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Volumn 16, Issue 1, 2015, Pages 77-91

Prospects of molecularly-targeted therapies for cervical cancer treatment

Author keywords

Cervical cancer; HPV; microRNA; Molecular targets; Therapy

Indexed keywords

3, 3' DIINDOLYLMETHANE; BEVACIZUMAB; CELECOXIB; CETUXIMAB; CISPLATIN; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; GLYCOPROTEIN E1; GLYCOPROTEIN E2; MICRORNA; MICRORNA 101; MICRORNA 143; MICRORNA 181A; MICRORNA 203; MICRORNA 21; MICRORNA 218; MICRORNA 29A; MICRORNA 34A; MICRORNA 424; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN E5; PROTEIN E6; PROTEIN E7; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VIRUS DNA;

EID: 84922294150     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450116666141205150942     Document Type: Article
Times cited : (37)

References (225)
  • 1
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006; 118: 3030-44.
    • (2006) Int J Cancer , vol.118 , pp. 3030-3044
    • Parkin, D.M.1
  • 2
    • 80054914456 scopus 로고    scopus 로고
    • Breast and cervical cancer in 187 countries between 1980 and 2010: A systematic analysis
    • Forouzanfar MH, Foreman KJ, Delossantos AM, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 2011; 378: 1461-84.
    • (2011) Lancet , vol.378 , pp. 1461-1484
    • Forouzanfar, M.H.1    Foreman, K.J.2    Delossantos, A.M.3
  • 3
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2: 342-50.
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • Zur Hausen, H.1
  • 4
    • 0036221471 scopus 로고    scopus 로고
    • The causal relation between human papillomavirus and cervical cancer
    • Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002; 55: 244-65.
    • (2002) J Clin Pathol , vol.55 , pp. 244-265
    • Bosch, F.X.1    Lorincz, A.2    Munoz, N.3    Meijer, C.J.4    Shah, K.V.5
  • 5
    • 0142062150 scopus 로고    scopus 로고
    • Chapter 1: Human papillomavirus and cervical cancer-burden and assessment of causality
    • Bosh FX, de Sanjose S. Chapter 1: human papillomavirus and cervical cancer-burden and assessment of causality. J Natl Cancer Inst Monogr 2003; 1: 3-13.
    • (2003) J Natl Cancer Inst Monogr , vol.1 , pp. 3-13
    • Bosh, F.X.1    de Sanjose, S.2
  • 7
    • 77950938389 scopus 로고    scopus 로고
    • Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    • Bernard HU, Burk RD, Chen Z, et al. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 2010; 401: 70-9.
    • (2010) Virology , vol.401 , pp. 70-79
    • Bernard, H.U.1    Burk, R.D.2    Chen, Z.3
  • 9
    • 84857882487 scopus 로고    scopus 로고
    • Immunomarkers in gynecologic cytology: The search for the ideal biomolecular papanicolaou test
    • Pinto AP, Degen M, Villa LL, Cibas ES. Immunomarkers in gynecologic cytology: the search for the ideal biomolecular papanicolaou test. Acta Cytol 2012; 56: 109-121.
    • (2012) Acta Cytol , vol.56 , pp. 109-121
    • Pinto, A.P.1    Degen, M.2    Villa, L.L.3    Cibas, E.S.4
  • 12
    • 42449153250 scopus 로고    scopus 로고
    • Mechanisms of human papillomavirus type 16 neutralization by L2 crossneutralizing and L1 type-specific antibodies
    • Day PM, Gambhira R, Roden RB, Lowy DR, Schiller JT. Mechanisms of human papillomavirus type 16 neutralization by L2 crossneutralizing and L1 type-specific antibodies. J Virol 2008; 82: 4638-4646.
    • (2008) J Virol , vol.82 , pp. 4638-4646
    • Day, P.M.1    Gambhira, R.2    Roden, R.B.3    Lowy, D.R.4    Schiller, J.T.5
  • 13
    • 77952006801 scopus 로고    scopus 로고
    • The role of the human papillomavirus (HPV) vaccine in developing countries
    • Kling M, Zeichner JA. The role of the human papillomavirus (HPV) vaccine in developing countries. Int J Dermatol 2010; 49: 377-379.
    • (2010) Int J Dermatol , vol.49 , pp. 377-379
    • Kling, M.1    Zeichner, J.A.2
  • 17
    • 33947723213 scopus 로고    scopus 로고
    • Antivirals Sexually Transmitted Infections; Human papillomaviruses
    • Ed. Sterling JC, Tyring SK: London
    • Greenfield I, Cuthill S. Antivirals. In: Sexually Transmitted Infections; Human papillomaviruses. Clinical and scientific advances, Ed. Sterling JC, Tyring SK: London 2001; Vol. 78: pp 120-30.
    • (2001) Clinical and scientific advances , vol.78 , pp. 120-130
    • Greenfield, I.1    Cuthill, S.2
  • 18
    • 1242352914 scopus 로고    scopus 로고
    • Established and potential strategies against papillomavirus infections
    • Bernard HU. Established and potential strategies against papillomavirus infections. J Antimicrob Chemother 2004; 53: 137-9.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 137-139
    • Bernard, H.U.1
  • 19
    • 0033767782 scopus 로고    scopus 로고
    • Persistence of human papillomavirus infection after therapeutic conization for CIN 3: Is it an alarm for disease recurrence?
    • Nagai Y, Maehama T, Asato T, Kanazawa K. Persistence of human papillomavirus infection after therapeutic conization for CIN 3: is it an alarm for disease recurrence? Gynecol Oncol 2000; 79: 294-9.
    • (2000) Gynecol Oncol , vol.79 , pp. 294-299
    • Nagai, Y.1    Maehama, T.2    Asato, T.3    Kanazawa, K.4
  • 20
    • 0041622838 scopus 로고    scopus 로고
    • Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization
    • Costa S, De Simone P, Venturoli S, et al. Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization. Gynecol Oncol 2003; 90: 358-65.
    • (2003) Gynecol Oncol , vol.90 , pp. 358-365
    • Costa, S.1    De Simone, P.2    Venturoli, S.3
  • 22
    • 84856690459 scopus 로고    scopus 로고
    • Comment on 'Quality of life and emotional distress in early stage and locally advanced cervical cancer pa tients: A prospective, longitudinal study' by Ferrandina et al
    • Yavas G, Yavas C. Comment on 'Quality of life and emotional distress in early stage and locally advanced cervical cancer pa tients: a prospective, longitudinal study' by Ferrandina et al. Gynecol Oncol 2012; 124: 389-94.
    • (2012) Gynecol Oncol , vol.124 , pp. 389-394
    • Yavas, G.1    Yavas, C.2
  • 24
    • 85056055141 scopus 로고    scopus 로고
    • Small molecule inhibitors of human papillomavirus protein-protein interactions
    • D'Abramo CM, Archambault J. Small molecule inhibitors of human papillomavirus protein-protein interactions. Open Virol J 2011; 5: 80-95.
    • (2011) Open Virol J , vol.5 , pp. 80-95
    • D'Abramo, C.M.1    Archambault, J.2
  • 25
    • 84892957649 scopus 로고    scopus 로고
    • Molecular targets of HPV oncoproteins: Potential biomarkers for cervical carcinogenesis
    • Freitas AC, Coimbra EC, Leitão MD. Molecular targets of HPV oncoproteins: Potential biomarkers for cervical carcinogenesis. Biochim Biophys Acta 2014; 1845: 91-103.
    • (2014) Biochim Biophys Acta , vol.1845 , pp. 91-103
    • Freitas, A.C.1    Coimbra, E.C.2    Leitão, M.D.3
  • 26
    • 14744285753 scopus 로고    scopus 로고
    • The papillomavirus life cycle
    • Doorbar J. The papillomavirus life cycle. J Clin Virol 2005; 32: 7-15.
    • (2005) J Clin Virol , vol.32 , pp. 7-15
    • Doorbar, J.1
  • 27
    • 0030913830 scopus 로고    scopus 로고
    • Human papillomaviruses: General features
    • Favre M, Ramoz N, Orth G. Human papillomaviruses: general features. Clin Dermatol 1997; 15: 181-98.
    • (1997) Clin Dermatol , vol.15 , pp. 181-198
    • Favre, M.1    Ramoz, N.2    Orth, G.3
  • 28
    • 0028598275 scopus 로고
    • Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein
    • Frattini MG, Laimins, LA. Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein. Proc Natl Acad Sci 1994; 91: 12398-402.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 12398-12402
    • Frattini, M.G.1    Laimins, L.A.2
  • 29
  • 30
    • 0030769058 scopus 로고    scopus 로고
    • Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins
    • Benson JD, Lawande R, Howley PM. Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins. J Virol 1997; 71: 8041-7.
    • (1997) J Virol , vol.71 , pp. 8041-8047
    • Benson, J.D.1    Lawande, R.2    Howley, P.M.3
  • 31
    • 0034629389 scopus 로고    scopus 로고
    • cAMP response elementbinding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription
    • Lee D, Lee B, Kim J, Kim DW, Choe J. cAMP response elementbinding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription. J Biol Chem 2000; 275: 7045-51.
    • (2000) J Biol Chem , vol.275 , pp. 7045-7051
    • Lee, D.1    Lee, B.2    Kim, J.3    Kim, D.W.4    Choe, J.5
  • 32
    • 0036838694 scopus 로고    scopus 로고
    • Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300
    • Muller A, Ritzkowsky A, Steger G. Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300. J Virol 2002; 76: 11042-53.
    • (2002) J Virol , vol.76 , pp. 11042-11053
    • Muller, A.1    Ritzkowsky, A.2    Steger, G.3
  • 33
    • 0032923884 scopus 로고    scopus 로고
    • Long-term episomal maintenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which Is mediated by the viral E2 protein and its binding sites
    • Ilves I, Kivi S, Ustav M. Long-term episomal maintenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which Is mediated by the viral E2 protein and its binding sites. J Virol 1999; 73: 4404-12.
    • (1999) J Virol , vol.73 , pp. 4404-4412
    • Ilves, I.1    Kivi, S.2    Ustav, M.3
  • 34
    • 0036086459 scopus 로고    scopus 로고
    • The papillomavirus E2 proteins: Structure, function, and biology
    • Hegde RS. The papillomavirus E2 proteins: structure, function, and biology. Annu Rev Biophys Biomol Struct 2002; 31: 343-60.
