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Volumn 13, Issue 1, 2003, Pages 59-67

Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system

Author keywords

Cervical cancer; E6 AP; HPV; p53; pRB

Indexed keywords

PROTEASOME; PROTEIN P53; REGULATOR PROTEIN; UBIQUITIN;

EID: 0037325976     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-579X(02)00100-1     Document Type: Article
Times cited : (139)

References (86)
  • 1
    • 0026594934 scopus 로고
    • A ubiquitin conjugating enzyme encoded by African swine fever virus
    • Hingamp P.M., Arnold J.E., Mayer R.J., Dixon L.K. A ubiquitin conjugating enzyme encoded by African swine fever virus. EMBO J. 11:1992;361-366.
    • (1992) EMBO J. , vol.11 , pp. 361-366
    • Hingamp, P.M.1    Arnold, J.E.2    Mayer, R.J.3    Dixon, L.K.4
  • 2
    • 0035945349 scopus 로고    scopus 로고
    • A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
    • Coscoy L., Sanchez D.J., Ganem D. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J. Cell Biol. 155:2001;1265-1273.
    • (2001) J. Cell Biol. , vol.155 , pp. 1265-1273
    • Coscoy, L.1    Sanchez, D.J.2    Ganem, D.3
  • 3
    • 0034608951 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis
    • Coscoy L., Ganem D. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc. Natl. Acad. Sci. U.S.A. 97:2000;8051-8056.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 8051-8056
    • Coscoy, L.1    Ganem, D.2
  • 4
    • 0034068631 scopus 로고    scopus 로고
    • Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
    • Ishido S., Wang C., Lee B.S., Cohen G.B., Jung J.U. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J. Virol. 74:2000;5300-5309.
    • (2000) J. Virol. , vol.74 , pp. 5300-5309
    • Ishido, S.1    Wang, C.2    Lee, B.S.3    Cohen, G.B.4    Jung, J.U.5
  • 5
  • 7
    • 0034700146 scopus 로고    scopus 로고
    • Ubiquitin is part of the retrovirus budding machinery
    • Patnaik A., Chau V., Wills J.W. Ubiquitin is part of the retrovirus budding machinery. Proc. Natl. Acad. Sci. U.S.A. 97:2000;13069-13074.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 13069-13074
    • Patnaik, A.1    Chau, V.2    Wills, J.W.3
  • 8
    • 0030577120 scopus 로고    scopus 로고
    • Papillomavirus infections - A major cause of human cancers
    • zur Hausen H. Papillomavirus infections - a major cause of human cancers. Biochim. Biophys. Acta. 1288:1996;F55-F78.
    • (1996) Biochim. Biophys. Acta , vol.1288
    • Zur Hausen, H.1
  • 9
    • 0034600355 scopus 로고    scopus 로고
    • Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis
    • zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer Inst. 92:2000;690-698.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 690-698
    • Zur Hausen, H.1
  • 10
    • 0035956215 scopus 로고    scopus 로고
    • The human papillomavirus E6 protein and its contribution to malignant progression
    • Mantovani F., Banks L. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene. 20:2001;7874-7887.
    • (2001) Oncogene , vol.20 , pp. 7874-7887
    • Mantovani, F.1    Banks, L.2
  • 11
    • 0035956258 scopus 로고    scopus 로고
    • Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
    • Munger K., Basile J.R., Duensing S., Eichten A., Gonzalez S.L., Grace M.et al. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene. 20:2001;7888-7898.
    • (2001) Oncogene , vol.20 , pp. 7888-7898
    • Munger, K.1    Basile, J.R.2    Duensing, S.3    Eichten, A.4    Gonzalez, S.L.5    Grace, M.6
  • 12
    • 0027211053 scopus 로고
    • Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice
    • Lambert P.F., Pan H., Pitot H.C., Liem A., Jackson M., Griep A.E. Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 90:1993;5583-5587.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 5583-5587
    • Lambert, P.F.1    Pan, H.2    Pitot, H.C.3    Liem, A.4    Jackson, M.5    Griep, A.E.6
  • 13
    • 0028233614 scopus 로고
    • Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice
    • Arbeit J.M., Munger K., Howley P.M., Hanahan D. Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J. Virol. 68:1994;4358-4368.
