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Volumn 12, Issue 2, 2012, Pages 170-184

Anticancer drugs aimed at E6 and E7 activity in HPV-positive cervical cancer

Author keywords

Apoptosis; Cervical cancer; Death receptors; E6; E7; HR HPV; TRAIL

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE DEOXYNUCLEOTIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; BUTYRIC ACID; CARBOPLATIN; CISPLATIN; CONATUMUMAB; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GEMCITABINE; LOPINAVIR; MAPATUMUMAB; PACLITAXEL; PROTEASOME; PROTEIN E6; PROTEIN E6/E7 INHIBITOR; PROTEIN E7; PROTEIN P53; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; RIBOZYME; SMALL INTERFERING RNA; TIGATUZUMAB; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 84856487409     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800912799095135     Document Type: Review
Times cited : (62)

References (166)
  • 4
    • 0034600355 scopus 로고    scopus 로고
    • Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis
    • zur Hausen, H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer Inst. 2000, 92, 690-698.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 690-698
    • zur Hausen, H.1
  • 5
    • 0042345044 scopus 로고    scopus 로고
    • Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: A meta-analysis
    • Clifford, G. M.; Smith, J. S.; Aguado, T.; Franceschi, S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br. J. Cancer 2003, 89, 101-105.
    • (2003) Br. J. Cancer , vol.89 , pp. 101-105
    • Clifford, G.M.1    Smith, J.S.2    Aguado, T.3    Franceschi, S.4
  • 9
    • 57449108492 scopus 로고    scopus 로고
    • Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: A systematic review and meta-analysis of individual patient data from 18 randomized trials
    • Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J. Clin. Oncol. 2008, 26, 5802-5812.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5802-5812
  • 10
    • 79955582400 scopus 로고    scopus 로고
    • Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix
    • Duenas-Gonzalez, A.; Zarba, J. J.; Patel, F.; Alcedo, J. C.; Beslija, S.; Casanova, L.; Pattaranutaporn, P.; Hameed, S.; Blair, J. M.; Barraclough, H.; Orlando, M. Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J. Clin. Oncol. 2011, 29, 1678-1685.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1678-1685
    • Duenas-Gonzalez, A.1    Zarba, J.J.2    Patel, F.3    Alcedo, J.C.4    Beslija, S.5    Casanova, L.6    Pattaranutaporn, P.7    Hameed, S.8    Blair, J.M.9    Barraclough, H.10    Orlando, M.11
  • 11
    • 33846283823 scopus 로고    scopus 로고
    • High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients
    • de Boer, M. A.; Jordanova, E. S.; Kenter, G. G.; Peters, A. A.; Corver, W. E.; Trimbos, J. B.; Fleuren, G. J. High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients. Clin. Cancer Res. 2007, 13, 132-138.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 132-138
    • de Boer, M.A.1    Jordanova, E.S.2    Kenter, G.G.3    Peters, A.A.4    Corver, W.E.5    Trimbos, J.B.6    Fleuren, G.J.7
  • 12
    • 68149158305 scopus 로고    scopus 로고
    • Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status
    • Hublarova, P.; Hrstka, R.; Rotterova, P.; Rotter, L.; Coupkova, M.; Badal, V.; Nenutil, R.; Vojtesek, B. Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status. Int. J. Gynecol. Cancer 2009, 19, 321-325.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 321-325
    • Hublarova, P.1    Hrstka, R.2    Rotterova, P.3    Rotter, L.4    Coupkova, M.5    Badal, V.6    Nenutil, R.7    Vojtesek, B.8
  • 13
    • 2542550364 scopus 로고    scopus 로고
    • Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract
    • Wentzensen, N.; Vinokurova, S.; Knebel Doeberitz, M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res. 2004, 64, 3878-3884.
    • (2004) Cancer Res. , vol.64 , pp. 3878-3884
    • Wentzensen, N.1    Vinokurova, S.2    Knebel Doeberitz, M.3
  • 14
    • 60849119264 scopus 로고    scopus 로고
    • Analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer
    • Cheung, J. L.; Cheung, T. H.; Ng, C. W.; Yu, M. Y.; Wong, M. C.; Siu, S. S.; Yim, S. F.; Chan, P. K. Analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer. J. Clin. Microbiol. 2009, 47, 287-293.
    • (2009) J. Clin. Microbiol. , vol.47 , pp. 287-293
    • Cheung, J.L.1    Cheung, T.H.2    Ng, C.W.3    Yu, M.Y.4    Wong, M.C.5    Siu, S.S.6    Yim, S.F.7    Chan, P.K.8
  • 15
    • 43549126202 scopus 로고    scopus 로고
    • Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis
    • Huang, L. W.; Chao, S. L.; Lee, B. H. Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis. J. Clin. Pathol. 2008, 61, 627-631.
    • (2008) J. Clin. Pathol. , vol.61 , pp. 627-631
    • Huang, L.W.1    Chao, S.L.2    Lee, B.H.3
  • 16
    • 40449129515 scopus 로고    scopus 로고
    • Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts
    • Häfner, N.; Driesch, C.; Gajda, M.; Jansen, L.; Kirchmayr, R.; Runnebaum, I. B.; Durst, M. Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts. Oncogene 2008, 27, 1610-1617.
    • (2008) Oncogene , vol.27 , pp. 1610-1617
    • Häfner, N.1    Driesch, C.2    Gajda, M.3    Jansen, L.4    Kirchmayr, R.5    Runnebaum, I.B.6    Durst, M.7
  • 17
    • 66349112294 scopus 로고    scopus 로고
    • Mechanism of genomic instability in cells infected with the highrisk human papillomaviruses
    • Kadaja, M.; Isok-Paas, H.; Laos, T.; Ustav, E.; Ustav, M. Mechanism of genomic instability in cells infected with the highrisk human papillomaviruses. PLoS Pathog. 2009, 5, e1000397-e1000412.
    • (2009) PLoS Pathog. , vol.5
    • Kadaja, M.1    Isok-Paas, H.2    Laos, T.3    Ustav, E.4    Ustav, M.5
  • 18
    • 34547099574 scopus 로고    scopus 로고
    • Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis?
    • Pett, M.; Coleman, N. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J. Pathol. 2007, 212, 356-367.
    • (2007) J. Pathol. , vol.212 , pp. 356-367
    • Pett, M.1    Coleman, N.2
  • 19
    • 20044366070 scopus 로고    scopus 로고
    • HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs
    • Longworth, M. S.; Wilson, R.; Laimins, L. A. HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs. EMBO J. 2005, 24, 1821-1830.
