Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

Genome Research

Volumn 24, Issue 5, 2014, Pages 733-742

  Holstege, Henne ^a   Pfeiffer, Wayne ^b   Sie, Daoud ^a   Hulsman, Marc ^c   Nicholas, Thomas J ^d   Lee, Clarence C ^e   Ross, Tristen ^e   Lin, Jue ^f   Miller, Mark A ^b   Ylstra, Bauke ^a   Meijers Heijboer, Hanne ^a   Brugman, Martijn H ^g   Staal, Frank J T ^g   Holstege, Gert ^h   Reinders, Marcel J T ^c   Harkins, Timothy T ^e   Levy, Samuel ^d   Sistermans, Erik A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE   (United States)

^e Life Technologies   (United States)

^f Advanced Applications Group Life Technologies ^*  (United States)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; AT RICH SEQUENCE; CASE REPORT; CELL CLONE; DNA REPAIR; FEMALE; FITNESS; GENE FREQUENCY; GENE SEQUENCE; GENETIC TRANSCRIPTION; GERMLINE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN GENOME; INDEL MUTATION; LEUKOCYTE; PRIORITY JOURNAL; PROGENY; SOMATIC MUTATION; TELOMERE HOMEOSTASIS; VERY ELDERLY; CELL LINEAGE; CLONAL EVOLUTION; CYTOLOGY; GENETICS; GENOME; LONGEVITY; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TELOMERE; TELOMERE SHORTENING;

AGED, 80 AND OVER; AT RICH SEQUENCE; CELL LINEAGE; CLONAL EVOLUTION; CONSERVED SEQUENCE; FEMALE; GENE FREQUENCY; GENOME; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKOCYTES; LONGEVITY; MUTATION; TELOMERE; TELOMERE SHORTENING;

EID: 84899817242     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.162131.113     Document Type: Article

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