Rational design of a ligand-controlled protein conformational switch

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 17, 2013, Pages 6800-6804

  Dagliyan, Onur ^a   Shirvanyants, David ^a   Karginov, Andrei V ^a   Ding, Feng ^a   Fee, Lanette ^a   Chandrasekaran, Srinivas N ^a   Freisinger, Christina M ^b   Smolen, Gromoslaw A ^b   Huttenlocher, Anna ^b   Hahn, Klaus M ^a   Dokholyan, Nikolay V ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cell motility; Endothelial mesenchymal transition; Spatiotemporal control

Indexed keywords

LIGAND; PROTEIN TYROSINE KINASE; RAPAMYCIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; UNIRAPR PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; COMPUTER MODEL; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE; SRC HOMOLOGY DOMAIN; ZEBRA FISH;

ANIMALS; COMPUTATIONAL BIOLOGY; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; HELA CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEINS; SRC-FAMILY KINASES; THERMODYNAMICS; ZEBRAFISH;

DANIO RERIO;

EID: 84876882853     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218319110     Document Type: Article

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