    • (2005) EMBO J. , vol.24 , pp. 1821-1830
    • Longworth, M.S.1    Wilson, R.2    Laimins, L.A.3
  • 20
    • 37649012742 scopus 로고    scopus 로고
    • Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification
    • Moody, C. A.; Fradet-Turcotte, A.; Archambault, J.; Laimins, L. A. Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 19541-19546.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19541-19546
    • Moody, C.A.1    Fradet-Turcotte, A.2    Archambault, J.3    Laimins, L.A.4
  • 21
    • 34447249060 scopus 로고    scopus 로고
    • Recent advances in the search for antiviral agents against human papillomaviruses
    • Fradet-Turcotte, A.; Archambault, J. Recent advances in the search for antiviral agents against human papillomaviruses. Antivir. Ther. 2007, 12, 431-451.
    • (2007) Antivir. Ther. , vol.12 , pp. 431-451
    • Fradet-Turcotte, A.1    Archambault, J.2
  • 22
    • 0037048297 scopus 로고    scopus 로고
    • Human papillomaviruses and centrosome duplication errors: Modeling the origins of genomic instability
    • Duensing, S.; Munger, K. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene 2002, 21, 6241-6248.
    • (2002) Oncogene , vol.21 , pp. 6241-6248
    • Duensing, S.1    Munger, K.2
  • 23
    • 27744566547 scopus 로고    scopus 로고
    • Distinct E2F-mediated transcriptional program regulates p14ARF gene expression
    • Komori, H.; Enomoto, M.; Nakamura, M.; Iwanaga, R.; Ohtani, K. Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J. 2005, 24, 3724-3736.
    • (2005) EMBO J. , vol.24 , pp. 3724-3736
    • Komori, H.1    Enomoto, M.2    Nakamura, M.3    Iwanaga, R.4    Ohtani, K.5
  • 24
  • 25
    • 0023116091 scopus 로고
    • Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products
    • Cole, S. T.; Danos, O. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products. J. Mol. Biol. 1987, 193, 599-608.
    • (1987) J. Mol. Biol. , vol.193 , pp. 599-608
    • Cole, S.T.1    Danos, O.2
  • 26
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • Huibregtse, J. M.; Scheffner, M.; Howley, P. M. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 1991, 10, 4129-4135.
    • (1991) EMBO J. , vol.10 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 27
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitinprotein ligase in the ubiquitination of p53
    • Scheffner, M.; Huibregtse, J. M.; Vierstra, R. D.; Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitinprotein ligase in the ubiquitination of p53. Cell 1993, 75, 495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 28
    • 0028907874 scopus 로고
    • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
    • Huibregtse, J. M.; Scheffner, M.; Beaudenon, S.; Howley, P. M. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 2563-2567.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 2563-2567
    • Huibregtse, J.M.1    Scheffner, M.2    Beaudenon, S.3    Howley, P.M.4
  • 29
    • 0027396829 scopus 로고
    • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
    • Huibregtse, J. M.; Scheffner, M.; Howley, P. M. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 1993, 13, 775-784.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 775-784
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 30
    • 0035814797 scopus 로고    scopus 로고
    • Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP
    • Be, X.; Hong, Y.; Wei, J.; Androphy, E. J.; Chen, J. J.; Baleja, J. D. Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. Biochemistry 2001, 40, 1293-1299.
    • (2001) Biochemistry , vol.40 , pp. 1293-1299
    • Be, X.1    Hong, Y.2    Wei, J.3    Androphy, E.J.4    Chen, J.J.5    Baleja, J.D.6
  • 31
    • 0032577466 scopus 로고    scopus 로고
    • Identification of an alpha helical motif sufficient for association with papillomavirus E6
    • Chen, J. J.; Hong, Y.; Rustamzadeh, E.; Baleja, J. D.; Androphy, E. J. Identification of an alpha helical motif sufficient for association with papillomavirus E6. J. Biol. Chem. 1998, 273, 13537-13544.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13537-13544
    • Chen, J.J.1    Hong, Y.2    Rustamzadeh, E.3    Baleja, J.D.4    Androphy, E.J.5
  • 33
    • 54249105821 scopus 로고    scopus 로고
    • HPV E6, E6AP and cervical cancer
    • Beaudenon, S.; Huibregtse, J. M. HPV E6, E6AP and cervical cancer. BMC Biochem. 2008, 9(Suppl 1), S4.
    • (2008) BMC Biochem. , vol.9 , Issue.SUPPL. 1
    • Beaudenon, S.1    Huibregtse, J.M.2
  • 34
    • 0033919402 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 induces selfubiquitination of the E6AP ubiquitin-protein ligase
    • Kao, W. H.; Beaudenon, S. L.; Talis, A. L.; Huibregtse, J. M.; Howley, P. M. Human papillomavirus type 16 E6 induces selfubiquitination of the E6AP ubiquitin-protein ligase. J. Virol. 2000, 74, 6408-6417.
    • (2000) J. Virol. , vol.74 , pp. 6408-6417
    • Kao, W.H.1    Beaudenon, S.L.2    Talis, A.L.3    Huibregtse, J.M.4    Howley, P.M.5
  • 35
    • 0036849734 scopus 로고    scopus 로고
    • Human papillomavirus immortalization and transformation functions
    • Münger, K.; Howley, P. M. Human papillomavirus immortalization and transformation functions. Virus Res. 2002, 89, 213-228.
    • (2002) Virus Res. , vol.89 , pp. 213-228
    • Münger, K.1    Howley, P.M.2
  • 36
    • 77953747537 scopus 로고    scopus 로고
    • E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice
    • Shai, A.; Pitot, H. C.; Lambert, P. F. E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice. Cancer Res. 2010, 70, 5064-5073.
    • (2010) Cancer Res. , vol.70 , pp. 5064-5073
    • Shai, A.1    Pitot, H.C.2    Lambert, P.F.3
  • 37
    • 0026530432 scopus 로고
    • Clonal p53 mutation in primary cervical cancer: Association with human-papillomavirus-negative tumours
    • Crook, T.; Wrede, D.; Tidy, J. A.; Mason, W. P.; Evans, D. J.; Vousden, K. H. Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours. Lancet 1992, 339, 1070-1073.
    • (1992) Lancet , vol.339 , pp. 1070-1073
    • Crook, T.1    Wrede, D.2    Tidy, J.A.3    Mason, W.P.4    Evans, D.J.5    Vousden, K.H.6
  • 41
    • 0033552585 scopus 로고    scopus 로고
    • The role of the E6-p53 interaction in the molecular pathogenesis of HPV
    • Thomas, M.; Pim, D.; Banks, L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene 1999, 18, 7690-7700.
