메뉴 건너뛰기




Volumn 52, Issue 5, 2003, Pages 342-346

Antibody-mediated EGF receptor blockade as an anticancer therapy: From the laboratory to the clinic

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 225; MONOCLONAL ANTIBODY 528; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 0038290555     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-002-0354-7     Document Type: Conference Paper
Times cited : (54)

References (67)
  • 1
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: An anti-cancer therapy
    • Mendelsohn J (2000) Blockade of receptors for growth factors: an anti-cancer therapy. Clin Cancer Res 6:747
    • (2000) Clin Cancer Res , vol.6 , pp. 747
    • Mendelsohn, J.1
  • 2
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J (2002) Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 20(18s):1s
    • (2002) J Clin Oncol , vol.20 , Issue.18 S
    • Mendelsohn, J.1
  • 3
    • 84916265276 scopus 로고
    • Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal
    • Cohen S (1962) Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem 237:1555
    • (1962) J Biol Chem , vol.237 , pp. 1555
    • Cohen, S.1
  • 4
    • 0019332558 scopus 로고
    • Epidermal growth factor receptor-kinase interactions: Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity
    • Cohen S, Carpenter G, King L Jr (1980) Epidermal growth factor receptor-kinase interactions: co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem 255:4834
    • (1980) J Biol Chem , vol.255 , pp. 4834
    • Cohen, S.1    Carpenter, G.2    King L., Jr.3
  • 5
    • 0019170218 scopus 로고
    • Serum-free cell culture: A unifying approach
    • Barnes D. Sato G (1980) Serum-free cell culture: a unifying approach. Cell 22:649
    • (1980) Cell , vol.22 , pp. 649
    • Barnes, D.1    Sato, G.2
  • 6
    • 0019782605 scopus 로고
    • Similarities and differences between the effect of epidermal growth factor and Rous sarcoma virus
    • Cooper JA, Hunter T (1981) Similarities and differences between the effect of epidermal growth factor and Rous sarcoma virus. J Cell Biol 91:878
    • (1981) J Cell Biol , vol.91 , pp. 878
    • Cooper, J.A.1    Hunter, T.2
  • 7
    • 0019829559 scopus 로고
    • Purified EGF receptor-kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein
    • Chinkers M, Cohen S (1981) Purified EGF receptor-kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein. Nature 290:516
    • (1981) Nature , vol.290 , pp. 516
    • Chinkers, M.1    Cohen, S.2
  • 8
    • 0019888611 scopus 로고
    • Evidence that viral transforming gene products and epidermal growth factor stimulate phosphorylation of the same cellular protein with similar specificity
    • Erickson E, Shealy DJ, Erickson RL (1981) Evidence that viral transforming gene products and epidermal growth factor stimulate phosphorylation of the same cellular protein with similar specificity. J Biol Chem 256:11381
    • (1981) J Biol Chem , vol.256 , pp. 11381
    • Erickson, E.1    Shealy, D.J.2    Erickson, R.L.3
  • 9
    • 0019320348 scopus 로고
    • Autocrine secretion and malignant transformation of cells
    • Sporn MB, Todaro GJ (1980) Autocrine secretion and malignant transformation of cells. N Engl J Med 303:878
    • (1980) N Engl J Med , vol.303 , pp. 878
    • Sporn, M.B.1    Todaro, G.J.2
  • 10
    • 0022542478 scopus 로고
    • Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas
    • Ozanne B, Richards CS, Hendler F, Burns D, Gusterson B (1986) Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas. J Pathol 149:9
    • (1986) J Pathol , vol.149 , pp. 9
    • Ozanne, B.1    Richards, C.S.2    Hendler, F.3    Burns, D.4    Gusterson, B.5
  • 11
    • 0002350734 scopus 로고
    • Antibodies to growth factors and receptors
    • DeVita VT Jr, Hellman S, Rosenberg SA (eds) JB. Lippincott, Philadelphia
    • Mendelsohn J, Baselga J (1995) Antibodies to growth factors and receptors. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Biologic therapy of cancer, 2nd edn. JB. Lippincott, Philadelphia, 607
    • (1995) Biologic Therapy of Cancer, 2nd Edn. , pp. 607
    • Mendelsohn, J.1    Baselga, J.2
  • 12
    • 0016714582 scopus 로고
    • Control of growth of mammalian cells in cell culture
    • Holley RW (1975) Control of growth of mammalian cells in cell culture. Nature 258:487
