Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12420-12425

  Chu, Pei Hsuan ^a   Tsygankov, Denis ^a   Berginski, Matthew E ^b   Dagliyan, Onur ^a   Gomez, Shawn M ^b   Elston, Timothy C ^a   Karginov, Andrei V ^a,d   Hahn, Klaus M ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Image analysis; Live cell imaging; Motion classification; Protein engineering; Rapamycin

Indexed keywords

FK 506 BINDING PROTEIN; ISOPROTEIN; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE YES; PROTEIN SH3; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP; RAPAMYCIN; HYBRID PROTEIN; ISOENZYME;

ACYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MEMBRANE; CELL MOTILITY; CELL MOTION; CELL SPREADING; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; COS 7 CELL LINE; DYNAMICS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETIC MANIPULATION; IMAGE ANALYSIS; MICROTUBULE; PALMITOYLATION; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BIOPHYSICS; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SRC HOMOLOGY DOMAIN;

ACYLATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BIOPHYSICAL PHENOMENA; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PROTEIN ENGINEERING; PROTO-ONCOGENE PROTEINS C-FYN; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; TACROLIMUS BINDING PROTEIN 1A;

EID: 84906679884     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404487111     Document Type: Article

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