Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

Aging Cell

Volumn 12, Issue 6, 2013, Pages 966-977

  Lerner, Chad ^a   Bitto, Alessandro ^a   Pulliam, Daniel ^b   Nacarelli, Timothy ^a   Konigsberg, Mina ^c   Van Remmen, Holly ^b   Torres, Claudio ^a   Sell, Christian ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c DEPARTAMENTO DE QUÍMICA   (Mexico)

Author keywords

Mammalian target of rapamycin; Mitochondria; Rapamycin; Senescence

Indexed keywords

CELL PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PROTEIN P62; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SEQUESTOSOME 1 PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONJUGATE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LONG TERM EXPOSURE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NORMAL HUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

MAMMALIA;

MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIA; RAPAMYCIN; SENESCENCE;

AUTOPHAGY; BIOLOGICAL MARKERS; CELL AGING; FIBROBLASTS; GENE EXPRESSION REGULATION; HALF-LIFE; HOMEOSTASIS; HUMANS; LYSINE; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS; TOR SERINE-THREONINE KINASES; UBIQUITIN;

EID: 84888135529     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12122     Document Type: Article

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