    • (2002) Annu Rev Biophys Biomol Struct , vol.31 , pp. 343-360
    • Hegde, R.S.1
  • 35
    • 77954955259 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins: Pathways to transformation
    • Moody CA, Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer 2010; 10: 550-60.
    • (2010) Nat Rev Cancer , vol.10 , pp. 550-560
    • Moody, C.A.1    Laimins, L.A.2
  • 36
    • 81055131727 scopus 로고    scopus 로고
    • Papillomavirus E5: The smallest oncoprotein with many functions
    • Venuti A, Paolini F, Nasir L, et al. Papillomavirus E5: the smallest oncoprotein with many functions. Mol Cancer 2011; 10: 140.
    • (2011) Mol Cancer , vol.10
    • Venuti, A.1    Paolini, F.2    Nasir, L.3
  • 37
    • 68949194550 scopus 로고    scopus 로고
    • Oncogenic activities of human papillomaviruses
    • McLaughlin-Drubin ME, Münger K. Oncogenic activities of human papillomaviruses. Virus Res 2009; 143: 195-208.
    • (2009) Virus Res , vol.143 , pp. 195-208
    • McLaughlin-Drubin, M.E.1    Münger, K.2
  • 38
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990; 248: 76-9.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 39
    • 0026403583 scopus 로고
    • Oncoproteins encoded by the cancerassociated papillomavirus target the products of retinoblastoma and p53 tumor suppressor genes
    • Howley PM, Scheffner M, Munger K. Oncoproteins encoded by the cancerassociated papillomavirus target the products of retinoblastoma and p53 tumor suppressor genes. Quant Biol 1991; 56: 149-55.
    • (1991) Quant Biol , vol.56 , pp. 149-155
    • Howley, P.M.1    Scheffner, M.2    Munger, K.3
  • 40
    • 0033511021 scopus 로고    scopus 로고
    • Human papillomavirus life cycle: Active and latent phases
    • Stubenrauch F, Laimins LA. Human papillomavirus life cycle: active and latent phases. Cancer Biology 1999; 9: 379-86.
    • (1999) Cancer Biology , vol.9 , pp. 379-386
    • Stubenrauch, F.1    Laimins, L.A.2
  • 41
    • 0027236269 scopus 로고
    • Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes
    • Vousden K. Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. The Faseb Journal 1993; 7: 872-79.
    • (1993) The Faseb Journal , vol.7 , pp. 872-879
    • Vousden, K.1
  • 42
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
    • Ren B, Cam H, Takahashi Y, et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 2002; 16: 245-56.
    • (2002) Genes Dev , vol.16 , pp. 245-256
    • Ren, B.1    Cam, H.2    Takahashi, Y.3
  • 43
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N, Howley PM, Münger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989; 243: 934-7.
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Münger, K.3    Harlow, E.4
  • 44
    • 0035160942 scopus 로고    scopus 로고
    • Ki-67 immunoquantitation in cervical intraepithelial neoplasia (CIN): A sensitive marker for grading
    • Kruse AJ, Baak JP, de Bruin PC, et al. Ki-67 immunoquantitation in cervical intraepithelial neoplasia (CIN): a sensitive marker for grading. J Pathol 2001; 193: 48-54.
    • (2001) J Pathol , vol.193 , pp. 48-54
    • Kruse, A.J.1    Baak, J.P.2    de Bruin, P.C.3
  • 45
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998; 153: 1741-48.
    • (1998) Am J Pathol , vol.153 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3    Fukuda, T.4    Nakajima, T.5
  • 46
    • 0035871985 scopus 로고    scopus 로고
    • Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    • Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001; 92: 276-84.
    • (2001) Int J Cancer , vol.92 , pp. 276-284
    • Klaes, R.1    Friedrich, T.2    Spitkovsky, D.3
  • 47
    • 0037363076 scopus 로고    scopus 로고
    • Translational approaches to improving cervical screening
    • Baldwin P, Laskey R, Coleman N. Translational approaches to improving cervical screening. Nat Rev Cancer 2003; 3: 217-26.
    • (2003) Nat Rev Cancer , vol.3 , pp. 217-226
    • Baldwin, P.1    Laskey, R.2    Coleman, N.3
  • 48
    • 19944427466 scopus 로고    scopus 로고
    • Gene expression profiles of primary HPV16-and HPV18-infected early stage cervical cancers and normal cervical epithelium: Identification of novel candidate molecular markers for cervical cancer diagnosis and therapy
    • Santin AD, Zhan F, Bignotti E, et al. Gene expression profiles of primary HPV16-and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 2005; 331: 269-91.
    • (2005) Virology , vol.331 , pp. 269-291
    • Santin, A.D.1    Zhan, F.2    Bignotti, E.3
  • 49
    • 12344253083 scopus 로고    scopus 로고
    • The role of human papilloma virus in the molecular biology of cervical carcinogenesis
    • Motoyama S, Ladnines-Llave CA, Villanueva SL, Maruo T. The role of human papilloma virus in the molecular biology of cervical carcinogenesis. Kobe J Med Sci 2004; 50: 9-19.
    • (2004) Kobe J Med Sci , vol.50 , pp. 9-19
    • Motoyama, S.1    Ladnines-Llave, C.A.2    Villanueva, S.L.3    Maruo, T.4
  • 50
    • 0142074905 scopus 로고    scopus 로고
    • Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: Association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia
    • Ueda Y, Enomoto T, Miyatake T, et al. Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Lab Investig 2003; 83: 1517-27.
    • (2003) Lab Investig , vol.83 , pp. 1517-1527
    • Ueda, Y.1    Enomoto, T.2    Miyatake, T.3
  • 51
    • 0028937867 scopus 로고
    • Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells
    • Jeon S, Allen-Hoffmann BL, Lambert PF. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J Virol 1995; 69: 2989-97.
    • (1995) J Virol , vol.69 , pp. 2989-2997
    • Jeon, S.1    Allen-Hoffmann, B.L.2    Lambert, P.F.3
  • 52
    • 0035956257 scopus 로고    scopus 로고
    • Mechanisms of cell transformation by papillomavirus E5 proteins
    • Dimaio D, Mattoon D. Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene 2001; 20: 7866-73.
    • (2001) Oncogene , vol.20 , pp. 7866-7873
    • Dimaio, D.1    Mattoon, D.2
  • 53
    • 0028262230 scopus 로고
    • Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix
    • Kristiansen E, Jenkins A, Holm R. Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix. J Clin Pathol 1994; 47: 253-6.
    • (1994) J Clin Pathol , vol.47 , pp. 253-256
    • Kristiansen, E.1    Jenkins, A.2    Holm, R.3
  • 54
    • 33646596267 scopus 로고    scopus 로고
    • Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    • Arias-Pulido H, Peyton CL, Joste NE, Vargas, H, Wheeler CM. Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol 2006; 44: 1755-62.
    • (2006) J Clin Microbiol , vol.44 , pp. 1755-1762
    • Arias-Pulido, H.1    Peyton, C.L.2    Joste, N.E.3    Vargas, H.4    Wheeler, C.M.5
  • 55
    • 0035068989 scopus 로고    scopus 로고
    • The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix
    • Chang JL, Tsao YP, Liu DW, Huang SJ, Lee WH, Chen SL. The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix. J Biomed Sci 2001; 8: 206-13.
    • (2001) J Biomed Sci , vol.8 , pp. 206-213
    • Chang, J.L.1    Tsao, Y.P.2    Liu, D.W.3    Huang, S.J.4    Lee, W.H.5    Chen, S.L.6
  • 57
    • 0028926718 scopus 로고
    • The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes
    • Straight SW, Herman B, McCance DJ. The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes. Journal of Virology 1995; 69: 3185-92.
    • (1995) Journal of Virology , vol.69 , pp. 3185-3192
    • Straight, S.W.1    Herman, B.2    McCance, D.J.3
  • 58
    • 13744254574 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and epidermal growth factor receptor: Pharmacologic targets for chemoprevention
    • Dannenberg AJ, Lippman SM, Mann JR, Subbaramaiah K, DuBois RN. Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. J Clin Oncol 2005; 23: 254-66.
    • (2005) J Clin Oncol , vol.23 , pp. 254-266
    • Dannenberg, A.J.1    Lippman, S.M.2    Mann, J.R.3    Subbaramaiah, K.4    DuBois, R.N.5
  • 59
    • 33646585409 scopus 로고    scopus 로고
    • Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor MEK/ERK1, 2 and PI3K/Akt
    • Kim SH, Juhnn YS, Kang S, Park SW, Sung MW, Bang YJ. Human papillomavirus 16 E5 up-regulates the expression of vascular endothelial growth factor through the activation of epidermal growth factor receptor MEK/ERK1, 2 and PI3K/Akt. Cell Mol Life Sci 2006; 63: 930-38.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 930-938
    • Kim, S.H.1    Juhnn, Y.S.2    Kang, S.3    Park, S.W.4    Sung, M.W.5    Bang, Y.J.6
  • 60
    • 0029839485 scopus 로고    scopus 로고
    • Human papillomavirus type 11 and 16 E5 represses p21(WafI/SdiI/CipI) gene expression in fibroblasts and keratino-cytes
    • Tsao YP, Li LY, Tsai TC, Chen SL. Human papillomavirus type 11 and 16 E5 represses p21(WafI/SdiI/CipI) gene expression in fibroblasts and keratino-cytes. J Virol 1996; 70: 7535-39.
    • (1996) J Virol , vol.70 , pp. 7535-7539
    • Tsao, Y.P.1    Li, L.Y.2    Tsai, T.C.3    Chen, S.L.4
  • 61
    • 77649182253 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27(Kip1)
    • Pedroza-Saavedra EW, Lam F, Esquivel-Guadarrama F, Gutierrez-Xicotencatl L. The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27(Kip1), Virology 2010; 400: 44-52.
