-
1
-
-
33644871979
-
What is healthy aging in the 21st century?
-
Westendorp RG. What is healthy aging in the 21st century? Am J Clin Nutr 2006;83: 404S-409S.
-
(2006)
Am J Clin Nutr
, vol.83
, pp. 404S-409S
-
-
Westendorp, R.G.1
-
4
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008;132:681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
5
-
-
33746617272
-
Hematopoietic stem cells: The paradigmatic tissuespecific stem cell
-
Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: The paradigmatic tissuespecific stem cell. Am J Pathol 2006;169: 338-346.
-
(2006)
Am J Pathol
, vol.169
, pp. 338-346
-
-
Bryder, D.1
Rossi, D.J.2
Weissman, I.L.3
-
6
-
-
1142275269
-
Age-related changes in lymphocyte development and function
-
Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-139.
-
(2004)
Nat Immunol
, vol.5
, pp. 133-139
-
-
Linton, P.J.1
Dorshkind, K.2
-
7
-
-
0042931219
-
The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
-
Miller JP, Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol 2003; 171:2326-2330.
-
(2003)
J Immunol
, vol.171
, pp. 2326-2330
-
-
Miller, J.P.1
Allman, D.2
-
8
-
-
21544467270
-
Cell intrinsic alterations underlie hematopoietic stem cell aging
-
Rossi DJ, Bryder D, Zahn JM et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005;102: 9194-9199.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9194-9199
-
-
Rossi, D.J.1
Bryder, D.2
Zahn, J.M.3
-
9
-
-
34548852838
-
Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia
-
Signer RA, Montecino-Rodriguez E, Witte ONet al. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood 2007;110:1831-1839.
-
(2007)
Blood
, vol.110
, pp. 1831-1839
-
-
Signer, R.A.1
Montecino-Rodriguez, E.2
Witte, O.N.3
-
10
-
-
2542473275
-
Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness
-
Muller-Sieburg CE, Cho RH, Karlsson L et al. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood 2004;103: 4111-4118.
-
(2004)
Blood
, vol.103
, pp. 4111-4118
-
-
Muller-Sieburg, C.E.1
Cho, R.H.2
Karlsson, L.3
-
11
-
-
59049088629
-
B-cell diversity decreases in old age and is correlated with poor health status
-
Gibson KL, Wu YC, Barnett Y et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 2009;8: 18-25.
-
(2009)
Aging Cell
, vol.8
, pp. 18-25
-
-
Gibson, K.L.1
Wu, Y.C.2
Barnett, Y.3
-
13
-
-
84880203894
-
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
-
Wahlestedt M, Norddahl GL, Sten G et al. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood 2013;121:4257-4264.
-
(2013)
Blood
, vol.121
, pp. 4257-4264
-
-
Wahlestedt, M.1
Norddahl, G.L.2
Sten, G.3
-
14
-
-
84855507486
-
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
-
Dykstra B, Olthof S, Schreuder J et al. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 2011;208:2691-2703.
-
(2011)
J Exp Med
, vol.208
, pp. 2691-2703
-
-
Dykstra, B.1
Olthof, S.2
Schreuder, J.3
-
15
-
-
79955698235
-
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
-
Norddahl GL, Pronk CJ, Wahlestedt M et al. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2011;8:499-510.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 499-510
-
-
Norddahl, G.L.1
Pronk, C.J.2
Wahlestedt, M.3
-
16
-
-
77950418688
-
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
-
Beerman I, Bhattacharya D, Zandi S et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA 2010;107:5465-5470.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5465-5470
-
-
Beerman, I.1
Bhattacharya, D.2
Zandi, S.3
-
17
-
-
84860634046
-
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
-
FlorianMC,DörrK,NiebelAet al.Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012;10:520-530.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 520-530
-
-
Florian, M.C.1
Dörr, K.2
Niebel, A.3
-
18
-
-
0034613690
-
Ageassociated characteristics of murine hematopoietic stem cells
-
Sudo K, Ema H, Morita Y et al. Ageassociated characteristics of murine hematopoietic stem cells. J Exp Med 2000;192: 1273-1280.
-
(2000)
J Exp Med
, vol.192
, pp. 1273-1280
-
-
Sudo, K.1
Ema, H.2
Morita, Y.3
-
19
-
-
47049099198
-
A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells
-
Cho RH, Sieburg HB, Muller-Sieburg CE. A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 2008;111:5553-5561.