    • (1999) Oncogene , vol.18 , pp. 7690-7700
    • Thomas, M.1    Pim, D.2    Banks, L.3
  • 43
    • 77955464738 scopus 로고    scopus 로고
    • Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
    • Baldwin, A.; Grueneberg, D. A.; Hellner, K.; Sawyer, J.; Grace, M.; Li, W.; Harlow, E.; Munger, K. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 12463-12468.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 12463-12468
    • Baldwin, A.1    Grueneberg, D.A.2    Hellner, K.3    Sawyer, J.4    Grace, M.5    Li, W.6    Harlow, E.7    Munger, K.8
  • 44
    • 23844494405 scopus 로고    scopus 로고
    • th ed.; Tannock, I., Hill, R. P., Bristow, R. G;. Harrington, L., Eds.; McGraw-Hill: New York
    • th ed.; Tannock, I., Hill, R. P., Bristow, R. G;. Harrington, L., Eds.; McGraw-Hill: New York, 2004; pp 261-280.
    • (2004) The Basic Science of Oncology , pp. 261-280
    • Bristow, R.G.1    Hill, R.P.2
  • 45
    • 62449278758 scopus 로고    scopus 로고
    • Targeting p53 for enhanced radio-and chemo-sensitivity
    • Lu, C.; El Deiry, W. S. Targeting p53 for enhanced radio-and chemo-sensitivity. Apoptosis 2009, 14, 597-606.
    • (2009) Apoptosis , vol.14 , pp. 597-606
    • Lu, C.1    El Deiry, W.S.2
  • 46
    • 0034598751 scopus 로고    scopus 로고
    • Tissue and cellspecific expression of the p53-target genes: Bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice
    • Bouvard, V.; Zaitchouk, T.; Vacher, M.; Duthu, A.; Canivet, M.; Choisy-Rossi, C.; Nieruchalski, M.; May, E. Tissue and cellspecific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene 2000, 19, 649-660.
    • (2000) Oncogene , vol.19 , pp. 649-660
    • Bouvard, V.1    Zaitchouk, T.2    Vacher, M.3    Duthu, A.4    Canivet, M.5    Choisy-Rossi, C.6    Nieruchalski, M.7    May, E.8
  • 47
    • 0035797473 scopus 로고    scopus 로고
    • Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
    • Burns, T. F.; Bernhard, E. J.; El Deiry, W. S. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 2001, 20, 4601-4612.
    • (2001) Oncogene , vol.20 , pp. 4601-4612
    • Burns, T.F.1    Bernhard, E.J.2    El Deiry, W.S.3
  • 48
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiationinduced cell death in the developing central nervous system
    • Herzog, K. H.; Chong, M. J.; Kapsetaki, M.; Morgan, J. I.; McKinnon, P. J. Requirement for Atm in ionizing radiationinduced cell death in the developing central nervous system. Science 1998, 280, 1089-1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 49
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt, A. J.; Potten, C. S.; Kemp, C. J.; Hickman, J. A.; Balmain, A.; Lane, D. P.; Hall, P. A. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 1994, 54, 614-617.
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 50
    • 0032478282 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways
    • Song, S.; Gulliver, G. A.; Lambert, P. F. Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 2290-2295.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 2290-2295
    • Song, S.1    Gulliver, G.A.2    Lambert, P.F.3
  • 52
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin, M. F.; Kozlov, S. ATM activation and DNA damage response. Cell Cycle 2007, 6, 931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 53
    • 0032935353 scopus 로고    scopus 로고
    • Relationship between p21/WAF-1/CIP-1 and apoptosis in cervical cancer during radiation therapy
    • Niibe, Y.; Nakano, T.; Ohno, T.; Tsujii, H.; Oka, K. Relationship between p21/WAF-1/CIP-1 and apoptosis in cervical cancer during radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1999, 44, 297-303.
    • (1999) Int. J. Radiat. Oncol. Biol. Phys. , vol.44 , pp. 297-303
    • Niibe, Y.1    Nakano, T.2    Ohno, T.3    Tsujii, H.4    Oka, K.5
  • 54
    • 1942476925 scopus 로고    scopus 로고
    • Radiation therapy induces the p53(+)p21(-) expression in squamous cell carcinomas of the uterine cervix
    • Oka, K.; Suzuki, Y.; Iida, H.; Nakano, T. Radiation therapy induces the p53(+)p21(-) expression in squamous cell carcinomas of the uterine cervix. Gynecol. Oncol. 2004, 93, 340-344.
    • (2004) Gynecol. Oncol. , vol.93 , pp. 340-344
    • Oka, K.1    Suzuki, Y.2    Iida, H.3    Nakano, T.4
  • 55
    • 0346216966 scopus 로고    scopus 로고
    • Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents
    • Mujoo, K.; Watanabe, M.; Nakamura, J.; Khokhar, A. R.; Siddik, Z. H. Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents. J. Cancer Res. Clin. Oncol. 2003, 129, 709-718.
    • (2003) J. Cancer Res. Clin. Oncol. , vol.129 , pp. 709-718
    • Mujoo, K.1    Watanabe, M.2    Nakamura, J.3    Khokhar, A.R.4    Siddik, Z.H.5
  • 56
    • 34247862218 scopus 로고    scopus 로고
    • Gene expression response to cisplatin treatment in drugsensitive and drug-resistant ovarian cancer cells
    • Li, J.; Wood, W. H., III; Becker, K. G.; Weeraratna, A. T.; Morin, P. J. Gene expression response to cisplatin treatment in drugsensitive and drug-resistant ovarian cancer cells. Oncogene 2007, 26, 2860-2872.
    • (2007) Oncogene , vol.26 , pp. 2860-2872
    • Li, J.1    Wood III, W.H.2    Becker, K.G.3    Weeraratna, A.T.4    Morin, P.J.5
  • 57
    • 0037049879 scopus 로고    scopus 로고
    • Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells
    • Qin, L. F.; Ng, I. O. Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells. Cancer Lett. 2002, 175, 27-38.
    • (2002) Cancer Lett. , vol.175 , pp. 27-38
    • Qin, L.F.1    Ng, I.O.2
  • 58
    • 33846404174 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance and toxicity associated with platinating agents
    • Rabik, C. A.; Dolan, M. E. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat. Rev. 2007, 33, 9-23.
    • (2007) Cancer Treat. Rev. , vol.33 , pp. 9-23
    • Rabik, C.A.1    Dolan, M.E.2
  • 59
    • 0029849578 scopus 로고    scopus 로고
    • Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression of E6/E7-oncogene expression and induction of apoptosis
    • Butz, K.; Geisen, C.; Ullmann, A.; Spitkovsky, D.; Hoppe-Seyler, F. Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis. Int. J. Cancer 1996, 68, 506-513.
    • (1996) Int. J. Cancer , vol.68 , pp. 506-513
    • Butz, K.1    Geisen, C.2    Ullmann, A.3    Spitkovsky, D.4    Hoppe-Seyler, F.5
  • 60
    • 9444266111 scopus 로고    scopus 로고
    • Cisplatin restores p53 function and enhances the radiosensitivity in HPV16 E6 containing SiHa cells
    • Huang, H.; Huang, S. Y.; Chen, T. T.; Chen, J. C.; Chiou, C. L.; Huang, T. M. Cisplatin restores p53 function and enhances the radiosensitivity in HPV16 E6 containing SiHa cells. J. Cell. Biochem. 2004, 91, 756-765.