    • (2010) Virology , vol.400 , pp. 44-52
    • Pedroza-Saavedra, E.W.1    Lam, F.2    Esquivel-Guadarrama, F.3    Gutierrez-Xicotencatl, L.4
  • 62
    • 0032529671 scopus 로고    scopus 로고
    • The E5 oncoprotein of human papillomavirus type 16 enhances endothelin-1-induced keratinocyte growth
    • Venuti A, Salani D, Poggiali F, Manni V, Bagnato A. The E5 oncoprotein of human papillomavirus type 16 enhances endothelin-1-induced keratinocyte growth. Virology 1998; 248: 1-5.
    • (1998) Virology , vol.248 , pp. 1-5
    • Venuti, A.1    Salani, D.2    Poggiali, F.3    Manni, V.4    Bagnato, A.5
  • 63
    • 33645504781 scopus 로고    scopus 로고
    • Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence
    • Chell SD, Witherden IR, Dobson RR, et al. Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Research 2006; 66: 3106-13.
    • (2006) Cancer Research , vol.66 , pp. 3106-3113
    • Chell, S.D.1    Witherden, I.R.2    Dobson, R.R.3
  • 64
    • 58949097580 scopus 로고    scopus 로고
    • Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells
    • Oh JM, Kim SH, Lee YI, et al. Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells. Carcinogenesis 2009; 30: 141-9.
    • (2009) Carcinogenesis , vol.30 , pp. 141-149
    • Oh, J.M.1    Kim, S.H.2    Lee, Y.I.3
  • 65
    • 65549096389 scopus 로고    scopus 로고
    • Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein
    • Kim SH, Oh JM, No JH, Bang YJ, Juhnn YS, Song YS. Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein. Carcinogenesis 2009; 30: 753-7.
    • (2009) Carcinogenesis , vol.30 , pp. 753-757
    • Kim, S.H.1    Oh, J.M.2    No, J.H.3    Bang, Y.J.4    Juhnn, Y.S.5    Song, Y.S.6
  • 66
    • 62349138124 scopus 로고    scopus 로고
    • The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
    • Greenhough A, Smartt HJ, Moore AE, et al. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009; 30: 377-86.
    • (2009) Carcinogenesis , vol.30 , pp. 377-386
    • Greenhough, A.1    Smartt, H.J.2    Moore, A.E.3
  • 67
    • 84869492245 scopus 로고    scopus 로고
    • Prognostic significance of cyclooxygenase-2 in cervical cancer: A meta-analysis
    • Huang M, Chen Q, Xiao J, Liu C, Zhao X. Prognostic significance of cyclooxygenase-2 in cervical cancer: a meta-analysis. Int J Cancer 2013; 132: 363-73.
    • (2013) Int J Cancer , vol.132 , pp. 363-373
    • Huang, M.1    Chen, Q.2    Xiao, J.3    Liu, C.4    Zhao, X.5
  • 68
    • 22144477115 scopus 로고    scopus 로고
    • MicroRNAs in vertebrate development
    • Harfe BD. MicroRNAs in vertebrate development. Curr Opin Genet Dev 2005; 15: 410-15.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 410-415
    • Harfe, B.D.1
  • 69
    • 84883805211 scopus 로고    scopus 로고
    • The role of miRNAs in regulating gene expression networks
    • Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. J Mol Biol 2013; 425: 3582-600.
    • (2013) J Mol Biol , vol.425 , pp. 3582-3600
    • Gurtan, A.M.1    Sharp, P.A.2
  • 70
    • 84860229754 scopus 로고    scopus 로고
    • The role of miRNAs in human papilloma virus (HPV)-associated cancers: Bridging between HPV-related head and neck cancer and cervical cancer
    • Lajer CB, Garnæs E, Friis-Hansen L, et al. The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer. Br J Cancer 2012; 106: 1526-34.
    • (2012) Br J Cancer , vol.106 , pp. 1526-1534
    • Lajer, C.B.1    Garnæs, E.2    Friis-Hansen, L.3
  • 72
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004; 101: 2999-3004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 73
    • 79959783574 scopus 로고    scopus 로고
    • Human papillomavirus 16 E5 modulates the expression of host microRNAs
    • Greco N, Kivi K, Qian SK, Leivonen P, Auvinen E. Human papillomavirus 16 E5 modulates the expression of host microRNAs. PLoS One 2011; 6: e21646.
    • (2011) PLoS One , vol.6
    • Greco, N.1    Kivi, K.2    Qian, S.K.3    Leivonen, P.4    Auvinen, E.5
  • 74
    • 80655127810 scopus 로고    scopus 로고
    • Regulation of cellular miRNA expression by human papillomaviruses
    • Zheng ZM, Wang X. Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta 2011; 1809: 668-77.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 668-677
    • Zheng, Z.M.1    Wang, X.2
  • 75
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-34.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3
  • 76
    • 34249822779 scopus 로고    scopus 로고
    • Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    • Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26: 731-43.
    • (2007) Mol Cell , vol.26 , pp. 731-743
    • Raver-Shapira, N.1    Marciano, E.2    Meiri, E.3
  • 77
    • 77951454817 scopus 로고    scopus 로고
    • Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins
    • Melar-New M, Laimins A. Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. J Virol 2010; 84: 5212-21.
    • (2010) J Virol , vol.84 , pp. 5212-5221
    • Melar-New, M.1    Laimins, A.2
  • 79
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006; 6: 714-27.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 80
    • 84893550460 scopus 로고    scopus 로고
    • Emerging Biological Treatments for Uterine Cervical Carcinoma
    • Vici P, Mariani L, Pizzuti L, et al. Emerging Biological Treatments for Uterine Cervical Carcinoma. J Cancer 2014; 5: 86-97e.
    • (2014) J Cancer , vol.5 , pp. 86-97e
    • Vici, P.1    Mariani, L.2    Pizzuti, L.3
  • 81
    • 37449004176 scopus 로고    scopus 로고
    • A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer
    • Goncalves A, Fabbro M, Lhommé C, et al. A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer. Gynecol Oncol 2008; 108: 42-6.
    • (2008) Gynecol Oncol , vol.108 , pp. 42-46
    • Goncalves, A.1    Fabbro, M.2    Lhommé, C.3
  • 82
    • 69449086850 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Lee YC, Mannel R. A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study. Int J Gynecol Cancer 2009; 19: 929-33.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 929-933
    • Schilder, R.J.1    Sill, M.W.2    Lee, Y.C.3    Mannel, R.4
  • 83
    • 80051551247 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or nonsquamous cell carcinoma of the cervix: A Gynecologic Oncology Group study
    • Santin AD, Sill MW, McMeekin DS, et al. Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or nonsquamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 2011; 122: 495-500.
    • (2011) Gynecol Oncol , vol.122 , pp. 495-500
    • Santin, A.D.1    Sill, M.W.2    McMeekin, D.S.3
  • 84
    • 74249122456 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND. 184
    • Mackay HJ, Tinker A, Winquist E, et al. A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND. 184. Gynecol Oncol 2010; 116: 163-67.
    • (2010) Gynecol Oncol , vol.116 , pp. 163-167
    • Mackay, H.J.1    Tinker, A.2    Winquist, E.3
  • 85
    • 84862679427 scopus 로고    scopus 로고
    • A phase II study of bevacizumab in combination with definitive radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma: Preliminary results of RTOG 0417
    • Schefter TE, Winter K, Kwon JS et al. A phase II study of bevacizumab in combination with definitive radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma: preliminary results of RTOG 0417. Int J Radiat Oncol Biol Phys 2012; 83: 1179-84.
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 1179-1184
    • Schefter, T.E.1    Winter, K.2    Kwon, J.S.3
  • 86
    • 84879111541 scopus 로고    scopus 로고
    • Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    • Zighelboim I, Wright JD, Gao F, et al. Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer. Gynecol Oncol 2013; 130: 64-8.
    • (2013) Gynecol Oncol , vol.130 , pp. 64-68
    • Zighelboim, I.1    Wright, J.D.2    Gao, F.3
  • 87
    • 10744219650 scopus 로고    scopus 로고
    • Celecoxib modulates the expression of cyclooxygenase-2, ki67, apoptosis-related marker, and microvessel density in human cervical cancer: A pilot study
    • Ferrandina G, Ranelletti FO, Legge F, et al. Celecoxib modulates the expression of cyclooxygenase-2, ki67, apoptosis-related marker, and microvessel density in human cervical cancer: a pilot study. Clin Cancer Res 2003; 9: 4324-31.
    • (2003) Clin Cancer Res , vol.9 , pp. 4324-4331
    • Ferrandina, G.1    Ranelletti, F.O.2    Legge, F.3
  • 88
    • 33845627724 scopus 로고    scopus 로고
    • A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment
    • Herrera FG, Chan P, Doll C, et al. A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. Int J Radiat Oncol Biol Phys 2007; 67: 97-103.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 97-103
    • Herrera, F.G.1    Chan, P.2    Doll, C.3
  • 89
    • 84872324978 scopus 로고    scopus 로고
    • COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: A quantitative immunohistochemical analysis of RTOG C0128
    • Doll CM, Winter K, Gaffney DK, et al. COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical analysis of RTOG C0128. Int J Gynecol Cancer 2013; 23: 176-83.
    • (2013) Int J Gynecol Cancer , vol.23 , pp. 176-183
    • Doll, C.M.1    Winter, K.2    Gaffney, D.K.3
  • 90
    • 84862896560 scopus 로고    scopus 로고
    • Small molecule inhibitors of the human papillomavirus e1-e2 interaction
    • White PW, Faucher AM, Goudreau N. Small molecule inhibitors of the human papillomavirus e1-e2 interaction. Curr Top Microbiol Immunol 2011; 348: 61-88.
    • (2011) Curr Top Microbiol Immunol , vol.348 , pp. 61-88
    • White, P.W.1    Faucher, A.M.2    Goudreau, N.3
  • 91
    • 0141730323 scopus 로고    scopus 로고
    • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus positive cancer cells
    • Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F. siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus positive cancer cells. Oncogene 2003; 22: 5938-45.
    • (2003) Oncogene , vol.22 , pp. 5938-5945
    • Butz, K.1    Ristriani, T.2    Hengstermann, A.3    Denk, C.4    Scheffner, M.5    Hoppe-Seyler, F.6
  • 92
    • 34447629237 scopus 로고    scopus 로고
    • Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells
    • Sima N, Wang S, Wang W, et al. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007; 106: 299-304.