-
(2008)
Blood
, vol.111
, pp. 5553-5561
-
-
Cho, R.H.1
Sieburg, H.B.2
Muller-Sieburg, C.E.3
-
20
-
-
0038806560
-
Major age-related changes of mouse hematopoietic stem/progenitor cells
-
Kim M, Moon HB, Spangrude GJ. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci 2003; 996:195-208.
-
(2003)
Ann N Y Acad Sci
, vol.996
, pp. 195-208
-
-
Kim, M.1
Moon, H.B.2
Spangrude, G.J.3
-
21
-
-
23744439044
-
Effects of aging onthe homingand engraftment of murine hematopoietic stem and progenitor cells
-
Liang Y, Van Zant G, Szilvassy SJ. Effects of aging onthe homingand engraftment of murine hematopoietic stem and progenitor cells. Blood 2005;106:1479-1487.
-
(2005)
Blood
, vol.106
, pp. 1479-1487
-
-
Liang, Y.1
Van Zant, G.2
Szilvassy, S.J.3
-
22
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007;447:725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
-
23
-
-
34548208677
-
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
-
Chambers SM, Shaw CA, Gatza C et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007;5:e201.
-
(2007)
PLoS Biol
, vol.5
-
-
Chambers, S.M.1
Shaw, C.A.2
Gatza, C.3
-
24
-
-
34147099672
-
Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging
-
Pearce DJ, Anjos-Afonso F, Ridler CM et al. Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging. STEM CELLS 2007;25:828-835.
-
(2007)
Stem Cells
, vol.25
, pp. 828-835
-
-
Pearce, D.J.1
Anjos-Afonso, F.2
Ridler, C.M.3
-
25
-
-
84875965163
-
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
-
Beerman I, Bock C, Garrison BS et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013;12:413-425.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 413-425
-
-
Beerman, I.1
Bock, C.2
Garrison, B.S.3
-
26
-
-
0031028973
-
Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity
-
de Haan G, Nijhof W, Van Zant G. Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity. Blood 1997;89:1543-1550.
-
(1997)
Blood
, vol.89
, pp. 1543-1550
-
-
de Haan, G.1
Nijhof, W.2
Van Zant, G.3
-
27
-
-
0035496909
-
Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: The effect of donor age
-
Kollman C,HoweCW,AnasettiCet al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: The effect of donor age. Blood 2001;98:2043-2051.
-
(2001)
Blood
, vol.98
, pp. 2043-2051
-
-
Kollman, C.1
Howe, C.W.2
Anasetti, C.3
-
28
-
-
84867404950
-
Prognostic factors affecting outcome after allogeneic transplantation for hematological malignancies from unrelated donors: Results from a randomized trial
-
Finke J, Schmoor C, Bethge WA et al. Prognostic factors affecting outcome after allogeneic transplantation for hematological malignancies from unrelated donors: Results from a randomized trial. Biol Blood Marrow Transplant 2012;18:1716-1726.
-
(2012)
Biol Blood Marrow Transplant
, vol.18
, pp. 1716-1726
-
-
Finke, J.1
Schmoor, C.2
Bethge, W.A.3
-
29
-
-
84921727791
-
Impact of donor age on outcome after allogeneic hematopoietic cell transplantation
-
[Epub ahead of print]
-
RezvaniAR, StorerBE,GuthrieKAet al. Impact of donor age on outcome after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2014 [Epub ahead of print].
-
(2014)
Biol Blood Marrow Transplant
-
-
Rezvani, A.R.1
Storer, B.E.2
Guthrie, K.A.3
-
30
-
-
34248339663
-
Lymphocyte reconstitution following allogeneic hematopoietic stem cell transplantation: A retrospective study including 148 patients
-
Heining C, Spyridonidis A, Bernhardt E et al. Lymphocyte reconstitution following allogeneic hematopoietic stem cell transplantation: A retrospective study including 148 patients. Bone Marrow Transplant 2007;39: 613-622.
-
(2007)
Bone Marrow Transplant
, vol.39
, pp. 613-622
-
-
Heining, C.1
Spyridonidis, A.2
Bernhardt, E.3
-
31
-
-
0035282934
-
Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
-
Weinberg K, Blazar BR, Wagner JE et al. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation. Blood 2001;97:1458-1466.