    • (1994) J. Virol. , vol.68 , pp. 4358-4368
    • Arbeit, J.M.1    Munger, K.2    Howley, P.M.3    Hanahan, D.4
  • 14
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness B.A., Levine A.J., Howley P.M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science. 248:1990;76-79.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 15
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N., Howley P.M., Munger K., Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 243:1989;934-937.
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 16
    • 0026464656 scopus 로고
    • Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
    • Dyson N., Guida P., Munger K., Harlow E. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:1992;6893-6902.
    • (1992) J. Virol. , vol.66 , pp. 6893-6902
    • Dyson, N.1    Guida, P.2    Munger, K.3    Harlow, E.4
  • 17
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M., Werness B.A., Huibregtse J.M., Levine A.J., Howley P.M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1990;1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 18
    • 0025988293 scopus 로고
    • Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
    • Crook T., Tidy J.A., Vousden K.H. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell. 67:1991;547-556.
    • (1991) Cell , vol.67 , pp. 547-556
    • Crook, T.1    Tidy, J.A.2    Vousden, K.H.3
  • 19
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner M., Huibregtse J.M., Vierstra R.D., Howley P.M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 75:1993;495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 20
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer S.N., Wazer D.E., Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 56:1996;4620-4624.
    • (1996) Cancer Res. , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 21
    • 0031442175 scopus 로고    scopus 로고
    • Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein
    • Berezutskaya E., Yu B., Morozov A., Raychaudhuri P., Bagchi S. Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein. Cell Growth Diff. 8:1997;1277-1286.
    • (1997) Cell Growth Diff. , vol.8 , pp. 1277-1286
    • Berezutskaya, E.1    Yu, B.2    Morozov, A.3    Raychaudhuri, P.4    Bagchi, S.5
  • 22
    • 0031438309 scopus 로고    scopus 로고
    • Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis
    • Jones D.L., Thompson D.A., Munger K. Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology. 239:1997;97-107.
    • (1997) Virology , vol.239 , pp. 97-107
    • Jones, D.L.1    Thompson, D.A.2    Munger, K.3
  • 23
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 12:1998;2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 24
    • 0033587681 scopus 로고    scopus 로고
    • Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes
    • Thomas J.T., Hubert W.G., Ruesch M.N., Laimins L.A. Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 96:1999;8449-8454.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 8449-8454
    • Thomas, J.T.1    Hubert, W.G.2    Ruesch, M.N.3    Laimins, L.A.4
  • 25
    • 0033947269 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle
    • Flores E.R., Allen-Hoffmann B.L., Lee D., Lambert P.F. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J. Virol. 74:2000;6622-6631.
    • (2000) J. Virol. , vol.74 , pp. 6622-6631
    • Flores, E.R.1    Allen-Hoffmann, B.L.2    Lee, D.3    Lambert, P.F.4
  • 26
    • 0025040837 scopus 로고
    • Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells
    • Banks L., Edmonds C., Vousden K.H. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells. Oncogene. 5:1990;1383-1389.
    • (1990) Oncogene , vol.5 , pp. 1383-1389
    • Banks, L.1    Edmonds, C.2    Vousden, K.H.3
  • 27
    • 0026597136 scopus 로고
    • Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes
    • Jewers R.J., Hildebrandt P., Ludlow J.W., Kell B., McCance D.J. Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes. J. Virol. 66:1992;1329-1335.
    • (1992) J. Virol. , vol.66 , pp. 1329-1335
    • Jewers, R.J.1    Hildebrandt, P.2    Ludlow, J.W.3    Kell, B.4    McCance, D.J.5
  • 28
    • 0028076872 scopus 로고
    • A mutational analysis of the amino terminal domain of the human papillomavirus type 16 E7 oncoprotein
    • Brokaw J.L., Yee C.L., Munger K. A mutational analysis of the amino terminal domain of the human papillomavirus type 16 E7 oncoprotein. Virology. 205:1994;603-607.
    • (1994) Virology , vol.205 , pp. 603-607
    • Brokaw, J.L.1    Yee, C.L.2    Munger, K.3
  • 30
    • 0028063429 scopus 로고
    • Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1
    • Schmitt A., Harry J.B., Rapp B., Wettstein F.O., Iftner T. Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1. J. Virol. 68:1994;7051-7059.
