Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 141-146

  Ye, Haifeng ^a   Charpin El Hamri, Ghislaine ^b   Zwicky, Katharina ^a   Christen, Matthias ^a   Folcher, Marc ^a   Fussenegger, Martin ^a,c  

^a ETH ZURICH   (Switzerland)

^b Institut Universitaire de Technologie   (France)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Gene expression; Gene regulation; Prosthetic networks; Synthetic gene circuits

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FC RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GUANABENZ; GUANABENZ ACETATE; LEPTIN; LIPID; NUCLEAR PROTEIN; PEPTIDE HORMONE; TRACEAMINE ASSOCIATED RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DYSLIPIDEMIA; FEMALE; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERTENSION; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GENE EXPRESSION REGULATION; GLUCAGON-LIKE PEPTIDE 1; GUANABENZ; LEPTIN; METABOLIC SYNDROME X; MICE; MODELS, MOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSGENES;

MUS;

EID: 84872001455     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1216801110     Document Type: Article

References (38)

1. Banegas JR, et al. (2007) Relationship between obesity, hypertension and diabetes, and health-related quality of life among the elderly. Eur J Cardiovasc Prev Rehabil 14(3):456-462. (Pubitemid 46945573)
2. Grundy SM (2006) Drug therapy of the metabolic syndrome: Minimizing the emerging crisis in polypharmacy. Nat Rev Drug Discov 5(4):295-309.
3. Després JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444 (7121):881-887.
4. Zitzmann M (2009) Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol 5(12):673-681.
5. Cleland SJ (2012) Cardiovascular risk in double diabetes mellitus - When two worlds collide. Nat Rev Endocrinol 8(8):476-485.
6. DeSouza C, Fonseca V (2009) Therapeutic targets to reduce cardiovascular disease in type 2 diabetes. Nat Rev Drug Discov 8(5):361-367.
7. Betteridge DJ (2011) Lipid control in patients with diabetes mellitus. Nat Rev Cardiol 8(5):278-290.
8. Caglayan E, Blaschke F, Takata Y, Hsueh WA (2005) Metabolic syndrome-interdependence of the cardiovascular and metabolic pathways. Curr Opin Pharmacol 5(2):135-142. (Pubitemid 40378743)
9. Hashimoto J, et al. (2003) Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension: Evaluation using home-based blood pressure measurements. J Hypertens 21(4):805-811. (Pubitemid 36549677)
10. Hu LA, et al. (2009) Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. Biochem J 424(1):39-45.
11. Liberles SD, Buck LB (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442(7103):645-650. (Pubitemid 44215313)
12. Borowsky B, et al. (2001) Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98(16):8966-8971. (Pubitemid 32743853)
13. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (1988) Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA. Science 242(4884):1430-1433. (Pubitemid 19008071)
14. Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell 119(5):679-691. (Pubitemid 39535755)
15. Holz GG, 4th, Kühtreiber WM, Habener JF (1993) Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 361(6410):362-365. (Pubitemid 23041630)
16. Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ (2011) GLP-1 and energy balance: An integrated model of short-term and long-term control. Nat Rev Endocrinol 7(9):507-516.
17. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395(6704):763-770. (Pubitemid 28485436)
18. Lundberg C, Jungles SJ, Mulligan RC (2001) Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy. Nat Biotechnol 19(2):169-172. (Pubitemid 32144448)
19. O'Shaughnessy EC, Palani S, Collins JJ, Sarkar CA (2011) Tunable signal processing in synthetic MAP kinase cascades. Cell 144(1):119-131.
20. Culler SJ, Hoff KG, Smolke CD (2010) Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science 330(6008):1251-1255.
21. Weber W, Fussenegger M (2012) Emerging biomedical applications of synthetic biology. Nat Rev Genet 13(1):21-35.
22. Ruder WC, Lu T, Collins JJ (2011) Synthetic biology moving into the clinic. Science 333 (6047):1248-1252.
23. Xie Z, Wroblewska L, Prochazka L, Weiss R, Benenson Y (2011) Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science 333(6047):1307- 1311.
24. Forbes NS (2010) Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer 10(11):785-794.
25. Xiang S, Fruehauf J, Li CJ (2006) Short hairpin RNA-expressing bacteria elicit RNA interference in mammals. Nat Biotechnol 24(6):697-702. (Pubitemid 43882121)
26. Larman HB, et al. (2011) Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol 29(6):535-541.
27. Coleman JR, et al. (2008) Virus attenuation by genome-scale changes in codon pair bias. Science 320(5884):1784-1787. (Pubitemid 351931294)
28. Ye H, Daoud-El Baba M, Peng RW, Fussenegger M (2011) A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332(6037):1565-1568.
29. Kemmer C, et al. (2010) Self-sufficient control of urate homeostasis in mice by a synthetic circuit. Nat Biotechnol 28(4):355-360.
30. Drucker DJ, Nauck MA (2006) The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368(9548):1696-1705. (Pubitemid 46048557)
31. Farooqi IS, et al. (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110(8):1093-1103.
32. Heymsfi eld SB, et al. (1999) Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial. JAMA 282(16):1568-1575.
33. Field BC, Chaudhri OB, Bloom SR (2009) Obesity treatment: Novel peripheral targets. Br J Clin Pharmacol 68(6):830-843.
34. Kemmer C, et al. (2011) A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms. J Control Release 150(1):23-29.
35. Kumar M, Hunag Y, Glinka Y, Prud'homme GJ, Wang Q (2007) Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Gene Ther 14(2):162-172. (Pubitemid 46043821)
36. Schlatter S, Rimann M, Kelm J, Fussenegger M (2002) SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase. Gene 282 (1-2):19-31. (Pubitemid 34117558)
37. Weber W, et al. (2004) Gas-inducible transgene expression in mammalian cells and mice. Nat Biotechnol 22(11):1440-1444. (Pubitemid 39482865)
38. Peng RW, Guetg C, Tigges M, Fussenegger M (2010) The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells. Metab Eng 12(1):18-25.