-
(2001)
Blood
, vol.97
, pp. 1458-1466
-
-
Weinberg, K.1
Blazar, B.R.2
Wagner, J.E.3
-
32
-
-
84899969010
-
Aging impairs long-term hematopoietic regeneration after autologous stem cell transplantation
-
Woolthuis CM, Mariani N, Verkaik-Schakel RN et al. Aging impairs long-term hematopoietic regeneration after autologous stem cell transplantation. Biol Blood Marrow Transplant 2014;20:865-871.
-
(2014)
Biol Blood Marrow Transplant
, vol.20
, pp. 865-871
-
-
Woolthuis, C.M.1
Mariani, N.2
Verkaik-Schakel, R.N.3
-
33
-
-
79955951566
-
Age-related changes inhumanhematopoietic stem/progenitor cells
-
Kuranda K, Vargaftig J, de la Rochere P et al. Age-related changes inhumanhematopoietic stem/progenitor cells. Aging Cell 2011;10: 542-546.
-
(2011)
Aging Cell
, vol.10
, pp. 542-546
-
-
Kuranda, K.1
Vargaftig, J.2
de la Rochere, P.3
-
34
-
-
84055200841
-
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
-
PangWW,Price EA, SahooDet al.Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 2011;108: 20012-20017.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 20012-20017
-
-
Pang, W.W.1
Price, E.A.2
Sahoo, D.3
-
35
-
-
40349113288
-
Battling the hematological malignancies: The 200 years' war
-
Lichtman MA. Battling the hematological malignancies: The 200 years' war. The Oncologist 2008;13:126-138.
-
(2008)
The Oncologist
, vol.13
, pp. 126-138
-
-
Lichtman, M.A.1
-
36
-
-
33947430631
-
Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement
-
Jansen MW, Corral L, van der Velden VH et al. Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement. Leukemia 2007;21:633-641.
-
(2007)
Leukemia
, vol.21
, pp. 633-641
-
-
Jansen, M.W.1
Corral, L.2
van der Velden, V.H.3
-
37
-
-
30444437486
-
Treatment of acute lymphoblastic leukemia
-
Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006; 354:166-178.
-
(2006)
N Engl J Med
, vol.354
, pp. 166-178
-
-
Pui, C.H.1
Evans, W.E.2
-
38
-
-
77449145533
-
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
-
Challen GA, Boles NC, ChambersSMet al. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell 2010;6:265-278.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 265-278
-
-
Challen, G.A.1
Boles, N.C.2
Chambers, S.M.3
-
39
-
-
34547692981
-
Longterm propagation of distinct hematopoietic differentiation programs in vivo
-
Dykstra B, Kent D, Bowie M et al. Longterm propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 2007;1:218-229.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 218-229
-
-
Dykstra, B.1
Kent, D.2
Bowie, M.3
-
40
-
-
77953512588
-
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
-
Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med 2010;207:1173-1182.
-
(2010)
J Exp Med
, vol.207
, pp. 1173-1182
-
-
Morita, Y.1
Ema, H.2
Nakauchi, H.3
-
41
-
-
84899817242
-
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
-
Holstege H, Pfeiffer W, Sie D et al. Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis. Genome Res 2014;24:733-742.
-
(2014)
Genome Res
, vol.24
, pp. 733-742
-
-
Holstege, H.1
Pfeiffer, W.2
Sie, D.3
-
42
-
-
33745614062
-
Stem cells, ageing and the quest for immortality
-
Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006;441: 1080-1086.
-
(2006)
Nature
, vol.441
, pp. 1080-1086
-
-
Rando, T.A.1
-
44
-
-
0000055057
-
Pleiotropy, natural selection, and the evolution of senescence
-
Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957;11:398-411.
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
46
-
-
0024625193
-
Natural selection, dietary restriction, and extended longevity
-
Phelan JP, Austad SN. Natural selection, dietary restriction, and extended longevity. Growth Dev Aging 1989;53:4-6.
-
(1989)
Growth Dev Aging
, vol.53
, pp. 4-6
-
-
Phelan, J.P.1
Austad, S.N.2
-
47
-
-
77950265945
-
Linking functional decline of telomeres, mitochondria and stem cells during ageing
-
Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010; 464:520-528.