    • (1994) J. Virol. , vol.68 , pp. 7051-7059
    • Schmitt, A.1    Harry, J.B.2    Rapp, B.3    Wettstein, F.O.4    Iftner, T.5
  • 31
    • 0034899522 scopus 로고    scopus 로고
    • Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7
    • Gonzalez S.L., Stremlau M., He X., Basile J.R., Munger K. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J. Virol. 75:2001;7583-7591.
    • (2001) J. Virol. , vol.75 , pp. 7583-7591
    • Gonzalez, S.L.1    Stremlau, M.2    He, X.3    Basile, J.R.4    Munger, K.5
  • 32
    • 0034959651 scopus 로고    scopus 로고
    • Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes
    • Helt A.M., Galloway D.A. Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes. J. Virol. 75:2001;6737-6747.
    • (2001) J. Virol. , vol.75 , pp. 6737-6747
    • Helt, A.M.1    Galloway, D.A.2
  • 33
    • 0035032328 scopus 로고    scopus 로고
    • Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle arrest
    • Giarre M., Caldeira S., Malanchi I., Ciccolini F., Leao M.J., Tommasino M. Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle arrest. J. Virol. 75:2001;4705-4712.
    • (2001) J. Virol. , vol.75 , pp. 4705-4712
    • Giarre, M.1    Caldeira, S.2    Malanchi, I.3    Ciccolini, F.4    Leao, M.J.5    Tommasino, M.6
  • 34
    • 0030728767 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome
    • Berezutskaya E., Bagchi S. The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome. J. Biol. Chem. 272:1997;30135-30140.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30135-30140
    • Berezutskaya, E.1    Bagchi, S.2
  • 35
    • 0033978257 scopus 로고    scopus 로고
    • Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
    • Higashitsuji H., Itoh K., Nagao T., Dawson S., Nonoguchi K., Kido T.et al. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat. Med. 6:2000;96-99.
    • (2000) Nat. Med. , vol.6 , pp. 96-99
    • Higashitsuji, H.1    Itoh, K.2    Nagao, T.3    Dawson, S.4    Nonoguchi, K.5    Kido, T.6
  • 36
    • 0037192842 scopus 로고    scopus 로고
    • Gankyrin: An ankyrin-repeat oncoprotein interacts with CDK4 kinase and the S6 ATPase of the 26S proteasome
    • Dawson S., Apcher S., Mee M., Higashitsuji H., Baker R., Uhle S.et al. Gankyrin: an ankyrin-repeat oncoprotein interacts with CDK4 kinase and the S6 ATPase of the 26S proteasome. J. Biol. Chem. 277:2002;10893-10902.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10893-10902
    • Dawson, S.1    Apcher, S.2    Mee, M.3    Higashitsuji, H.4    Baker, R.5    Uhle, S.6
  • 37
    • 0023201676 scopus 로고
    • The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein
    • Smotkin D., Wettstein F.O. The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein. J. Virol. 61:1987;1686-1689.
    • (1987) J. Virol. , vol.61 , pp. 1686-1689
    • Smotkin, D.1    Wettstein, F.O.2
  • 38
    • 0034735901 scopus 로고    scopus 로고
    • Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the N-terminal residue
    • Reinstein E., Scheffner M., Oren M., Ciechanover A., Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene. 19:2000;5944-5950.
    • (2000) Oncogene , vol.19 , pp. 5944-5950
    • Reinstein, E.1    Scheffner, M.2    Oren, M.3    Ciechanover, A.4    Schwartz, A.5
  • 39
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
    • Sellers W.R., Novitch B.G., Miyake S., Heith A., Otterson G.A., Kaye F.J.et al. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 12:1998;95-106.
    • (1998) Genes Dev. , vol.12 , pp. 95-106
    • Sellers, W.R.1    Novitch, B.G.2    Miyake, S.3    Heith, A.4    Otterson, G.A.5    Kaye, F.J.6
  • 40
    • 0033511021 scopus 로고    scopus 로고
    • Human papillomavirus life cycle: Active and latent phases
    • Stubenrauch F., Laimins L.A. Human papillomavirus life cycle: active and latent phases. Semin. Cancer Biol. 9:1999;379-386.
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 379-386
    • Stubenrauch, F.1    Laimins, L.A.2
  • 41
    • 0030050770 scopus 로고    scopus 로고
    • Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells
    • Dalal S., Gao Q., Androphy E.J., Band V. Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells. J. Virol. 70:1996;683-688.