    • (2004) J. Cell. Biochem. , vol.91 , pp. 756-765
    • Huang, H.1    Huang, S.Y.2    Chen, T.T.3    Chen, J.C.4    Chiou, C.L.5    Huang, T.M.6
  • 61
    • 0037115548 scopus 로고    scopus 로고
    • Chemoradiation of cervical cancer cells: Targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand
    • Koivusalo, R.; Krausz, E.; Ruotsalainen, P.; Helenius, H.; Hietanen, S. Chemoradiation of cervical cancer cells: targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand. Cancer Res. 2002, 62, 7364-7371.
    • (2002) Cancer Res. , vol.62 , pp. 7364-7371
    • Koivusalo, R.1    Krausz, E.2    Ruotsalainen, P.3    Helenius, H.4    Hietanen, S.5
  • 62
    • 22144484889 scopus 로고    scopus 로고
    • The cytotoxicity of chemotherapy drugs varies in cervical cancer cells depending on the p53 status
    • Koivusalo, R.; Hietanen, S. The cytotoxicity of chemotherapy drugs varies in cervical cancer cells depending on the p53 status. Cancer Biol. Ther. 2004, 3, 1177-1183.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 1177-1183
    • Koivusalo, R.1    Hietanen, S.2
  • 63
    • 0037056222 scopus 로고    scopus 로고
    • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy
    • Wesierska-Gadek, J.; Schloffer, D.; Kotala, V.; Horky, M. Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy. Int. J. Cancer 2002, 101, 128-136.
    • (2002) Int. J. Cancer , vol.101 , pp. 128-136
    • Wesierska-Gadek, J.1    Schloffer, D.2    Kotala, V.3    Horky, M.4
  • 65
    • 0023259716 scopus 로고
    • Effect of cisplatin resistance on cellular radiation response
    • Wallner, K. E.; Li, G. C. Effect of cisplatin resistance on cellular radiation response. Int. J. Radiat. Oncol. Biol. Phys. 1987, 13, 587-591.
    • (1987) Int. J. Radiat. Oncol. Biol. Phys. , vol.13 , pp. 587-591
    • Wallner, K.E.1    Li, G.C.2
  • 66
    • 67449127097 scopus 로고    scopus 로고
    • Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitization
    • Ahsan, A.; Hiniker, S. M.; Davis, M. A.; Lawrence, T. S.; Nyati, M. K. Role of cell cycle in epidermal growth factor receptor inhibitor-mediated radiosensitization. Cancer Res. 2009, 69, 5108-5114.
    • (2009) Cancer Res. , vol.69 , pp. 5108-5114
    • Ahsan, A.1    Hiniker, S.M.2    Davis, M.A.3    Lawrence, T.S.4    Nyati, M.K.5
  • 67
    • 34247130456 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance
    • Brozovic, A.; Osmak, M. Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer Lett. 2007, 251, 1-16.
    • (2007) Cancer Lett. , vol.251 , pp. 1-16
    • Brozovic, A.1    Osmak, M.2
  • 69
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout, J. A.; Patel, S. A.; Simon, M. C. The impact of O2 availability on human cancer. Nat. Rev. Cancer 2008, 8, 967-975.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 71
    • 0033922706 scopus 로고    scopus 로고
    • Hypoxiainduced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
    • Rofstad, E. K.; Sundfor, K.; Lyng, H.; Trope, C. G. Hypoxiainduced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br. J. Cancer 2000, 83, 354-359.
    • (2000) Br. J. Cancer , vol.83 , pp. 354-359
    • Rofstad, E.K.1    Sundfor, K.2    Lyng, H.3    Trope, C.G.4
  • 72
    • 54549103311 scopus 로고    scopus 로고
    • Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation
    • An, J.; Mo, D.; Liu, H.; Veena, M. S.; Srivatsan, E. S.; Massoumi, R.; Rettig, M. B. Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. Cancer Cell 2008, 14, 394-407.
    • (2008) Cancer Cell , vol.14 , pp. 394-407
    • An, J.1    Mo, D.2    Liu, H.3    Veena, M.S.4    Srivatsan, E.S.5    Massoumi, R.6    Rettig, M.B.7
  • 73
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin, A. S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 2001, 107, 241-246.
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 74
    • 73349106810 scopus 로고    scopus 로고
    • Association of constitutive nuclear factor-kappaB activation with aggressive aspects and poor prognosis in cervical cancer
    • Li, J.; Jia, H.; Xie, L.; Wang, X.; Wang, X.; He, H.; Lin, Y.; Hu, L. Association of constitutive nuclear factor-kappaB activation with aggressive aspects and poor prognosis in cervical cancer. Int. J. Gynecol. Cancer 2009, 19, 1421-1426.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 1421-1426
    • Li, J.1    Jia, H.2    Xie, L.3    Wang, X.4    Wang, X.5    He, H.6    Lin, Y.7    Hu, L.8
  • 75
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosisinducing ligand (rhApo2L/TRAIL)
    • Ashkenazi, A.; Holland, P.; Eckhardt, S. G. Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosisinducing ligand (rhApo2L/TRAIL). J. Clin. Oncol. 2008, 26, 3621-3630.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 77
    • 33747195054 scopus 로고    scopus 로고
    • Radiation therapy induced changes in apoptosis and its major regulatory proteins, Bcl-2, Bcl-XL, and Bax, in locally advanced invasive squamous cell carcinoma of the cervix
    • Adhya, A. K.; Srinivasan, R.; Patel, F. D. Radiation therapy induced changes in apoptosis and its major regulatory proteins, Bcl-2, Bcl-XL, and Bax, in locally advanced invasive squamous cell carcinoma of the cervix. Int. J. Gynecol. Pathol. 2006, 25, 281-287.
    • (2006) Int. J. Gynecol. Pathol. , vol.25 , pp. 281-287
    • Adhya, A.K.1    Srinivasan, R.2    Patel, F.D.3
  • 78
    • 41749116097 scopus 로고    scopus 로고
    • The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer
    • Iwakawa, M.; Ohno, T.; Imadome, K.; Nakawatari, M.; Ishikawa, K.; Sakai, M.; Katoh, S.; Ishikawa, H.; Tsujii, H.; Imai, T. The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer. Cancer Biol. Ther. 2007, 6, 905-911.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 905-911
    • Iwakawa, M.1    Ohno, T.2    Imadome, K.3    Nakawatari, M.4    Ishikawa, K.5    Sakai, M.6    Katoh, S.7    Ishikawa, H.8    Tsujii, H.9    Imai, T.10
  • 79
    • 0042128628 scopus 로고    scopus 로고
    • Differential gene expression in cervical cancer cell lines before and after ionizing radiation
    • Liu, S. S.; Cheung, A. N.; Ngan, H. Y. Differential gene expression in cervical cancer cell lines before and after ionizing radiation. Int. J. Oncol. 2003, 22, 1091-1099.