    • (1975) Nature , vol.258 , pp. 487
    • Holley, R.W.1
  • 13
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee AB (1989) G1 events and regulation of cell proliferation. Science 246:603
    • (1989) Science , vol.246 , pp. 603
    • Pardee, A.B.1
  • 14
    • 0025162778 scopus 로고
    • Receptor autoimmunity in endocrine disorders
    • Wilkin T (1990) Receptor autoimmunity in endocrine disorders. N Engl J Med 323:1318
    • (1990) N Engl J Med , vol.323 , pp. 1318
    • Wilkin, T.1
  • 15
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495
    • (1975) Nature , vol.256 , pp. 495
    • Köhler, G.1    Milstein, C.2
  • 16
    • 0010233988 scopus 로고
    • Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
    • Kawamoto TK, Sato JD, Le A, Polikoff J, Sato GH, Mendelsohn J (1983) Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci USA 80:1337
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 1337
    • Kawamoto, T.K.1    Sato, J.D.2    Le, A.3    Polikoff, J.4    Sato, G.H.5    Mendelsohn, J.6
  • 17
    • 0020933452 scopus 로고
    • Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
    • Sato JD, Kawamoto T, Le AD, Mendelsohn J, Polikoff J, Sato GH (1983) Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1:511
    • (1983) Mol Biol Med , vol.1 , pp. 511
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3    Mendelsohn, J.4    Polikoff, J.5    Sato, G.H.6
  • 18
    • 0021254542 scopus 로고
    • Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
    • Gill GN, Kawamoto T, Cochet C, Le A, Sato JD, Masui H, McLeod C, Mendelsohn J (1984) Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259:7755
    • (1984) J Biol Chem , vol.259 , pp. 7755
    • Gill, G.N.1    Kawamoto, T.2    Cochet, C.3    Le, A.4    Sato, J.D.5    Masui, H.6    McLeod, C.7    Mendelsohn, J.8
  • 19
    • 0021363327 scopus 로고
    • Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies
    • Masui H, Kawamoto T, Sato JD, Wolf B, Sato G, Mendelsohn J (1984) Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 44:1002
    • (1984) Cancer Res , vol.44 , pp. 1002
    • Masui, H.1    Kawamoto, T.2    Sato, J.D.3    Wolf, B.4    Sato, G.5    Mendelsohn, J.6
  • 20
    • 0027383312 scopus 로고
    • Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies
    • Fan Z, Mendelsohn J, Masui H, Kumar R (1993) Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies. J Biol Chem 268:21073
    • (1993) J Biol Chem , vol.268 , pp. 21073
    • Fan, Z.1    Mendelsohn, J.2    Masui, H.3    Kumar, R.4
  • 21
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X, Mendelsohn J (1994) Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 269:27595
    • (1994) J Biol Chem , vol.269 , pp. 27595
    • Fan, Z.1    Lu, Y.2    Wu, X.3    Mendelsohn, J.4
  • 23
    • 0028819660 scopus 로고    scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1:1311
    • Clin Cancer Res , vol.1 , pp. 1311
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 25
    • 0020659319 scopus 로고
    • Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies
    • Schreiber AB, Libermann TA, Lax I, Yarden Y, Schlessinger J (1983) Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem 258:846
    • (1983) J Biol Chem , vol.258 , pp. 846
    • Schreiber, A.B.1    Libermann, T.A.2    Lax, I.3    Yarden, Y.4    Schlessinger, J.5
  • 28
    • 0021257637 scopus 로고
    • Expression cloning of human EGF receptor complementary DNA: Gene amplification and three related messenger RNA products in A431 cells
    • Lin CR, Chen WS, Kruiger W, Stolarsky LS, Weber W, Evans RM, Verma IM, Gill GN, Rosenfeld MG (1984) Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. Science 224:843
    • (1984) Science , vol.224 , pp. 843
    • Lin, C.R.1    Chen, W.S.2    Kruiger, W.3    Stolarsky, L.S.4    Weber, W.5    Evans, R.M.6    Verma, I.M.7    Gill, G.N.8    Rosenfeld, M.G.9
  • 30
    • 0024261027 scopus 로고
    • Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
    • Aboud-Pirak E, Hurwitz E, Pirak ME, Bellot F, Schlessinger J, Sela M. (1988) Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 80:1605
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1605
    • Aboud-Pirak, E.1    Hurwitz, E.2    Pirak, M.E.3    Bellot, F.4    Schlessinger, J.5    Sela, M.6
  • 31
