Specific ion and buffer effects on protein-protein interactions of a monoclonal antibody

Molecular Pharmaceutics

Volumn 12, Issue 1, 2015, Pages 179-193

  Roberts, D ^a   Keeling, R ^a   Tracka, M ^b   Van Der Walle, C F ^b   Uddin, S ^b   Warwicker, J ^a   Curtis, R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

Hofmeister; monoclonal antibody; protein protein interactions; second virial coefficients; specific ion effects; thiocyanate

Indexed keywords

ACETIC ACID; ANION; CALCIUM CHLORIDE; CITRIC ACID; HISTIDINE; MONOCLONAL ANTIBODY; PHOSPHATE; SODIUM CHLORIDE; SODIUM SULFATE; SUCCINIC ACID; THIOCYANATE SODIUM; TROMETAMOL; BUFFER; CHLORIDE; INORGANIC SALT; ION; SULFATE; THIOCYANATE; THIOCYANIC ACID DERIVATIVE; CATION; GLOBULAR PROTEIN;

ARTICLE; BINDING AFFINITY; ELECTROPHORETIC MOBILITY; IONIC STRENGTH; LIGHT SCATTERING; PH; PROTEIN PROTEIN INTERACTION; CHEMISTRY; DOSE RESPONSE; KINETICS; LIGHT; PROTEIN ANALYSIS; RADIATION SCATTERING; ADSORPTION; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; STATIC ELECTRICITY;

ANTIBODIES, MONOCLONAL; BUFFERS; CALCIUM CHLORIDE; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; IONS; KINETICS; LIGHT; PROTEIN INTERACTION MAPPING; SALTS; SCATTERING, RADIATION; SODIUM CHLORIDE; SULFATES; THIOCYANATES;

EID: 84920449254     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500533c     Document Type: Article

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