Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association

Pharmaceutical Research

Volumn 21, Issue 7, 2004, Pages 1087-1093

  Sukumar, Muppalla ^a   Doyle, Brandon L ^a   Combs, Jessica L ^a   Pekar, Allen H ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

light scattering; protein aggregation; protein formulation; reversible association; turbidity

Indexed keywords

IMMUNOGLOBULIN G1; MONOMER;

ARTICLE; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; CORRELATION COEFFICIENT; DRUG FORMULATION; HUMAN; HYDRODYNAMICS; INTERFEROMETER; LIGHT SCATTERING; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NEPHELOMETRY; NONHUMAN; PRIORITY JOURNAL; ROOM TEMPERATURE; TURBIDITY; ULTRACENTRIFUGATION;

CHEMISTRY, PHYSICAL; DRUG STABILITY; IMMUNOGLOBULIN G; LIGHT; NEPHELOMETRY AND TURBIDIMETRY; REFRIGERATION; SCATTERING, RADIATION; TEMPERATURE; ULTRACENTRIFUGATION;

EID: 3242670796     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000032993.98705.73     Document Type: Article

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