    • 0027428571 scopus 로고
    • Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamine dichloroplatinum on well established A431 cell xenografts
    • Fan Z, Baselga J, Masui H, Mendelsohn J (1993) Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamine dichloroplatinum on well established A431 cell xenografts. Cancer Res 53:4637
    • (1993) Cancer Res , vol.53 , pp. 4637
    • Fan, Z.1    Baselga, J.2    Masui, H.3    Mendelsohn, J.4
  • 33
    • 0001687355 scopus 로고
    • Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts
    • Baselga J, Norton L, Coplan K, Shalaby R, Mendelsohn J (1994) Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts. Proc Am Assoc Cancer Res 35:A2262
    • (1994) Proc Am Assoc Cancer Res , vol.35
    • Baselga, J.1    Norton, L.2    Coplan, K.3    Shalaby, R.4    Mendelsohn, J.5
  • 35
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang SM, Bock JM, Harari PM (1999) Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 59:1935
    • (1999) Cancer Res , vol.59 , pp. 1935
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 39
    • 0000329007 scopus 로고    scopus 로고
    • A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC)
    • Perez-Soler R, Chachoua A, Huberman M, Karp D, Rigas J, Hammond L, Rowinsky E, Preston G, Ferrante KJ, Allen LF, Nadler PI, Bonomi P (2001) A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 20:1235
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 1235
    • Perez-Soler, R.1    Chachoua, A.2    Huberman, M.3    Karp, D.4    Rigas, J.5    Hammond, L.6    Rowinsky, E.7    Preston, G.8    Ferrante, K.J.9    Allen, L.F.10    Nadler, P.I.11    Bonomi, P.12
  • 40
    • 0001100596 scopus 로고    scopus 로고
    • A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI166, a novel tyrosine kinase inhibitor, in patients with advanced cancers
    • Murren JR, Papadimitrakopoulou VA, Sizer KC, Vaidyanathan S, Ravera C, Abbruzzese J (2002) A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI166, a novel tyrosine kinase inhibitor, in patients with advanced cancers. Proc Am Soc Clin Oncol 21:95
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 95
    • Murren, J.R.1    Papadimitrakopoulou, V.A.2    Sizer, K.C.3    Vaidyanathan, S.4    Ravera, C.5    Abbruzzese, J.6
  • 42
    • 0000061252 scopus 로고    scopus 로고
    • The effects of the novel EGFR/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and transformed cell lines
    • Rusnak DW, Affleck K, Gilmer TM, Jowett A, Lackey K, Spector N, Xia W (2001) The effects of the novel EGFR/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and transformed cell lines. Proc Am Assoc Cancer Res 42:4309
    • (2001) Proc Am Assoc Cancer Res , vol.42 , pp. 4309
    • Rusnak, D.W.1    Affleck, K.2    Gilmer, T.M.3    Jowett, A.4    Lackey, K.5    Spector, N.6    Xia, W.7
  • 44
    • 0041629450 scopus 로고    scopus 로고
    • Status of EGF-receptor antagonists in the biology and treatment of cancer
    • in press
    • Mendelsohn J, Baselga J (2003) Status of EGF-receptor antagonists in the biology and treatment of cancer. J Clin Oncol (in press)
    • (2003) J Clin Oncol
    • Mendelsohn, J.1    Baselga, J.2
  • 47
    • 0032572699 scopus 로고    scopus 로고
    • Nuclear targeting of Bax during epidermal growth factor receptor-induced apoptosis in colorectal cancer cells
    • Mandal M, Adam L, Mendelsohn J, Kumar R (1998) Nuclear targeting of Bax during epidermal growth factor receptor-induced apoptosis in colorectal cancer cells. Oncogene 17:999
    • (1998) Oncogene , vol.17 , pp. 999
    • Mandal, M.1    Adam, L.2    Mendelsohn, J.3    Kumar, R.4
  • 48
    • 0034038282 scopus 로고    scopus 로고
    • Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
    • Liu B, Fang M, Schmidt M, Lu Y, Mendelsohn J, Fan Z (2000) Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 82:1991
    • (2000) Br J Cancer , vol.82 , pp. 1991
    • Liu, B.1    Fang, M.2    Schmidt, M.3    Lu, Y.4    Mendelsohn, J.5    Fan, Z.6
  • 49
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM. Rak J, Hung MC, Rockwell P, Goldstein N, Fendly B, Kerbel RS (1997) Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523
    • (1997) Am J Pathol , vol.151 , pp. 1523
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3    Rockwell, P.4    Goldstein, N.5    Fendly, B.6    Kerbel, R.S.7