-
(2010)
Nature
, vol.464
, pp. 520-528
-
-
Sahin, E.1
Depinho, R.A.2
-
48
-
-
0030248792
-
Telomerase activity in hematopoietic cells is associated with self-renewal potential
-
Morrison SJ, Prowse KR, Ho P et al. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 1996;5:207-216.
-
(1996)
Immunity
, vol.5
, pp. 207-216
-
-
Morrison, S.J.1
Prowse, K.R.2
Ho, P.3
-
49
-
-
0032980506
-
In vivo proliferation and cell cycle kinetics of longterm self-renewing hematopoietic stem cells
-
Cheshier SH, Morrison SJ, Liao X et al. In vivo proliferation and cell cycle kinetics of longterm self-renewing hematopoietic stem cells. Proc Natl Acad Sci USA 1999;96:3120-3125.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3120-3125
-
-
Cheshier, S.H.1
Morrison, S.J.2
Liao, X.3
-
50
-
-
33745322046
-
Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
-
Nygren JM, Bryder D, Jacobsen SE. Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property. J Immunol 2006;177:201-208.
-
(2006)
J Immunol
, vol.177
, pp. 201-208
-
-
Nygren, J.M.1
Bryder, D.2
Jacobsen, S.E.3
-
51
-
-
0035896731
-
Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
-
Allsopp RC, Cheshier S, Weissman IL. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med 2001; 193:917-924.
-
(2001)
J Exp Med
, vol.193
, pp. 917-924
-
-
Allsopp, R.C.1
Cheshier, S.2
Weissman, I.L.3
-
52
-
-
0345636016
-
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
-
Allsopp RC, Morin GB, HornerJWet al. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 2003;9:369-371.
-
(2003)
Nat Med
, vol.9
, pp. 369-371
-
-
Allsopp, R.C.1
Morin, G.B.2
Horner, J.W.3
-
53
-
-
0036242246
-
Influences of inbreeding and genetics on telomere length in mice
-
Manning EL, Crossland J, Dewey MJ et al. Influences of inbreeding and genetics on telomere length in mice. Mamm Genome 2002; 13:234-238.
-
(2002)
Mamm Genome
, vol.13
, pp. 234-238
-
-
Manning, E.L.1
Crossland, J.2
Dewey, M.J.3
-
54
-
-
13944249618
-
DNA repair, genome stability, and aging
-
Lombard DB, Chua KF, Mostoslavsky R et al. DNA repair, genome stability, and aging. Cell 2005;120:497-512.
-
(2005)
Cell
, vol.120
, pp. 497-512
-
-
Lombard, D.B.1
Chua, K.F.2
Mostoslavsky, R.3
-
55
-
-
34250001450
-
DNA repair is limiting for haematopoietic stem cells during ageing
-
Nijnik A, Woodbine L, Marchetti C et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007;447:686-690.
-
(2007)
Nature
, vol.447
, pp. 686-690
-
-
Nijnik, A.1
Woodbine, L.2
Marchetti, C.3
-
56
-
-
84874819726
-
Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair
-
Cho JS, Kook SH, Robinson AR et al. Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. STEM CELLS 2013;31:511-525.
-
(2013)
Stem Cells
, vol.31
, pp. 511-525
-
-
Cho, J.S.1
Kook, S.H.2
Robinson, A.R.3
-
57
-
-
84897574744
-
Gadd45a regulates hematopoietic stem cell stress responses in mice
-
Chen Y, Ma X, Zhang M et al. Gadd45a regulates hematopoietic stem cell stress responses in mice. Blood 2014;123:851-862.
-
(2014)
Blood
, vol.123
, pp. 851-862
-
-
Chen, Y.1
Ma, X.2
Zhang, M.3
-
58
-
-
0036713424
-
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice
-
Bender CF, Sikes ML, Sullivan R et al. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.Genes Dev 2002;16:2237-2251.
-
(2002)
Genes Dev
, vol.16
, pp. 2237-2251
-
-
Bender, C.F.1
Sikes, M.L.2
Sullivan, R.3
-
59
-
-
33748043345
-
Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1
-
Navarro S, Meza NW, Quintana-Bustamante O et al. Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1. Mol Ther 2006;14:525-535.
-
(2006)
Mol Ther
, vol.14
, pp. 525-535
-
-
Navarro, S.1
Meza, N.W.2
Quintana-Bustamante, O.3
-
60
-
-
79952338609
-
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
-
Rübe CE, Fricke A, Widmann TA et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One 2011;6:e17487.
