Synthetic protein switches: Design principles and applications

Trends in Biotechnology

Volumn 33, Issue 2, 2015, Pages 101-110

  Stein, Viktor ^a   Alexandrov, Kirill ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Biosensors; Molecular diagnostics; Protein engineering; Protein switches; Signaling; Synthetic biology

Indexed keywords

BIOSENSORS; MACHINERY; PROTEINS; SIGNAL TRANSDUCTION; SIGNALING; TIME SWITCHES;

BIOLOGICAL SIGNALS; INTEGRATED FASHION; MOLECULAR DIAGNOSTICS; MOLECULAR FUNCTION; PHYSIOLOGICAL STATE; PROTEIN ENGINEERING; PROTEIN SWITCHES; SYNTHETIC BIOLOGY;

CELL SIGNALING;

BETA LACTAMASE; CYTOSINE DEAMINASE; FIREFLY LUCIFERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MALTOSE BINDING PROTEIN; PROTEIN; PROTEIN KINASE B; PROTEIN TAG; CALMODULIN; CALMODULIN BINDING PROTEIN; LUCIFERASE;

ALLOSTERIC FLUORESCENT PROTEIN SWITCH; ALLOSTERISM; BINDING AFFINITY; BIOSENSOR; CELL FUNCTION; CONFORMATIONAL TRANSITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HOST CELL; HUMAN; LIGHT DEPENDENT PROTEIN SWITCH; LUCIFERASE BASED INDICATORS OF DRUG; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; PROTEIN SWITCH; PROTEIN UNFOLDING; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SNAP TAG BASED INDICATOR WITH A FLUORESCENT INTRAMOLECULAR TETHER; SYNTHETIC BIOLOGY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; METABOLISM; PHOTOTRANSDUCTION; PROCEDURES; REPORTER GENE;

ALLOSTERIC REGULATION; BETA-LACTAMASES; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER TECHNIQUES; CALMODULIN; CALMODULIN-BINDING PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION; GENES, REPORTER; HUMANS; LIGHT SIGNAL TRANSDUCTION; LUCIFERASES; MALTOSE-BINDING PROTEINS; PROTEIN ENGINEERING; PROTEIN FOLDING; SYNTHETIC BIOLOGY;

EID: 84921565935     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2014.11.010     Document Type: Review

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