    • (2003) Int. J. Oncol. , vol.22 , pp. 1091-1099
    • Liu, S.S.1    Cheung, A.N.2    Ngan, H.Y.3
  • 80
    • 0042631357 scopus 로고    scopus 로고
    • Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents
    • Ma, B. B.; Bristow, R. G.; Kim, J.; Siu, L. L. Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents. J. Clin. Oncol. 2003, 21, 2760-2776.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2760-2776
    • Ma, B.B.1    Bristow, R.G.2    Kim, J.3    Siu, L.L.4
  • 82
    • 33646054140 scopus 로고    scopus 로고
    • Analysis of differential protein expression by cisplatin treatment in cervical carcinoma cells
    • Yim, E. K.; Lee, K. H.; Kim, C. J.; Park, J. S. Analysis of differential protein expression by cisplatin treatment in cervical carcinoma cells. Int. J. Gynecol. Cancer 2006, 16, 690-697.
    • (2006) Int. J. Gynecol. Cancer , vol.16 , pp. 690-697
    • Yim, E.K.1    Lee, K.H.2    Kim, C.J.3    Park, J.S.4
  • 83
    • 18144377959 scopus 로고    scopus 로고
    • Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: Relationship with Fas, caspase-8, and Bid
    • Hougardy, B. M.; van der Zee, A. G.; van den Heuvel, F. A.; Timmer, T.; de Vries, E. G.; de Jong, S. Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid. Gynecol. Oncol. 2005, 97, 353-364.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 353-364
    • Hougardy, B.M.1    van der Zee, A.G.2    van den Heuvel, F.A.3    Timmer, T.4    de Vries, E.G.5    de Jong, S.6
  • 85
    • 1242352914 scopus 로고    scopus 로고
    • Established and potential strategies against papillomavirus infections
    • Bernard, H. U. Established and potential strategies against papillomavirus infections. J. Antimicrob. Chemother. 2004, 53, 137-139.
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 137-139
    • Bernard, H.U.1
  • 87
    • 34247185985 scopus 로고    scopus 로고
    • The development and future of oligonucleotide-based therapies for cervical cancer
    • Gu, W.; Putral, L. N.; Irving, A.; McMillan, N. A. The development and future of oligonucleotide-based therapies for cervical cancer. Curr. Opin. Mol. Ther. 2007, 9, 126-131.
    • (2007) Curr. Opin. Mol. Ther. , vol.9 , pp. 126-131
    • Gu, W.1    Putral, L.N.2    Irving, A.3    McMillan, N.A.4
  • 89
    • 55649097304 scopus 로고    scopus 로고
    • Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer
    • Jonson, A. L.; Rogers, L. M.; Ramakrishnan, S.; Downs, L. S., Jr. Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer. Gynecol. Oncol. 2008, 111, 356-364.
    • (2008) Gynecol. Oncol. , vol.111 , pp. 356-364
    • Jonson, A.L.1    Rogers, L.M.2    Ramakrishnan, S.3    Downs Jr., L.S.4
  • 90
    • 33646028216 scopus 로고    scopus 로고
    • Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo
    • Niu, X. Y.; Peng, Z. L.; Duan, W. Q.; Wang, H.; Wang, P. Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo. Int. J. Gynecol. Cancer 2006, 16, 743-751.
    • (2006) Int. J. Gynecol. Cancer , vol.16 , pp. 743-751
    • Niu, X.Y.1    Peng, Z.L.2    Duan, W.Q.3    Wang, H.4    Wang, P.5
  • 92
    • 27544455180 scopus 로고    scopus 로고
    • RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin
    • Putral, L. N.; Bywater, M. J.; Gu, W.; Saunders, N. A.; Gabrielli, B. G.; Leggatt, G. R.; McMillan, N. A. RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Mol. Pharmacol. 2005, 68, 1311-1319.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1311-1319
    • Putral, L.N.1    Bywater, M.J.2    Gu, W.3    Saunders, N.A.4    Gabrielli, B.G.5    Leggatt, G.R.6    McMillan, N.A.7
  • 93
    • 23044502867 scopus 로고    scopus 로고
    • Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: Opposite effect of siRNA in combination with different drugs
    • Koivusalo, R.; Krausz, E.; Helenius, H.; Hietanen, S. Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: opposite effect of siRNA in combination with different drugs. Mol. Pharmacol. 2005, 68, 372-382.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 372-382
    • Koivusalo, R.1    Krausz, E.2    Helenius, H.3    Hietanen, S.4
  • 94
    • 70349209205 scopus 로고    scopus 로고
    • Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma
    • Liu, W. L.; Green, N.; Seymour, L. W.; Stevenson, M. Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma. Cancer Gene Ther. 2009, 16, 764-775.
    • (2009) Cancer Gene Ther. , vol.16 , pp. 764-775
    • Liu, W.L.1    Green, N.2    Seymour, L.W.3    Stevenson, M.4
  • 95
    • 22144475879 scopus 로고    scopus 로고
    • Ribozyme targeting HPV16 E6E7 transcripts in cervical cancer cells suppresses cell growth and sensitizes cells to chemotherapy and radiotherapy
    • Zheng, Y.; Zhang, J.; Rao, Z. Ribozyme targeting HPV16 E6E7 transcripts in cervical cancer cells suppresses cell growth and sensitizes cells to chemotherapy and radiotherapy. Cancer Biol. Ther. 2004, 3, 1129-1134.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 1129-1134
    • Zheng, Y.1    Zhang, J.2    Rao, Z.3
  • 96
    • 34247512483 scopus 로고    scopus 로고
    • Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation
    • Yamayoshi, A.; Kato, K.; Suga, S.; Ichinoe, A.; Arima, T.; Matsuda, T.; Kato, H.; Murakami, A.; Wake, N. Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation. Oligonucleotides 2007, 17, 66-79.
    • (2007) Oligonucleotides , vol.17 , pp. 66-79
    • Yamayoshi, A.1    Kato, K.2    Suga, S.3    Ichinoe, A.4    Arima, T.5    Matsuda, T.6    Kato, H.7    Murakami, A.8    Wake, N.9
  • 97
    • 85056055141 scopus 로고    scopus 로고
    • Small molecule inhibitors of human papillomavirus protein-protein interactions
    • D'Abramo, C. M.; Archambault, J. Small molecule inhibitors of human papillomavirus protein-protein interactions. Open Virol. J. 2011, 5, 80-95.
    • (2011) Open Virol. J. , vol.5 , pp. 80-95
    • D'Abramo, C.M.1    Archambault, J.2
  • 99
    • 60549088863 scopus 로고    scopus 로고
    • A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein
    • Dymalla, S.; Scheffner, M.; Weber, E.; Sehr, P.; Lohrey, C.; Hoppe-Seyler, F.; Hoppe-Seyler, K. A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein. J. Mol. Med. (Berl) 2009, 87, 321-331.