-
(2011)
PLoS One
, vol.6
-
-
Rübe, C.E.1
Fricke, A.2
Widmann, T.A.3
-
61
-
-
84904043095
-
Quiescent hematopoietic stem cells accumulate DNA damageduring aging that is repaired uponentry into cell cycle
-
Beerman I, Seita J, Inlay MA et al. Quiescent hematopoietic stem cells accumulate DNA damageduring aging that is repaired uponentry into cell cycle. Cell Stem Cell 2014;15:37-50.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 37-50
-
-
Beerman, I.1
Seita, J.2
Inlay, M.A.3
-
62
-
-
84865433349
-
DNA damage checkpoints in stem cells, ageing and cancer
-
Sperka T, Wang J, Rudolph KL. DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol 2012;13:579-590.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 579-590
-
-
Sperka, T.1
Wang, J.2
Rudolph, K.L.3
-
63
-
-
33746016268
-
Mitochondria: More than just a powerhouse
-
McBride HM, Neuspiel M, Wasiak S. Mitochondria: More than just a powerhouse. Curr Biol 2006;16:R551-R560.
-
(2006)
Curr Biol
, vol.16
, pp. R551-R560
-
-
McBride, H.M.1
Neuspiel, M.2
Wasiak, S.3
-
64
-
-
84877922143
-
The role of mitochondrial DNA mutations and free radicals in disease and ageing
-
Lagouge M, Larsson NG. The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med 2013;273: 529-543.
-
(2013)
J Intern Med
, vol.273
, pp. 529-543
-
-
Lagouge, M.1
Larsson, N.G.2
-
65
-
-
0037375044
-
Oxidative stressinduced mitochondrial DNA damage in human retinal pigment epithelial cells: A possible mechanism for RPE aging and age-related macular degeneration
-
Liang FQ, Godley BF. Oxidative stressinduced mitochondrial DNA damage in human retinal pigment epithelial cells: A possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res 2003;76: 397-403.
-
(2003)
Exp Eye Res
, vol.76
, pp. 397-403
-
-
Liang, F.Q.1
Godley, B.F.2
-
66
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D. The biologic clock: The mitochondria? J Am Geriatr Soc 1972;20:145-147.
-
(1972)
J Am Geriatr Soc
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
67
-
-
77953627194
-
Somatic mitochondrial DNA mutations in mammalian aging
-
Larsson NG. Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 2010;79:683-706.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 683-706
-
-
Larsson, N.G.1
-
68
-
-
84898997182
-
Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects
-
Wahlestedt M, Ameur A, Moraghebi R et al. Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects. STEM CELLS 2014;32:1173-1182.
-
(2014)
Stem Cells
, vol.32
, pp. 1173-1182
-
-
Wahlestedt, M.1
Ameur, A.2
Moraghebi, R.3
-
69
-
-
84883489939
-
Mitochondrial regulation in pluripotent stem cells
-
Xu X, Duan S, Yi F et al. Mitochondrial regulation in pluripotent stem cells. Cell Metab 2013;18:325-332.
-
(2013)
Cell Metab
, vol.18
, pp. 325-332
-
-
Xu, X.1
Duan, S.2
Yi, F.3
-
70
-
-
65049086788
-
Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression
-
Noda S, Ichikawa H, Miyoshi H. Hematopoietic stem cell aging is associated with functional decline and delayed cell cycle progression. Biochem Biophys Res Commun 2009;383:210-215.
-
(2009)
Biochem Biophys Res Commun
, vol.383
, pp. 210-215
-
-
Noda, S.1
Ichikawa, H.2
Miyoshi, H.3
-
71
-
-
84899768899
-
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
-
Sun D, Luo M, JeongMet al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 2014;14:673-688.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 673-688
-
-
Sun, D.1
Luo, M.2
Jeong, M.3
-
72
-
-
84884938274
-
DNA methylation analysis of murine hematopoietic side population cells during aging
-
Taiwo O, Wilson GA, Emmett W et al. DNA methylation analysis of murine hematopoietic side population cells during aging. Epigenetics 2013;8:1114-1122.