    • (1996) J. Virol. , vol.70 , pp. 683-688
    • Dalal, S.1    Gao, Q.2    Androphy, E.J.3    Band, V.4
  • 42
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T., Foster S.A., Koop J.I., McDougall J.K., Galloway D.A., Klingelhutz A.J. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature. 396:1998;84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 43
    • 0035051806 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells
    • Gao Q., Singh L., Kumar A., Srinivasan S., Wazer D.E., Band V. Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells. J. Virol. 75:2001;4459-4466.
    • (2001) J. Virol. , vol.75 , pp. 4459-4466
    • Gao, Q.1    Singh, L.2    Kumar, A.3    Srinivasan, S.4    Wazer, D.E.5    Band, V.6
  • 44
    • 0031841384 scopus 로고    scopus 로고
    • IARC Database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools
    • Hainaut P., Hernandez T., Robinson A., Rodriguez-Tome P., Flores T., Hollstein M.et al. IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res. 26:1998;205-213.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 205-213
    • Hainaut, P.1    Hernandez, T.2    Robinson, A.3    Rodriguez-Tome, P.4    Flores, T.5    Hollstein, M.6
  • 46
    • 0029849578 scopus 로고    scopus 로고
    • Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression of E6/E7-oncogene expression and induction of apoptosis
    • Butz K., Geisen C., Ullmann A., Spitkovsky D., Hoppe-Seyler F. Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis. Int. J. Cancer. 68:1996;506-513.
    • (1996) Int. J. Cancer , vol.68 , pp. 506-513
    • Butz, K.1    Geisen, C.2    Ullmann, A.3    Spitkovsky, D.4    Hoppe-Seyler, F.5
  • 47
    • 8944239884 scopus 로고    scopus 로고
    • High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation
    • Li X., Coffino P. High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation. J. Virol. 70:1996;4509-4516.
    • (1996) J. Virol. , vol.70 , pp. 4509-4516
    • Li, X.1    Coffino, P.2
  • 48
    • 0031455732 scopus 로고    scopus 로고
    • A comparative analysis of the interactions of the E6 proteins from cutaneous and genital papillomaviruses with p53 and E6AP in correlation to their transforming potential
    • Elbel M., Carl S., Spaderna S., Iftner T. A comparative analysis of the interactions of the E6 proteins from cutaneous and genital papillomaviruses with p53 and E6AP in correlation to their transforming potential. Virology. 239:1997;132-149.
    • (1997) Virology , vol.239 , pp. 132-149
    • Elbel, M.1    Carl, S.2    Spaderna, S.3    Iftner, T.4
  • 49
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner M., Huibregtse J.M., Vierstra R.D., Howley P.M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 75:1993;495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 50
    • 0031780665 scopus 로고    scopus 로고
    • Ubiquitin, E6-AP, and their role in p53 inactivation
    • Scheffner M. Ubiquitin, E6-AP, and their role in p53 inactivation. Pharmacol. Ther. 78:1998;129-139.
    • (1998) Pharmacol. Ther. , vol.78 , pp. 129-139
    • Scheffner, M.1
  • 51
    • 0031058283 scopus 로고    scopus 로고
    • Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells
    • Beer-Romero P., Glass S., Rolfe M. Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene. 14:1997;595-602.
    • (1997) Oncogene , vol.14 , pp. 595-602
    • Beer-Romero, P.1    Glass, S.2    Rolfe, M.3
  • 52
    • 0032513114 scopus 로고    scopus 로고
    • The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells
    • Talis A.L., Huibregtse J.M., Howley P.M. The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J. Biol. Chem. 273:1998;6439-6445.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6439-6445
    • Talis, A.L.1    Huibregtse, J.M.2    Howley, P.M.3
  • 53
    • 0032481111 scopus 로고    scopus 로고
    • Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation
    • Hengstermann A., Whitaker N.J., Zimmer D., Zentgraf H., Scheffner M. Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation. Oncogene. 17:1998;2933-2941.
    • (1998) Oncogene , vol.17 , pp. 2933-2941
    • Hengstermann, A.1    Whitaker, N.J.2    Zimmer, D.3    Zentgraf, H.4    Scheffner, M.5
  • 54
    • 0032192481 scopus 로고    scopus 로고
    • Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
    • Jiang Y.H., Armstrong D., Albrecht U., Atkins C.M., Noebels J.L., Eichele G.et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 21:1998;799-811.
