Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma

International Journal of Oncology

Volumn 43, Issue 6, 2013, Pages 1855-1863

  Yamamoto, Noriko ^a   Kinoshita, Takashi ^a   Nohata, Nijiro ^a   Yoshino, Hirofumi ^b   Itesako, Toshihiko ^b   Fujimura, Lisa ^c   Mitsuhashi, Akira ^a   Usui, Hirokazu ^a   Enokida, Hideki ^b   Nakagawa, Masayuki ^b   Shozu, Makio ^a   Seki, Naohiko ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Cervical cancer; HSP47; Invasion; Migration; miR 29a; Tumor suppressor

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 47; MICRORNA; MICRORNA 29A; SERINE PROTEINASE INHIBITOR;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CLINICAL ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUCIFERASE ASSAY; METASTASIS; MICRORNA29A GENE; MIDDLE AGED; MOLECULAR BIOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HSP47 HEAT-SHOCK PROTEINS; HUMANS; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; UTERINE CERVICAL NEOPLASMS;

EID: 84891959580     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2145     Document Type: Article

References (34)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Walboomers JM, Jacobs MV, Manos MM, et al: Human papil?lomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189: 12-19, 1999.
3. Munoz N, Bosch FX, de Sanjose S, et al: Epidemiologic classi?fication of human papillomavirus types associated with cervical cancer. N Engl J Med 348: 518-527, 2003.
4. Clifford GM, Smith JS, Plummer M, Munoz N and Franceschi S: Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer 88: 63-73, 2003.
5. Munger K and Howley PM: Human papillomavirus immortal?ization and transformation functions. Virus Res 89: 213-228, 2002.
6. Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114, 2008.
7. Nelson KM and Weiss GJ: MicroRNAs and cancer: past, present, and potential future. Mol Cancer Ther 7: 3655-3660, 2008.
8. Kano M, Seki N, Kikkawa N, et al: miR-145, miR-133a andmiR-133b: Tumor-suppressive miRNAs target FSCN1 in esopha?geal squamous cell carcinoma. Int J Cancer 127: 2804-2814, 2010.
9. Moriya Y, Nohata N, Kinoshita T, et al: Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. J Hum Genet 57: 38-45, 2012.
10. Hidaka H, Seki N, Yoshino H, et al: Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma. Oncotarget 3: 44-57, 2012.
11. Ichimi T, Enokida H, Okuno Y, et al: Identification of novel microRNA targets based on microRNA signatures in bladder cancer. Int J Cancer 125: 345-352, 2009.
12. Kojima S, Chiyomaru T, Kawakami K, et al: Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br J Cancer 106: 405-413, 2012.
13. Kikkawa N, Hanazawa T, Fujimura L, et al: miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC). Br J Cancer 103: 877-884, 2010.
14. Nohata N, Hanazawa T, Kikkawa N, et al: Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. Br J Cancer 105: 833-841, 2011.
15. Yamamoto N, Kinoshita T, Nohata N, et al: Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. Int J Oncol 42: 1523-1532, 2013.
16. Wang Y, Zhang X, Li H, Yu J and Ren X: The role of miRNA-29 family in cancer. Eur J Cell Biol 92: 123-128, 2013.
17. Li Y, Wang F, Xu J, et al: Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol 224: 484-495, 2011.
18. Mott JL, Kurita S, Cazanave SC, Bronk SF, Werneburg NW and Fernandez-Zapico ME: Transcriptional suppression of miR-29b-1/miR-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem 110: 1155-1164, 2010.
19. Wang H, Garzon R, Sun H, et al: NF-kappaB-YY1-miR-29 regu?latory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 14: 369-381, 2008.
20. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
21. Nagata K, Saga S and Yamada KM: Characterization of a novel transformation-sensitive heat-shock protein (HSP47) that binds to collagen. Biochem Biophys Res Commun 153: 428-434, 1988.
22. Nagai N, Tetuya Y, Hosokawa N and Nagata K: The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47). Gene 227: 241-248, 1999.
23. Ishida Y and Nagata K: Hsp47 as a collagen-specific molecular chaperone. Methods Enzymol 499: 167-182, 2011.
24. Sauk JJ, Nikitakis N and Siavash H: Hsp47 a novel collagen binding serpin chaperone, autoantigen and therapeutic target. Front Biosci 10: 107-118, 2005.
25. Hubmacher D and Apte SS: The biology of the extracellular matrix: novel insights. Curr Opin Rheumatol 25: 65-70, 2013.
26. Kriegel AJ, Liu Y, Fang Y, Ding X and Liang M: The miR-29 family: genomics, cell biology, and relevance to renal and cardio-vascular injury. Physiol Genomics 44: 237-244, 2012.
27. Maitra A, Iacobuzio-Donahue C, Rahman A, et al: Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. Am J Clin Pathol 118: 52-59, 2002.
28. Hirai K, Kikuchi S, Kurita A, et al: Immunohistochemical distri?bution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach. Anticancer Res 26: 71-78, 2006.
29. Lee SS, Tseng LH, Li YC, Tsai CH and Chang YC: Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells. J Oral Pathol Med 40: 390-396, 2011.
30. Jing Y, Han Z, Zhang S, Liu Y and Wei L: Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1: 29, 2011.
31. De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13: 97-110, 2013.
32. Gebeshuber CA, Zatloukal K and Martinez J: miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep 10: 400-405, 2009.
33. Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ and Johnson KR: Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol 180: 1277-1289, 2008.
34. Shintani Y, Maeda M, Chaika N, Johnson KR and Wheelock MJ: Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 38: 95-104, 2008.