    • (2007) Gynecol Oncol , vol.106 , pp. 299-304
    • Sima, N.1    Wang, S.2    Wang, W.3
  • 94
    • 57849084800 scopus 로고    scopus 로고
    • Nucleic acids as therapeutic agents
    • Alvarez-Salas LM. Nucleic acids as therapeutic agents. Curr Top Med Chem 2008; 85: 1379-404.
    • (2008) Curr Top Med Chem , vol.85 , pp. 1379-1404
    • Alvarez-Salas, L.M.1
  • 96
    • 0038032792 scopus 로고    scopus 로고
    • RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces Senescence in HeLa Cells
    • Hall AH, Alexander KA. RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces Senescence in HeLa Cells. J Virol 2003; 77: 6066-9.
    • (2003) J Virol , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 97
    • 21644448222 scopus 로고    scopus 로고
    • Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53
    • Hengstermann A, D'silva MA, Kuballa P, Butz K, Hoppe-Seyler F, Scheffner M. Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol 2005; 79: 9296-300.
    • (2005) J Virol , vol.79 , pp. 9296-9300
    • Hengstermann, A.1    D'silva, M.A.2    Kuballa, P.3    Butz, K.4    Hoppe-Seyler, F.5    Scheffner, M.6
  • 98
    • 32844470329 scopus 로고    scopus 로고
    • Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNA
    • Yamato K, Fen J, Kobuchi H. Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNA. Cancer Gene Ther 2006; 13: 234-41.
    • (2006) Cancer Gene Ther , vol.13 , pp. 234-241
    • Yamato, K.1    Fen, J.2    Kobuchi, H.3
  • 99
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-66.
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 100
    • 33846188098 scopus 로고    scopus 로고
    • microRNAs as oncogenes and tumor suppressors
    • Zhang B, Pan X, Cobb GP, et al. microRNAs as oncogenes and tumor suppressors. Dev Biol 2007; 302: 1-12.
    • (2007) Dev Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3
  • 101
    • 64149121172 scopus 로고    scopus 로고
    • MicroRNA-based therapeutics for cancer
    • Wang V, Wu W. MicroRNA-based therapeutics for cancer. Bio-Drugs 2009; 23: 15-23.
    • (2009) Bio-Drugs , vol.23 , pp. 15-23
    • Wang, V.1    Wu, W.2
  • 102
    • 78651517597 scopus 로고    scopus 로고
    • MicroRNA-based Cancer Therapeutics: Big Hope from Small RNAs
    • Bhardwaj A, Singh S, Singh AP. MicroRNA-based Cancer Therapeutics: Big Hope from Small RNAs. Mol Cell Pharmacol 2010; 2: 213-219.
    • (2010) Mol Cell Pharmacol , vol.2 , pp. 213-219
    • Bhardwaj, A.1    Singh, S.2    Singh, A.P.3
  • 103
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 104
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: An anticancer therapy-the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture
    • Mendelsohn J. Blockade of receptors for growth factors: an anticancer therapy-the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture. Clin Cancer Res 2000; 6(3): 747-53.
    • (2000) Clin Cancer Res , vol.6 , Issue.3 , pp. 747-753
    • Mendelsohn, J.1
  • 105
    • 0038290555 scopus 로고    scopus 로고
    • Antibody-mediated EGF receptor blockade as an anticancer therapy: From the laboratory to the clinic
    • Epub 2003 Mar 14., May
    • Mendelsohn J. Antibody-mediated EGF receptor blockade as an anticancer therapy: from the laboratory to the clinic. Cancer Immunol Immunother. 2003 May; 52(5): 342-6. Epub 2003 Mar 14.
    • (2003) Cancer Immunol Immunother , vol.52 , Issue.5 , pp. 342-346
    • Mendelsohn, J.1
  • 106
    • 84898028011 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced cervical cancer
    • Nogueira-Rodrigues A, Moralez G, Grazziotin R, et al. Phase 2 trial of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced cervical cancer. Cancer 2014; 120: 1187-93.
    • (2014) Cancer , vol.120 , pp. 1187-1193
    • Nogueira-Rodrigues, A.1    Moralez, G.2    Grazziotin, R.3
  • 107
    • 62749156047 scopus 로고    scopus 로고
    • Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial
    • Kurtz JE, Hardy-Bessard AC, Deslandres M, et al. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial. Gynecol Oncol 2009; 113: 16-20.
    • (2009) Gynecol Oncol , vol.113 , pp. 16-20
    • Kurtz, J.E.1    Hardy-Bessard, A.C.2    Deslandres, M.3
  • 108
    • 78751582338 scopus 로고    scopus 로고
    • Cetuximab monotherapy in advanced cervical cancer: A retrospective study with five patients
    • Hertlein L, Lenhard M, Kirschenhofer A, et al. Cetuximab monotherapy in advanced cervical cancer: a retrospective study with five patients. Arch Gynecol Obstet 2011; 283: 109-13.
    • (2011) Arch Gynecol Obstet , vol.283 , pp. 109-113
    • Hertlein, L.1    Lenhard, M.2    Kirschenhofer, A.3
  • 109
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 110
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 111
    • 84894207820 scopus 로고    scopus 로고
    • Improved survival with bevacizumab in advanced cervical cancer
    • Tewari KS, Sill MW, Long HJ 3rd, et al. Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med 2014; 370: 734-43.
    • (2014) N Engl J Med , vol.370 , pp. 734-743
    • Tewari, K.S.1    Sill, M.W.2    Long, H.J.3
  • 112
    • 84879111541 scopus 로고    scopus 로고
    • Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    • Zighelboim I, Wright JD, Gao F, et al. Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer. Gynecol Oncol 2013; 130: 64-8.
    • (2013) Gynecol Oncol , vol.130 , pp. 64-68
    • Zighelboim, I.1    Wright, J.D.2    Gao, F.3
  • 113
    • 84890446419 scopus 로고    scopus 로고
    • Int J RTOG 0417: Efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma
    • Schefter T, Winter K, Kwon JS, et al. Int J RTOG 0417: efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma. Radiat Oncol Biol Phys 2014; 88: 101-5.
    • (2014) Radiat Oncol Biol Phys , vol.88 , pp. 101-105
    • Schefter, T.1    Winter, K.2    Kwon, J.S.3
  • 114
    • 84896730318 scopus 로고    scopus 로고
    • Management of advanced or recurrent cervical cancer: Chemotherapy and beyond
    • Elit LM, Hirte H. Management of advanced or recurrent cervical cancer: chemotherapy and beyond. Expert Rev Anticancer Ther 2014; 14: 319-32.
    • (2014) Expert Rev Anticancer Ther , vol.14 , pp. 319-332
    • Elit, L.M.1    Hirte, H.2
  • 115
    • 33750160826 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled phase II trial of the cyclooxygenase-2 inhibitor Celecoxib in the treatment of cervical dysplasia
    • Farley JH, Truong V, Goo E, Uyehara C, Belnap C, Larsen WI. A randomized double-blind placebo-controlled phase II trial of the cyclooxygenase-2 inhibitor Celecoxib in the treatment of cervical dysplasia. Gynecol Oncol 2006; 103: 425-30.
    • (2006) Gynecol Oncol , vol.103 , pp. 425-430
    • Farley, J.H.1    Truong, V.2    Goo, E.3    Uyehara, C.4    Belnap, C.5    Larsen, W.I.6
  • 116
    • 33645885343 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial
    • Hefler LA, Grimm C, Speiser P, Sliutz G, Reinthaller A. The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial. Eur J Obstet Gynecol Reprod Biol 2006; 125: 251-4.
    • (2006) Eur J Obstet Gynecol Reprod Biol , vol.125 , pp. 251-254
    • Hefler, L.A.1    Grimm, C.2    Speiser, P.3    Sliutz, G.4    Reinthaller, A.5
  • 118
    • 85041954791 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory agents to induce regression and prevent the pro gression of cervical intraepithelial neoplasia
    • Grabosch SM, Shariff OM, Wulff JL, Helm CW. Non-steroidal anti-inflammatory agents to induce regression and prevent the pro gression of cervical intraepithelial neoplasia. Cochrane Database Syst Rev 2014; 4: CD004121.
    • (2014) Cochrane Database Syst Rev , vol.4
    • Grabosch, S.M.1    Shariff, O.M.2    Wulff, J.L.3    Helm, C.W.4
  • 119
    • 34748923100 scopus 로고    scopus 로고
    • COX-2 overexpression as a biomarker of early cervical carcinogenesis: A pilot study
    • Saldivar JS, Lopez D, Feldman RA. COX-2 overexpression as a biomarker of early cervical carcinogenesis: a pilot study. Gynecol Oncol 2007; 107: S155-S162.
    • (2007) Gynecol Oncol , vol.107 , pp. S155-S162
    • Saldivar, J.S.1    Lopez, D.2    Feldman, R.A.3
  • 120
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 121
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5: 921-29.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 122
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009; 9: 550-62.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 123
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel HG, De Stanchina E, Fridman JS, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004; 428: 332-37.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1    De Stanchina, E.2    Fridman, J.S.3
  • 124
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008; 27: 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 125
    • 47849125855 scopus 로고    scopus 로고
    • Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer
    • Zhang XY, Zhang HY, Zhang PN, Lu X, Sun H. Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer. Eur J Obstet Gynecol Reprod Biol 2008; 139: 237-44.
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.139 , pp. 237-244
    • Zhang, X.Y.1    Zhang, H.Y.2    Zhang, P.N.3    Lu, X.4    Sun, H.5
  • 126
    • 79956124813 scopus 로고    scopus 로고
    • Phase II trial of capecitabine and cisplatin in advanced; persistent; or recurrent carcinoma of the cervix
    • Errihani H, M'Rabti H, Ismaili N, Inrhaoun H, Elghissassi I. Phase II trial of capecitabine and cisplatin in advanced; persistent; or recurrent carcinoma of the cervix. Int J Gynecol Cancer 2011, 21: 373-77.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 373-377
    • Errihani, H.1    M'Rabti, H.2    Ismaili, N.3    Inrhaoun, H.4    Elghissassi, I.5
  • 127
    • 84855349371 scopus 로고    scopus 로고
    • Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities, Double-blind; randomised; controlled trial
    • Castanon A, Tristram A, Mesher D, et al. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities, Double-blind; randomised; controlled trial. Br J Cancer 2012; 106: 45-52.
