Effects of liposomal antisense oligonucleotides on mRNA and protein levels of the HPV 16 E7 oncogene

Anticancer Research

Volumn 16, Issue 5 A, 1996, Pages 2485-2492

  Lappalainen, Katriina ^a,b,d   Pirilä, Laura ^a,c   Jääskeläinen, Ilpo ^d   Syrjänen, Kari ^d   Syrjänen, Stina ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antisense oligonucleotides; CaSki cells; Cationic liposomes; Human papillomavirus

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; LIPOSOME; MESSENGER RNA; PROTEIN;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; UTERINE CERVIX CANCER; WART VIRUS;

ANTIVIRAL AGENTS; CELL DIVISION; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LIPOSOMES; OLIGONUCLEOTIDES, ANTISENSE; ONCOGENE PROTEINS, VIRAL; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; RNA, VIRAL; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0029969074     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Eck SL and Nabel GJ: Antisense oligonucleotides for therapeutic intervention. Curr Opin Biotechnol 2: 897-904, 1991.
2. Crooke ST: Therapeutic applications of oligonucleotides. BioTechnol 10: 882-886, 1992.
3. Stein CA: Anti-sense oligodeoxynucleotides - promises and pittfalls. Leukemia 6: 967-974, 1992.
4. Crooke ST: Progress toward oligonuceotide therapeutics: pharmacodynamic properties. FASEB J 7: 533-539, 1993.
5. Kiely JS: Recent advances in antisense technology. Annu Rep Med Chem 29: 297-306, 1994.
6. Perez JR, Li Y, Stein CA, Majumder S, von Oorschot A and Narayanan R: Sequenceindependent induction of Spl transcription factor activity by phosphorothioate oligodeoxynucleotides. Proc Natl Acad Sci USA 91: 5957-5961, 1994.
7. Ojwang JA, Elbaggari HB, Marshall K, Jayaraman K, McGrath MS and Rando RF: Inhibition of human immunodeficiency virus type 1 activity in vitro by oligonucleotides composed entirely of guanosine and thymidine. J Acq Immun Def Synd 7: 560-570, 1994.
8. Gao W-Y, Jaroszewski JW, Cohen JS and Cheng YC: Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine. J Biol Chem 265: 20172-20178, 1990.
9. Stec WJ and Wilk A: Stereocontrolled synthesis of oligo(nucleoside phosphorothioate)s, Angew Chem Int Edit Engl 33: 709-722, 1994.
10. Davis AR: Current potential of antisense oligonucleotides as therapeutic drugs. TCM 4: 51-55, 1994.
11. Marshall WS and Caruthers, MH: Phosphorodithioate DNA as a potentialtherapeutic drug. Science. 259: 1564-1570, 1993.
12. Bennett CF, Chiang MY, Chan H, Shoemaker JEE and Mirabelli CK: Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 41: 1023-1033, 1992.
13. Capaccioli S, Di Pasquale G, Mini E, Mazzei T and Guattrone A: Catonic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Biochem Bioph Res Commun 197: 818-825, 1993.
14. zur Hausen H: Human papillomavirus in the pathogenesis of anogenital cancer. Virology 184: 9-13, 1991.
15. Lowy DR, Kirnbauer R and Schiller JT: Genital human papillomavirus in anogenital cancer Proc Acad Sci USA 91: 2436-2440, 1994.
16. Mansur C and Androphy JE: Cellular transformation by papillomavirus oncoproteins. Biochim Biophys Acta 1155: 323-345, 1993.
17. Werness BA, Levine AJ, and Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248: 76-79, 1990.
18. Dyson N, Howley PM, Munger K and Harlow E: The human papillomavirus 16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934-937, 1989.
19. Phelps WC, Yee CL, Munger K and Howley PM: The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Cell 53: 539-547, 1988.
20. Storey A, Pim D, Murray A, Osbom K, Banks L and Crawford I: Comparison of the in vitro transforming activities of human papillomavirus types. EMBO J 7: 1815-1820, 1988.
21. Lappalainen K, Urtti A, Söderling E, Jääskelänen I, Syrjänen K and Syrjänen S: Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells. Biochim Biophys Acta 1196: 201-208, 1994.
