Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair

Stem Cells

Volumn 31, Issue 3, 2013, Pages 511-525

  Cho, Joon Seok ^a,b   Kook, Sung Ho ^a,b   Robinson, Andria Rasile ^a,c   Niedernhofer, Laura J ^a,b,d   Lee, Byeong Chel ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Aging; Nich; Oxidative DNA damage; Progerias; Stem cell

Indexed keywords

ENDONUCLEASE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DEATH; CELL FUNCTION; CELL LOSS; CELL POPULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HEMATOPOIETIC STEM CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; OSTEOCLAST ACTIVITY; PROTEIN EXPRESSION; SENESCENCE;

ANIMALS; CELL GROWTH PROCESSES; CELLULAR MICROENVIRONMENT; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ENDONUCLEASES; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MUTATION;

EID: 84874819726     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1261     Document Type: Article

References (51)

1. Beerman I, Maloney WJ, Weissmann IL et al. Stem cells and the aging hematopoietic system. Curr Opin Immunol 2010;22: 500-506.
2. Morrison SJ, Wandycz AM, Akashi K et al. The aging of hematopoietic stem cells. Nat Med 1996;2: 1011-1016.
3. Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010;464: 520-528.
4. Niedernhofer LJ. DNA repair is crucial for maintaining hematopoietic stem cell function. DNA Repair (Amst) 2008;7: 523-529.
5. Barnes DE, Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 2004; 38: 445-476.
6. Rossi DJ, Bryder D, Seita J et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725-729.
7. Nijnik A, Woodbine L, Marchetti C et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007;447: 686-690.
8. Lucas D, Escudero B, Ligos JM et al. Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. PLoS Genet 2009;5:e1000389.
9. Parmar K, Kim J, Sykes SM et al. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells 2010;28: 1186-1195.
10. Niedernhofer LJ, Odijk H, Budzowska M et al. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol 2004;24: 5776-5787.
11. Bhagwat N, Olsen AL, Wang AT et al. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol 2009; 29: 6427-6437.
12. Ahmad A, Robinson AR, Duensing A et al. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol 2008; 28: 5082-5092.
13. Gregg SQ, Robinson AR, Niedernhofer LJ. Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease. DNA Repair (Amst) 2011;10: 781-791.
14. Gregg SQ, Gutierrez V, Robinson AR et al. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology 2012;55: 609-621.
15. Vo N, Seo HY, Robinson A et al. Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res 2010;28: 1600-1607.
16. Lavasani M, Robinson AR, Lu A et al. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012;3: 608.
17. Rossi DJ, Bryder D, Zahn JM et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005;102: 9194-9199.
18. Prasher JM, Lalai AS, Heijmans-Antonissen C et al. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J 2005;24: 861-871.
19. Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol 2006;176: 1007-1012.
20. Schofield R, Dexter TM, Lord BI et al. Comparison of haemopoiesis in young and old mice. Mech Ageing Dev 1986;34: 1-12.
21. Ju Z, Jiang H, Jaworski M et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 2007;13: 742-747.
22. Osawa M, Hanada K, Hamada H et al. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996;273: 242-245.
23. Kiel MJ, Yilmaz OH, Iwashita T et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121: 1109-1121.
24. Akashi K, Traver D, Miyamoto T et al. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193-197.
25. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997;91: 661-672.
26. Parrinello S, Samper E, Krtolica A et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003;5: 741-747.
27. Tothova Z, Gilliland DG. FoxO transcription factors and stem cell homeostasis: Insights from the hematopoietic system. Cell Stem Cell 2007;1: 140-152.
28. Benarafa C, LeCuyer TE, Baumann M et al. SerpinB1 protects the mature neutrophil reserve in the bone marrow. J Leukoc Biol 2011; 90: 21-29.
29. Calvi LM, Adams GB, Weibrecht KW et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425: 841-846.
30. Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425: 836-841.
31. Kollet O, Dar A, Shivtiel S et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 2006;12: 657-664.
32. Purton LE, Scadden DT. Osteoclasts eat stem cells out of house and home. Nat Med 2006;12: 610-611.
33. Ogawa T, Kitagawa M, Hirokawa K. Age-related changes of human bone marrow: A histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev 2000;117: 57-68.
34. Naka K, Hirao A. Maintenance of genomic integrity in hematopoietic stem cells. Int J Hematol 2011;93: 434-439.
35. Rossi DJ, Bryder D, Weissman IL. Hematopoietic stem cell aging: Mechanism and consequence. Exp Gerontol 2007;42: 385-390.
36. Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007;8: 703-713.
37. Zhu XD, Niedernhofer L, Kuster B et al. ERCC1/XPF removes the overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell 2003; 12: 1489-1498.
38. Schrader CE, Vardo J, Linehan E et al. Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med 2004;200: 321-330.
39. Abbas HA, Maccio DR, Coskun S et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell 2010;7: 606-617.
40. Gu BW, Fan JM, Bessler M et al. Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment. Aging Cell 2011;10: 338-348.
41. Ito K, Hirao A, Arai F et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004; 431: 997-1002.
42. Satyanarayana A, Rudolph KL. p16 and ARF: Activation of teenage proteins in old age. J Clin Invest 2004;114: 1237-1240.
43. Janzen V, Forkert R, Fleming HE et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006;443: 421-426.
44. Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008;132: 681-696.
45. Silva H, Conboy IM. Aging and stem cell renewal.2008. StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; Jul 15. http://www.ncbi.nlm.nih.gov/pubmed/20614587.
46. Walkley CR, Shea JM, Sims NA et al. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 2007;129: 1081-1095.
47. Peled A, Petit I, Kollet O et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999;283: 845-848.
48. Tothova Z, Kollipara R, Huntly BJ et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007;128: 325-339.
49. Park IK, Qian D, Kiel M et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423: 302-305.
50. de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999;93: 3294-3301.
51. Cho J, Shen H, Yu H et al. Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood 2011;117: 1156-1166.