    • (2012) Br J Cancer , vol.106 , pp. 45-52
    • Castanon, A.1    Tristram, A.2    Mesher, D.3
  • 128
    • 84865312769 scopus 로고    scopus 로고
    • Anti-proliferative and proapoptotic effects of 3, 3'-diindolylmethane in human cervical cancer cells
    • Zhu J, Li Y, Guan C, Chen Z. Anti-proliferative and proapoptotic effects of 3, 3'-diindolylmethane in human cervical cancer cells. Oncol Rep 2012; 28: 1063-68.
    • (2012) Oncol Rep , vol.28 , pp. 1063-1068
    • Zhu, J.1    Li, Y.2    Guan, C.3    Chen, Z.4
  • 129
    • 77949281423 scopus 로고    scopus 로고
    • Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
    • Ji J, Zheng PS. Activation of mTOR signaling pathway contributes to survival of cervical cancer cells. Gynecol Oncol 2010; 117: 103-8.
    • (2010) Gynecol Oncol , vol.117 , pp. 103-108
    • Ji, J.1    Zheng, P.S.2
  • 130
    • 84899738743 scopus 로고    scopus 로고
    • Regulation of paclitaxelinduced programmed cell death by autophagic induction: A model for cervical cancer
    • Chi EY, Viriyapak B, Kwack HS, et al. Regulation of paclitaxelinduced programmed cell death by autophagic induction: A model for cervical cancer. Obstet Gynecol Sci 2013; 56: 84-92.
    • (2013) Obstet Gynecol Sci , vol.56 , pp. 84-92
    • Chi, E.Y.1    Viriyapak, B.2    Kwack, H.S.3
  • 131
    • 77951938324 scopus 로고    scopus 로고
    • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
    • Temkin SM, Yamada SD, Fleming GF. A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 2010; 117: 473-6.
    • (2010) Gynecol Oncol , vol.117 , pp. 473-476
    • Temkin, S.M.1    Yamada, S.D.2    Fleming, G.F.3
  • 132
    • 84880289115 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)
    • Tinker AV, Ellard S, Welch S, et al. Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199). Gynecol Oncol 2013; 130: 269-74.
    • (2013) Gynecol Oncol , vol.130 , pp. 269-274
    • Tinker, A.V.1    Ellard, S.2    Welch, S.3
  • 133
    • 84876848181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling as a therapeutic target for cervical cancer
    • Wu J, Chen C, Zhao KN. Phosphatidylinositol 3-kinase signaling as a therapeutic target for cervical cancer. Curr Cancer Drug Targets 2013; 13: 143-56.
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 143-156
    • Wu, J.1    Chen, C.2    Zhao, K.N.3
  • 134
    • 10044287192 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer
    • Rao GG, Rogers P, Drake RD, Nguyen P, Coleman RL. Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer. Gynecol Oncol 2005; 96: 168-72.
    • (2005) Gynecol Oncol , vol.96 , pp. 168-172
    • Rao, G.G.1    Rogers, P.2    Drake, R.D.3    Nguyen, P.4    Coleman, R.L.5
  • 135
    • 74249100353 scopus 로고    scopus 로고
    • A phase II trial of less than 7 weeks of concomitant cisplatin-paclitaxel chemoradiation in locally advanced cervical cancer
    • Martínez-Monge R, Gaztañaga M, Aramendía JM. A phase II trial of less than 7 weeks of concomitant cisplatin-paclitaxel chemoradiation in locally advanced cervical cancer. Int J Gynecol Cancer 2010; 20: 133-40.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 133-140
    • Martínez-Monge, R.1    Gaztañaga, M.2    Aramendía, J.M.3
  • 136
    • 84900456293 scopus 로고    scopus 로고
    • Phase II Trial on Cisplatin-Adriamycin-Paclitaxel Combination as Neoadjuvant Chemotherapy for Locally Advanced Cervical Adenocarcinoma
    • Lorusso D, Ramondino S, Mancini M, Zanaboni F, Ditto A, Raspagliesi F. Phase II Trial on Cisplatin-Adriamycin-Paclitaxel Combination as Neoadjuvant Chemotherapy for Locally Advanced Cervical Adenocarcinoma. Int J Gynecol Cancer 2014; 24: 729-34.
    • (2014) Int J Gynecol Cancer , vol.24 , pp. 729-734
    • Lorusso, D.1    Ramondino, S.2    Mancini, M.3    Zanaboni, F.4    Ditto, A.5    Raspagliesi, F.6
  • 137
    • 0028870107 scopus 로고
    • The bovine papillomavirus 1 E2 protein contains two activation domains: One that interacts with TBP and another that functions after TBP binding
    • Steger G, Ham J, Lefebvre O, Yaniv M. The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding. EMBO J 1995; 14: 329-40.
    • (1995) EMBO J , vol.14 , pp. 329-340
    • Steger, G.1    Ham, J.2    Lefebvre, O.3    Yaniv, M.4
  • 138
    • 59549085974 scopus 로고    scopus 로고
    • Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma
    • Thierry F. Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology 2009; 384: 375-9.
    • (2009) Virology , vol.384 , pp. 375-379
    • Thierry, F.1
  • 139
    • 0032401759 scopus 로고    scopus 로고
    • Recruitment and loading of the E1 initiator protein: An ATP-dependent process catalysed by a transcription factor
    • Sanders CM, Stenlund A. Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factor. EMBO J 1998; 17: 7044-55.
    • (1998) EMBO J , vol.17 , pp. 7044-7055
    • Sanders, C.M.1    Stenlund, A.2
  • 140
    • 0035933838 scopus 로고    scopus 로고
    • Characterization of recombinant HPV6 and 11 E1 helicases: Effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain
    • White PW, Pelletier A, Brault K, et al. Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain. J Biol Chem 2001; 276: 22426-38.
    • (2001) J Biol Chem , vol.276 , pp. 22426-22438
    • White, P.W.1    Pelletier, A.2    Brault, K.3
  • 141
    • 18844475267 scopus 로고    scopus 로고
    • Replication-associated activities of purified human papillomavirus type 11 E1 helicase
    • Rocque WJ, Porter DJ, Barnes JA, et al. Replication-associated activities of purified human papillomavirus type 11 E1 helicase. Protein Expr Purif 2000; 18: 148-59.
    • (2000) Protein Expr Purif , vol.18 , pp. 148-159
    • Rocque, W.J.1    Porter, D.J.2    Barnes, J.A.3
  • 142
    • 0033852428 scopus 로고    scopus 로고
    • Identification of domains of VOL. 49, 2005 HPV E1 ATPase INHIBITORS 4841the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin
    • Titolo S, Pelletier A, Pulichino AM, et al. Identification of domains of VOL. 49, 2005 HPV E1 ATPase INHIBITORS 4841the human papillomavirus type 11 E1 helicase involved in oligomerization and binding to the viral origin. J Virol 2000; 74: 7349-61.
    • (2000) J Virol , vol.74 , pp. 7349-7361
    • Titolo, S.1    Pelletier, A.2    Pulichino, A.M.3
  • 143
    • 0346731236 scopus 로고    scopus 로고
    • Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase
    • Faucher AM, White PW, Brochu C, Grand-Maître C, Rancourt J, Fazal G. Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase. J Med Chem 2004; 47: 18-21.
    • (2004) J Med Chem , vol.47 , pp. 18-21
    • Faucher, A.M.1    White, P.W.2    Brochu, C.3    Grand-Maître, C.4    Rancourt, J.5    Fazal, G.6
  • 144
    • 28844467115 scopus 로고    scopus 로고
    • Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486
    • White PW, Faucher AM, Massariol MJ, et al. Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486. Antimicrob Agents Chemother 2005; 49: 4834-42.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4834-4842
    • White, P.W.1    Faucher, A.M.2    Massariol, M.J.3
  • 145
    • 10744227840 scopus 로고    scopus 로고
    • Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor
    • Wang Y, Coulombe R, Cameron DR, et al. Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor. J Biol Chem 2004; 279: 6976-85.
    • (2004) J Biol Chem , vol.279 , pp. 6976-6985
    • Wang, Y.1    Coulombe, R.2    Cameron, D.R.3
  • 146
    • 85067706855 scopus 로고    scopus 로고
    • Molecular Dynamics Simulation Study on the Mechanism of the Inhibition of ATP Hydrolysis with Inhibitors in Human Papillomavirus Type 18 E1 Helicase
    • Lu X, Zhang Y, Chen S, et al. Molecular Dynamics Simulation Study on the Mechanism of the Inhibition of ATP Hydrolysis with Inhibitors in Human Papillomavirus Type 18 E1 Helicase. ICCNCE 2013 2013; 30: 44-7.
    • (2013) ICCNCE 2013 , vol.30 , pp. 44-47
    • Lu, X.1    Zhang, Y.2    Chen, S.3
  • 147
    • 58049208165 scopus 로고    scopus 로고
    • Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1
    • Terenzi F, Saikia P, Sen GC, et al. Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J 2008; 27: 3311-21.
    • (2008) EMBO J , vol.27 , pp. 3311-3321
    • Terenzi, F.1    Saikia, P.2    Sen, G.C.3
  • 148
    • 78649423523 scopus 로고    scopus 로고
    • The Inhibitory Action of P56 on Select Functions of E1 Mediates Interferon's Effect on Human Papillomavirus DNA Replication
    • Saikia P, Fensterl V, Sen GC. The Inhibitory Action of P56 on Select Functions of E1 Mediates Interferon's Effect on Human Papillomavirus DNA Replication. J Virol 2010; 84: 13036-9.
    • (2010) J Virol , vol.84 , pp. 13036-13039
    • Saikia, P.1    Fensterl, V.2    Sen, G.C.3
  • 149
    • 84861312473 scopus 로고    scopus 로고
    • Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide
    • Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG, Archambault J. Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide. J Virol 2012; 86: 3486-500.
