MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene

Oncogene

Volumn 32, Issue 25, 2013, Pages 3019-3027

  Ke, G ^a,b   Liang, L ^c   Yang, J M ^d   Huang, X ^a,b   Han, D ^a,b   Huang, S ^c   Zhao, Y ^c   Zha, R ^c   He, X ^c   Wu, X ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d PENN STATE CANCER INSTITUTE   (United States)

Author keywords

apoptosis; cervical cancer; miR 181a; PRKCD; radiation therapy

Indexed keywords

BIOLOGICAL MARKER; CISPLATIN; MICRORNA; MICRORNA 181A; PRKCD PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RESISTANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; REPORTER GENE; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; MIDDLE AGED; NEOPLASM TRANSPLANTATION; PROTEIN KINASE C-DELTA; RADIATION TOLERANCE; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA;

EID: 84879414000     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.323     Document Type: Article

References (21)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global Cancer Statistics. Ca Cancer J Clin 2011; 61: 69-90.
2. Waggoner SE. Cervical cancer. Lancet 2003; 361: 2217-2225.
3. Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribbo-nuclease in the initiation step of RNA interference. Nature 2001; 409: 363-366.
4. Sevignani C, Calin GA, Siracusa LD, Croce CM. Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome 2006; 17: 189-202.
5. Zhang B, Wang Q, Pan X. MicroRNAs and their regulatory roles in animals and plants. J Cell Physiol 2007; 210: 279-289.
6. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adeno-sines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
7. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H. Reduced expression of the let-7 MicroRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64: 3753-3756.
8. Hamano R, Miyata H, Yamasaki M, Kurokawa Y, Hara J, Moon J et al. Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin Cancer Res 2011; 17: 3029-3038.
9. Hu X, Schwarz JK, Lewis JS, Huettner PC, Rader JS, Deasy JO et al. A microRNA expression signature for cervical cancer prognosis. Cancer Res 2001; 70: 1441-1448.
10. Begg1 Adrian C., Fiona A, Vens SC. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 2011 239-253.
11. Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M et al. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 2007; 67: 11111-11116.
12. Chen G, Zhu W, Shi D, Lv L, Zhang C, Liu P et al. MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol Rep 2010; 23: 997-1003.
13. Gschwendt M. Protein kinase C. Eur J Biochem 1999; 259: 555-564.
14. Watanabe T, Ono Y, Taniyama Y, Hazama K, Igarashi K, Ogita K et al. Cell divi-sionarrest induced by phorbol ester in CHO cells overexpressing protein kinase C-subspecies. Proc Natl Acad Sci 1992; 89: 10159-10163.
15. Lu Z, Hornia A, Jiang YW, Zang Q, Ohno S, Foster DA. Tumor promotion by depleting cells of protein kinase C. Mol Cell Biol 1997; 17: 3418-3428.
16. Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphor-ylation of protein kinase C d isessential for its apoptotic effect in response to etoposide. Mol Cell Biol 2002; 22: 182-195.
17. Basu A, Woolard MD, Johnson CL. Involvement of protein kinase C-d in DNA damage-induced apoptosis. Cell Death Differ 2001; 8: 899-908.
18. Denning MF, Wang Y, Tibudan S, Alkan S, Nickoloff BJ. Caspase activation and disruption of mitochondrial membrane potential during UV radiation induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ 2002; 9: 40-52.
19. Yuan ZMUT, Ishiko T, Nakada S, Huang Y, Kharbanda S. Activation of protein kinse C d by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 1998; 16: 1643-1648.
20. Denning MF, Wang Y, Nickoloff BJ, Wrone-Smith T. Protein kinase C d is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of humankeratinocytes. J Biol. Chem 1998; 273: 29995-30002.
21. Basu A, Akkaraju GR. Regulation of caspase activation and cis-diamminedi-chloroplatinum(II)-induced cell death by protein kinase C. Biochemistry 1999; 38: 4245-4251.