-
(2013)
Epigenetics
, vol.8
, pp. 1114-1122
-
-
Taiwo, O.1
Wilson, G.A.2
Emmett, W.3
-
73
-
-
33847084602
-
Genome regulation by polycomb and trithorax proteins
-
SchuettengruberB,Chourrout D,Vervoort Met al. Genome regulation by polycomb and trithorax proteins. Cell 2007;128:735-745.
-
(2007)
Cell
, vol.128
, pp. 735-745
-
-
Schuettengruber, B.1
Chourrout, D.2
Vervoort, M.3
-
74
-
-
33947134834
-
The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
BrackenAP, Kleine-Kohlbrecher D, Dietrich N et al. The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 2007;21: 525-530.
-
(2007)
Genes Dev
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
Kleine-Kohlbrecher, D.2
Dietrich, N.3
-
76
-
-
67349161638
-
Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence
-
Attema JL, Pronk CJ, Norddahl GL et al. Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence. Oncogene 2009;28:2238-2243.
-
(2009)
Oncogene
, vol.28
, pp. 2238-2243
-
-
Attema, J.L.1
Pronk, C.J.2
Norddahl, G.L.3
-
77
-
-
77449159608
-
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1
-
Oguro H, Yuan J, Ichikawa H et al. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010;6: 279-286.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 279-286
-
-
Oguro, H.1
Yuan, J.2
Ichikawa, H.3
-
78
-
-
84891740118
-
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stagespecific manner
-
Xie H, Xu J, Hsu JH et al. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stagespecific manner. Cell Stem Cell 2014;14:68-80.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 68-80
-
-
Xie, H.1
Xu, J.2
Hsu, J.H.3
-
79
-
-
84906791827
-
Circulating small noncoding RNAs as biomarkers of aging
-
Dhahbi JM. Circulating small noncoding RNAs as biomarkers of aging. Ageing Res Rev 2014;17:86-98.
-
(2014)
Ageing Res Rev
, vol.17
, pp. 86-98
-
-
Dhahbi, J.M.1
-
80
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
81
-
-
84886859638
-
Chromatin dynamics during cellular reprogramming
-
Apostolou E, Hochedlinger K. Chromatin dynamics during cellular reprogramming. Nature 2013;502:462-471.
-
(2013)
Nature
, vol.502
, pp. 462-471
-
-
Apostolou, E.1
Hochedlinger, K.2
-
82
-
-
80054726357
-
Direct lineage conversions: Unnatural but useful?
-
Vierbuchen T, Wernig M. Direct lineage conversions: Unnatural but useful? Nat Biotechnol 2011;29:892-907.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 892-907
-
-
Vierbuchen, T.1
Wernig, M.2
-
83
-
-
78649471039
-
Direct conversion of human fibroblasts to multilineage blood progenitors
-
Szabo E, Rampalli S, Risue~no RMet al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010;468: 521-526.
-
(2010)
Nature
, vol.468
, pp. 521-526
-
-
Szabo, E.1
Rampalli, S.2
Risue~no, R.M.3
-
84
-
-
84881149632
-
Induction of a hemogenic program in mouse fibroblasts
-
Pereira CF, Chang B, Qiu J et al. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013;13:205-218.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 205-218
-
-
Pereira, C.F.1
Chang, B.2
Qiu, J.3
-
85
-
-
84885115285
-
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors
-
Doulatov S, Vo LT, Chou SS et al. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell 2013;13:459-470.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 459-470
-
-
Doulatov, S.1
Vo, L.T.2
Chou, S.S.3
-
86
-
-
84899527626
-
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors
-
Riddell J, Gazit R, Garrison BS et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 2014;157:549-564.
-
(2014)
Cell
, vol.157
, pp. 549-564
-
-
Riddell, J.1
Gazit, R.2
Garrison, B.S.3
-
87
-
-
84879588905
-
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages
-
Satoh Y, Yokota T, Sudo T et al. The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages. Immunity 2013;38:1105-1115.
-
(2013)
Immunity
, vol.38
, pp. 1105-1115
-
-
Satoh, Y.1
Yokota, T.2
Sudo, T.3
-
88
-
-
84874238886
-
SIRT3 reverses aging-associated degeneration
-
Brown K, Xie S, Qiu X et al. SIRT3 reverses aging-associated degeneration. Cell Reports 2013;3:319-327.
-
(2013)
Cell Reports
, vol.3
, pp. 319-327
-
-
Brown, K.1
Xie, S.2
Qiu, X.3
-
89
-
-
84872527628
-
mTOR is a key modulator of ageing and age-related disease
-
Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013;493:338-345.