22. Lappalainen K, Urtti A, Jääskeläinen I, Syrjänen S and Syrjänen S: Cationic liposomes mediated delivery of antisenseoligonucleotides targeted to HPV 16 E7 mRNA in CaSki cells. Antiviral Res 23: 119-130, 1994.
23. Lappalainen K, Jääskeläinen I, SyrjÄnen K, Urtti A and Syrjänen S: Comparison of cell proliferation and toxicity assays using two cationic liposomes. Pharmaceut Res 11: 1127-1131, 1994.
24. Rose JK, Buonocore L and Whitt: A new cationic liposome reagent mediating nearly quantitative transfection of animal cells. Biotechniques 10: 520-525, 1991.
25. Hawley-Nelson P, Ciccarone V, Gebeyehu G, Jessee J and Felgner PL: LipofectAMINE reagent: a new, higher efficiency polycationic liposome transfection reagent. Focus 15: 73-79, 1994.
26. Sambrook J, Fritsch EF and Maniatis T: In Molecular Cloning: A Laboratory Manual 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor. NY, 1989.
27. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-choroform extraction. Anal Biohem 162: 156-159, 1987.
28. Smotkin D and Wettstein FO: Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc Natl Acad Sci USA 83: 4680-4684, 1986.
29. Inki P, Larjava H, Haapasalmi K, Miettinen HM, Grenman R and Jalkanen M: Expression of syndecan-1 is induced by differentiation and suppressed by malignant transformation of human keratinocytes. Eur J Cell Biol 63: 43-51, 1994.
30. Gao W-Y, Storm C, Egan W and Cheng Y-C Cellular Pharmacology of phosphorothioate homooligodeoxynucleotides in human cells. Mol Pharm 43: 45-50, 1993.
31. Tan TMC, Gloss B, Bernard HU and Ting RCY: Mechanism of translation of the bicistronic mRNA encoding human papillomavirus type 16 E6-E7 genes. J Gen Virol 75: 2663-2670, 1994.
32. Wagner RW: Gene inhibition using antisense oligodeoxynucleotides. Nature 372: 333-335, 1994.
33. Cornish KG; Iversen P, Smith L, Arneson M and Bayever E: Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey. Pharmacol Commun 3: 239-247, 1993.
34. Galbraith WM, Hobson WC, Giclas PC, Schechter PJ and Agrawal S: Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey. Antisense Res Dev 4: 201-206, 1994.
35. Weidner D and Busch H: Antisense phosphorothioate oligonucleotides direct both site-specific and nonspecific RNase H cleavage of in vitro synthesized p120 RNA. Oncol Res 6: 237-242, 1994.
36. Gottikh M, Baud-Demattei MV, Lescot E, Giorgi-Renault S, Shabarova Z, Dautry F, Malvy C and Bertrand JR: In vitro inhibition of the pim-1 protooncogene by chimeric oligodeoxyribonucleotides composed of α- and β-anomeric fragments. Gene 149: 5-12, 1994.
37. Zabner, J, Fasbender AJ, Moninger T, Poellinger KA and Welsh M: Cellular and molecular barriers to gene transfer by cationic lipid. J Biol Chem 270: 18997-19007, 1995.
38. Gura TT Antisense has growing pains. Science 270: 575-5M, 1995.
39. Lappalainen K, Miettinen R, Kellokoski J, Jääskeläinen I and Syrjänen S: Intracellular distribution of oligonucleotides delivered by cationic liposomes: light and electron microscopic study. Submined.
40. Helene C: Control of oncogene expression by antisense nucleic acids. Eur J Cancer 30: 1721-1726, 1994.
41. Storey A, Oates D, Banks L, Crawford L and Crook T: Antisense phosphorothioate oligonucleotides have both specific and nonspecific effects on cells containing human papillomavirus type 16. Nucleic Acids Res 19: 4109-4114, 1991.
42. Stein CA: Does antisense exist? Nature Medicine 1: 1119-1121, 1995.
43. Ghosh MK and Cohen JS: Oligodeoxynucleotides as antisense inhibitors of gene expression. Prog Nucleic Acid Res Mol Biol 42: 79-126, 1992.
44. Tan TMC and Ting RCY: In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes. Cancer Res 55: 4599-4605, 1995.