    • (2009) J. Mol. Med. (Berl) , vol.87 , pp. 321-331
    • Dymalla, S.1    Scheffner, M.2    Weber, E.3    Sehr, P.4    Lohrey, C.5    Hoppe-Seyler, F.6    Hoppe-Seyler, K.7
  • 100
    • 33747881135 scopus 로고    scopus 로고
    • Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
    • Baleja, J. D.; Cherry, J. J.; Liu, Z.; Gao, H.; Nicklaus, M. C.; Voigt, J. H.; Chen, J. J.; Androphy, E. J. Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res. 2006, 72, 49-59.
    • (2006) Antiviral Res. , vol.72 , pp. 49-59
    • Baleja, J.D.1    Cherry, J.J.2    Liu, Z.3    Gao, H.4    Nicklaus, M.C.5    Voigt, J.H.6    Chen, J.J.7    Androphy, E.J.8
  • 102
    • 77951067833 scopus 로고    scopus 로고
    • Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation
    • Zhao, C. Y.; Szekely, L.; Bao, W.; Selivanova, G. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010, 70, 3372-3381.
    • (2010) Cancer Res. , vol.70 , pp. 3372-3381
    • Zhao, C.Y.1    Szekely, L.2    Bao, W.3    Selivanova, G.4
  • 103
    • 79952678427 scopus 로고    scopus 로고
    • Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway
    • Guo, C. P.; Liu, K. W.; Luo, H. B.; Chen, H. B.; Zheng, Y.; Sun, S. N.; Zhang, Q.; Huang, L. Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway. PLoS One 2011, 6, e17734.
    • (2011) PLoS One , vol.6
    • Guo, C.P.1    Liu, K.W.2    Luo, H.B.3    Chen, H.B.4    Zheng, Y.5    Sun, S.N.6    Zhang, Q.7    Huang, L.8
  • 104
    • 36049007464 scopus 로고    scopus 로고
    • Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening
    • Kim, M. K.; Min, J.; Choi, B. Y.; Lim, H.; Cho, Y. H.; Lee, C. H. Discovery of cyclin-dependent kinase inhibitor, CR229, using structurebased drug screening. J. Microbiol. Biotechnol. 2007, 17, 1712-1716.
    • (2007) J. Microbiol. Biotechnol. , vol.17 , pp. 1712-1716
    • Kim, M.K.1    Min, J.2    Choi, B.Y.3    Lim, H.4    Cho, Y.H.5    Lee, C.H.6
  • 105
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres, M.; Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 2009, 9, 153-166.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 107
    • 33845588574 scopus 로고    scopus 로고
    • The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation
    • Pajonk, F.; Grumann, T.; McBride, W. H. The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation. Neoplasia 2006, 8, 1037-1041.
    • (2006) Neoplasia , vol.8 , pp. 1037-1041
    • Pajonk, F.1    Grumann, T.2    McBride, W.H.3
  • 108
    • 58149295169 scopus 로고    scopus 로고
    • Targeting the ubiquitin-proteasome system for cancer therapy
    • Yang, Y.; Kitagaki, J.; Wang, H.; Hou, D. X.; Perantoni, A. O. Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009, 100, 24-28.
    • (2009) Cancer Sci. , vol.100 , pp. 24-28
    • Yang, Y.1    Kitagaki, J.2    Wang, H.3    Hou, D.X.4    Perantoni, A.O.5
  • 109
    • 56549108276 scopus 로고    scopus 로고
    • Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade (bortezomib, PS-341)
    • Kamer, S.; Ren, Q.; Dicker, A. P. Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade (bortezomib, PS-341). Arch. Gynecol. Obstet. 2009, 279, 41-46.
    • (2009) Arch. Gynecol. Obstet. , vol.279 , pp. 41-46
    • Kamer, S.1    Ren, Q.2    Dicker, A.P.3
  • 110
    • 33847751015 scopus 로고    scopus 로고
    • Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors
    • Birle, D. C.; Hedley, D. W. Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. Cancer Res. 2007, 67, 1735-1743.
    • (2007) Cancer Res. , vol.67 , pp. 1735-1743
    • Birle, D.C.1    Hedley, D.W.2
  • 113
    • 79959453367 scopus 로고    scopus 로고
    • Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells
    • Batman, G.; Oliver, A. W.; Zehbe, I.; Richard, C.; Hampson, L.; Hampson, I. N. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir. Ther. 2011, 16, 515-525.
    • (2011) Antivir. Ther. , vol.16 , pp. 515-525
    • Batman, G.1    Oliver, A.W.2    Zehbe, I.3    Richard, C.4    Hampson, L.5    Hampson, I.N.6
  • 114
    • 33749342391 scopus 로고    scopus 로고
    • Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro
    • Hampson, L.; Kitchener, H. C.; Hampson, I. N. Specific HIV protease inhibitors inhibit the ability of HPV16 E6 to degrade p53 and selectively kill E6-dependent cervical carcinoma cells in vitro. Antivir. Ther. 2006, 11, 813-825.
    • (2006) Antivir. Ther. , vol.11 , pp. 813-825
    • Hampson, L.1    Kitchener, H.C.2    Hampson, I.N.3
  • 115
    • 67649866050 scopus 로고    scopus 로고
    • Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone
    • Duncan, K. J.; Eckert, K. A.; Clawson, G. A. Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone. J. Pharmacol. Exp. Ther. 2009, 330, 359-366.
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 359-366
    • Duncan, K.J.1    Eckert, K.A.2    Clawson, G.A.3
  • 116
    • 33646856018 scopus 로고    scopus 로고
    • A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes
    • Drubin, D. A.; McLaughlin-Drubin, M. E.; Clawson, G. A.; Meyers, C. A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes. Mol. Ther. 2006, 13, 1142-1148.
    • (2006) Mol. Ther. , vol.13 , pp. 1142-1148
    • Drubin, D.A.1    McLaughlin-Drubin, M.E.2    Clawson, G.A.3    Meyers, C.4
  • 117
    • 67349222049 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as anti-neoplastic agents
    • Batty, N.; Malouf, G. G.; Issa, J. P. Histone deacetylase inhibitors as anti-neoplastic agents. Cancer Lett. 2009, 280, 192-200.
    • (2009) Cancer Lett. , vol.280 , pp. 192-200
    • Batty, N.1    Malouf, G.G.2    Issa, J.P.3
  • 118
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Lane, A. A.; Chabner, B. A. Histone deacetylase inhibitors in cancer therapy. J. Clin. Oncol. 2009, 27, 5459-5468.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 119
    • 64549139803 scopus 로고    scopus 로고
    • Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics
    • Selvi, R. B.; Kundu, T. K. Reversible acetylation of chromatin: implication in regulation of gene expression, disease and therapeutics. Biotechnol. J. 2009, 4, 375-390.