    • (2012) J Virol , vol.86 , pp. 3486-3500
    • Lehoux, M.1    Fradet-Turcotte, A.2    Lussier-Price, M.3    Omichinski, J.G.4    Archambault, J.5
  • 150
    • 0025613266 scopus 로고
    • Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
    • Mohr IJ, Clark R, Sun S, Androphy EJ, MacPherson P, Botchan MR. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science 1990; 250: 1694-9.
    • (1990) Science , vol.250 , pp. 1694-1699
    • Mohr, I.J.1    Clark, R.2    Sun, S.3    Androphy, E.J.4    McPherson, P.5    Botchan, M.R.6
  • 151
    • 0028598275 scopus 로고
    • Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein
    • Frattini MG, Laimins LA. Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein. Proc Natl Acad Sci USA 1994; 91: 12398-402.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12398-12402
    • Frattini, M.G.1    Laimins, L.A.2
  • 152
    • 0030971469 scopus 로고    scopus 로고
    • Functional interactions between papillomavirus E1 and E2 proteins
    • Berg M, Stenlund A. Functional interactions between papillomavirus E1 and E2 proteins. J Virol 1997; 71: 3853-63.
    • (1997) J Virol , vol.71 , pp. 3853-3863
    • Berg, M.1    Stenlund, A.2
  • 153
    • 0038648223 scopus 로고    scopus 로고
    • Discovery of the first series of inhibitors of human papillomavirus type 11: Inhibition of the assembly of the E1-E2-Origin DNA complex
    • Yoakim C, Ogilvie WW, Goudreau N, et al. Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex. Bioorg Med Chem Lett 2003; 13: 2539-41.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 2539-2541
    • Yoakim, C.1    Ogilvie, W.W.2    Goudreau, N.3
  • 154
    • 0038035868 scopus 로고    scopus 로고
    • Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction
    • White PW, Titolo S, Brault K, et al. Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction. J Biol Chem 2003; 278: 26765-72.
    • (2003) J Biol Chem , vol.278 , pp. 26765-26772
    • White, P.W.1    Titolo, S.2    Brault, K.3
  • 155
    • 84888091849 scopus 로고    scopus 로고
    • The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus
    • Guardado-Mendoza R, Prioletta A, Jiménez-Ceja LM, et al. The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus. Arch Med Sci 2013; 9: 936-43.
    • (2013) Arch Med Sci , vol.9 , pp. 936-943
    • Guardado-Mendoza, R.1    Prioletta, A.2    Jiménez-Ceja, L.M.3
  • 156
    • 10744227840 scopus 로고    scopus 로고
    • Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor
    • Wang Y, Coulombe R, Cameron DR, et al. Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor. J Biol Chem 2004; 279: 6976-85.
    • (2004) J Biol Chem , vol.279 , pp. 6976-6985
    • Wang, Y.1    Coulombe, R.2    Cameron, D.R.3
  • 157
    • 34447249060 scopus 로고    scopus 로고
    • Recent advances in the search for antiviral agents against human papillomaviruses
    • Fradet-Turcotte A, Archambault J. Recent advances in the search for antiviral agents against human papillomaviruses. Antivir Ther 2007; 12: 431-51.
    • (2007) Antivir Ther , vol.12 , pp. 431-451
    • Fradet-Turcotte, A.1    Archambault, J.2
  • 158
    • 21644441975 scopus 로고    scopus 로고
    • Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin
    • McPhillips MG, Ozato K, McBride AA. Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J Virol 2005; 79: 8920-32.
    • (2005) J Virol , vol.79 , pp. 8920-8932
    • McPhillips, M.G.1    Ozato, K.2    McBride, A.A.3
  • 159
    • 84875508147 scopus 로고    scopus 로고
    • Recruitment of Brd4 to the Human Papillomavirus Type 16 DNA Replication Complex Is Essential for Replication of Viral DNA
    • Wang X, Helfer CM, Pancholi N, Bradner JE, You J. Recruitment of Brd4 to the Human Papillomavirus Type 16 DNA Replication Complex Is Essential for Replication of Viral DNA. J Virol 2013; 87: 3871-84.
    • (2013) J Virol , vol.87 , pp. 3871-3884
    • Wang, X.1    Helfer, C.M.2    Pancholi, N.3    Bradner, J.E.4    You, J.5
  • 160
    • 84888234857 scopus 로고    scopus 로고
    • Brd4 Is Displaced from HPV Replication Factories as They Expand and Amplify Viral DNA
    • Sakakibara N, Chen D, Jang MK, et al. Brd4 Is Displaced from HPV Replication Factories as They Expand and Amplify Viral DNA. PLoS Pathog 2013; 9: e1003777.
    • (2013) PLoS Pathog , vol.9
    • Sakakibara, N.1    Chen, D.2    Jang, M.K.3
  • 161
    • 2942625637 scopus 로고    scopus 로고
    • Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus
    • Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus. Biochemistry 2004; 43: 7421-31.
    • (2004) Biochemistry , vol.43 , pp. 7421-7431
    • Liu, Y.1    Liu, Z.2    Androphy, E.3    Chen, J.4    Baleja, J.D.5
  • 162
    • 33747881135 scopus 로고    scopus 로고
    • Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
    • Baleja JD, Cherry JJ, Liu Z, et al. Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res 2006; 72: 49-59.
    • (2006) Antiviral Res , vol.72 , pp. 49-59
    • Baleja, J.D.1    Cherry, J.J.2    Liu, Z.3
  • 163
    • 84883252571 scopus 로고    scopus 로고
    • Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells
    • Kim MS, Bak Y, Park YS, et al. Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. Cell Biol Toxicol 2013; 29: 259-72.
    • (2013) Cell Biol Toxicol , vol.29 , pp. 259-272
    • Kim, M.S.1    Bak, Y.2    Park, Y.S.3
  • 164
    • 84898651816 scopus 로고    scopus 로고
    • Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2
    • Kim JE, Lee JI, Jin DH, et al. Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2. Oncol Rep 2014; 31: 2429-37.
    • (2014) Oncol Rep , vol.31 , pp. 2429-2437
    • Kim, J.E.1    Lee, J.I.2    Jin, D.H.3
  • 165
    • 83055165661 scopus 로고    scopus 로고
    • YY1 is a novel potential therapeutic target for treatment of HPV-infection induced cervical cancer by arsenic trioxide
    • He G, Wang Q, Zhou Y, et al. YY1 is a novel potential therapeutic target for treatment of HPV-infection induced cervical cancer by arsenic trioxide. Int J Gynecol Cancer 2011; 21: 1097-1104.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 1097-1104
    • He, G.1    Wang, Q.2    Zhou, Y.3
  • 166
    • 84896467025 scopus 로고    scopus 로고
    • Anthracene-9, 10-dione derivatives induced apoptosis in human cervical cancer cell line (CaSki) by interfering with HPV E6 expression
    • Sangthong S, Sangphech N, Palaga T, et al. Anthracene-9, 10-dione derivatives induced apoptosis in human cervical cancer cell line (CaSki) by interfering with HPV E6 expression. Eur J Med Chem 2014; 77: 334-42.
    • (2014) Eur J Med Chem , vol.77 , pp. 334-342
    • Sangthong, S.1    Sangphech, N.2    Palaga, T.3
  • 167
    • 33749342391 scopus 로고    scopus 로고
    • Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro
    • Hampson L, Kitchener HC, Hampson IN. Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro. Antivir Ther 2006; 11: 813-25.
    • (2006) Antivir Ther , vol.11 , pp. 813-825
    • Hampson, L.1    Kitchener, H.C.2    Hampson, I.N.3
  • 168
    • 77952834659 scopus 로고    scopus 로고
    • Combining metabolic fingerprinting and footprinting to understand the phenotypic response of HPV16 E6 expressing cervical carcinoma cells exposed to the HIV anti-viral drug lopinavir
    • Kim DH, Jarvis RM, Xu Y, et al. Combining metabolic fingerprinting and footprinting to understand the phenotypic response of HPV16 E6 expressing cervical carcinoma cells exposed to the HIV anti-viral drug lopinavir. Analyst 2010; 135: 1235-44.
    • (2010) Analyst , vol.135 , pp. 1235-1244
    • Kim, D.H.1    Jarvis, R.M.2    Xu, Y.3
  • 169
    • 0037325976 scopus 로고    scopus 로고
    • Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system
    • Scheffner M, Whitaker NJ. Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. Semin Cancer Biol 2003; 13: 59-67.
    • (2003) Semin Cancer Biol , vol.13 , pp. 59-67
    • Scheffner, M.1    Whitaker, N.J.2
  • 170
    • 84893283522 scopus 로고    scopus 로고
    • An in silico appraisal of azoic and disulphide derivatives for anticancer activity against HPV E6 oncoprotein to medicate cervical cancer
    • Choudhury AD, Choudhury MD, Chetia P, Chowdhury A, Talukdar AD. An in silico appraisal of azoic and disulphide derivatives for anticancer activity against HPV E6 oncoprotein to medicate cervical cancer. Comb Chem High Throughput Screen 2014; 17: 38-46.
    • (2014) Comb Chem High Throughput Screen , vol.17 , pp. 38-46
    • Choudhury, A.D.1    Choudhury, M.D.2    Chetia, P.3    Chowdhury, A.4    Talukdar, A.D.5
  • 171
    • 84896396415 scopus 로고    scopus 로고
    • A In vivo antitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16
    • Accardi L, Paolini F, Mandarino A, et al. A. In vivo antitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16. Int J Cancer 2014; 134: 2742-7.
    • (2014) Int J Cancer , vol.134 , pp. 2742-2747
    • Accardi, L.1    Paolini, F.2    Mandarino, A.3
  • 172
    • 82755161958 scopus 로고    scopus 로고
    • Gene silencing by siRNAs and antisense oligonucleotides in the laboratory and the clinic
    • Watts JK, Corey DR. Gene silencing by siRNAs and antisense oligonucleotides in the laboratory and the clinic. The Journal of pathology 2012; 226: 365-79.
    • (2012) The Journal of pathology , vol.226 , pp. 365-379
    • Watts, J.K.1    Corey, D.R.2
  • 173
    • 34447629237 scopus 로고    scopus 로고
    • Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells
    • Sima N, Wang S, Wang W, et al. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007; 106: 299-304.