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
90
-
-
75549090275
-
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen C, Liu Y, Liu Y et al. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009;2:ra75.
-
(2009)
Sci Signal
, vol.2
-
-
Chen, C.1
Liu, Y.2
Liu, Y.3
-
91
-
-
84888021623
-
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
-
Florian MC, Nattamai KJ, Dörr K et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 2013;503:392-396.
-
(2013)
Nature
, vol.503
, pp. 392-396
-
-
Florian, M.C.1
Nattamai, K.J.2
Dörr, K.3
-
92
-
-
84858649330
-
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
-
Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 2012;119:2500-2509.
-
(2012)
Blood
, vol.119
, pp. 2500-2509
-
-
Ergen, A.V.1
Boles, N.C.2
Goodell, M.A.3
-
93
-
-
84869187141
-
Lnk deficiency partially mitigates hematopoietic stem cell aging
-
Bersenev A, Rozenova K, Balcerek J et al. Lnk deficiency partially mitigates hematopoietic stem cell aging. Aging Cell 2012;11:949-959.
-
(2012)
Aging Cell
, vol.11
, pp. 949-959
-
-
Bersenev, A.1
Rozenova, K.2
Balcerek, J.3
-
94
-
-
84869186672
-
Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function
-
Norddahl GL,WahlestedtM, Gisler S et al. Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function. Aging Cell 2012;11:1128-1131.
-
(2012)
Aging Cell
, vol.11
, pp. 1128-1131
-
-
Norddahl, G.L.1
Wahlestedt, M.2
Gisler, S.3
-
95
-
-
84902185782
-
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
-
Cheng CW, Adams GB, Perin L et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 2014;14:810-823.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 810-823
-
-
Cheng, C.W.1
Adams, G.B.2
Perin, L.3
-
96
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
Loffredo FS, Steinhauser ML, JaySMet al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 2013;153:828-839.
-
(2013)
Cell
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
Steinhauser, M.L.2
Jay, S.M.3
-
97
-
-
84900338737
-
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
-
Katsimpardi L, Litterman NK, Schein PA et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 2014;344:630-634.
-
(2014)
Science
, vol.344
, pp. 630-634
-
-
Katsimpardi, L.1
Litterman, N.K.2
Schein, P.A.3
-
98
-
-
84900323323
-
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
-
SinhaM, Jang YC,OhJ et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 2014;344:649-652.
-
(2014)
Science
, vol.344
, pp. 649-652
-
-
Sinha, M.1
Jang, Y.C.2
Oh, J.3
-
99
-
-
84886794616
-
Senescence and aging: The critical roles of p53
-
Rufini A, Tucci P, Celardo I et al. Senescence and aging: The critical roles of p53. Oncogene 2013;32:5129-5143.
-
(2013)
Oncogene
, vol.32
, pp. 5129-5143
-
-
Rufini, A.1
Tucci, P.2
Celardo, I.3
-
100
-
-
84901033538
-
Germline TP53 mutations and the changing landscape of Li-Fraumeni syndrome
-
Kamihara J, Rana HQ, Garber JE. Germline TP53 mutations and the changing landscape of Li-Fraumeni syndrome. Hum Mutat 2014;35:654-662.
-
(2014)
Hum Mutat
, vol.35
, pp. 654-662
-
-
Kamihara, J.1
Rana, H.Q.2
Garber, J.E.3
-
101
-
-
84898049056
-
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in b-thalassemia
-
Dussiot M, Maciel TT, Fricot A et al. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in b-thalassemia. Nat Med 2014;20:398-407.
-
(2014)
Nat Med
, vol.20
, pp. 398-407
-
-
Dussiot, M.1
Maciel, T.T.2
Fricot, A.3
-
102
-
-
84898042418
-
Transforming growth factor-bsuperfamily ligand trap ACE-536 corrects anemiaby promoting late-stage erythropoiesis
-
Suragani RN, Cadena SM, Cawley SM et al. Transforming growth factor-bsuperfamily ligand trap ACE-536 corrects anemiaby promoting late-stage erythropoiesis. NatMed2014;20: 408-414.
-
(2014)
NatMed
, vol.20
, pp. 408-414
-
-
Suragani, R.N.1
Cadena, S.M.2
Cawley, S.M.3
|