    • (2009) Biotechnol. J. , vol.4 , pp. 375-390
    • Selvi, R.B.1    Kundu, T.K.2
  • 120
    • 0033522479 scopus 로고    scopus 로고
    • The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth
    • Brehm, A.; Nielsen, S. J.; Miska, E. A.; McCance, D. J.; Reid, J. L.; Bannister, A. J.; Kouzarides, T. The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J. 1999, 18, 2449-2458.
    • (1999) EMBO J. , vol.18 , pp. 2449-2458
    • Brehm, A.1    Nielsen, S.J.2    Miska, E.A.3    McCance, D.J.4    Reid, J.L.5    Bannister, A.J.6    Kouzarides, T.7
  • 121
    • 33847772150 scopus 로고    scopus 로고
    • The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study
    • de la Cruz-Hernandez, E.; Perez-Cardenas, E.; Contreras-Paredes, A.; Cantu, D.; Mohar, A.; Lizano, M.; Duenas-Gonzalez, A. The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study. Virol. J. 2007, 4, 18-28.
    • (2007) Virol. J. , vol.4 , pp. 18-28
    • de la Cruz-Hernandez, E.1    Perez-Cardenas, E.2    Contreras-Paredes, A.3    Cantu, D.4    Mohar, A.5    Lizano, M.6    Duenas-Gonzalez, A.7
  • 122
    • 3042723615 scopus 로고    scopus 로고
    • HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway
    • Finzer, P.; Krueger, A.; Stohr, M.; Brenner, D.; Soto, U.; Kuntzen, C.; Krammer, P. H.; Rosl, F. HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway. Oncogene 2004, 23, 4807-4817.
    • (2004) Oncogene , vol.23 , pp. 4807-4817
    • Finzer, P.1    Krueger, A.2    Stohr, M.3    Brenner, D.4    Soto, U.5    Kuntzen, C.6    Krammer, P.H.7    Rosl, F.8
  • 123
    • 0034676439 scopus 로고    scopus 로고
    • Deacetylation of p53 modulates its effect on cell growth and apoptosis
    • Luo, J.; Su, F.; Chen, D.; Shiloh, A.; Gu, W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000, 408, 377-381.
    • (2000) Nature , vol.408 , pp. 377-381
    • Luo, J.1    Su, F.2    Chen, D.3    Shiloh, A.4    Gu, W.5
  • 124
    • 53949094562 scopus 로고    scopus 로고
    • Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells
    • Luczak, M. W.; Jagodzinski, P. P. Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells. Cancer Lett. 2008, 272, 53-60.
    • (2008) Cancer Lett. , vol.272 , pp. 53-60
    • Luczak, M.W.1    Jagodzinski, P.P.2
  • 125
    • 59449084559 scopus 로고    scopus 로고
    • Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment
    • Lin, Z.; Bazzaro, M.; Wang, M. C.; Chan, K. C.; Peng, S.; Roden, R. B. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin. Cancer Res. 2009, 15, 570-577.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 570-577
    • Lin, Z.1    Bazzaro, M.2    Wang, M.C.3    Chan, K.C.4    Peng, S.5    Roden, R.B.6
  • 127
    • 0037043594 scopus 로고    scopus 로고
    • The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosisinducing ligand (TRAIL)-induced apoptosis in HeLa cells
    • Lee, M. W.; Park, S. C.; Kim, J. H.; Kim, I. K.; Han, K. S.; Kim, K. Y.; Lee, W. B.; Jung, Y. K.; Kim, S. S. The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosisinducing ligand (TRAIL)-induced apoptosis in HeLa cells. Cancer Lett. 2002, 182, 75-82.
    • (2002) Cancer Lett. , vol.182 , pp. 75-82
    • Lee, M.W.1    Park, S.C.2    Kim, J.H.3    Kim, I.K.4    Han, K.S.5    Kim, K.Y.6    Lee, W.B.7    Jung, Y.K.8    Kim, S.S.9
  • 128
    • 33644515676 scopus 로고    scopus 로고
    • Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model
    • Straughn, J. M., Jr.; Oliver, P. G.; Zhou, T.; Wang, W.; Alvarez, R. D.; Grizzle, W. E.; Buchsbaum, D. J. Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Gynecol. Oncol. 2006, 101, 46-54.
    • (2006) Gynecol. Oncol. , vol.101 , pp. 46-54
    • Straughn Jr., J.M.1    Oliver, P.G.2    Zhou, T.3    Wang, W.4    Alvarez, R.D.5    Grizzle, W.E.6    Buchsbaum, D.J.7
  • 129
    • 0033696418 scopus 로고    scopus 로고
    • Expression of TRAIL (TNF-related apoptosis-inducing ligand) receptors in cervical cancer
    • Ryu, H. S.; Chang, K. H.; Chang, S. J.; Kim, M. S.; Joo, H. J.; Oh, K. S. Expression of TRAIL (TNF-related apoptosis-inducing ligand) receptors in cervical cancer. Int. J. Gynecol. Cancer 2000, 10, 417-424.
    • (2000) Int. J. Gynecol. Cancer , vol.10 , pp. 417-424
    • Ryu, H.S.1    Chang, K.H.2    Chang, S.J.3    Kim, M.S.4    Joo, H.J.5    Oh, K.S.6
  • 134
    • 0037698697 scopus 로고    scopus 로고
    • Reovirus-induced apoptosis: A minireview
    • Clarke, P.; Tyler, K. L. Reovirus-induced apoptosis: A minireview. Apoptosis 2003, 8, 141-150.
    • (2003) Apoptosis , vol.8 , pp. 141-150
    • Clarke, P.1    Tyler, K.L.2
  • 135
    • 79551496194 scopus 로고    scopus 로고
    • Efficacy of TRAIL treatment against HPV16 infected cervical cancer cells undergoing senescence following siRNA knockdown of E6/E7 genes
    • Eaton, S.; Wiktor, P.; Thirstrup, D.; Lake, D.; Nagaraj, V. J. Efficacy of TRAIL treatment against HPV16 infected cervical cancer cells undergoing senescence following siRNA knockdown of E6/E7 genes. Biochem. Biophys. Res. Commun. 2011, 405, 1-6.
    • (2011) Biochem. Biophys. Res. Commun. , vol.405 , pp. 1-6
    • Eaton, S.1    Wiktor, P.2    Thirstrup, D.3    Lake, D.4    Nagaraj, V.J.5
  • 136
    • 2942525121 scopus 로고    scopus 로고
    • The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis
    • Filippova, M.; Parkhurst, L.; Duerksen-Hughes, P. J. The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis. J. Biol. Chem. 2004, 279, 25729-25744.
