Engineering an artificial zymogen by alternate frame protein folding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 2824-2829

  Mitrea, Diana M ^a   Parsons, Lee S ^a   Loh, Stewart N ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Design; HIV protease; Molecular switch; Mutually exclusive folding

Indexed keywords

ENZYME PRECURSOR; POLYPEPTIDE; PROTEINASE; RIBONUCLEASE; RIBONUCLEASE BARNASE; TRYPSIN; UNCLASSIFIED DRUG; UREA;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BIOENGINEERING; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; STRUCTURE ANALYSIS; SURFACE PROPERTY; THERMODYNAMICS; X RAY ANALYSIS;

AMINO ACID SEQUENCE; ENZYME PRECURSORS; HIV PROTEASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; RIBONUCLEASES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77649241924     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907668107     Document Type: Article

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