    • (1998) Neuron , vol.21 , pp. 799-811
    • Jiang, Y.H.1    Armstrong, D.2    Albrecht, U.3    Atkins, C.M.4    Noebels, J.L.5    Eichele, G.6
  • 55
    • 0028243099 scopus 로고
    • Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene
    • Demers G.W., Halbert C.L., Galloway D.A. Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene. Virology. 198:1994;169-174.
    • (1994) Virology , vol.198 , pp. 169-174
    • Demers, G.W.1    Halbert, C.L.2    Galloway, D.A.3
  • 56
    • 1842293961 scopus 로고    scopus 로고
    • Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein
    • Jones D.L., Munger K. Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol. 71:1997;2905-2912.
    • (1997) J. Virol. , vol.71 , pp. 2905-2912
    • Jones, D.L.1    Munger, K.2
  • 58
    • 0031029963 scopus 로고    scopus 로고
    • The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function
    • Nevels M., Rubenwolf S., Spruss T., Wolf H., Dobner T. The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1206-1211.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 1206-1211
    • Nevels, M.1    Rubenwolf, S.2    Spruss, T.3    Wolf, H.4    Dobner, T.5
  • 59
    • 0030935013 scopus 로고    scopus 로고
    • Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells
    • Querido E., Marcellus R.C., Lai A., Charbonneau R., Teodoro J.G., Ketner G.et al. Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells. J. Virol. 71:1997;3788-3798.
    • (1997) J. Virol. , vol.71 , pp. 3788-3798
    • Querido, E.1    Marcellus, R.C.2    Lai, A.3    Charbonneau, R.4    Teodoro, J.G.5    Ketner, G.6
  • 60
    • 0035577765 scopus 로고    scopus 로고
    • Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
    • Querido E., Blanchette P., Yan Q., Kamura T., Morrison M., Boivin D.et al. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev. 15:2001;3104-3117.
    • (2001) Genes Dev. , vol.15 , pp. 3104-3117
    • Querido, E.1    Blanchette, P.2    Yan, Q.3    Kamura, T.4    Morrison, M.5    Boivin, D.6
  • 62
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • Huibregtse J.M., Scheffner M., Howley P.M. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10:1991;4129-4135.
    • (1991) EMBO J. , vol.10 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 63
    • 0027396829 scopus 로고
    • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
    • Huibregtse J.M., Scheffner M., Howley P.M. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell Biol. 13:1993;775-784.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 775-784
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 64
    • 0028907874 scopus 로고
    • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
    • Huibregtse J.M., Scheffner M., Beaudenon S., Howley P.M. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92:1995;2563-2567.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 2563-2567
    • Huibregtse, J.M.1    Scheffner, M.2    Beaudenon, S.3    Howley, P.M.4
  • 65
    • 0028898424 scopus 로고
    • Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
    • Scheffner M., Nuber U., Huibregtse J.M. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature. 373:1995;81-83.
    • (1995) Nature , vol.373 , pp. 81-83
    • Scheffner, M.1    Nuber, U.2    Huibregtse, J.M.3
  • 66
    • 0032524621 scopus 로고    scopus 로고
    • Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7
    • Schwarz S.E., Rosa J.L., Scheffner M. Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7. J. Biol. Chem. 273:1998;12148-12154.
    • (1998) J. Biol. Chem. , vol.273 , pp. 12148-12154
    • Schwarz, S.E.1    Rosa, J.L.2    Scheffner, M.3
  • 70
    • 0033603339 scopus 로고    scopus 로고
    • Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination
    • Kumar S., Talis A.L., Howley P.M. Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination. J. Biol. Chem. 274:1999;18785-18792.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18785-18792
    • Kumar, S.1    Talis, A.L.2    Howley, P.M.3
  • 71
    • 0033578418 scopus 로고    scopus 로고
    • Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination
    • Oda H., Kumar S., Howley P.M. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9557-9562.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9557-9562
    • Oda, H.1    Kumar, S.2    Howley, P.M.3
  • 72
    • 0032506698 scopus 로고    scopus 로고
    • Inhibition of Bak-induced apoptosis by HPV-18 E6
    • Thomas M., Banks L. Inhibition of Bak-induced apoptosis by HPV-18 E6. Oncogene. 17:1998;2943-2954.