    • (2007) Gynecol Oncol , vol.106 , pp. 299-304
    • Sima, N.1    Wang, S.2    Wang, W.3
  • 174
    • 84875919097 scopus 로고    scopus 로고
    • Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53
    • Reschner A, Bontems S, Le Gac S, et al. Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53. Gene Ther 2013; 20: 435-43.
    • (2013) Gene Ther , vol.20 , pp. 435-443
    • Reschner, A.1    Bontems, S.2    Le Gac, S.3
  • 175
    • 34247512483 scopus 로고    scopus 로고
    • Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation
    • Yamayoshi A, Kato K, Suga S, et al. Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation. Oligonucleotides 2007; 17: 66-79.
    • (2007) Oligonucleotides , vol.17 , pp. 66-79
    • Yamayoshi, A.1    Kato, K.2    Suga, S.3
  • 176
    • 33646028216 scopus 로고    scopus 로고
    • Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo
    • Niu XY, Peng ZL, Duan WQ, Wang H, Wang P. Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo. Int J Gynecol Cancer 2006; 16: 743-751.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 743-751
    • Niu, X.Y.1    Peng, Z.L.2    Duan, W.Q.3    Wang, H.4    Wang, P.5
  • 177
    • 84855596633 scopus 로고    scopus 로고
    • Silencing of HPV16 E6 and E7 oncogenic activities by small interference RNA induces autophagy and apoptosis in human cervical cancer cells
    • Salazar-León J, Reyes-Román F, Meneses-Acosta A, et al. Silencing of HPV16 E6 and E7 oncogenic activities by small interference RNA induces autophagy and apoptosis in human cervical cancer cells. J Nucleic Acids Investig 2011; 2: 59-69.
    • (2011) J Nucleic Acids Investig , vol.2 , pp. 59-69
    • Salazar-León, J.1    Reyes-Román, F.2    Meneses-Acosta, A.3
  • 178
    • 84905088454 scopus 로고    scopus 로고
    • Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women
    • Hillemanns P, Jentschke M, Evans TG, Soergel P, Hass R. Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women. Arch Gynecol Obstet 2014; 289: 1281-6.
    • (2014) Arch Gynecol Obstet , vol.289 , pp. 1281-1286
    • Hillemanns, P.1    Jentschke, M.2    Evans, T.G.3    Soergel, P.4    Hass, R.5
  • 179
    • 78349311997 scopus 로고    scopus 로고
    • Highly potent and specific siRNAs against E6 or E7 genes of HPV16-or HPV18-infected cervical cancers
    • Chang JT, Kuo TF, Chen YJ, et al. Highly potent and specific siRNAs against E6 or E7 genes of HPV16-or HPV18-infected cervical cancers. Cancer Gene Ther 2010; 17: 827-836.
    • (2010) Cancer Gene Ther , vol.17 , pp. 827-836
    • Chang, J.T.1    Kuo, T.F.2    Chen, Y.J.3
  • 180
    • 78650997059 scopus 로고    scopus 로고
    • Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models
    • Wu SY, Singhania A, Burgess M, et al. Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models. Gene Ther 2011; 18: 14-22.
    • (2011) Gene Ther , vol.18 , pp. 14-22
    • Wu, S.Y.1    Singhania, A.2    Burgess, M.3
  • 181
    • 79951722564 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs
    • Gu W, Payne E, Sun S, Burgess M, McMillan NA. Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs. Cancer Gene Ther 2011; 18: 219-27.
    • (2011) Cancer Gene Ther , vol.18 , pp. 219-227
    • Gu, W.1    Payne, E.2    Sun, S.3    Burgess, M.4    McMillan, N.A.5
  • 182
    • 84887641308 scopus 로고    scopus 로고
    • Induction of apoptosis by chitosan/HPV16 E7 siRNA complexes incervical cancer cells
    • Yang J, Li S, Guo F, Zhang W, Wang Y, Pan Y. Induction of apoptosis by chitosan/HPV16 E7 siRNA complexes incervical cancer cells. Mol Med Rep 2013; 7: 998-1002.
    • (2013) Mol Med Rep , vol.7 , pp. 998-1002
    • Yang, J.1    Li, S.2    Guo, F.3    Zhang, W.4    Wang, Y.5    Pan, Y.6
  • 183
    • 84922273681 scopus 로고    scopus 로고
    • Dose-effect research using nanopatch to deliver siRNA in the inhibition of HPV gene expression
    • Xiong Z, Dong X, Sun P, Zhang Y. Dose-effect research using nanopatch to deliver siRNA in the inhibition of HPV gene expression. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2013; 30: 1283-9.
    • (2013) Sheng Wu Yi Xue Gong Cheng Xue Za Zhi , vol.30 , pp. 1283-1289
    • Xiong, Z.1    Dong, X.2    Sun, P.3    Zhang, Y.4
  • 184
    • 84875997721 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes
    • Zhou J, Li B, Peng C, et al. Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. Antiviral Res 2013; 98: 305-13.
    • (2013) Antiviral Res , vol.98 , pp. 305-313
    • Zhou, J.1    Li, B.2    Peng, C.3
  • 185
    • 55649097304 scopus 로고    scopus 로고
    • Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer
    • Jonson AL, Rogers LM, Ramakrishnan S, Downs LS Jr. Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer. Gynecol Oncol 2008; 111: 356-64.
    • (2008) Gynecol Oncol , vol.111 , pp. 356-364
    • Jonson, A.L.1    Rogers, L.M.2    Ramakrishnan, S.3    Downs, L.S.4
  • 186
    • 70349209205 scopus 로고    scopus 로고
    • Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma
    • Liu WL, Green N, Seymour LW, Stevenson M. Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma. Cancer Gene Therapy 2009; 75: 764-75.
    • (2009) Cancer Gene Therapy , vol.75 , pp. 764-775
    • Liu, W.L.1    Green, N.2    Seymour, L.W.3    Stevenson, M.4
  • 187
    • 0034612296 scopus 로고    scopus 로고
    • Induction of apoptosis in human papillomavirus positive cancer cells by peptide aptamers targeting the viral E6 onco protein
    • Butz K, Denk C, Ullmann A, Scheffner M, Hoppe-Seyler F. Induction of apoptosis in human papillomavirus positive cancer cells by peptide aptamers targeting the viral E6 onco protein. Proc Natl Acad Sci USA 2000; 97: 6693-7.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6693-6697
    • Butz, K.1    Denk, C.2    Ullmann, A.3    Scheffner, M.4    Hoppe-Seyler, F.5
  • 188
    • 84875997721 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes
    • Zhou J, Li B, Peng C, et al. Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. Antiviral Res 2013; 98: 305-13.
    • (2013) Antiviral Res , vol.98 , pp. 305-313
    • Zhou, J.1    Li, B.2    Peng, C.3
  • 189
    • 27544455180 scopus 로고    scopus 로고
    • RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin
    • Putral LN, Bywater MJ, Gu W, et al. RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Mol Pharmacol 2005; 68: 1311-19.
    • (2005) Mol Pharmacol , vol.68 , pp. 1311-1319
    • Putral, L.N.1    Bywater, M.J.2    Gu, W.3
  • 190
    • 84857507756 scopus 로고    scopus 로고
    • The synergistic therapeutic effect of cisplatin with Human papillomavirus E6/E7 short interfering RNA on cervical cancer cell lines in vitro and in vivo
    • Jung HS, Erkin OC, Kwon MJ, et al. The synergistic therapeutic effect of cisplatin with Human papillomavirus E6/E7 short interfering RNA on cervical cancer cell lines in vitro and in vivo. Int J Cancer. 2012; 130: 1925-36.
    • (2012) Int J Cancer , vol.130 , pp. 1925-1936
    • Jung, H.S.1    Erkin, O.C.2    Kwon, M.J.3
  • 191
  • 192
    • 84859945722 scopus 로고    scopus 로고
    • Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptormediated apoptosis in human cervical carcinoma cells
    • Tan S, Hougardy BM, Meersma GJ, et al. Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptormediated apoptosis in human cervical carcinoma cells. Mol Pharmacol 2012; 81: 701-9.
    • (2012) Mol Pharmacol , vol.81 , pp. 701-709
    • Tan, S.1    Hougardy, B.M.2    Meersma, G.J.3
  • 193
    • 84878468438 scopus 로고    scopus 로고
    • Plasmid-based E6-specific siRNA and coexpression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivo
    • Li X, Li Y, Hu J, et al. Plasmid-based E6-specific siRNA and coexpression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivo. Cancer Lett 2013; 335: 242-50.
    • (2013) Cancer Lett , vol.335 , pp. 242-250
    • Li, X.1    Li, Y.2    Hu, J.3
  • 194
    • 84894049741 scopus 로고    scopus 로고
    • Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16
    • Li W and Anderson RA. Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16. Oncogene 2014; 33: 928-32.
    • (2014) Oncogene , vol.33 , pp. 928-932
    • Li, W.1    Anderson, R.A.2
  • 195
    • 23044502867 scopus 로고    scopus 로고
    • Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: Opposite effect of siRNA in combination with different drugs
    • Koivusalo R, Krausz E, Helenius H, Hietanen S. Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: Opposite effect of siRNA in combination with different drugs. Mol Pharmacol 2005; 68: 372-82.
    • (2005) Mol Pharmacol , vol.68 , pp. 372-382
    • Koivusalo, R.1    Krausz, E.2    Helenius, H.3    Hietanen, S.4
  • 196
    • 0029969074 scopus 로고    scopus 로고
    • Effects of liposomal antisense oligonucleotides on mRNA and protein levels of the HPV 16 E7 oncogene
    • Lappalainen K, Pirila L, Jaaskelainen I, Syrjanen K, Syrjanen S. Effects of liposomal antisense oligonucleotides on mRNA and protein levels of the HPV 16 E7 oncogene. Anticancer Res 1996; 16: 2485-92.
    • (1996) Anticancer Res , vol.16 , pp. 2485-2492
    • Lappalainen, K.1    Pirila, L.2    Jaaskelainen, I.3    Syrjanen, K.4    Syrjanen, S.5
  • 197
    • 9444280836 scopus 로고    scopus 로고
    • High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies
    • Fiedler M, Muller-Holzner E, Viertler HP, et al. High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies. FASEB J 2004; 18: 1120-22.