  • 50
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, Matsumoto T, Inoue K, Kuniyasu H, Eve BY, Hicklin DJ, Radinsky R, Dinney CP (1999) Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 5:257
    • (1999) Clin Cancer Res , vol.5 , pp. 257
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3    Kuniyasu, H.4    Eve, B.Y.5    Hicklin, D.J.6    Radinsky, R.7    Dinney, C.P.8
  • 51
    • 18844473781 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by anti-angiogenic mechanisms
    • Bruns CJ, Harbison MT, Davis DW, Portera CA, Tsan R, McConkey DJ, Evans DB, Abbruzzese JL, Hicklin DJ, Radinsky R (2000) Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by anti-angiogenic mechanisms. Clin Cancer Res 6:1936
    • (2000) Clin Cancer Res , vol.6 , pp. 1936
    • Bruns, C.J.1    Harbison, M.T.2    Davis, D.W.3    Portera, C.A.4    Tsan, R.5    McConkey, D.J.6    Evans, D.B.7    Abbruzzese, J.L.8    Hicklin, D.J.9    Radinsky, R.10
  • 52
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • Huang SM, Li J, Armstrong EA, Harari PM (2002) Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res 62:4300
    • (2002) Cancer Res , vol.62 , pp. 4300
    • Huang, S.M.1    Li, J.2    Armstrong, E.A.3    Harari, P.M.4
  • 53
    • 0027442527 scopus 로고
    • Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma
    • Naramura M, Gillies SD, Mendelsohn J, Reisfeld RA, Mueller BM (1993) Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 37:343
    • (1993) Cancer Immunol Immunother , vol.37 , pp. 343
    • Naramura, M.1    Gillies, S.D.2    Mendelsohn, J.3    Reisfeld, R.A.4    Mueller, B.M.5
  • 55
    • 0033763084 scopus 로고    scopus 로고
    • ZD1839 ('Iressa') as an anticancer agent
    • Baselga J, Averbuch SD, (2000) ZD1839 ('Iressa') as an anticancer agent. Drugs 60:33
    • (2000) Drugs , vol.60 , pp. 33
    • Baselga, J.1    Averbuch, S.D.2
  • 56
    • 3543024857 scopus 로고
    • Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen
    • Drebin JA, Link VC, Weinberg RA, Greene MI (1986) Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen. Proc Natl Acad Sci USA 83:9129
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9129
    • Drebin, J.A.1    Link, V.C.2    Weinberg, R.A.3    Greene, M.I.4
  • 61
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang XD, Jia XC, Corvalan JR, Wang P, Davis CG, Jakobovits A (1999) Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 59:1236
    • (1999) Cancer Res , vol.59 , pp. 1236
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5    Jakobovits, A.6
  • 62
    • 0035001584 scopus 로고    scopus 로고
    • Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72 000 in patients with advanced squamous cell carcinoma of the larynx and hypopharynx
    • Bier H, Hoffmann T, Hauser U, Wink M, Ochler M, Kovar A, Muser M, Knecht R (2001) Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72 000 in patients with advanced squamous cell carcinoma of the larynx and hypopharynx. Cancer Chemother Pharmacol 47:519
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 519
    • Bier, H.1    Hoffmann, T.2    Hauser, U.3    Wink, M.4    Ochler, M.5    Kovar, A.6    Muser, M.7    Knecht, R.8
  • 65
  • 66
    • 0031567893 scopus 로고    scopus 로고
    • Cytolytic and cytostatic properties of an anti-human Fc gammaRI (CD64) x epidermal growth factor bispecific fusion protein
    • Goldstein J, Graziano RF, Sundarapandiyan K, Somasundaram C, Deo YM (1997) Cytolytic and cytostatic properties of an anti-human Fc gammaRI (CD64) x epidermal growth factor bispecific fusion protein. J Immunol 158:872
    • (1997) J Immunol , vol.158 , pp. 872
    • Goldstein, J.1    Graziano, R.F.2    Sundarapandiyan, K.3    Somasundaram, C.4    Deo, Y.M.5
  • 67
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-225) plus Irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • Saltz L, Rubin M, Hochster H, Tchekmevdian NS, Waksal H, Needle M, LoBuglio AF (2001) Cetuximab (IMC-225) plus Irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 20:7
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 7
    • Saltz, L.1    Rubin, M.2    Hochster, H.3    Tchekmevdian, N.S.4    Waksal, H.5    Needle, M.6    LoBuglio, A.F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.