    • (2004) J. Biol. Chem. , vol.279 , pp. 25729-25744
    • Filippova, M.1    Parkhurst, L.2    Duerksen-Hughes, P.J.3
  • 137
    • 33749617478 scopus 로고    scopus 로고
    • Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis
    • Garnett, T. O.; Filippova, M.; Duerksen-Hughes, P. J. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. Cell Death Differ. 2006, 13, 1915-1926.
    • (2006) Cell Death Differ. , vol.13 , pp. 1915-1926
    • Garnett, T.O.1    Filippova, M.2    Duerksen-Hughes, P.J.3
  • 138
    • 75349110228 scopus 로고    scopus 로고
    • Modulation of apoptosis by early human papillomavirus proteins in cervical cancer
    • Lagunas-Martínez, A.; Madrid-Marina, V.; Gariglio, P. Modulation of apoptosis by early human papillomavirus proteins in cervical cancer. Biochim. Biophys. Acta 2010, 1805, 6-16.
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 6-16
    • Lagunas-Martínez, A.1    Madrid-Marina, V.2    Gariglio, P.3
  • 141
    • 77955635418 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor-induced sensitization to TNFalpha/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression
    • Darvas, K.; Rosenberger, S.; Brenner, D.; Fritsch, C.; Gmelin, N.; Krammer, P. H.; Rosl, F. Histone deacetylase inhibitor-induced sensitization to TNFalpha/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression. Int. J. Cancer 2010, 127, 1384-1392.
    • (2010) Int. J. Cancer , vol.127 , pp. 1384-1392
    • Darvas, K.1    Rosenberger, S.2    Brenner, D.3    Fritsch, C.4    Gmelin, N.5    Krammer, P.H.6    Rosl, F.7
  • 142
    • 49749094091 scopus 로고    scopus 로고
    • A robust ex vivo model for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants
    • Hougardy, B. M.; Reesink-Peters, N.; van den Heuvel, F. A.; ten Hoor, K. A.; Hollema, H.; de Vries, E. G.; de Jong, S.; van der Zee, A. G. A robust ex vivo model for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants. Int. J. Cancer 2008, 123, 1457-1465.
    • (2008) Int. J. Cancer , vol.123 , pp. 1457-1465
    • Hougardy, B.M.1    Reesink-Peters, N.2    van den Heuvel, F.A.3    ten Hoor, K.A.4    Hollema, H.5    de Vries, E.G.6    de Jong, S.7    van der Zee, A.G.8
  • 144
    • 77951894266 scopus 로고    scopus 로고
    • Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer
    • Soria, J. C.; Smit, E.; Khayat, D.; Besse, B.; Yang, X.; Hsu, C. P.; Reese, D.; Wiezorek, J.; Blackhall, F. Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer. J. Clin. Oncol. 2010, 28, 1527-1533.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1527-1533
    • Soria, J.C.1    Smit, E.2    Khayat, D.3    Besse, B.4    Yang, X.5    Hsu, C.P.6    Reese, D.7    Wiezorek, J.8    Blackhall, F.9
  • 149
    • 63449085543 scopus 로고    scopus 로고
    • Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspasedependent manner
    • Wu, X. X.; Kakehi, Y. Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspasedependent manner. Clin. Cancer Res. 2009, 15, 2039-2047.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2039-2047
    • Wu, X.X.1    Kakehi, Y.2
  • 151
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1
    • Tolcher, A. W.; Mita, M.; Meropol, N. J.; von Mehren, M.; Patnaik, A.; Padavic, K.; Hill, M.; Mays, T.; McCoy, T.; Fox, N. L.; Halpern, W.; Corey, A.; Cohen, R. B. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1. J. Clin. Oncol. 2007, 25, 1390-1395.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3    von Mehren, M.4    Patnaik, A.5    Padavic, K.6    Hill, M.7    Mays, T.8    McCoy, T.9    Fox, N.L.10    Halpern, W.11    Corey, A.12    Cohen, R.B.13
  • 152
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced nonsmall cell lung cancer
    • Greco, F. A.; Bonomi, P.; Crawford, J.; Kelly, K.; Oh, Y.; Halpern, W.; Lo, L.; Gallant, G.; Klein, J. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced nonsmall cell lung cancer. Lung Cancer 2008, 61, 82-90.
    • (2008) Lung Cancer , vol.61 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3    Kelly, K.4    Oh, Y.5    Halpern, W.6    Lo, L.7    Gallant, G.8    Klein, J.9
  • 154
    • 76349085626 scopus 로고    scopus 로고
    • Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
    • Trarbach, T.; Moehler, M.; Heinemann, V.; Kohne, C. H.; Przyborek, M.; Schulz, C.; Sneller, V.; Gallant, G.; Kanzler, S. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br. J. Cancer 2010, 102, 506-512.
    • (2010) Br. J. Cancer , vol.102 , pp. 506-512
    • Trarbach, T.1    Moehler, M.2    Heinemann, V.3    Kohne, C.H.4    Przyborek, M.5    Schulz, C.6    Sneller, V.7    Gallant, G.8    Kanzler, S.9
  • 162
    • 0025953696 scopus 로고
    • The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
    • Scheffner, M.; Munger, K.; Byrne, J. C.; Howley, P. M. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 5523-5527.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 5523-5527
    • Scheffner, M.1    Munger, K.2    Byrne, J.C.3    Howley, P.M.4
  • 163
    • 0022586617 scopus 로고
    • Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from Japanese patients
    • Tsunokawa, Y.; Takebe, N.; Nozawa, S.; Kasamatsu, T.; Gissmann, L.; zur Hausen, H.; Terada, M.; Sugimura, T. Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from Japanese patients. Int. J. Cancer 1986, 37, 499-503.
    • (1986) Int. J. Cancer , vol.37 , pp. 499-503
    • Tsunokawa, Y.1    Takebe, N.2    Nozawa, S.3    Kasamatsu, T.4    Gissmann, L.5    zur Hausen, H.6    Terada, M.7    Sugimura, T.8
  • 164
    • 0023113532 scopus 로고
    • Conservation of E6 and E7 regions of human papillomavirus types 16 and 18 present in cervical cancers
    • Takebe, N.; Tsunokawa, Y.; Nozawa, S.; Terada, M.; Sugimura, T. Conservation of E6 and E7 regions of human papillomavirus types 16 and 18 present in cervical cancers. Biochem. Biophys. Res. Commun. 1987, 143, 837-844.
    • (1987) Biochem. Biophys. Res. Commun. , vol.143 , pp. 837-844
    • Takebe, N.1    Tsunokawa, Y.2    Nozawa, S.3    Terada, M.4    Sugimura, T.5
  • 166
    • 84856469330 scopus 로고    scopus 로고
    • Available from:, [Accessed July 19, 2011]
    • ATCC-LGC Standards. Available from: http://www.lgcstandardsatcc.org/ [Accessed July 19, 2011].
    • ATCC-LGC Standards


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