Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2429-2437

  Kim, Jee Eun ^a,b   Lee, Ji In ^a   Jin, Dong Hoon ^b   Lee, Wang Jae ^c   Park, Ga Bin ^d   Kim, Seonghan ^d   Kim, Yeong Seok ^d   Wu, T C ^e   Hur, Dae Young ^d   Kim, Daejin ^d  

^a Chung Ang University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

^d Inje University   (South Korea)

^e DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Bortezomib; Celecoxib; Cyclin D1; P38 MAPK; TC 1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BORTEZOMIB; CELECOXIB; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN E6; PROTEIN E7; PROTEIN P21; STAT3 PROTEIN; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; CCND1 PROTEIN, MOUSE; CDK2 PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLOOXYGENASE 2 INHIBITOR; DDIT3 PROTEIN, MOUSE; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; IMIDAZOLE DERIVATIVE; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOPROTEIN; PYRAZINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; REPRESSOR PROTEIN; STAT3 PROTEIN, MOUSE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT DURATION; TUMOR GROWTH; UTERINE CERVIX CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL PROLIFERATION; DRUG EFFECTS; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BORONIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLOOXYGENASE 2 INHIBITORS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; IMIDAZOLES; MICE; MICE, INBRED C57BL; ONCOGENE PROTEINS, VIRAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAPILLOMAVIRUS E7 PROTEINS; PYRAZINES; PYRAZOLES; PYRIDINES; REPRESSOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; SULFONAMIDES; TRANSCRIPTION FACTOR CHOP; UTERINE CERVICAL NEOPLASMS;

EID: 84898651816     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3082     Document Type: Article

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