain ferritin gene in cultured oligodendrocytes. Soc Neurosci Abstr 1995;21:3
34. Mancuso M, Davidzon G, Kurlan RM, et al. Hereditary ferritinopathy: A novel mutation, its cellular pathology, and pathogenetic insights. J Neuropathol Exp Neurol 2005;64:280-94
35. Vig M, Srivastava S, Kandpal U, et al. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. J Clin Invest 2004;113:1734-42
36. Meij JTA, Haselton CL, Hillman KL, Muralikrishan D, Ebadi M, Yu L. Differential mechanisms of nitric oxide- and peroxynitrite-induced cell death. Mol Pharmacol 2004;66:1043-53
37. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A 1995;92:7162-66
38. Mitrovic B, Ignarro LJ, Vinters HV, Akers M-A, et al. Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience 1995;65:531-39
39. Montine TJ, Neely MD, Quinn JF, et al. Serial review: Causes and consequences of oxidative stress in Alzheimer's disease. Free Radic Biol Med 2002;33:620-26
40. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81-128
41. Shevach EM. Organ-specific autoimmunity. In: Paul WE, ed. Fundamental Immunology. Philadelphia: Lippincott-Raven Publishers, 1999:1089-125
42. Leonard WJ. Type I cytokines and interferons and their receptors. In: Paul WE, ed. Fundamental Immunology. Philadelphia: Lippincott-Raven Publishers, 1999:765-66
43. McGuinness MC, Powers JM, Bias WB, et al. Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis. J Neuroimmunol 1997;75:174-82
44. Di Biase A, Merendino N, Avellino C, Cappa M, Salvati S. Th 1 cytokine production by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy. J Neurol Sci 2001;182:161-65
45. Paintlia AS, Gilg AG, Khan M, Singh AK, Barbosa E, Singh I. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: Implications for potential therapies. Neurobiol Dis 2003;14:425-39
46. Rosenberg HF, Gallin JI. Inflammation. In: Paul WE, ed. Fundamental Immunology. Philadelphia: Lippincott-Raven Publishers, 1999:1055
47. Dong Y, Benveniste EN. Immune function of astrocytes. Glia 2001;36:180-90
48. Aloisi F. Immune function of microglia. Glia 2001;36:165-79