    • (2004) FASEB J , vol.18 , pp. 1120-1122
    • Fiedler, M.1    Muller-Holzner, E.2    Viertler, H.P.3
  • 198
    • 33745813943 scopus 로고    scopus 로고
    • Deregulation of eIF4E: 4EBP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein
    • Oh KJ, Kalinina A, Park NH, Bagchi S. Deregulation of eIF4E: 4EBP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein. J Virol 2006; 80: 7079-88.
    • (2006) J Virol , vol.80 , pp. 7079-7088
    • Oh, K.J.1    Kalinina, A.2    Park, N.H.3    Bagchi, S.4
  • 199
    • 0034735901 scopus 로고    scopus 로고
    • Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the Nterminal residue
    • Reinstein E, Scheffner M, Oren M, Ciechanover A, Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the Nterminal residue. Oncogene 2000; 19: 5944-50.
    • (2000) Oncogene , vol.19 , pp. 5944-5950
    • Reinstein, E.1    Scheffner, M.2    Oren, M.3    Ciechanover, A.4    Schwartz, A.5
  • 200
    • 0036635470 scopus 로고    scopus 로고
    • Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7
    • Kanduc D. Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. J Virol 2002; 76: 7040-48.
    • (2002) J Virol , vol.76 , pp. 7040-7048
    • Kanduc, D.1
  • 201
    • 79952678427 scopus 로고    scopus 로고
    • Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway
    • Guo CP, Liu KW, Luo HB, et al. Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway. PLoS One 2011; 6: e17734.
    • (2011) PLoS One , vol.6
    • Guo, C.P.1    Liu, K.W.2    Luo, H.B.3
  • 202
  • 203
    • 0033818848 scopus 로고    scopus 로고
    • Disruption of cell cycle control by human papillomavirus with special reference to cervical carcinoma
    • Southern SA, Herrington CS. Disruption of cell cycle control by human papillomavirus with special reference to cervical carcinoma. Int J Gynecol Cancer 2000; 10: 263-74.
    • (2000) Int J Gynecol Cancer , vol.10 , pp. 263-274
    • Southern, S.A.1    Herrington, C.S.2
  • 204
    • 0034005996 scopus 로고    scopus 로고
    • Development and assessment of a general theory of cervical carcinogenesis utilizing a se vere combined immonodeficiency murinehuman xenograft model
    • Tewari KS, Taylor JA, Liao SY, et al. Development and assessment of a general theory of cervical carcinogenesis utilizing a se vere combined immonodeficiency murinehuman xenograft model. Gyn Onco 2000; 77: 137-48.
    • (2000) Gyn Onco , vol.77 , pp. 137-148
    • Tewari, K.S.1    Taylor, J.A.2    Liao, S.Y.3
  • 205
    • 0033522479 scopus 로고    scopus 로고
    • The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth
    • Brehm A, Nielsen SJ, Miska EA, et al. The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J 1999; 18: 2449-58.
    • (1999) EMBO J , vol.18 , pp. 2449-2458
    • Brehm, A.1    Nielsen, S.J.2    Miska, E.A.3
  • 207
    • 84863011861 scopus 로고    scopus 로고
    • Wang, miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2
    • Liu L, Yu X, Guo X, et al. Wang, miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. Mol Med Rep 2012; 5: 753-760.
    • (2012) Mol Med Rep , vol.5 , pp. 753-760
    • Liu, L.1    Yu, X.2    Guo, X.3
  • 208
    • 84874775434 scopus 로고    scopus 로고
    • Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer
    • Xu J, Li Y, Wang F, et al. Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. Oncogene 2013; 32: 976-87.
    • (2013) Oncogene , vol.32 , pp. 976-987
    • Xu, J.1    Li, Y.2    Wang, F.3
  • 209
    • 84890451958 scopus 로고    scopus 로고
    • MicroRNA-101 inhibits cell proliferation, invasion, and promotes apoptosis by regulating cyclooxygenase-2 in Hela cervical carcinoma cells
    • Huang F, Lin C, Shi YH, Kuerban G. MicroRNA-101 inhibits cell proliferation, invasion, and promotes apoptosis by regulating cyclooxygenase-2 in Hela cervical carcinoma cells. Asian Pac J Cancer Prev 2013; 14: 5915-20.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 5915-5920
    • Huang, F.1    Lin, C.2    Shi, Y.H.3    Kuerban, G.4
  • 210
    • 84891959580 scopus 로고    scopus 로고
    • Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma
    • Yamamoto N, Kinoshita T, Nohata N, et al. Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma. Int J Oncol 2013; 43: 1855-63.
    • (2013) Int J Oncol , vol.43 , pp. 1855-1863
    • Yamamoto, N.1    Kinoshita, T.2    Nohata, N.3
  • 211
    • 84861375543 scopus 로고    scopus 로고
    • Study on effects of microRNA-21 antisense oligonucleotide in vivo and in vitro on bionomics of human cervical squamous carcinoma cell lines SiHa
    • Wang XM, Xu J, Cheng ZQ, et al. Study on effects of microRNA-21 antisense oligonucleotide in vivo and in vitro on bionomics of human cervical squamous carcinoma cell lines SiHa. Zhonghua Bing Li Xue Za Zhi 2012; 41: 254-9.
    • (2012) Zhonghua Bing Li Xue Za Zhi , vol.41 , pp. 254-259
    • Wang, X.M.1    Xu, J.2    Cheng, Z.Q.3
  • 212
    • 62549156668 scopus 로고    scopus 로고
    • Oncogenic HPV infection interrupts the expression of tumorsuppressive miR-34a through viral oncoprotein E6
    • Wang X, Wang HK, McCoy JP, et al. Oncogenic HPV infection interrupts the expression of tumorsuppressive miR-34a through viral oncoprotein E6. RNA 2009; 15: 637-47.
    • (2009) RNA , vol.15 , pp. 637-647
    • Wang, X.1    Wang, H.K.2    McCoy, J.P.3
  • 213
    • 77952273515 scopus 로고    scopus 로고
    • Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection
    • Li B, Hu Y, Ye F, Li Y, Lv W, Xie X. Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection. Int J Gynecol Cancer 2010; 20: 597-604.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 597-604
    • Li, B.1    Hu, Y.2    Ye, F.3    Li, Y.4    Lv, W.5    Xie, X.6
  • 214
    • 34547458550 scopus 로고    scopus 로고
    • p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007; 17: 1298-1307.
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3
  • 215
    • 34848868157 scopus 로고    scopus 로고
    • Tumorsuppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Tumorsuppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci 2007; 104: 15472-77.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 216
    • 77953920780 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
    • Pang RT, Leung CO, Ye TM, et al. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 2010; 31: 1037-44.
    • (2010) Carcinogenesis , vol.31 , pp. 1037-1044
    • Pang, R.T.1    Leung, C.O.2    Ye, T.M.3
  • 217
    • 84880322064 scopus 로고    scopus 로고
    • Aberrant expression of miR-20a and miR-203 in cervical cancer
    • Zhao S, Yao DS, Chen JY, Ding N. Aberrant expression of miR-20a and miR-203 in cervical cancer. Asian Pac J Cancer Prev 2013; 14: 2289-93.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 2289-2293
    • Zhao, S.1    Yao, D.S.2    Chen, J.Y.3    Ding, N.4
  • 218
    • 42249105032 scopus 로고    scopus 로고
    • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    • Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, Khan SA. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 2008; 27: 2575-82.
    • (2008) Oncogene , vol.27 , pp. 2575-2582
    • Martinez, I.1    Gardiner, A.S.2    Board, K.F.3    Monzon, F.A.4    Edwards, R.P.5    Khan, S.A.6
  • 219
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    • Wang X, Tang S, Le SY, et al. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 2008; 3: e2557.
    • (2008) PLoS One , vol.3
    • Wang, X.1    Tang, S.2    Le, S.Y.3
  • 220
    • 77950189124 scopus 로고    scopus 로고
    • Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a casecontrol study in Chinese women
    • Zhou X, Chen X, Hu L, et al. Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a casecontrol study in Chinese women. Gynecol Oncol 2010; 117: 287-90.
    • (2010) Gynecol Oncol , vol.117 , pp. 287-290
    • Zhou, X.1    Chen, X.2    Hu, L.3
  • 221
    • 84871709212 scopus 로고    scopus 로고
    • MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
    • Li J, Ping Z, Ning H. MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer. Int J Mol Sci 2012; 13: 16053-64.
    • (2012) Int J Mol Sci , vol.13 , pp. 16053-16064
    • Li, J.1    Ping, Z.2    Ning, H.3
  • 222
    • 84888204275 scopus 로고    scopus 로고
    • MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD
    • Chen Y, Ke G, Han D, Liang S, Yang G, Wu X. MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD. Exp Cell Res 2014; 320: 12-20.
    • (2014) Exp Cell Res , vol.320 , pp. 12-20
    • Chen, Y.1    Ke, G.2    Han, D.3    Liang, S.4    Yang, G.5    Wu, X.6
  • 223
    • 84879414000 scopus 로고    scopus 로고
    • MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the proapoptotic PRKCD gene
    • Ke G, Liang L, Yang JM, et al. MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the proapoptotic PRKCD gene. Oncogene 2013; 32: 3019-27.
    • (2013) Oncogene , vol.32 , pp. 3019-3027
    • Ke, G.1    Liang, L.2    Yang, J.M.3
  • 224
    • 84877258007 scopus 로고    scopus 로고
    • Treatment of HCV infection by targeting MicroRNA
    • Janssen HL, Reesink HW, Lawitz EJ, et al. Treatment of HCV infection by targeting MicroRNA. N Engl J Med 2013; 368: 1685-94.
    • (2013) N Engl J Med , vol.368 , pp. 1685-1694
    • Janssen, H.L.1    Reesink, H.W.2    Lawitz, E.J.3
  • 225
    • 84869219338 scopus 로고    scopus 로고
    • miR-34-a microRNA replacement therapy is headed to the clinic
    • Bader AG. miR-34-a microRNA replacement therapy is headed to the clinic. Front Genet 2012; 3: 120.
    • (2012) Front Genet , vol.3
    • Bader, A.G.1


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