Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

Nature

Volumn 447, Issue 7144, 2007, Pages 596-600

  Yeh, Brian J ^a   Rutigliano, Robert J ^b   Deb, Anrica ^a   Bar Sagi, Dafna ^b,c   Lim, Wendell A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR;

CYTOPLASM; EUKARYOTE; GENOME; HOMOLOGY; MORPHOLOGY; MOTILITY; ORGANIC COMPOUND; PROTEIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL FUNCTION; CELL STRUCTURE; EMBRYO; EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN STRUCTURE; RAT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EUKARYOTA;

EID: 34249894454     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05851     Document Type: Article

References (30)

1. Jaffe, A. B. & Hall, A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269 (2005).
2. Hoffman, G. R. & Cerione, R. A. Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett. 513, 85-91 (2002).
3. Rossman, K. L., Der, C. J. & Sondek, J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Rev. Mol. Cell Biol. 6, 167-180 (2005).
4. Pawson, T. & Nash, P. Assembly of cell regulatory systems through protein interaction domains. Science 300, 445-452 (2003).
5. Bhattacharyya, R. P., Remenyi, A., Yeh, B. J. & Lim, W. A. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu. Rev. Biochem. 75, 655-680 (2006).
6. Walsh, D. A. & Van Patten, S. M. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J. 8, 1227-1236 (1994).
7. Kim, E. & Sheng, M. PDZ domain proteins of synapses. Nature Rev. Neurosci. 5, 771-781 (2004).
8. Wiedemann, U. et al. Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J. Mol. Biol. 343, 703-718 (2004).
9. Songyang, Z. et al. Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr. Biol. 4, 973-982 (1994).
10. Snyder, J. T. et al. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Struct. Biol. 9, 468-475 (2002).
11. Zamanian, J. L. & Kelly, R. B. Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis. Mol. Biol. Cell 14, 1624-1637 (2003).
12. Debant, A. et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl Acad. Sci. USA 93, 5466-5471 (1996).
13. Dueber, J. E., Mirsky, E. A. & Lim, W. A. Engineering synthetic signaling proteins with ultrasensitive input/output contol. Nature Biotech. (in the press) (2007).
14. Nimnual, A. S., Yatsula, B. A. & Bar-Sagi, D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279, 560-563 (1998).
15. Seamon, K. B. & Daly, J. W. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res. 7, 201-224 (1981).
16. Ferrell, J. E. Jr. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21, 460-466 (1996).
17. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E. M. & Chan, J. R. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc. Natl Acad. Sci. USA 102, 14889-14894 (2005).
18. Miki, H., Sasaki, T., Takai, Y. & Takenawa, T. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 391, 93-96 (1998).
19. Rohatgi, R. et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97, 221-231 (1999).
20. Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A. & Rosen, M. K. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404, 151-158 (2000).
21. Prehoda, K. E., Scott, J. A., Mullins, R. D. & Lim, W. A. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science 290, 801-806 (2000).
22. Hooshangi, S., Thiberge, S. & Weiss, R. Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. Proc. Natl Acad. Sci. USA 102, 3581-3586 (2005).
23. Colicelli, J. Human RAS superfamily proteins and related GTPases. Sci. STKE 2004, RE13 (2004).
24. Dueber, J. E., Yeh, B. J., Chak, K. & Lim, W. A. Reprogramming control of an allosteric signaling switch through modular recombination. Science 301, 1904-1908 (2003).
25. Howard, P. L., Chia, M. C., Del Rizzo, S., Liu, F. F. & Pawson, T. Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc. Natl Acad. Sci. USA 100, 11267-11272 (2003).
26. Park, S. H., Zarrinpar, A. & Lim, W. A. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299, 1061-1064 (2003).
27. Inoue, T., Heo, W. D., Grimley, J. S., Wandless, T. J. & Meyer, T. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nature Methods 2, 415-418 (2005).
28. Sprinzak, D. & Elowitz, M. B. Reconstruction of genetic circuits. Nature 438, 443-448 (2005).
29. Voigt, C. A. Genetic parts to program bacteria. Curr. Opin. Biotechnol. 17, 548-557 (2006).
30. Patel, J. C. & Galan, J. E. Manipulation of the host actin cytoskeleton by Salmonella - all in the name of entry. Curr. Opin. Microbiol. 8, 10-15 (2005).