    • (1998) Oncogene , vol.17 , pp. 2943-2954
    • Thomas, M.1    Banks, L.2
  • 73
    • 0032545368 scopus 로고    scopus 로고
    • E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box
    • Kuhne C., Banks L. E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. J. Biol. Chem. 273:1998;34302-34309.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34302-34309
    • Kuhne, C.1    Banks, L.2
  • 74
    • 0033919402 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase
    • Kao W.H., Beaudenon S.L., Talis A.L., Huibregtse J.M., Howley P.M. Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase. J. Virol. 74:2000;6408-6417.
    • (2000) J. Virol. , vol.74 , pp. 6408-6417
    • Kao, W.H.1    Beaudenon, S.L.2    Talis, A.L.3    Huibregtse, J.M.4    Howley, P.M.5
  • 75
    • 0029093605 scopus 로고
    • Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
    • Pan H., Griep A.E. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev. 9:1995;2157-2169.
    • (1995) Genes Dev. , vol.9 , pp. 2157-2169
    • Pan, H.1    Griep, A.E.2
  • 76
    • 0029756780 scopus 로고    scopus 로고
    • P53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene
    • Spitkovsky D., Aengeneyndt F., Braspenning J., von Knebel Doeberitz M. p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene. Oncogene. 13:1996;1027-1035.
    • (1996) Oncogene , vol.13 , pp. 1027-1035
    • Spitkovsky, D.1    Aengeneyndt, F.2    Braspenning, J.3    Von Knebel Doeberitz, M.4
  • 77
    • 0032977612 scopus 로고    scopus 로고
    • Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types
    • Thomas M., Banks L. Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types. J. Gen. Virol. 80:1999;1513-1517.
    • (1999) J. Gen. Virol. , vol.80 , pp. 1513-1517
    • Thomas, M.1    Banks, L.2
  • 78
    • 0033637306 scopus 로고    scopus 로고
    • Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
    • Jackson S., Harwood C., Thomas M., Banks L., Storey A. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev. 14:2000;3065-3073.
    • (2000) Genes Dev. , vol.14 , pp. 3065-3073
    • Jackson, S.1    Harwood, C.2    Thomas, M.3    Banks, L.4    Storey, A.5
  • 80
    • 0030774987 scopus 로고    scopus 로고
    • Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
    • Kiyono T., Hiraiwa A., Fujita M., Hayashi Y., Akiyama T., Ishibashi M. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11612-11616.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 11612-11616
    • Kiyono, T.1    Hiraiwa, A.2    Fujita, M.3    Hayashi, Y.4    Akiyama, T.5    Ishibashi, M.6
  • 81
    • 0034617129 scopus 로고    scopus 로고
    • Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    • Bilder D., Li M., Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 289:2000;113-116.
    • (2000) Science , vol.289 , pp. 113-116
    • Bilder, D.1    Li, M.2    Perrimon, N.3
  • 82
    • 0033776810 scopus 로고    scopus 로고
    • Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
    • Nakagawa S., Huibregtse J.M. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell Biol. 20:2000;8244-8253.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8244-8253
    • Nakagawa, S.1    Huibregtse, J.M.2
  • 83
    • 0034628567 scopus 로고    scopus 로고
    • HPV E6 targeted degradation of the discs large protein: Evidence for the involvement of a novel ubiquitin ligase
    • Pim D., Thomas M., Javier R., Gardiol D., Banks L. HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase. Oncogene. 19:2000;719-725.
    • (2000) Oncogene , vol.19 , pp. 719-725
    • Pim, D.1    Thomas, M.2    Javier, R.3    Gardiol, D.4    Banks, L.5
  • 84
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan H., Griep A.E. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1994;1285-1299.
    • (1994) Genes Dev. , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.E.2
  • 85
    • 0034652546 scopus 로고    scopus 로고
    • Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis
    • Song S., Liem A., Miller J.A., Lambert P.F. Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis. Virology. 267:2000;141-150.
    • (2000) Virology , vol.267 , pp. 141-150
    • Song, S.1    Liem, A.2    Miller, J.A.3    Lambert, P.F.4
  • 86
    • 0034612296 scopus 로고    scopus 로고
    • Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
    • Butz K., Denk C., Ullmann A., Scheffner M., Hoppe-Seyler F. Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proc. Natl. Acad. Sci. U.S.A. 97:2000;6693-6697.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6693-6697
    • Butz, K.1    Denk, C.2    Ullmann, A.3    Scheffner, M.4    Hoppe-Seyler, F.5


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